BS: PUC-Rio, Brazil; Physics (1989)
MS: PUC-Rio, Brazil; Biophysics (1992)
PhD: Imperial College, UK; Biophysics (1997)
Postdoctoral Fellow - Yale University - Department of Physiology (1997-2000)
Postdoctoral Fellow - Mount Sinai School of Medicine - Department of Physiology and Biophysics (2000-2003)
2003-2004: Instructor - Mount Sinai School of Medicine - Department of Physiology and Biophysics
2004-2012: Assistant Professor - University of Rochester - Department of medicine - Cardiovascular Research Institute
2013-now: Associate Professor (Research) - University of Rochester - Department of medicine - Cardiovascular Research Institute
Patient Care Bio
Sudden arrhythmic death is the major cause of death in patients with congestive heart failure. In addition, heart failure increases the proarrhythmic effect of antiarrhythmic drugs, with the risk of drug induced Torsades de Pointes arrhythmias being approximately doubled by heart failure. Nonetheless the mechanisms of regulation of ion channels in heart failure are incompletely understood. Our works aims to undertand the pathological remodeling of cardiac ion currents in heart failure in order to develop novel treatements to reverse these effects and treat life treatening arrhythmias. We also study the effect of genetic mutations linked to the inherited cardiac arrhythmia Long QT syndrome.
We try to understand the role of specific genetic mutations on the patient clinical phenotype and response to treatment. Identification of disease- and mutation- specific therapies will ultimately allow tailoring of therapy to patients, optimizing treatment and lowering the overall risk of life threatening cardiac arrhythmias.