Peter J. Sims, M.D., Ph.D.

Peter J. Sims, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box MED
Rochester, NY 14642

Office: (585) 276-3007
Fax: (585) 276-2272

Research Bio

We originally discovered and cloned phospholipid scramblase as a membrane protein with capacity to promote rapid transbilayer movement of phospholipids in response to Ca2+ . This protein turned out to be the first of four that together form the phospholipid scramblase (PLSCR) gene family. Our research during the last few years has revealed that PLSCRs may have functions beyond their putative role as membrane phospholipid scramblases. Taking advantage of gene knockout technology, we discovered that mice with a targeted deletion of PLSCR1 display perinatal granulocytopenia due to defective response to hematologic precursors to granulocyte colony-stimulating factor and stem cell factor.

Interestingly, PLSCR3-/- mice have a phenotype reminiscent of metabolic syndrome in man: they display aberrant accumulation of abdominal fat, accompanied by the development of insulin resistance, glucose intolerance, and dyslipidemia. These observations and our in vitro data suggest that PLSCRs are involved in signal transduction through growth factor receptors and may be required for normal cell maturation. Furthermore, we have shown that aberrant expression of PLSCR1 may play a role in tumor formation and increased susceptibility to viral infection. Current efforts are focused on unraveling the molecular mechanisms by which PLSCRs mediate these diverse functions.

Awards & Honors (Local)

Adjunct Professor Shanghai Second Medical University Shanghai, China 2004
Chairman, N.I.H. Hematology 1 Study Section 1999 - 2001
N.I.H. (NHLBI) MERIT Award 1995
Walter H. Schroeder Chair in Research, The Blood Center of Southeastern Wisconsin 1993 - 1999
Chairman, Veterans Administration Merit Review Board - Hematology 1991 - 1992
President, American Heart Association, Oklahoma Affiliate 1990 - 1991
Man-of-the-Year Award, American Heart Association, Oklahoma Affiliate Chapter 1989
American Society for Clinical Investigation 1988
S. Graham Smith Endowment Distinguished Scientist, Oklahoma Medical Research Foundation, 1988 - 1992
N.I.H. Research Career Development Award (Awarded but not activated in lieu of AHA Estabished Investigatorship) 1985
Established Investigator of American Heart Association #85-128 1985 - 1990
Clinician-Scientist Award, American Heart Association (Awarded but not activated in lieu of Hartford Fellowship) 1982
John A. and George L. Hartford Fellowship in Biomedical Research 1982 - 1985
Southern Medical Association Research Award 1981
Alpha Omega Alpha, Duke University School of Medicine 1976
B.A., Summa Cum Laude, Amherst College 1974
Medical Scientist Traineeship (PHS), GM-07171 1974 - 1980
Sigma Xi, Amherst College 1972
Phi Beta Kappa, Amherst College 1972

Recent Journal Articles

Showing the 5 most recent journal articles. 128 available »

2014
Kassas A, Moura IC, Yamashita Y, Scheffel J, Guérin-Marchand C, Blank U, Sims PJ, Wiedmer T, Monteiro RC, Rivera J, Charles N, Benhamou M. "Regulation of the Tyrosine Phosphorylation of Phospholipid Scramblase 1 in Mast Cells That Are Stimulated through the High-Affinity IgE Receptor." PloS one. 2014 9(10):e109800. Epub 2014 Oct 07.
2013 Feb 20
Ory S, Ceridono M, Momboisse F, Houy S, Chasserot-Golaz S, Heintz D, Calco V, Haeberlé AM, Espinoza FA, Sims PJ, Bailly Y, Bader MF, Gasman S. "Phospholipid scramblase-1-induced lipid reorganization regulates compensatory endocytosis in neuroendocrine cells." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Feb 20; 33(8):3545-56.
2013
"Phospholipid Scramblase 1, an interferon-regulated gene located at 3q23, is regulated by SnoN/SkiL in ovarian cancer cells." Molecular cancer. 2013 12:32. Epub 2013 Apr 26.
2012 Mar
Kirov A, Al-Hashimi H, Solomon P, Mazur C, Thorpe PE, Sims PJ, Tarantini F, Kumar TK, Prudovsky I. "Phosphatidylserine externalization and membrane blebbing are involved in the nonclassical export of FGF1." Journal of cellular biochemistry. 2012 Mar; 113(3):956-66.
2012
Li D, Yang H, Nan H, Liu P, Pang S, Zhao Q, Karni R, Kamps MP, Xu Y, Zhou J, Wiedmer T, Sims PJ, Wang F. "Identification of key regulatory pathways of myeloid differentiation using an mESC-based karyotypically normal cell model." Blood. 2012 120(24):4712-9. Epub 2012 Oct 18.

Current Appointments

Professor Emeritus - Department of Medicine (SMD) - Primary

Education

MD | Medicine | Duke University Sch Medicine1980
PhD | Pharmacology | Duke University Sch Medicine1980
BA | Biophysics | Amherst College1974