Alan E. Friedman, Ph.D.

Alan E. Friedman, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box EHSC
Rochester, NY 14642

Office: (585) 273-4066

Journal Articles

Showing all 39 journal articles available.

2014 Nov 6
Lapek JD, Tombline G, Kellersberger KA, Friedman MR, Friedman AE. "Evidence of histidine and aspartic acid phosphorylation in human prostate cancer cells." Naunyn-Schmiedeberg's archives of pharmacology. 2014 Nov 6; Epub 2014 Nov 06.
2014 Feb 7
Rahman I, Sundar IK, Nevid MZ, Friedman AE. "Cigarette smoke induces distinct histone modifications in lung cells: implications for the pathogenesis of COPD and lung cancer." Journal of proteome research. 2014 Feb 7; 13(2):982-96. Epub 2013 Dec 13.
2013 Nov 1
Yao H, Hwang JW, Sundar IK, Friedman AE, McBurney MW, Guarente LP, Gu W, Kinnula VL, Rahman I. "SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD." American journal of physiology. Lung cellular and molecular physiology. 2013 Nov 1; 305(9):L615-24. Epub 2013 Sep 13.
2013 Apr
Badding MA, Lapek JD, Friedman AE, Dean DA. "Proteomic and functional analyses of protein-DNA complexes during gene transfer." Molecular therapy : the journal of the American Society of Gene Therapy. 2013 Apr; 21(4):775-85. Epub 2012 Nov 20.
2013
Tombline G, Schwingel JM, Lapek JD, Friedman AE, Darrah T, Maguire M, Van Alst NE, Filiatrault MJ, Iglewski BH. "Pseudomonas aeruginosa PA1006 is a persulfide-modified protein that is critical for molybdenum homeostasis." PloS one. 2013 8(2):e55593. Epub 2013 Feb 08.
2012 Aug
Macgilvray ME, Lapek JD, Friedman AE, Quivey RG. "Cardiolipin biosynthesis in Streptococcus mutans is regulated in response to external pH." Microbiology. 2012 Aug; 158(Pt 8):2133-43. Epub 2012 May 24.
2012 Jun 19
Jaffré F, Friedman AE, Hu Z, Mackman N, Blaxall BC. "?-adrenergic receptor stimulation transactivates protease-activated receptor 1 via matrix metalloproteinase 13 in cardiac cells." Circulation. 2012 Jun 19; 125(24):2993-3003. Epub 2012 May 18.
2012 Apr 15
Lapek JD, McGrath JL, Ricke WA, Friedman AE. "LC/LC-MS/MS of an innovative prostate human epithelial cancer (PHEC) in vitro model system." Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Apr 15; 893-894:34-42. Epub 2012 Mar 03.
2012 Apr 2
Deane R, Singh I, Sagare AP, Bell RD, Ross NT, Larue B, Love R, Perry S, Paquette N, Deane RJ, Meenakshisundaram T, Zarcone T, Fritz G, Friedman AE, Miller BL, Zlokovic BV. "A multimodal RAGE-specific inhibitor reduces amyloid ?-mediated brain disorder in a mouse model of Alzheimer disease." The Journal of clinical investigation. 2012 Apr 2; 122(4):1377-92. Epub 2012 Mar 12.
2012
Sundar IK, Chung S, Hwang JW, Lapek JD, Bulger M, Friedman AE, Yao H, Davie JR, Rahman I. "Mitogen- and stress-activated kinase 1 (MSK1) regulates cigarette smoke-induced histone modifications on NF-?B-dependent genes." PloS one. 2012 7(2):e31378. Epub 2012 Feb 01.
2011 Mar 21
Mattiacio J, Walter S, Brewer M, Domm W, Friedman AE, Dewhurst S. "Dense display of HIV-1 envelope spikes on the lambda phage scaffold does not result in the generation of improved antibody responses to HIV-1 Env." Vaccine. 2011 Mar 21; 29(14):2637-47. Epub 2011 Feb 18.
