Peter J. Sims, M.D., Ph.D.

Peter J. Sims, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box MED
Rochester, NY 14642

Office: (585) 276-3007
Fax: (585) 276-2272

Books

1994
Petri,W. Jrs, Sims,P.J.. "Entamoeba Histolytica Resistance to Lysis by the Complement Membrand Attack Complex". Constitutional Resistance to Infection. Verheof,J., van Dijk,H., Verduin,C.M., Watson,D.a.. Austin: RG Landes, 1994.
1993
Sims,P.J., Wiedmer,T.. "Complement Biology". Hematology: Basic Principles and Practice. Benz,E., Cohen,H., Furie,B., Hoffman,R., Shattil,S.. N.Y.: Churchill Livingstone, 1993.
1993
Sims,P.J.. "CD59". Human Protein Data. Haeberli. Weinheim: VCH Verlagsgesellschaft, 1993.
1993
Sims,P.J.. "Structure and Function of CD59". Biology of Vitronectins and Their Receptors. Preissner,K.T., Rosenblatt,S., Kost, C., Wegerhoff,J., Mosher,D.F.. Amsterdam: Elsevier, 1993. 243-248
1990
Sims,P.J.. "Plasma Proteins: Complement". Hematology: Basic Principles and Practice. Benz,E., Cohen,H., Furie,B., Hoffman,R., Shattil,S.. N.Y.: Churchill Livingstone, 1990. 1582-1591
1989
Sims, P.J.. "Interaction of Human Platelets with the Completment System". Platelet Immunobiology, Molecular and Clinical Aspects. Kunicki,T.J., George,J.N.. Philidelphia: JB Lippincott, 1989. 354-383
1989
Spivak, J.L., Sims,P.J., Selby, G.B.. "The Anemias". Hematology. Levine, P.H.. Philidelphia: Grune & Stratton, 1989. 1-8

Journal Articles

Showing all 127 journal articles available.

2013 Feb 20
Ory S, Ceridono M, Momboisse F, Houy S, Chasserot-Golaz S, Heintz D, Calco V, Haeberlé AM, Espinoza FA, Sims PJ, Bailly Y, Bader MF, Gasman S. "Phospholipid scramblase-1-induced lipid reorganization regulates compensatory endocytosis in neuroendocrine cells." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2013 Feb 20; 33(8):3545-56.
2013
"Phospholipid Scramblase 1, an interferon-regulated gene located at 3q23, is regulated by SnoN/SkiL in ovarian cancer cells." Molecular cancer. 2013 12:32. Epub 2013 Apr 26.
2012 Mar
Kirov A, Al-Hashimi H, Solomon P, Mazur C, Thorpe PE, Sims PJ, Tarantini F, Kumar TK, Prudovsky I. "Phosphatidylserine externalization and membrane blebbing are involved in the nonclassical export of FGF1." Journal of cellular biochemistry. 2012 Mar; 113(3):956-66.
2012
Li D, Yang H, Nan H, Liu P, Pang S, Zhao Q, Karni R, Kamps MP, Xu Y, Zhou J, Wiedmer T, Sims PJ, Wang F. "Identification of key regulatory pathways of myeloid differentiation using an mESC-based karyotypically normal cell model." Blood.. 2012 120(24):4712-9. Epub 2012 Oct 18.
2011 Aug 12
Lott K, Bhardwaj A, Sims PJ, Cingolani G. "A minimal nuclear localization signal (NLS) in human phospholipid scramblase 4 that binds only the minor NLS-binding site of importin alpha1." The Journal of biological chemistry.. 2011 Aug 12; 286(32):28160-9. Epub 2011 Jun 20.
2011 Aug
Chen CW, Sowden M, Zhao Q, Wiedmer T, Sims PJ. "Nuclear phospholipid scramblase 1 prolongs the mitotic expansion of granulocyte precursors during G-CSF-induced granulopoiesis." Journal of leukocyte biology.. 2011 Aug; 90(2):221-33. Epub 2011 Mar 29.
2010
Suzuki J, Umeda M, Sims PJ, Nagata S. "Calcium-dependent phospholipid scrambling by TMEM16F." Nature. 2010 468(7325):834-8. Epub 2010 Nov 24.
2009 Jan 15
Bateman A, Finn RD, Sims PJ, Wiedmer T, Biegert A, Söding J. "Phospholipid scramblases and Tubby-like proteins belong to a new superfamily of membrane tethered transcription factors." Bioinformatics (Oxford, England). 2009 Jan 15; 25(2):159-62. Epub 2008 Nov 13.
