Research Bio
The Becker lab studies malignant stem cell populations in myeloid neoplasms. By combining the power of cell sorting, qPCR based gene expression analysis and advanced normal and cancer stem cell models, we are now able to characterize the contribution of normal somatic tissue stem cells to the development of cancers, including Acute Myelogenous Leukemia and MDS. Our lab uses model systems and gene expression analysis to compare normal stem cells with their malignant counterparts with the goal of an improved understanding of the origins of cancer stem cells and to identify novel targets for therapy.
We have employed a unique flow cytometry platform and analysis approach to differentiate normal and malignant stem cell and progenitor populations in patients undergoing treatment for AML and MDS. This platform allows us to assess the impact of therapy on malignant stem cell populations and their gene signatures in patients undergoing treatment of their disease. In addition, we are interested in the role of the microenvironment in supporting malignant stem cell populations.
2013 May
Liesveld J, Pawlowski J, Chen R, Hyrien O, Debolt J, Becker M, Phillips G, Chen Y. "Clinical factors affecting engraftment and transfusion needs in SCT: a single-center retrospective analysis." Bone marrow transplantation. 2013 May 0; 48(5):691-7. Epub 2012 Oct 22. |
2013 Mar 7
Lagadinou ED, Sach A, Callahan K, Rossi RM, Neering SJ, Minhajuddin M, Ashton JM, Pei S, Grose V, O'Dwyer KM, Liesveld JL, Brookes PS, Becker MW, Jordan CT. "BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells." Cell stem cell. 2013 Mar 7; 12(3):329-41. Epub 2013 Jan 17. |
2012 Jul
Reid R, Bennett JM, Becker M, Chen Y, Milner L, Phillips Ii GL, Liesveld J. "Use of eltrombopag, a thrombopoietin receptor agonist, in post-transplantation thrombocytopenia." American journal of hematology. 2012 Jul 0; 87(7):743-5. Epub 2012 May 10. |
2012 May
Ban-Hoefen M, Kelly JL, Bernstein SH, Liesveld J, Constine L, Becker M, Milner L, Phillips G, Friedberg JW. "High-dose therapy and autologous stem cell transplant for transformed non-Hodgkin lymphoma in the rituximab era." Leukemia & lymphoma. 2012 May 0; 53(5):830-5. Epub 2011 Dec 06. |
2012 Jan 12
Frisch BJ, Ashton JM, Xing L, Becker MW, Jordan CT, Calvi LM. "Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia." Blood. 2012 Jan 12; 119(2):540-50. Epub 2011 Sep 28. |