2011 Feb 4
Lapek JD, Tombline G, Friedman AE. "Mass spectrometry detection of histidine phosphorylation on NM23-H1." Journal of proteome research. 2011 Feb 4; 10(2):751-5. Epub 2010 Dec 28.
2010 Sep
Caito S, Rajendrasozhan S, Cook S, Chung S, Yao H, Friedman AE, Brookes PS, Rahman I. "SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2010 Sep; 24(9):3145-59. Epub 2010 Apr 12.
2010 May
McCloskey R, Menges C, Friedman A, Patel D, McCance DJ. "Human papillomavirus type 16 E6/E7 upregulation of nucleophosmin is important for proliferation and inhibition of differentiation." Journal of virology. 2010 May; 84(10):5131-9. Epub 2010 Mar 17.
2009 Jun
Burwell, LS.; Spencer, CM.; Friedman, AE.; Brookes, PS. "In vivo cardioprotection by S-nitroso-2-mercaptopropionyl glycine". J Mol Cell Cardiol. 2009; 46(6): 960-8.
2009 Feb
Hedley-Whyte, ET.; Goldman, JE.; Nedergaard, M.; Friedman, A.; Han, X.; Schmidt, RE.; Powers, JM. "Hyaline Protoplasmic Astrocytopathy of Neocortex". J Neuropathol Exp Neurol. 2009; 68(2): 136-47.
2009 Feb
Ehrenberg MS, Friedman AE, Finkelstein JN, Oberdörster G, McGrath JL. "The influence of protein adsorption on nanoparticle association with cultured endothelial cells." Biomaterials. 2009 Feb; 30(4):603-10. Epub 2008 Nov 13.
2008
Ryan, EP.; Bushnell, TP.; Friedman, AE.; Rahman, I.; Phipps, RP. "Cyclooxygenase-2 independent effects of cyclooxyganase-2 inhibitors on oxidative stress and intracellular glutathione content in normal and malignant human B cells". Cancer Immunology Immunotherapy. 2008; 57(3): 347-58.
2007
Malkowski, MG.; Quartley, E.; Friedman AE.; Babulski, J.; Kong, Y.; Wolfley, J.; Said, M.; Luft, JM.; Phizicky, EM.; DeTitta, GT.; Grayhack, EJ. "Blocking S-adenosylmethionine synthesis in yeast allows selenomethionine incorporation and multiwavelength anomalous dispersion phasing". Proc Natl Acad Sci USA. 2007; 104: 6678-6683.
2007
Friedman, AE.; Lapek, JD.; Jensen, L.; Williams, K.; Ricke, WA. "Proteomic analyses of human prostate cancer progression cell lines". BJU Int. 2007; 100(3): 25.
2006
Bell, RD.; Sagare, AP.; Friedman, AE.; Bedi, GS.; Holzman, DM.; Deane, R.; Zlokovic, BV. "Transport pathways for clearance of human Alzheimer's amyloid-peptide and apolipoproteins E and J in the mouse central nervous system". J. Cereb. Blood Flow & Met. 2006; : 1-10.
1996
Dett, MR.; Zhou, F.; Friedman, AE. "Positive Halogens from Halides and Hydrogen Peroxide and Organotellurium Catalysts". J. Am. Chem. Soc. 1996; 118: 313-318.
1995
Wang, S.; Friedman, AE.; Kool, ET. "Origins of High Sequence Selectivity: A Stopped-flow UV Kinetics Study of Single-stranded Nucleic Acid Binding by Triplex-forming Oligonucleotides". Biochemistry. 1995; 34: 9774-9784.
1995
Miller, VP.; Goodin, DP.; Friedman, AE. "Horseradish Peroxidase PHE-172->TYR Mutant: Sequential Formation of Compound I with a Porphyrin Radical Cation and a Protein Radical". J. Bio. Chem. 1995; 270: 18413-18419.
1995
