Fabeha Fazal, Ph.D.

Fabeha Fazal, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 850
Rochester, NY 14642

Office: (585) 275-9917
Fax: (585) 756-7780
Administrative: (585) 275-5948

Research Bio

A major focus of research in my laboratory deals with understanding the role and regulation of actin-myosin interactions in endothelial cell (EC) inflammation, permeability, and apoptosis, especially in the settings of acute and chronic lung injury. We study pathways of EC inflammation, barrier dysfunction and apoptosis on the molecular, cellular, and animal level.

We have uncovered novel and previously unrecognized role of actin cytoskeleton and non-muscle myosin light chain kinase (nmMLCK) in the regulation of cytoplasmic trafficking of NF-k? for its nuclear import to cause EC inflammation associate with intravascular coagulation and sepsis. More recently we have been involved in the identification of endoplasmic reticulum (ER) stress as an important determinant of EC inflammation and permeability associated with acute lung injury (ALI). In our most recent work, we have focused on understanding the role of nmMLCK in the pathogenesis of pulmonary emphysema caused by cigarette smoke (CS). The approaches ranging from biochemical, cellular, and molecular biology to in vivo gene delivery and lung physiology to study how pulmonary endothelium responds during acute and chronic lung inflammation/injury.

Recent Journal Articles

Showing the 5 most recent journal articles. 15 available »

2013
Fazal F, Bijli KM, Murrill M, Leonard A, Minhajuddin M, Anwar, KN, Finkelstein JN, Watterson DM, Rahman A. "Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN recruitment". PLOS ONE. 2013; . Link
2012
Bijli KM, Fazal F, Rahman A. ". Regulation of RelA/65 and endothelial cell inflammation by proline-rich tyrosine kinase 2". Am J Respir Cell Mol Biol. 2012; 47: 660-668. Link
2011
Yang L, Chen G, Mohanty S, Scott G, Fazal F, Rahman A, Begum S, Hynes R, Xu L. "GPR56 regulates VEGF production and angiogenesis during melanoma progression." Cancer Res. 2011; 71: 5558-5568. Link
2011
Rahman A, Fazal F. "Blocking NF-?B: An Inflammatory Issue". Proc Am Thorac Soc. 2011; 8: 497-503. Link
2009
Fazal, F.; Rahman, A. "Hug tightly and say goodbye: role of endothelial ICAM-1 in leukocyte transmigration." Antioxid Redox Signal. 2009; 11: 823-829. Link

Education

PhD | Biochemistry | A.M. University1992
MSc | Biochemistry | A.M. University1987
BSc | Chemistry | A.M. University1985

Post-Doctoral Training & Residency

Research Associate, Loyola University Medical Center, Maywood, IL 1998
Research Associate, Loyola University Medical Center, Maywood, IL; Advisor: Susan Baker, PhD 1995