Hani A. Awad, Ph.D.

Hani A. Awad, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 665
Rochester, NY 14642

Office: (585) 273-5268

Lab Information

My Laboratory interfaces Biomedical Engineering and Orthopaedics. We provide opportunities for state of the art training related to Tissue Engineering and Biomechanics.

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Professional Bio

I completed my graduate work at the University of Cincinnati under the mentorship of Dr. David Butler, a leading expert in tendon and ligament injury and repair, and having later completed a post-doctoral fellowship with Dr. Farshid Guilak at Duke University, at one of the leading orthopaedic research laboratories in the country. In the Fall of 2004, I joined the faculty of the University of Rochester as an Assistant Professor in the Departments of Orthopaedics and Biomedical Engineering. My research focuses primarily on tissue engineering of load bearing connective tissues, including ligament and tendon, cartilage, and bone.

Research Bio

My research focuses primarily on Musculoskeletal Tissue Engineering with an emphasis on challenging clinical problems and translational solutions.
Our approach is to develop in vivo and in vitro models of musculoskeletal injury and clinically-translatable outcome measures to assess the efficacy of regenerative and tissue engineering solutions.
Current research projects include:



1. Tissue Engineering of Massive Bone Allograft Union
2. Allografts and Gdf5 Gene Therapy in Flexor Tendon Tissue Engineering
3. Modulating Stem Cell Differentiation using Novel Allograft Scaffolds for Cartilage Repair
4. Fashioning a Superficial Zone-Like Layer in Bioreactor-Cultivated Tissue Engineered Cartilage
5. Evaluating models of human musculoskeletal disease and trauma

Awards & Honors (National)

Kappa Delta - Ann Doner Vaughan Award | ORS/AAOS 2007
Early Career Translational Research Award in Biomedical Engineering | Wallace H. Coulter Foundation 2005

Awards & Honors (Local)

Finalist, PhD Student Presentation Competition | ASME IMEC&E – Bioengineering Division 1998
Finalist, PhD Student Presentation Competition | ASME Bioengineering Division 1997

Patents

Freeze-Dried Tendon Allografts as Delivery Vehicles for Genes

United States Serial NO.: 12/513,161
Filed Date: October 31, 2007
Title: Targeted Delivery of Therapeutic Agents With Lyophilized Matrices
Invented by: Hani Awad, Edward Schwarz
Repair and Regeneration of Articular Cartilage, and the Repair and Regeneration of Fibrocartilaginous Tissues

United States Serial NO.: 13/124,002
Filed Date: October 13, 2009
Title: Protecting and Repairing Cartilage and Musculoskeletal Soft Tissues
Invented by: Randy Rosier, Michael Zuscik, Erik Sampson, Susan Bukata, J. Edward Puzas, Regis O'Keefe, Hani Awad
Repair and Regeneration of Articular Cartilage, and the Repair and Regeneration of Fibrocartilaginous Tissues

United States Serial NO.: 13/971,366
Filed Date: August 20, 2013
Title: Protecting and Repairing Cartilage and Musculoskeletal Soft Tissues
Invented by: Randy Rosier, Michael Zuscik, Erik Sampson, Susan Bukata, J. Edward Puzas, Regis O'Keefe, Hani Awad

Recent Journal Articles

Showing the 5 most recent journal articles. 77 available »

2014 Sep 29
Lee DJ, Southgate RD, Farhat YM, Loiselle AE, Hammert WC, Awad HA, O'Keefe RJ. "Parathyroid hormone 1-34 enhances extracellular matrix deposition and organization during flexor tendon repair." Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2014 Sep 29; Epub 2014 Sep 29.
2014 Jun 24
Farhat YM, Al-Maliki AA, Easa A, O'Keefe RJ, Schwarz EM, Awad HA. "TGF-beta1 Suppresses Plasmin and MMP Activity in Flexor Tendon Cells via PAI-1: Implications for Scarless Flexor Tendon Repair." Journal of cellular physiology. 2014 Jun 24; Epub 2014 Jun 24.
2014 May
Yukata K, Xie C, Li TF, Takahata M, Hoak D, Kondabolu S, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ. "Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment." Bone. 2014 May; 62:79-89. Epub 2014 Feb 12.
2014 Apr
Inzana JA, Olvera D, Fuller SM, Kelly JP, Graeve OA, Schwarz EM, Kates SL, Awad HA. "3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration." Biomaterials. 2014 Apr; 35(13):4026-34. Epub 2014 Feb 14.
2014 Mar
Juneja SC, Vonica A, Zeiss C, Lezon-Geyda K, Yatsula B, Sell DR, Monnier VM, Lin S, Ardito T, Eyre D, Reynolds D, Yao Z, Awad HA, Yu H, Wilson M, Honnons S, Boyce BF, Xing L, Zhang Y, Perkins AS. "Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia." Bone. 2014 Mar; 60:148-61. Epub 2013 Dec 04.

Current Appointments

Professor - Department of Biomedical Engineering (SMD) - Primary
Professor - Department of Orthopaedics (SMD)
Professor - Center for Musculoskeletal Research

Education

PhD | Engineering Mechanics/Biomechanics | University of Cincinnati1999
MS | Engineering Mechanics/Biomechanics | University of Cincinnati1995
BS | Mechanical Engineering | University of Jordan1993

Post-Doctoral Training & Residency

Bioengineering Laboratory (Mentor: Farshid Guilak), Department of Surgery - Division of Orthopaedic Surgery, Duke University 2004