Professional Bio
Dr. Xiaochun Long earned her Ph.D. in Pathogenic Biology in 2003 from Tongji Medical College, Huazhong University of Science and Technology. She started her postdoctoral training in Texas A&M University at Commerce in the middle of 2004. In the beginning of 2005, she switched her postdoctoral training to University of Rochester in the laboratory of Dr. Joseph Miano where she has gained intensive training in molecular biology, particularly transcriptional regulation of gene expression. At the same time, she is gaining abilities towards an independent investigator. Her general research interest is the molecular regulation of smooth muscle phenotypic modulation, which includes the regulation of key regulators ( Myocardin, miR-143/145) and the functionality of novel microRNAs to smooth muscle differentiation based on her microRNA array results
Research Bio
My research interest is focused on the regulation of SMC differentiation, particularly the regulation of Myocardin and miR-143/145, which are the key components of molecular switch of SMC differentiation. My approach is to utilize comparative genomics integrated with wet lab experiments to define the important cis-elements in the gene locus and screen for potential transcriptional factors. I am also interested in the study of functional role of novel microRNAs on SMC phenotypic modulation. By using different model systems, I screened a subset of microRNAs whose expression is closely linked to SMC phenotypic modulation. My long term goal is to uncover the functionality of those novel microRNA targets to SMC differentiation in vitro and in vivo.
2010
Imamura, M.; Long, X.; Nanda, V.; Miano, J.M. "Expression and Functional Activity of Four Myocardin Isoforms. Gene". Gene. 2010; . |
2010
Benson, C.C.; Long, X.; Miano, J.M. "Method of identifying single nucleotide polymorphisms in the human CArGome." Bioinformatics.. 2010; . |
2009
Bell, R.D.; Deane, R.; Chow, N.; Long, X.; Sagare, A.; Singh, I.; Streb, J.W.; Guo, H.; Rubio, A.; Van Nostrand, W.; Miano, J.M.; Zlokovic, B.V. "SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells." Nat Cell Biol.. 2009; 11(2): 143-153. |
2009
Sun, Q.; Taurin, S.; Sethakorn, N.; Long, X.; Imamura, M.; Wang, D.Z.; Zimmer, W.E.; Dulin, N.O.; Miano, J.M. "Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein. 2009, 284(47):32582-90." J Biol Chem.. 2009; 284(47): 32582-32590. |
2009
Long, X.; Tharp, D.L.; Georger, M.A.; Slivano, O.J.; Lee, M.Y.; Wamhoff. B.R.; Bowles, D.K,; Miano, J.M. "The smooth muscle cell-restricted KCNMB1 ion channel subunit is a direct transcriptional target of serum response factor and myocardin." J Biol Chem. 2009; 284(48): 33671-33682. |
