Damian J. Krysan, M.D., Ph.D.

Damian J. Krysan, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 850
Rochester, NY 14642

Office: (585) 275-9729
Fax: (585) 273-1104
Lab: (585) 275-6814

Journal Articles

Showing all 38 journal articles available.

2013 Jan
Chabrier-Roselló Y, Gerik KJ, Koselny K, Didone L, Lodge JK, Krysan DJ. "Cryptococcus neoformans phosphoinositide-dependent kinase 1 (PDK1) ortholog is required for stress tolerance and survival in murine phagocytes." Eukaryotic cell. 2013 Jan 0; 12(1):12-22. Epub 2012 Oct 19.
2012 Jun
Saputo S, Chabrier-Rosello Y, Luca FC, Kumar A, Krysan DJ. "The RAM network in pathogenic fungi." Eukaryotic cell. 2012 Jun 0; 11(6):708-17. Epub 2012 Apr 27.
2011 Aug
Didone L, Oga D, Krysan DJ. "A novel assay of biofilm antifungal activity reveals that amphotericin B and caspofungin lyse Candida albicans cells in biofilms." Yeast (Chichester, England). 2011 Aug 0; 28(8):561-8. Epub 2011 Jun 15.
2011 Apr
Bharucha N, Chabrier-Roselló Y, Xu T, Johnson C, Sobczynski S, Song Q, Dobry CJ, Eckwahl MJ, Anderson CP, Benjamin AJ, Kumar A, Krysan DJ. "A Large-Scale Complex Haploinsufficiency-Based Genetic Interaction Screen in Candida albicans: Analysis of the RAM Network during Morphogenesis." PLoS genetics. 2011 Apr 0; 7(4):e1002058. Epub 2011 Apr 28.
2010 Nov
Miller KA, Didone L, Krysan DJ. "Extracellular secretion of overexpressed glycosylphosphatidylinositol-linked cell wall protein Utr2/Crh2p as a novel protein quality control mechanism in Saccharomyces cerevisiae." Eukaryotic cell. 2010 Nov 0; 9(11):1669-79. Epub 2010 Sep 10.
2010 Jun
Didone L, Scrimale T, Baxter BK, Krysan DJ. "A high-throughput assay of yeast cell lysis for drug discovery and genetic analysis." Nature protocols. 2010 Jun 0; 5(6):1107-14. Epub 2010 May 27.
2009 Aug
Dolan K, Montgomery S, Bucchiet B, Didone L, Wellington M, Krysan DJ. "Antifungal activity of tamoxifen: in vitro and in vivo activities and mechanistic characterization." Antimicrobial agents and chemotherapy. 2009 Aug 0; 53(8):3337-46. Epub 2009 Jun 01.
2009 May
Krysan DJ. "The cell wall and endoplasmic reticulum stress responses are coordinately regulated in Saccharomyces cerevisiae." Communicative & integrative biology. 2009 May 0; 2(3):233-5.
2009 Jan
Scrimale T, Didone L, de Mesy Bentley KL, Krysan DJ. "The unfolded protein response is induced by the cell wall integrity mitogen-activated protein kinase signaling cascade and is required for cell wall integrity in Saccharomyces cerevisiae." Molecular biology of the cell. 2009 Jan 0; 20(1):164-75. Epub 2008 Oct 29.
2009
Wellington M; Dolan K; Krysan DJ. "Live Candida albicans suppresses production of reactive oxygen species in phagocytes." Infect Immun. 2009; 77(1): 405-13.
2008 Jun 30
Vadaie N, Dionne H, Akajagbor DS, Nickerson SR, Krysan DJ, Cullen PJ. "Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeast." The Journal of cell biology. 2008 Jun 30; 181(7):1073-81.
2008
Vadaie N.; Dionne H.; Nickerson SR; Akajagbor DS; Krysan DJ; Cullen PJ. "Cleavage-dependent activation of a signaling mucin in yeast." J Cell Biol. 2008; 181(7): 1073-81.
2008
Krysan DJ.; DiDone L. "A high-throughput screening assay for small molecules that disrupt yeast cell integrity." J Biomolec Screen. 2008; 13(7): 657-64.
2008
Ma, J; Dobry, CJ; Krysan, DJ; Kumar, A. "An unconventional genomic architecture in the budding yeast masks the nested antisense gene NAG1." Eukaryot Cell. 2008; 7(8): 1289-98.
2005
Krysan DJ; Ting EL; Abeijon C; Kroos L; Fuller RS. "Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae." Eukaryot Cell. 2005; 4(8): 1364-74.
2004
Rozan L; Krysan DJ; Rockwell NC; Fuller RS. "Plasticity of extended subsites facilitates divergent substrate recognition by Kex2 and Furin." J Biol Chem. 2004; 279(34): 35656-63.
2004
Krysan D. "Effectiveness of inactivated influenza vaccine in preventing acute otitis media in young children: a randomized controlled trial." J Pediatr. 2004; 144(3): 406-7.