2007 Sep
Lu B, Sims PJ, Wiedmer T, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR. "Expression of the phospholipid scramblase (PLSCR) gene family during the acute phase response." Biochimica et biophysica acta.. 2007 Sep; 1771(9):1177-85. Epub 2007 May 26.
2007
Mutch DM, O'Maille G, Wikoff WR, Wiedmer T, Sims PJ, Siuzdak G. "Mobilization of pro-inflammatory lipids in obese Plscr3-deficient mice." Genome biology. 2007 8(3):R38.
2006 Oct 26
Huang Y, Zhao Q, Zhou CX, Gu ZM, Li D, Xu HZ, Wiedmer T, Sims PJ, Zhao KW, Chen GQ. "Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells." Oncogene. 2006 Oct 26; 25(50):6618-27. Epub 2006 May 15.
2006 May
Li Y, Rogulski K, Zhou Q, Sims PJ, Prochownik EV. "The negative c-Myc target onzin affects proliferation and apoptosis via its obligate interaction with phospholipid scramblase 1." Molecular and cellular biology. 2006 May; 26(9):3401-13.
2005 Oct 14
Zhou Q, Ben-Efraim I, Bigcas JL, Junqueira D, Wiedmer T, Sims PJ. "Phospholipid scramblase 1 binds to the promoter region of the inositol 1,4,5-triphosphate receptor type 1 gene to enhance its expression." The Journal of biological chemistry.. 2005 Oct 14; 280(41):35062-8. Epub 2005 Aug 09.
2005 Mar 18
Chen MH, Ben-Efraim I, Mitrousis G, Walker-Kopp N, Sims PJ, Cingolani G. "Phospholipid scramblase 1 contains a nonclassical nuclear localization signal with unique binding site in importin alpha." The Journal of biological chemistry.. 2005 Mar 18; 280(11):10599-606. Epub 2004 Dec 17.
2005
Zhao KW, Li D, Zhao Q, Huang Y, Silverman RH, Sims PJ, Chen GQ. "Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK." The Journal of biological chemistry.. 2005 280(52):42707-14. Epub 2005 Oct 28.
2004 Sep 7
Wiedmer T, Zhao J, Li L, Zhou Q, Hevener A, Olefsky JM, Curtiss LK, Sims PJ. "Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3)." Proceedings of the National Academy of Sciences of the United States of America.. 2004 Sep 7; 101(36):13296-301. Epub 2004 Aug 24.
2004 Sep
Dong B, Zhou Q, Zhao J, Zhou A, Harty RN, Bose S, Banerjee A, Slee R, Guenther J, Williams BR, Wiedmer T, Sims PJ, Silverman RH. "Phospholipid scramblase 1 potentiates the antiviral activity of interferon." Journal of virology.. 2004 Sep; 78(17):8983-93.
2004 Mar 30
Ben-Efraim I, Zhou Q, Wiedmer T, Gerace L, Sims PJ. "Phospholipid scramblase 1 is imported into the nucleus by a receptor-mediated pathway and interacts with DNA." Biochemistry.. 2004 Mar 30; 43(12):3518-26.
2004
Zhao KW, Li X, Zhao Q, Huang Y, Li D, Peng ZG, Shen WZ, Zhao J, Zhou Q, Chen Z, Sims PJ, Wiedmer T, Chen GQ. "Protein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation." Blood.. 2004 104(12):3731-8. Epub 2004 Aug 12.
2004
Ben-Efraim,I.; Zhou,Q.; Wiedmer,T.; Gerace,L.; Sims,P. J.;. "Phospholipid scramblase 1 is imported into the nucleus by a receptor-mediated pathway and interacts with DNA". Biochemistry (John Wiley & Sons). 2004; 43(12): 3518-3526. Link
2004
Giddings KS, Zhao J, Sims PJ, Tweten RK. "Human CD59 is a receptor for the cholesterol-dependent cytolysin intermedilysin." Nature structural & molecular biology. 2004 11(12):1173-8. Epub 2004 Nov 14.
2003 Sep 26
Nanjundan M, Sun J, Zhao J, Zhou Q, Sims PJ, Wiedmer T. "Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor." The Journal of biological chemistry.. 2003 Sep 26; 278(39):37413-8. Epub 2003 Jul 18.
2003 Jul
Rami A, Sims J, Botez G, Winckler J. "Spatial resolution of phospholipid scramblase 1 (PLSCR1), caspase-3 activation and DNA-fragmentation in the human hippocampus after cerebral ischemia." Neurochemistry international. 2003 Jul; 43(1):79-87.
2003 Jun
de Vries KJ, Wiedmer T, Sims PJ, Gadella BM. "Caspase-independent exposure of aminophospholipids and tyrosine phosphorylation in bicarbonate responsive human sperm cells." Biology of reproduction.. 2003 Jun; 68(6):2122-34. Epub 2003 Jan 22.
