Damian J. Krysan, M.D., Ph.D.

Damian J. Krysan, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 850
Rochester, NY 14642

Office: (585) 275-9729
Fax: (585) 273-1104
Lab: (585) 275-6814

Professional Bio

Associate Chair of Basic Research

Research Bio

Dr. Krysan's research focuses on two broad areas: 1) antifungal and antibiotic drug discovery and 2) fungal pathogenesis.



First, our antifungal and antibiotic drug discovery work involves high-throughput screening, characterizing in vitro and in vivo activity, determining mechanism of action and structure-activity optimization of new leads. We are currently studying triphenylethylene-bases molecules similar to tamoxifen as anti-cryptococcal agents, PDK1 kinase inhibitors as antifungal agents (in collaboration with Dr. Robert Boeckman from the Department of Chemistry), and a variety of new molecular scaffolds. High-throughput screening projects involve (in collaboration with Dr. Paul Dunman from the Department of Microbiology) the ESKAPE (Enterococcus, Staphylococcus, Klebsiella, Acinetobacter, Pseudomonas and Enterobacter) bacterial pathogens and Mycobacterium tuberculosis.

Second, we use large-scale genetic approaches to study the pathogenesis and host-pathogen interactions of Candida albicans, the most common human fungal pathogen. These studies are carried out in collaboration with Dr. Anuj Kumar (University of Michigan), and Dr. Melanie Wellington (University of Rochester, Pediatric Infectious Diseases). We are particularly interested in how genetic networks regulate morphogenesis and interactions with macrophages.

Awards & Honors (Local)

Featured APS New Member of the Month 2013
Elected to American Pediatric Society 2013
1st Tennessee Chair Distinguished Visiting Professor 2012
Ruth A. Lawrence Academic Faculty Service Award in Research 2012

Recent Journal Articles

Showing the 5 most recent journal articles. 48 available »

2014 Jun
Krysan DJ, Sutterwala FS, Wellington M. "Catching fire: Candida albicans, macrophages, and pyroptosis." PLoS pathogens.. 2014 Jun; 10(6):e1004139. Epub 2014 Jun 26.
2014 May
Falsetta ML, Klein MI, Colonne PM, Scott-Anne K, Gregoire S, Pai CH, Gonzalez M, Watson G, Krysan DJ, Bowen WH, Koo H. "Symbiotic relationship between Streptococcus mutans and Candida albicans synergizes virulence of plaque biofilms in vivo." Infection and immunity.. 2014 May; 82(5):1968-81. Epub 2014 Feb 24.
2014 May
Roemer T, Krysan DJ. "Antifungal drug development: challenges, unmet clinical needs, and new approaches." Cold Spring Harbor perspectives in medicine. 2014 May; 4(5)Epub 2014 May 01.
2014 Feb
Wellington M, Koselny K, Sutterwala FS, Krysan DJ. "Candida albicans triggers NLRP3-mediated pyroptosis in macrophages." Eukaryotic cell.. 2014 Feb; 13(2):329-40. Epub 2013 Dec 27.
2014
Butts A, Koselny K, Chabrier-Roselló Y, Semighini CP, Brown JC, Wang X, Annadurai S, Didone L, Tabroff J, Childers WE, Abou-Gharbia M, Wellington M, Cardenas ME, Madhani HD, Heitman J, Krysan DJ. "Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo." mBio. 2014 5(1):e00765-13. Epub 2014 Feb 11.

Current Appointments

Associate Professor - Department of Pediatrics, Infectious Diseases (SMD) - Primary

Specialties

Pediatric Infectious Diseases - American Board of Pediatrics
Pediatrics - American Board of Pediatrics

Education

MD | Medicine | University of Michigan Medical School2000
PhD | Organic Chemistry | Northwestern University1989
BA | Chemistry | Grinnell College1984

Post-Doctoral Training & Residency

Fellowship in Pediatric Infectious Disease at University of Michigan Medical Center07/01/2002 - 06/30/2005
Residency in Pediatrics at University of Michigan Medical Center07/01/2001 - 06/30/2002
Internship in Pediatrics at University of Michigan Medical Center06/24/2000 - 06/30/2001