Damian J. Krysan, M.D., Ph.D.

Damian J. Krysan, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 850
Rochester, NY 14642

Office: (585) 275-9729
Fax: (585) 273-1104
Lab: (585) 275-6814

Professional Bio

Associate Chair of Basic Research

Research Bio

Dr. Krysan's research focuses on two broad areas: 1) antifungal and antibiotic drug discovery and 2) fungal pathogenesis.



First, our antifungal and antibiotic drug discovery work involves high-throughput screening, characterizing in vitro and in vivo activity, determining mechanism of action and structure-activity optimization of new leads. We are currently studying triphenylethylene-bases molecules similar to tamoxifen as anti-cryptococcal agents, PDK1 kinase inhibitors as antifungal agents (in collaboration with Dr. Robert Boeckman from the Department of Chemistry), and a variety of new molecular scaffolds. High-throughput screening projects involve (in collaboration with Dr. Paul Dunman from the Department of Microbiology) the ESKAPE (Enterococcus, Staphylococcus, Klebsiella, Acinetobacter, Pseudomonas and Enterobacter) bacterial pathogens and Mycobacterium tuberculosis.

Second, we use large-scale genetic approaches to study the pathogenesis and host-pathogen interactions of Candida albicans, the most common human fungal pathogen. These studies are carried out in collaboration with Dr. Anuj Kumar (University of Michigan), and Dr. Melanie Wellington (University of Rochester, Pediatric Infectious Diseases). We are particularly interested in how genetic networks regulate morphogenesis and interactions with macrophages.

Awards & Honors (Local)

Featured APS New Member of the Month 2013
Elected to American Pediatric Society 2013
1st Tennessee Chair Distinguished Visiting Professor 2012
Ruth A. Lawrence Academic Faculty Service Award in Research 2012

Recent Journal Articles

Showing the 5 most recent journal articles. 46 available »

2014 Feb 24
Falsetta ML, Klein MI, Colonne PM, Scott-Anne K, Gregoire S, Pai CH, Gonzalez M, Watson G, Krysan DJ, Bowen WH, Koo H. "Symbiotic relationship between Streptococcus mutans and Candida albicans synergizes the virulence of plaque-biofilms in vivo." Infection and immunity.. 2014 Feb 24; Epub 2014 Feb 24.
2014 Feb
Wellington M, Koselny K, Sutterwala FS, Krysan DJ. "Candida albicans triggers NLRP3-mediated pyroptosis in macrophages." Eukaryotic cell.. 2014 Feb; 13(2):329-40. Epub 2013 Dec 27.
2014
Butts A, Koselny K, Chabrier-Roselló Y, Semighini CP, Brown JC, Wang X, Annadurai S, Didone L, Tabroff J, Childers WE, Abou-Gharbia M, Wellington M, Cardenas ME, Madhani HD, Heitman J, Krysan DJ. "Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo." mBio. 2014 5(1):e00765-13. Epub 2014 Feb 11.
2013 Feb
Butts A, Didone L, Koselny K, Baxter BK, Chabrier-Rosello Y, Wellington M, Krysan DJ. "A repurposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis." Eukaryotic cell.. 2013 Feb; 12(2):278-87. Epub 2012 Dec 14.
2013 Jan
Chabrier-Roselló Y, Gerik KJ, Koselny K, Didone L, Lodge JK, Krysan DJ. "Cryptococcus neoformans phosphoinositide-dependent kinase 1 (PDK1) ortholog is required for stress tolerance and survival in murine phagocytes." Eukaryotic cell.. 2013 Jan; 12(1):12-22. Epub 2012 Oct 19.

Current Appointments

Associate Professor - Department of Pediatrics, Infectious Diseases (SMD) - Primary
Associate Professor - Department of Microbiology and Immunology (SMD)

Specialties

Pediatric Infectious Diseases - American Board of Pediatrics
Pediatrics - American Board of Pediatrics

Education

MD | Medicine | University of Michigan Medical School2000
PhD | Organic Chemistry | Northwestern University1989
BA | Chemistry | Grinnell College1984

Post-Doctoral Training & Residency

Fellowship in Pediatric Infectious Disease at University of Michigan Medical Center07/01/2002 - 06/30/2005
Residency in Pediatrics at University of Michigan Medical Center07/01/2001 - 06/30/2002
Internship in Pediatrics at University of Michigan Medical Center06/24/2000 - 06/30/2001