2003 Apr 25
Kametaka S, Shibata M, Moroe K, Kanamori S, Ohsawa Y, Waguri S, Sims PJ, Emoto K, Umeda M, Uchiyama Y. "Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))." The Journal of biological chemistry.. 2003 Apr 25; 278(17):15239-45. Epub 2003 Feb 13.
2003 Feb 11
Wiedmer T, Zhao J, Nanjundan M, Sims PJ. "Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane." Biochemistry.. 2003 Feb 11; 42(5):1227-33.
2003
Wiedmer,T.; Zhao,J.; Nanjundan,M.; Sims,P. J.;. "Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane". Biochemistry (John Wiley & Sons). 2003; 42(5): 1227-1233. Link
2002 Jun 1
Zhou Q, Zhao J, Wiedmer T, Sims PJ. "Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1." Blood.. 2002 Jun 1; 99(11):4030-8.
2002 May 21
Sun J, Nanjundan M, Pike LJ, Wiedmer T, Sims PJ. "Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor." Biochemistry.. 2002 May 21; 41(20):6338-45.
2002 Jan 15
Silverman RH, Halloum A, Zhou A, Dong B, Al-Zoghaibi F, Kushner D, Zhou Q, Zhao J, Wiedmer T, Sims PJ. "Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1." Cancer research.. 2002 Jan 15; 62(2):397-402.
2002
Sun,J.; Nanjundan,M.; Pike,L. J.; Wiedmer,T.; Sims,P. J.;. "Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor". Biochemistry (John Wiley & Sons). 2002; 41(20): 6338-6345. Link
2001 Aug 3
Sun J, Zhao J, Schwartz MA, Wang JY, Wiedmer T, Sims PJ. "c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1." The Journal of biological chemistry.. 2001 Aug 3; 276(31):28984-90. Epub 2001 Jun 04.
2001 Jul
Sims PJ, Wiedmer T. "Unraveling the mysteries of phospholipid scrambling." Thrombosis and haemostasis.. 2001 Jul; 86(1):266-75.
2000 Jul 31
Wiedmer T, Zhou Q, Kwoh DY, Sims PJ. "Identification of three new members of the phospholipid scramblase gene family." Biochimica et biophysica acta.. 2000 Jul 31; 1467(1):244-53.
2000 Jul 10
Tepper AD, Ruurs P, Wiedmer T, Sims PJ, Borst J, van Blitterswijk WJ. "Sphingomyelin hydrolysis to ceramide during the execution phase of apoptosis results from phospholipid scrambling and alters cell-surface morphology." The Journal of cell biology. 2000 Jul 10; 150(1):155-64.
2000 Apr 15
Zhou Q, Zhao J, Al-Zoghaibi F, Zhou A, Wiedmer T, Silverman RH, Sims PJ. "Transcriptional control of the human plasma membrane phospholipid scramblase 1 gene is mediated by interferon-alpha." Blood.. 2000 Apr 15; 95(8):2593-9.
1999 Apr 23
Wilson HA, Waldrip JB, Nielson KH, Judd AM, Han SK, Cho W, Sims PJ, Bell JD. "Mechanisms by which elevated intracellular calcium induces S49 cell membranes to become susceptible to the action of secretory phospholipase A2." The Journal of biological chemistry.. 1999 Apr 23; 274(17):11494-504.
1999
Fadeel B, Gleiss B, Högstrand K, Chandra J, Wiedmer T, Sims PJ, Henter JI, Orrenius S, Samali A. "Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression." Biochemical and biophysical research communications.. 1999 266(2):504-11.
1998 Oct 20
Stout JG, Zhou Q, Wiedmer T, Sims PJ. "Change in conformation of plasma membrane phospholipid scramblase induced by occupancy of its Ca2+ binding site." Biochemistry.. 1998 Oct 20; 37(42):14860-6.
1998 Sep 1
Zhou Q, Sims PJ, Wiedmer T. "Expression of proteins controlling transbilayer movement of plasma membrane phospholipids in the B lymphocytes from a patient with Scott syndrome." Blood.. 1998 Sep 1; 92(5):1707-12.
1998 May 5
Zhao J, Zhou Q, Wiedmer T, Sims PJ. "Palmitoylation of phospholipid scramblase is required for normal function in promoting Ca2+-activated transbilayer movement of membrane phospholipids." Biochemistry.. 1998 May 5; 37(18):6361-6.
1998 Apr 24
Zhao XJ, Zhao J, Zhou Q, Sims PJ. "Identity of the residues responsible for the species-restricted complement inhibitory function of human CD59." The Journal of biological chemistry.. 1998 Apr 24; 273(17):10665-71.
