Research Bio
The primary interest of my lab is to study the mechanisms of neurodegeneration induced by genetic mutations, environmental toxicants and gene-environment interactions in Parkinson's disease. Our ultimate goal is to utilize this mechanistic knowledge to develop neuroprotective therapies for Parkinson's disease and perhaps other neurodegenerative disorders as well.
Our experimental approach is to use both genetic and toxicant induced cell culture and animal models of Parkinson's disease. Major techniques that are routinely used in our lab include stereotactic surgery, in vivo microdialysis, HPLC, stereological cell counting, confocal imaging, immunohistochemistry and other standard molecular biology methods such as immunoblotting, RT-PCR, gene cloning and more recently, rAAV mediated gene transfer.
2012 Apr 17
Lovatt D, Xu Q, Liu W, Takano T, Smith NA, Schnermann J, Tieu K, Nedergaard M. "Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity." Proceedings of the National Academy of Sciences of the United States
of America. 2012 Apr 17; 109(16):6265-70. Epub 2012 Mar 15. |
2012 Jan
Fujita T, Williams EK, Jensen TK, Smith NA, Takano T, Tieu K, Nedergaard M. "Cultured astrocytes do not release adenosine during hypoxic conditions." Journal of cerebral blood flow and metabolism : official journal of
the International Society of Cerebral Blood Flow and Metabolism. 2012 Jan 0; 32(1):e1-7. Epub 2011 Oct 12. |
2011 Sep
Tieu K. "A guide to neurotoxic animal models of Parkinson's disease." . 2011 Sep 0; 1(1):a009316. |
2011
Rappold PM, Cui M, Chesser AS, Tibbett J, Grima JC, Duan L, Sen N, Javitch JA, Tieu K. "Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3." Proceedings of the National Academy of Sciences of the United States
of America. 2011 108(51):20766-71. Epub 2011 Dec 05. |
2011
Lim S, Chesser AS, Grima JC, Rappold PM, Blum D, Przedborski S, Tieu K. "D-?-hydroxybutyrate is protective in mouse models of Huntington's disease." PloS one. 2011 6(9):e24620. Epub 2011 Sep 12. |
