Hulin Wu, Ph.D.

Hulin Wu, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 630
Rochester, NY 14642

Office: (585) 275-6767
Fax: (585) 273-1031

Professional Bio

Longitudinal Data: Nonparametric regression methods and mixed-effects models.
Statistical Methodologies: Markov chain Monte Carlo (MCMC), Bayesian methods, state-space models, measurement error models, missing data, and spatial statistics.
Computational Biology/Bioengineering: Clinical trial modeling and simulations, modeling HIV RNA/cellular dynamics, dynamic prediction of antiviral responses, and modeling AIDS and SARS epidemics. Immunological modeling and data analysis.
Biomedical informatics.
Clinical Trials: AIDS clinical trials, HIV dynamic studies, pharmacokinetics and pharmacodynamics(PK/PD) trials.
Mathematical models of Immunity

Research Bio

My recent research interests include nonparametric regression methods and mixed-effects models for longitudinal data analysis, Bayesian and Monte Carlo filtering approaches for state-space models of biological systems, modeling HIV dynamics and AIDS clinical trials, pharmacokinetics and pharmacodynamics (PK/PD) modeling, and stochastic simulations and modeling of bioterrorist attacks. I am also expanding my research in the area of theoretical immunology.



I received my college education in engineering from the National University of Defense Technology, P.R. China (B.Sc., 1984; M.Sc., 1987). I earned my Ph.D. in statistics from Florida State University in 1994. After two years as a visiting Assistant Professor at the
University of Memphis (TN), I joined Frontier Science & Technology Research Foundation in 1996 as a Senior Statistician to work for Statistical Data Analysis Center (SDAC), currently Center for Biostatistics in AIDS Research (CBAR), Harvard School of Public Health, where I became involved in AIDS clinical trials and HIV dynamic modeling. I served as the Head of Pharmacology/Dynamic Modeling Section at SDAC, Adults AIDS Clinical Trials Group (AACTG) from 1999-2002. I also held an Adjunct Lecturership position at the Department of Biostatistics, Harvard University from 2000-2003. I joined the Department of Biostatistics and Computational Biology, University of Rochester as Professor in 2003.

Since 1998, I have been awarded four research grants to develop statistical methods and mathematical models for HIV dynamics and AIDS clinical trials by NIH. I have advised 9 postdoctoral research fellows from 1998-2005, and most of them obtained academic or research positions at major Universities or Research Institutes after completing their postdoctoral training. I am currently leading a group of faculty and postdoc fellows to work in several NIH-sponsored projects related to modeling of infectious diseases and immune response that include HIV/AIDS and influenza virus.

Recently I received a grant (contract) totaling $10 million over 5 years to establish a Center for Biodefense Immune Modeling (CBIM) where I serve as the Director. I also serve as Chief of the newly established Division of Biomedical Modeling and Informatics (DBMI) in the Department of Biostatistics and Computational Biology.

I received the First Prize Student Paper Award from the Statistics and the Environment Section, American Statistical Association in 1993; the ENAR Student Paper Award from the Eastern North American Region of the Biometrics Society (ENAR) in 1994; the Ralph A. Bradley Award from Department of Statistics, Florida State University in 1994; the Young Investigator Award from the Epidemiology Section, American Statistical Association in 1995; and the Young Scientist Scholarship Fund Award from the International Workshop on HIV Drug Resistance and Treatment Strategies in 1997 and 1998. I served as a grant review member for several AIDS and Related Research sections and special emphasis panels, National Institutes of Health (NIH). I also served as a consultant for other NIH grant review sections and the National Science Foundation (NSF).

Awards & Honors (Local)

Long-term Visitor, the Statistical and Applied Mathematical Science Institute (SAMSI) | Research Triangle Park, NC 2011
The Scientific Advisory Board member, the BMGF-funded (Gate's Foundation) Vaccine Immunology Statistical Center | Fred Hutchinson Cancer Research Center, Seattle, WA 2009 - Present
Fellow of the American Statistical Association 2008
The First Independent Research Support & Transition (FIRST) Awards, National Institutes of Health (NIH) 1998 - 2003
Young Scientist Scholarship Fund Award, the 2nd International Workshop on HIV Drug Resistance and Treatment Strategies | Lake Maggiore, Italy 1998
Young Scientist Scholarship Fund Award, International Workshop on HIV Drug Resistance, Treatment Strategies and Eradication | St. Petersburg, FL 1997
The Young Investigator Award, the 1995 Joint Statistical Meetings, Epidemiology Section, American Statistical Association. 1995
The ENAR Student Paper Award, the 1994 Spring Meetings, the Eastern North American Region of the Biometrics Society (ENAR) | Cleveland, Ohio 1994
Ralph A. Bradley Award (for the most outstanding Ph.D graduate), Department of Statistics, Florida State University (FSU). 1994
First Prize, Student Paper Awards, 1993 Joint Statistical Meetings, Section on Statistics & the Environment, ASA | San Franciso, California 1993
Best First-Year Student Award, Department of Statistics, Florida State University. 1990

Recent Journal Articles

Showing the 5 most recent journal articles. 92 available »

2014 Jul 12
Linel P, Wu S, Deng N, Wu H. "Dynamic transcriptional signatures and network responses for clinical symptoms in influenza-infected human subjects using systems biology approaches." Journal of pharmacokinetics and pharmacodynamics. 2014 Jul 12; Epub 2014 Jul 12.
2014 Jul
Wu S, Xue H, Wu Y, Wu H. "Variable Selection for Sparse High-Dimensional Nonlinear Regression Models by Combining Nonnegative Garrote and Sure Independence Screening." Statistica Sinica. 2014 Jul; 24(3):1365-1387.
2014
Miao H, Sangster MY, Livingstone AM, Hilchey SP, Zhang L, Topham DJ, Mosmann TR, Holden-Wiltse J, Perelson AS, Wu H, Zand MS. "Modeling the dynamics and migratory pathways of virus-specific antibody-secreting cell populations in primary influenza infection." PloS one. 2014 9(8):e104781. Epub 2014 Aug 29.
2014
Liu ZP, Wu H, Zhu J, Miao H. "Systematic identification of transcriptional and post-transcriptional regulations in human respiratory epithelial cells during influenza A virus infection." BMC bioinformatics. 2014 15:336. Epub 2014 Oct 04.
2011
Liu, D.; Lu, T.; Niu, X.; Wu, H. "Mixed-Effects State Space Models for Analysis of Longitudinal Dynamic Systems,". Biometrics. 2011; 67(2): 476-485. Link

Current Appointments

Dean's Professorship - Department of Biostatistics and Computational Biology (SMD)
Professor - Department of Biostatistics and Computational Biology (SMD) - Primary
Professor - Department of Public Health Sciences (SMD)

Education

PhD | Statistics | Florida State University1994
MS | Statistics | Florida State University1991
BS | Engineering | China - Non-Medical School1984