1998 Mar 20
Zhao J, Zhou Q, Wiedmer T, Sims PJ. "Level of expression of phospholipid scramblase regulates induced movement of phosphatidylserine to the cell surface." The Journal of biological chemistry.. 1998 Mar 20; 273(12):6603-6.
1998 Feb 24
Zhou Q, Sims PJ, Wiedmer T. "Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids." Biochemistry.. 1998 Feb 24; 37(8):2356-60.
1998
Stout,J. G.; Zhou,Q.; Wiedmer,T.; Sims,P. J.;. "Change in conformation of plasma membrane phospholipid scramblase induced by occupancy of its Ca2+ binding site". Biochemistry (John Wiley & Sons). 1998; 37(42): 14860-14866. Link
1998
Zhao,J.; Zhou,Q.; Wiedmer,T.; Sims,P. J.;. "Palmitoylation of phospholipid scramblase is required for normal function in promoting Ca2+-activated transbilayer movement of membrane phospholipids". Biochemistry (John Wiley & Sons). 1998; 37(18): 6361-6366. Link
1998
Zhou,Q.; Sims,P. J.; Wiedmer,T.;. "Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids". Biochemistry (John Wiley & Sons). 1998; 37(8): 2356-2360. Link
1997 Jul 18
Zhou Q, Zhao J, Stout JG, Luhm RA, Wiedmer T, Sims PJ. "Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids." The Journal of biological chemistry.. 1997 Jul 18; 272(29):18240-4.
1997 Jun 5
Zhao J, Sims PJ, Wiedmer T. "Production and characterization of a mutant cell line defective in aminophospholipid translocase." Biochimica et biophysica acta.. 1997 Jun 5; 1357(1):57-64.
1997 May 1
Stout JG, Bassé F, Luhm RA, Weiss HJ, Wiedmer T, Sims PJ. "Scott syndrome erythrocytes contain a membrane protein capable of mediating Ca2+-dependent transbilayer migration of membrane phospholipids." The Journal of clinical investigation.. 1997 May 1; 99(9):2232-8.
1997 Jan
Christiansen VJ, Sims PJ, Hamilton KK. "Complement C5b-9 increases plasminogen binding and activation on human endothelial cells." Arteriosclerosis, thrombosis, and vascular biology.. 1997 Jan; 17(1):164-71.
1996 Oct
Zhou Q, Zhao J, Hüsler T, Sims PJ. "Expression of recombinant CD59 with an N-terminal peptide epitope facilitates analysis of residues contributing to its complement-inhibitory function." Molecular immunology.. 1996 Oct; 33(14):1127-34.
1996 Sep 27
Rother RP, Zhao J, Zhou Q, Sims PJ. "Elimination of potential sites of glycosylation fails to abrogate complement regulatory function of cell surface CD59." The Journal of biological chemistry.. 1996 Sep 27; 271(39):23842-5.
1996 Jul 19
Bassé F, Stout JG, Sims PJ, Wiedmer T. "Isolation of an erythrocyte membrane protein that mediates Ca2+-dependent transbilayer movement of phospholipid." The Journal of biological chemistry.. 1996 Jul 19; 271(29):17205-10.
1996 Mar 12
Husler T, Lockert DH, Sims PJ. "Role of a disulfide-bonded peptide loop within human complement C9 in the species-selectivity of complement inhibitor CD59." Biochemistry.. 1996 Mar 12; 35(10):3263-9.
1996
Husler,T.; Lockert,D. H.; Sims,P. J.;. "Role of a disulfide-bonded peptide loop within human complement C9 in the species-selectivity of complement inhibitor CD59". Biochemistry (John Wiley & Sons). 1996; 35(10): 3263-3269. Link
1996
Petranka J, Zhao J, Norris J, Tweedy NB, Ware RE, Sims PJ, Rosse WF. "Structure-function relationships of the complement regulatory protein, CD59." Blood cells, molecules & diseases.. 1996 22(3):281-96.
1995 Oct
Sims PJ, Wiedmer T. "Induction of cellular procoagulant activity by the membrane attack complex of complement." Seminars in cell biology. 1995 Oct; 6(5):275-82.
1995 Sep 1
Bevers EM, Wiedmer T, Comfurius P, Zhao J, Smeets EF, Schlegel RA, Schroit AJ, Weiss HJ, Williamson P, Zwaal RF, Sims PJ. "The complex of phosphatidylinositol 4,5-bisphosphate and calcium ions is not responsible for Ca2+-induced loss of phospholipid asymmetry in the human erythrocyte: a study in Scott syndrome, a disorder of calcium-induced phospholipid scrambling." Blood.. 1995 Sep 1; 86(5):1983-91.
