Research Bio
The primary interest of my lab is to study the mechanisms of neurodegeneration induced by genetic mutations, environmental toxicants and gene-environment interactions in Parkinson's disease. Our ultimate goal is to utilize this mechanistic knowledge to develop neuroprotective therapies for Parkinson's disease and perhaps other neurodegenerative disorders as well.
Please note that I have relocated my lab to the UK (www.plymouth.ac.uk/staff/ktieu#)
2013
Jin YN, Yu YV, Gundemir S, Jo C, Cui M, Tieu K, Johnson GV. "Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin." PloS one. 2013 8(3):e57932. Epub 2013 Mar 01. |
2012 Apr 17
Lovatt D, Xu Q, Liu W, Takano T, Smith NA, Schnermann J, Tieu K, Nedergaard M. "Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity." Proceedings of the National Academy of Sciences of the United States
of America. 2012 Apr 17; 109(16):6265-70. Epub 2012 Mar 15. |
2012 Jan
Fujita T, Williams EK, Jensen TK, Smith NA, Takano T, Tieu K, Nedergaard M. "Cultured astrocytes do not release adenosine during hypoxic conditions." Journal of cerebral blood flow and metabolism : official journal of
the International Society of Cerebral Blood Flow and Metabolism. 2012 Jan 0; 32(1):e1-7. Epub 2011 Oct 12. |
2011 Sep
Tieu K. "A guide to neurotoxic animal models of Parkinson's disease." . 2011 Sep 0; 1(1):a009316. |
2011
Rappold PM, Cui M, Chesser AS, Tibbett J, Grima JC, Duan L, Sen N, Javitch JA, Tieu K. "Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3." Proceedings of the National Academy of Sciences of the United States
of America. 2011 108(51):20766-71. Epub 2011 Dec 05. |