2004
Krysan DJ. "Effectiveness over time of varicella vaccine." J Pediatr. 2004; 145(3): 416-7.
2002
Kemper AR; Krysan DJ. "Reevaluating the efficacy of naturopathic ear drops." Arch Pediatr Adoles Med. 2002; 156(1): 88-9.
2002
Krysan DJ; Kemper AR. "Claims of equivalence in randomized controlled trials of the treatment of bacterial meningitis in children." Pediatr Infect Dis J. 2002; 21(8): 753-8.
2002
Rockwell NC; Krysan DJ; Komiyama T; Fuller RS. "Precursor processing by kex2/furin proteases." Chem Reviews. 2002; 102(12): 4525-48.
2001
Krysan DJ; Flynn JT. "Renal transplantation after Streptococcus pneumoniae-associated hemolytic uremic syndrome." Am J Kidney Dis. 2001; 37(2): E15.
2000 May
Rockwell NC; Krysan DJ; Fuller RS. "Synthesis of peptidyl methylcoumarin esters as substrates and active-site titrants for the prohormone processing proteases Kex2 and PC2." Annal Biochem. 2000; 280(2): 201-8.
1999
Krysan DJ; Rockwell NC; Fuller RS. "Quantitative characterization of furin specificity. Energetics of substrate discrimination using an internally consistent set of hexapeptidyl methylcoumarinamides." J Biol Chem. 1999; 274(33): 23229-34.
1996
Krysan, DJ. "A dramatic reversal of facial selectivity in the Sharpless asymmetric dihydroxylation of a sterically hindered 3-methylidene-benzofuran." Tetrahedron. 1996; 37: 1375.
1996
Krysan, DJ. "A practical synthesis of alpha-acylamino-beta-keto esters: acylation of alkyl hydrogen (acylamino)malonates via the MgCl2/R3N base system." Tetrahedron. 1996; 37: 3303.
1996
Ayers, TA; Schnettler, RA; Marciniak, G; Stewart, KT; Mishra, RK; Krysan, DJ; Bernas, BR; Bhardwaj, P; Fevig, TL. "Enzymatic resolution for an improved enantioselective synthesis of benzofuranyl derivatives: precursors to a class of vitamin E-related antioxidants." Tetrahedron: Asymmetry. 1996; 6: 827.
1995
Krysan DJ. "p-Allyl complexes in organic synthesis: p-allylnickel halides and other (Mo, W, Co, Fe) p-allyl complexes (excluding Pd) in synthesis." Comprehensive Organometallic Chemistry II. 1995; .
1994
Krysan, DJ. "An expedient route to enantiomerically pure allylic alcohols via 1,3-dioxolanone derivatives of 2-hydroxy-carboxylic acids." Synth Commun. 1994; 24: 1589.
1994
Krysan, DJ; Rockway, TR; Haight, AR. "Diastereoselectivity in the osmium-catalyzed dihydroxylation of allylic amides and carbamates." Tetrahedron: Asymmetry. 1994; 4: 625.
1994
Krysan, DJ; Haight, AR; Menzia, JA; Welch, N. "A stereoselective synthesis of the dihydroxyethylene dipeptide isostere A-82768." Tetrahedron. 1994; 21: 6163.
1993
Krysan, DJ; Haight, AR; Lallaman, JE; Landridge, DC; Menzia, JA; Narayanan, BA; Pariza, JR; Reno, DS; Rockway, TW; Stuk, TL; Tien, J. "An improved preparation of (S)-N-(boc)-cyclohexylalaninal: on the Moffat/Swern oxidation of alpha-amino alcohols." Org Prep Proc Inter. 1993; 25: 437.
1993
Edwards, JP; Krysan, DJ; Liebeskind, LS. "A general, regioselective synthesis of substituted benzocyclobutenedione monoacetals." J Organ Chem. 1993; 58: 3942.
1993
Edwards, JP; Krysan, DJ; Liebeskind, LS. "Benannulation of stannylquinones. A new regiocontrolled construction of substituted naptho- and anthraquinones." J Am Chem Soc. 1993; 115: 9868.
1992
Krysan, DJ; Gurski, A; Liebeskind, LS. "A synthesis of highly substituted aromatics through the regiocontrolled construction of cyclobutenones bearing unsaturated substituents at the 4- position." J Am Chem Soc. 1992; 114: 1412.
1992
Friebe, TL; Johnson, JJ; Krysan, DJ; Mackenzie, PB; Sabat, M. "High velocity palladium catalysis." Homogeneous Transition Metal Catalyzed Reactions, Advances in Chemistry Series 230.. 1992; : 529-40.
1990
Krysan, DJ; Mackenzie, PB. "A new, convenient synthesis of bis(1,5-cyclooctadiene)nickel(0)." J Organ Chem. 1990; 55: 4109.
1988
Krysan DJ; Mackenzie PB. "Optically active 2-ethenyl-1,3-dioxolanones as 3-carbon synthons. Allylnickel derivates as homoenolate equivalents." J Am Chem Soc. 1988; 110: 6273.