1995 Aug 25
Lockert DH, Kaufman KM, Chang CP, Hüsler T, Sodetz JM, Sims PJ. "Identity of the segment of human complement C8 recognized by complement regulatory protein CD59." The Journal of biological chemistry.. 1995 Aug 25; 270(34):19723-8.
1995 Feb 24
Hüsler T, Lockert DH, Kaufman KM, Sodetz JM, Sims PJ. "Chimeras of human complement C9 reveal the site recognized by complement regulatory protein CD59." The Journal of biological chemistry.. 1995 Feb 24; 270(8):3483-6.
1994 Oct 21
Chang CP, Hüsler T, Zhao J, Wiedmer T, Sims PJ. "Identity of a peptide domain of human C9 that is bound by the cell-surface complement inhibitor, CD59." The Journal of biological chemistry.. 1994 Oct 21; 269(42):26424-30.
1994 Sep 15
Menu E, Tsai BC, Bothwell AL, Sims PJ, Bierer BE. "CD59 costimulation of T cell activation. CD58 dependence and requirement for glycosylation." The Journal of immunology : official journal of the American Association of Immunologists.. 1994 Sep 15; 153(6):2444-56.
1994 May 27
Kennedy SP, Rollins SA, Burton WV, Sims PJ, Bothwell AL, Squinto SP, Zavoico GB. "Protection of porcine aortic endothelial cells from complement-mediated cell lysis and activation by recombinant human CD59." Transplantation. 1994 May 27; 57(10):1494-501.
1994
Kojima H, Newton-Nash D, Weiss HJ, Zhao J, Sims PJ, Wiedmer T. "Production and characterization of transformed B-lymphocytes expressing the membrane defect of Scott syndrome." The Journal of clinical investigation.. 1994 94(6):2237-44.
1993 Aug 15
Wiedmer T, Hall SE, Ortel TL, Kane WH, Rosse WF, Sims PJ. "Complement-induced vesiculation and exposure of membrane prothrombinase sites in platelets of paroxysmal nocturnal hemoglobinuria." Blood.. 1993 Aug 15; 82(4):1192-6.
1993 Apr 5
Chang CP, Zhao J, Wiedmer T, Sims PJ. "Contribution of platelet microparticle formation and granule secretion to the transmembrane migration of phosphatidylserine." The Journal of biological chemistry.. 1993 Apr 5; 268(10):7171-8.
1993 Feb 15
Hamilton KK, Zhao J, Sims PJ. "Interaction between apolipoproteins A-I and A-II and the membrane attack complex of complement. Affinity of the apoproteins for polymeric C9." The Journal of biological chemistry.. 1993 Feb 15; 268(5):3632-8.
1992 Sep 15
Shattil SJ, Cunningham M, Wiedmer T, Zhao J, Sims PJ, Brass LF. "Regulation of glycoprotein IIb-IIIa receptor function studied with platelets permeabilized by the pore-forming complement proteins C5b-9." The Journal of biological chemistry.. 1992 Sep 15; 267(26):18424-31.
1992 Sep
Braga LL, Ninomiya H, McCoy JJ, Eacker S, Wiedmer T, Pham C, Wood S, Sims PJ, Petri WA. "Inhibition of the complement membrane attack complex by the galactose-specific adhesion of Entamoeba histolytica." The Journal of clinical investigation.. 1992 Sep; 90(3):1131-7.
1992 Jul 5
Ninomiya H, Sims PJ. "The human complement regulatory protein CD59 binds to the alpha-chain of C8 and to the "b"domain of C9." The Journal of biological chemistry.. 1992 Jul 5; 267(19):13675-80.
1992 Jun 26
Hahn WC, Menu E, Bothwell AL, Sims PJ, Bierer BE. "Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59." Science.. 1992 Jun 26; 256(5065):1805-7.
1992 Apr 25
Ninomiya H, Stewart BH, Rollins SA, Zhao J, Bothwell AL, Sims PJ. "Contribution of the N-linked carbohydrate of erythrocyte antigen CD59 to its complement-inhibitory activity." The Journal of biological chemistry.. 1992 Apr 25; 267(12):8404-10.
1992 Jan 15
Bevers EM, Wiedmer T, Comfurius P, Shattil SJ, Weiss HJ, Zwaal RF, Sims PJ. "Defective Ca(2+)-induced microvesiculation and deficient expression of procoagulant activity in erythrocytes from a patient with a bleeding disorder: a study of the red blood cells of Scott syndrome." Blood.. 1992 Jan 15; 79(2):380-8.
1992
Dahlbäck B, Wiedmer T, Sims PJ. "Binding of anticoagulant vitamin K-dependent protein S to platelet-derived microparticles." Biochemistry.. 1992 31(51):12769-77.
