Professional Bio
Longitudinal Data: Nonparametric regression methods and mixed-effects models.
Statistical Methodologies: Markov chain Monte Carlo (MCMC), Bayesian methods, state-space models, measurement error models, missing data, and spatial statistics.
Computational Biology/Bioengineering: Clinical trial modeling and simulations, modeling HIV RNA/cellular dynamics, dynamic prediction of antiviral responses, and modeling AIDS and SARS epidemics. Immunological modeling and data analysis.
Biomedical informatics.
Clinical Trials: AIDS clinical trials, HIV dynamic studies, pharmacokinetics and pharmacodynamics(PK/PD) trials.
Mathematical models of Immunity
Research Bio
My recent research interests include nonparametric regression methods and mixed-effects models for longitudinal data analysis, Bayesian and Monte Carlo filtering approaches for state-space models of biological systems, modeling HIV dynamics and AIDS clinical trials, pharmacokinetics and pharmacodynamics (PK/PD) modeling, and stochastic simulations and modeling of bioterrorist attacks. I am also expanding my research in the area of theoretical immunology.
I received my college education in engineering from the National University of Defense Technology, P.R. China (B.Sc., 1984; M.Sc., 1987). I earned my Ph.D. in statistics from Florida State University in 1994. After two years as a visiting Assistant Professor at the
University of Memphis (TN), I joined Frontier Science & Technology Research Foundation in 1996 as a Senior Statistician to work for Statistical Data Analysis Center (SDAC), currently Center for Biostatistics in AIDS Research (CBAR), Harvard School of Public Health, where I became involved in AIDS clinical trials and HIV dynamic modeling. I served as the Head of Pharmacology/Dynamic Modeling Section at SDAC, Adults AIDS Clinical Trials Group (AACTG) from 1999-2002. I also held an Adjunct Lecturership position at the Department of Biostatistics, Harvard University from 2000-2003. I joined the Department of Biostatistics and Computational Biology, University of Rochester as Professor in 2003.
Since 1998, I have been awarded four research grants to develop statistical methods and mathematical models for HIV dynamics and AIDS clinical trials by NIH. I have advised 9 postdoctoral research fellows from 1998-2005, and most of them obtained academic or research positions at major Universities or Research Institutes after completing their postdoctoral training. I am currently leading a group of faculty and postdoc fellows to work in several NIH-sponsored projects related to modeling of infectious diseases and immune response that include HIV/AIDS and influenza virus.
Recently I received a grant (contract) totaling $10 million over 5 years to establish a Center for Biodefense Immune Modeling (CBIM) where I serve as the Director. I also serve as Chief of the newly established Division of Biomedical Modeling and Informatics (DBMI) in the Department of Biostatistics and Computational Biology.
I received the First Prize Student Paper Award from the Statistics and the Environment Section, American Statistical Association in 1993; the ENAR Student Paper Award from the Eastern North American Region of the Biometrics Society (ENAR) in 1994; the Ralph A. Bradley Award from Department of Statistics, Florida State University in 1994; the Young Investigator Award from the Epidemiology Section, American Statistical Association in 1995; and the Young Scientist Scholarship Fund Award from the International Workshop on HIV Drug Resistance and Treatment Strategies in 1997 and 1998. I served as a grant review member for several AIDS and Related Research sections and special emphasis panels, National Institutes of Health (NIH). I also served as a consultant for other NIH grant review sections and the National Science Foundation (NSF).
| Long-term Visitor, the Statistical and Applied Mathematical Science Institute (SAMSI) | Research Triangle Park, NC |
2011 |
| The Scientific Advisory Board member, the BMGF-funded (Gate's Foundation) Vaccine Immunology Statistical Center | Fred Hutchinson Cancer Research Center, Seattle, WA |
2009 - Present |
| Fellow of the American Statistical Association |
2008 |
| The First Independent Research Support & Transition (FIRST) Awards, National Institutes of Health (NIH) |
1998 - 2003 |
| Young Scientist Scholarship Fund Award, the 2nd International Workshop on HIV Drug Resistance and Treatment Strategies | Lake Maggiore, Italy |
1998 |
| Young Scientist Scholarship Fund Award, International Workshop on HIV Drug Resistance, Treatment Strategies and Eradication | St. Petersburg, FL |
1997 |
| The Young Investigator Award, the 1995 Joint Statistical Meetings, Epidemiology Section, American Statistical Association. |
1995 |
| The ENAR Student Paper Award, the 1994 Spring Meetings, the Eastern North American Region of the Biometrics Society (ENAR) | Cleveland, Ohio |
1994 |
| Ralph A. Bradley Award (for the most outstanding Ph.D graduate), Department of Statistics, Florida State University (FSU). |
1994 |
| First Prize, Student Paper Awards, 1993 Joint Statistical Meetings, Section on Statistics & the Environment, ASA | San Franciso, California |
1993 |
| Best First-Year Student Award, Department of Statistics, Florida State University. |
1990 |
2011
Liu, D.; Lu, T.; Niu, X.; Wu, H. "Mixed-Effects State Space Models for Analysis of Longitudinal
Dynamic Systems,". Biometrics. 2011; 67(2): 476-485. |
2011
Miao, H.; Xia, X.; Perelson, A.S.; Wu, H. "On Identifiability of Nonlinear ODE Models and Applications in Viral Dynamics". SIAM Review. 2011; 38(4): 3-39. |
2011
Zhang, J.T.; Wu, H. "Modeling HIV Dynamics Using Unified Mixed-effects Models". American Journal of Mathematical and Management Sciences. 2011; . |
2011
Fang, Y.; Wu, H.; Zhu, L. "A Two-Stage Estimation Method for Random Coefficient Differential Equation Models with Application to Longitudinal HIV Dynamic Data". Statistica Sinica. 2011; 21: 1145-1170. |
2011
Huang, Y.; Wu, H.; Holden-Wiltse, J.; Acosta, P. "A Dynamic Bayesian Nonlinear Mixed-Effects Model of HIV Response Incorporating Medication Adherence, Drug Resistance and Covariates,". The Annals of Applied Statistics. 2011; 5(1): 551-577. |