Dett, MR.; Friedman, AE.; McMillan, M. "Step-wise Mechanism for Oxidative Addition of Iodine to Organotellurium(II) Compounds". Organometallics. 1995; 14: 1442.
1994
Detty, MR.; Friedman, AE.; Oseroff, A. "A Mechanism for the Oxidation of glutathione to Glutathione Disulfide with Organotellurium(IV) and Organoselenium(IV) Compounds. A Step-wise Process with Implications for Photodynamic Therapy and Other Oxidative Chemotherapy". J. ORg. Chem. 1994; 59: 8245.
1994
Detty, MR.; Friedman, AE.; McMillan, M. "A Step-Wise Mechanism for Oxidation Addition of Bromine to Organoselenium(II) and Organotellurium(II) Compounds". Organometallics. 1994; 13: 3338.
1994
Dett, MR.; Friedman, AE. "Oxidation of Telluropyrylium Dyes with Ozone, Chlorine, and Bromine, Differing Regiochemical and Kinetic Behavior with respect to Oxidations of Oxygen-, Sulfur-, and Selenium-Containing Dyes". Organometallics. 1994; 13: 2138.
1994
Detty, MR.; Friedman, AE. "Oxidation of Telluropyrylium Dyes with Ozone, Chlorine, and Bromine." Organometalilcs. 1994; 13: 533.
1992
Jenkins, Y.; Friedman, AE.; Turro, NJ.; Barton, JK. "Characterization of Dipyridophenazine complexes of Ruthenium(II): The Light Switch Effect as a Function of Nucleic Acid Sequence and Conformation". Biochemistry. 1992; 31: 10809.
1991
Friedman, AE.; Kumar, CV.; Turro, NJ.; Barton, JK. "Luminescence Enhancement, Polarization, and Luminescent Quenching of Ruthenium(II) Polypyriyls with DNA: Evidence for Intercalation Into Z-DNA". Nucleic Acids Res. 1991; 19: 2595.
1990
Friedman, AE.; Chambron, J-C.; Sauvage, J-P.; Turro, NJ.; Barton, JK. "Molecular 'Light Switch' for DNA: Ru(bpy)2(dppz)2+"". J. Am. Chem. Soc. 1990; 112: 4960.
1989
Friedman, AE.; Kumar, CV.; Turro, NJ.; Barton, JK. "Polarization and Luminescent Quenching of Ruthenium(II) Polypyridyls with DNA evidence for Intercalation into Z-DNA". J. Inor. Biochem. 1989; 36: 289.
1989
Friedman, AE.; Ford, PC. "Photoreactions of the Triruthenium Cluster HRu3(CO)10(u-COCH3), Photoisomerization of the bridging Alkylidyne Ligand and Competing Ligand Photosubstitutions". J. AM. Chem. Soc. 1989; 111: 551.
1988
Fetterolf, M.; Freidman, AE.; Yang, Y-Y.; Offen, H.; Ford, PC. "Pressure Effects on the Photophysical Properties of the Platium(II) Dimer Pt2(POP)44- (POP=u-n-H2P2052-) and Related d8-d8 Dinuclear Complex in Solution". J. Phys. Chem. 1988; 92: 3760.
1988
Vandenberg, DM.; Friedman, AE.; Ford, PC. "Photoreactions of Ir8(CO)22 2-. Homolytic Cleavage of an Unsupported Metal-Metal Bond Linking Two Tetrahedral Iridium Carbonyl Clusters". Inorg. Chem. 1988; 27: 594.
1986
Friedman, AE.; Ford, PC. "Photoisomerization of the Ruthenium Cluster HRu3(CO)10(u-COCH3): An Unprecedented Oxygen-to-Carbon Alkyl Migration". J. Am. Chem. Soc. 1986; 108: 7851.
1986
Desrosiers, MF.; Wink, DA.; Troutman, R.; Friedman, AE.; Ford, PC. "Photoreactions of the Triruthenium Cluster Ru3(CO)12 and Substituted Analogues". J. Am. Chem. Soc. 1986; 108: 1917.
0
Badding, M.A.; Lapek, J.D.; Friedman, A.E,; Dean, D.A. "Proteomic and functional analyses of protein-DNA complexes during gene transfer". Molecular Therapy 2012. .