1992
Dahlback,B.; Wiedmer,T.; Sims,P. J.;. "Binding of anticoagulant vitamin K-dependent protein S to platelet-derived microparticles". Biochemistry (John Wiley & Sons). 1992; 31(51): 12769-12777. Link
1992
Braga LL, Ninomiya H, McCoy JJ, Adal K, Wiedmer T, Pham C, Sims PJ, Petri WA. "Inhibition of the complement membrane attack complex by the galactose-specific adhesin of Entamoeba histolytica." Archives of medical research. 1992 23(2):133.
1991 Sep 15
Gilbert GE, Sims PJ, Wiedmer T, Furie B, Furie BC, Shattil SJ. "Platelet-derived microparticles express high affinity receptors for factor VIII." The Journal of biological chemistry.. 1991 Sep 15; 266(26):17261-8.
1991 Sep
Sims PJ, Wiedmer T. "The response of human platelets to activated components of the complement system." Immunology today. 1991 Sep; 12(9):338-42.
1991 Jul 15
Zhao J, Rollins SA, Maher SE, Bothwell AL, Sims PJ. "Amplified gene expression in CD59-transfected Chinese hamster ovary cells confers protection against the membrane attack complex of human complement." The Journal of biological chemistry.. 1991 Jul 15; 266(20):13418-22.
1991 Jul 5
Tweten RK, Harris RW, Sims PJ. "Isolation of a tryptic fragment from Clostridium perfringens theta-toxin that contains sites for membrane binding and self-aggregation." The Journal of biological chemistry.. 1991 Jul 5; 266(19):12449-54.
1991 Jul
Harris RW, Sims PJ, Tweten RK. "Evidence that Clostridium perfringens theta-toxin induces colloid-osmotic lysis of erythrocytes." Infection and immunity.. 1991 Jul; 59(7):2499-501.
1991 Apr 25
Sims PJ, Ginsberg MH, Plow EF, Shattil SJ. "Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex." The Journal of biological chemistry.. 1991 Apr 25; 266(12):7345-52.
1991 Apr 15
Harris RW, Sims PJ, Tweten RK. "Kinetic aspects of the aggregation of Clostridium perfringens theta-toxin on erythrocyte membranes. A fluorescence energy transfer study." The Journal of biological chemistry.. 1991 Apr 15; 266(11):6936-41.
1991 Apr 1
Rollins SA, Zhao J, Ninomiya H, Sims PJ. "Inhibition of homologous complement by CD59 is mediated by a species-selective recognition conferred through binding to C8 within C5b-8 or C9 within C5b-9." The Journal of immunology : official journal of the American Association of Immunologists.. 1991 Apr 1; 146(7):2345-51.
1991 Jan 1
Gerrard JM, Lint D, Sims PJ, Wiedmer T, Fugate RD, McMillan E, Robertson C, Israels SJ. "Identification of a platelet dense granule membrane protein that is deficient in a patient with the Hermansky-Pudlak syndrome." Blood.. 1991 Jan 1; 77(1):101-12.
1991
Wiedmer T, Sims PJ. "Participation of protein kinases in complement C5b-9-induced shedding of platelet plasma membrane vesicles." Blood.. 1991 78(11):2880-6.
1991
Rollins,S. A.; Zhao,J.; Ninomiya,H.; Sims,P. J.;. "Inhibition of homologous complement by CD59 is mediated by a species-selective recognition conferred through binding to C8 within C5b-8 or C9 within C5b-9". Journal of immunology (Baltimore, Md.). 1991; 146(7): 2345-2351. Link
1991
Hamilton KK, Sims PJ. "The terminal complement proteins C5b-9 augment binding of high density lipoprotein and its apolipoproteins A-I and A-II to human endothelial cells." The Journal of clinical investigation.. 1991 88(6):1833-40.
1990 May 1
Rollins SA, Sims PJ. "The complement-inhibitory activity of CD59 resides in its capacity to block incorporation of C9 into membrane C5b-9." The Journal of immunology : official journal of the American Association of Immunologists.. 1990 May 1; 144(9):3478-83.
1990 Mar 5
Hamilton KK, Hattori R, Esmon CT, Sims PJ. "Complement proteins C5b-9 induce vesiculation of the endothelial plasma membrane and expose catalytic surface for assembly of the prothrombinase enzyme complex." The Journal of biological chemistry.. 1990 Mar 5; 265(7):3809-14.
1990 Jan 23
Wiedmer T, Shattil SJ, Cunningham M, Sims PJ. "Role of calcium and calpain in complement-induced vesiculation of the platelet plasma membrane and in the exposure of the platelet factor Va receptor." Biochemistry.. 1990 Jan 23; 29(3):623-32.
