James M. Roger, D.D.S.

James M. Roger, D.D.S.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 611
Rochester, NY 14642

Lab: (585) 275-1639
Fax: (585) 276-0190

Research Bio

B cells have been implicated as central players in the autoimmune diseases Sjögren's Syndrome (SS), Systemic Lupus Erythematosus (SLE), and Rheumatoid Arthritis (RA). While it has been reported that B cells participate in both immune and autoimmune response through their traditional role of antibody (and auto-antibody) production--B cells are also known to participate, possibly pathologically, through antibody independent functions such as cytokine production and antigen presentation. It has long been reported that B cells are capable of cytokine production; B cells activated through the B cell Receptor (BCR) or Toll-Like Receptors (TLR) produce cytokines such as IL-10, IL-6 and TNFa.

Preliminary data has shown that B cells produce a large and diverse array of cytokines in biologically significant quantities. Further data has shown that B cells can be induced to make pro-inflammatory cytokines (IFNg, IL-12p40, and TNFa) when stimulated by Th1 cells, or cytokines associated with allergic responses (IL-4) when stimulated by Th2 cells. This B / T cell communication indicates potentially complex effector roles when considering cytokine-producing B cells. In mice, IL-10 producing B cells seem to ameliorate symptoms of autoimmune diseases of RA and Inflammatory Bowel Disease. While the observation that B cells are capable of producing a variety of effector cytokines under differing stimulation conditions is tantalizing, a systematic approach to dissect the function of these cytokine producing B cells is necessary to elucidate their effector functions in both health and autoimmune disease. The immuno-modulatory effects of the cytokines produced and the hypothesis that cytokine-producing B cells contribute in both the healthy state as well as the autoimmune conditions of Sjögren's Syndrome, Lupus and Rheumatoid, through systemic inflammatory modulation and target-tissue influences are being evaluated.

Awards & Honors (National)

Best Manuscript, Journal of Dental Education | American Association for Dental Education 2006
Academic Dental Careers Fellowship Program Fellow | ADEA 2006 - 2007

Awards & Honors (Local)

2008 Volpe Prize for Periodontal Research, Finalist | The Ohio State University, Columbus, OH 2008
Dentsply/SCADA Student Clinician Research Program, Marquette representative at the ADA Annual Meeting 2007
Sjögren's Syndrome Foundation Fellowship; "Autoantibody characterization in salivary gland B cells in primary Sjögren' 2007 - 2008
1st Prize Dental Research Division, Poster Presentation | Marquette University Research Day 2006
Recipient of the Robert Burkhardt Memorial Scholarship | Pennsylvania Academy of Stomatology 2005

Recent Journal Articles

2008 Apr
Rogér JM. "The Academic Dental Careers Fellowship Program: a pilot program to introduce dental students to academia." Journal of dental education. 2008 Apr; 72(4):438-47.
2008 Apr
Rogér JM, Wehmeyer MM, Milliner MS. "Reflections on academic careers by current dental school faculty." Journal of dental education. 2008 Apr; 72(4):448-57.
2007 May
Rogér JM, Javarone JA, Ealba EL, Markiewicz MR, Morlandt AB. "The National Student Research Group of the AADR--an introduction." Journal of dental research.. 2007 May; 86(5):388-91.
2006 Sep
Rogér JM. "A survey of dual-degree training opportunities at US dental schools." Journal of dental education. 2006 Sep; 70(9):909-17.

Education

M.S. | Immunology | University of Rochester, School of Medicine and Dentistry2011
D.D.S. | Dentistry | Marquette University2008
Sc.B. | Chemistry | Brown University1998