1990
Hamilton KK, Ji Z, Rollins S, Stewart BH, Sims PJ. "Regulatory control of the terminal complement proteins at the surface of human endothelial cells: neutralization of a C5b-9 inhibitor by antibody to CD59." Blood.. 1990 76(12):2572-7.
1990
Rollins,S. A.; Sims,P. J.;. "The complement-inhibitory activity of CD59 resides in its capacity to block incorporation of C9 into membrane C5b-9". Journal of immunology (Baltimore, Md.). 1990; 144(9): 3478-3483. Link
1990
Wiedmer,T.; Shattil,S. J.; Cunningham,M.; Sims,P. J.;. "Role of calcium and calpain in complement-induced vesiculation of the platelet plasma membrane and in the exposure of the platelet factor Va receptor". Biochemistry (John Wiley & Sons). 1990; 29(3): 623-632. Link
1989 Nov 15
Sims PJ, Rollins SA, Wiedmer T. "Regulatory control of complement on blood platelets. Modulation of platelet procoagulant responses by a membrane inhibitor of the C5b-9 complex." The Journal of biological chemistry.. 1989 Nov 15; 264(32):19228-35.
1989 Nov
Van der Meer BW, Fugate RD, Sims PJ. "Complement proteins C5b-9 induce transbilayer migration of membrane phospholipids." Biophysical journal.. 1989 Nov; 56(5):935-46.
1989 Oct 15
Sims PJ, Wiedmer T, Esmon CT, Weiss HJ, Shattil SJ. "Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. Studies in Scott syndrome: an isolated defect in platelet procoagulant activity." The Journal of biological chemistry.. 1989 Oct 15; 264(29):17049-57.
1989 May 25
Hattori R, Hamilton KK, McEver RP, Sims PJ. "Complement proteins C5b-9 induce secretion of high molecular weight multimers of endothelial von Willebrand factor and translocation of granule membrane protein GMP-140 to the cell surface." The Journal of biological chemistry.. 1989 May 25; 264(15):9053-60.
1989 May 15
Hattori R, Hamilton KK, Fugate RD, McEver RP, Sims PJ. "Stimulated secretion of endothelial von Willebrand factor is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140." The Journal of biological chemistry.. 1989 May 15; 264(14):7768-71.
1989 Feb
Ando B, Wiedmer T, Sims PJ. "The secretory release reaction initiated by complement proteins C5b-9 occurs without platelet aggregation through glycoprotein IIb-IIIa." Blood.. 1989 Feb; 73(2):462-7.
1988 Aug 25
Ando B, Wiedmer T, Hamilton KK, Sims PJ. "Complement proteins C5b-9 initiate secretion of platelet storage granules without increased binding of fibrinogen or von Willebrand factor to newly expressed cell surface GPIIb-IIIa." The Journal of biological chemistry.. 1988 Aug 25; 263(24):11907-14.
1988 Jan 15
Stearns DJ, Kurosawa S, Sims PJ, Esmon NL, Esmon CT. "The interaction of a Ca2+-dependent monoclonal antibody with the protein C activation peptide region. Evidence for obligatory Ca2+ binding to both antigen and antibody." The Journal of biological chemistry.. 1988 Jan 15; 263(2):826-32.
1988
Sims PJ, Faioni EM, Wiedmer T, Shattil SJ. "Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity." The Journal of biological chemistry.. 1988 263(34):18205-12.
1987 Oct 5
Wiedmer T, Ando B, Sims PJ. "Complement C5b-9-stimulated platelet secretion is associated with a Ca2+-initiated activation of cellular protein kinases." The Journal of biological chemistry.. 1987 Oct 5; 262(28):13674-81.
1987 Feb
Hamilton KK, Sims PJ. "Changes in cytosolic Ca2+ associated with von Willebrand factor release in human endothelial cells exposed to histamine. Study of microcarrier cell monolayers using the fluorescent probe indo-1." The Journal of clinical investigation.. 1987 Feb; 79(2):600-8.
1986 Nov 5
Wiedmer T, Esmon CT, Sims PJ. "On the mechanism by which complement proteins C5b-9 increase platelet prothrombinase activity." The Journal of biological chemistry.. 1986 Nov 5; 261(31):14587-92.
1986 Oct
Wiedmer T, Esmon CT, Sims PJ. "Complement proteins C5b-9 stimulate procoagulant activity through platelet prothrombinase." Blood.. 1986 Oct; 68(4):875-80.
1986 Aug
Sims PJ, Wiedmer T. "Repolarization of the membrane potential of blood platelets after complement damage: evidence for a Ca++ -dependent exocytotic elimination of C5b-9 pores." Blood.. 1986 Aug; 68(2):556-61.
1986
Benz R, Schmid A, Wiedmer T, Sims PJ. "Single-channel analysis of the conductance fluctuations induced in lipid bilayer membranes by complement proteins C5b-9." The Journal of membrane biology. 1986 94(1):37-45.
1985 Jul 5
Wiedmer T, Sims PJ. "Effect of complement proteins C5b-9 on blood platelets. Evidence for reversible depolarization of membrane potential." The Journal of biological chemistry.. 1985 Jul 5; 260(13):8014-9.
1985 Jul
Cheng KH, Wiedmer T, Sims PJ. "Fluorescence resonance energy transfer study of the associative state of membrane-bound complexes of complement proteins C5b-8." The Journal of immunology : official journal of the American Association of Immunologists.. 1985 Jul; 135(1):459-64.
1985 Jun
Parker CJ, Wiedmer T, Sims PJ, Rosse WF. "Characterization of the complement sensitivity of paroxysmal nocturnal hemoglobinuria erythrocytes." The Journal of clinical investigation.. 1985 Jun; 75(6):2074-84.
1985
Wiedmer T, Sims PJ. "Cyanine dye fluorescence used to measure membrane potential changes due to the assembly of complement proteins C5b-9." The Journal of membrane biology. 1985 84(3):249-58.
1984 Jul 3
Sims PJ. "Complement protein C9 labeled with fluorescein isothiocyanate can be used to monitor C9 polymerization and formation of the cytolytic membrane lesion." Biochemistry.. 1984 Jul 3; 23(14):3248-60.
1984 Jul 3
Sims PJ, Wiedmer T. "Kinetics of polymerization of a fluoresceinated derivative of complement protein C9 by the membrane-bound complex of complement proteins C5b-8." Biochemistry.. 1984 Jul 3; 23(14):3260-7.
1984
Sims,P. J.;. "Complement protein C9 labeled with fluorescein isothiocyanate can be used to monitor C9 polymerization and formation of the cytolytic membrane lesion". Biochemistry (John Wiley & Sons). 1984; 23(14): 3248-3260. Link
1984
Sims,P. J.; Wiedmer,T.;. "Kinetics of polymerization of a fluoresceinated derivative of complement protein C9 by the membrane-bound complex of complement proteins C5b-8". Biochemistry (John Wiley & Sons). 1984; 23(14): 3260-3267. Link
1984
Sims PJ, Wiedmer T. "The influence of electrochemical gradients of Na+ and K+ upon the membrane binding and pore forming activity of the terminal complement proteins." The Journal of membrane biology. 1984 78(2):169-76.
1983 Sep
Sims PJ, Boswell EB. "The measurement of platelet-associated IgG by a microplate quantitative antiglobulin consumption assay using automated through-the-well spectrophotometry." The Journal of laboratory and clinical medicine. 1983 Sep; 102(3):352-60.
1983 Aug 10
Sims PJ. "Complement pores in erythrocyte membranes. Analysis of C8/C9 binding required for functional membrane damage." Biochimica et biophysica acta.. 1983 Aug 10; 732(3):541-52.
1981 Oct
Sims PJ, Boswell EB. "Elevated platelet-bound IgG associated with an episode of thrombotic thrombocytopenic purpura." Blood.. 1981 Oct; 58(4):682-4.
1981 Mar
Sims PJ. "Permeability characteristics of complement-damaged membranes: evaluation of the membrane leak generated by the complement proteins C5b-9." Proceedings of the National Academy of Sciences of the United States of America.. 1981 Mar; 78(3):1838-42.
1980
Sims PJ, Lauf PK. "Analysis of solute diffusion across the C5b-9 membrane lesion of complement: evidence that individual C5b-9 complexes do not function as discrete, uniform pores." The Journal of immunology : official journal of the American Association of Immunologists.. 1980 125(6):2617-25.
1978 Nov
Sims PJ, Lauf PK. "Steady-state analysis of tracer exchange across the C5b-9 complement lesion in a biological membrane." Proceedings of the National Academy of Sciences of the United States of America.. 1978 Nov; 75(11):5669-73.
1974 Jul 30
Sims PJ, Waggoner AS, Wang CH, Hoffman JF. "Studies on the mechanism by which cyanine dyes measure membrane potential in red blood cells and phosphatidylcholine vesicles." Biochemistry.. 1974 Jul 30; 13(16):3315-30.
1974
Sims,P. J.; Waggoner,A. S.; Wang,C. H.; Hoffman,J. F.;. "Studies on the mechanism by which cyanine dyes measure membrane potential in red blood cells and phosphatidylcholine vesicles". Biochemistry (John Wiley & Sons). 1974; 13(16): 3315-3330. Link