Thiyagarajan Meenakshisundaram, Ph.D.

Thiyagarajan Meenakshisundaram, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 670
Rochester, NY 14642

Office: (585) 276-6268
Lab: (585) 276-6268

Journal Articles

Showing all 19 journal articles available.

2013 Oct 18
Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, O'Donnell J, Christensen DJ, Nicholson C, Iliff JJ, Takano T, Deane R, Nedergaard M. "Sleep drives metabolite clearance from the adult brain." Science. 2013 Oct 18; 342(6156):373-7.
Yang L, Kress BT, Weber HJ, Thiyagarajan M, Wang B, Deane R, Benveniste H, Iliff JJ, Nedergaard M. "Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer." Journal of translational medicine. 2013 11:107. Epub 2013 May 01.
Rangroo Thrane V, Thrane AS, Plog BA, Thiyagarajan M, Iliff JJ, Deane R, Nagelhus EA, Nedergaard M. "Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain." Scientific reports. 2013 3:2582.
Deane R; Singh I; Sagare AP; Bell RD; Ross NT; LaRue B; Love R; Perry S; Paquette N; Deane RJ; Thiyagarajan M; Zarcone T; Fritz G; Friedman AE; Miller BL; Zlokovic BV. "A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease." J Clin Invest. 2012; 122(4): 1377-1392. Link
2010 Jan
Petraglia AL, Marky AH, Walker C, Thiyagarajan M, Zlokovic BV. "Activated protein C is neuroprotective and mediates new blood vessel formation and neurogenesis after controlled cortical impact." Neurosurgery. 2010 Jan; 66(1):165-71; discussion 171-2.
2009 Nov
Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino FJ, Stojanovic K, Cleveland DW, Zlokovic BV. "Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells." The Journal of clinical investigation. 2009 Nov; 119(11):3437-49. Epub 2009 Oct 19.
2009 May
Wang Y, Thiyagarajan M, Chow N, Singh I, Guo H, Davis TP, Zlokovic BV. "Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity." Stroke; a journal of cerebral circulation. 2009 May; 40(5):1864-9. Epub 2008 Dec 04.
2008 Nov 26
Thiyagarajan M, Fernández JA, Lane SM, Griffin JH, Zlokovic BV. "Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Nov 26; 28(48):12788-97.
2007 Feb 2
Thiyagarajan M, Cheng T, Zlokovic BV. "Endothelial cell protein C receptor: role beyond endothelium?" Circulation research. 2007 Feb 2; 100(2):155-7.
2006 Nov
Cheng T, Petraglia AL, Li Z, Thiyagarajan M, Zhong Z, Wu Z, Liu D, Maggirwar SB, Deane R, Fernández JA, LaRue B, Griffin JH, Chopp M, Zlokovic BV. "Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage." Nature medicine. 2006 Nov; 12(11):1278-85. Epub 2006 Oct 29.
2006 Nov
Wang J, Ho L, Zhao Z, Seror I, Humala N, Dickstein DL, Thiyagarajan M, Percival SS, Talcott ST, Pasinetti GM. "Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer's disease." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006 Nov; 20(13):2313-20.
2006 Aug 4
Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, MacGrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, Sauve AA, Pasinetti GM. "Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction." The Journal of biological chemistry. 2006 Aug 4; 281(31):21745-54. Epub 2006 Jun 02.
Zhao Z, Lange DJ, Voustianiouk A, MacGrogan D, Ho L, Suh J, Humala N, Thiyagarajan M, Wang J, Pasinetti GM. "A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis." BMC neuroscience. 2006 7:29. Epub 2006 Apr 03.
2004 Oct
Sharma SS, Munusamy S, Thiyagarajan M, Kaul CL. "Neuroprotective effect of peroxynitrite decomposition catalyst and poly(adenosine diphosphate-ribose) polymerase inhibitor alone and in combination in rats with focal cerebral ischemia." Journal of neurosurgery. 2004 Oct; 101(4):669-75.
2004 Jul
Thiyagarajan M, Kaul CL, Sharma SS. "Neuroprotective efficacy and therapeutic time window of peroxynitrite decomposition catalysts in focal cerebral ischemia in rats." British journal of pharmacology. 2004 Jul; 142(5):899-911. Epub 2004 Jun 14.
2004 Feb 1
Kabra DG, Thiyagarajan M, Kaul CL, Sharma SS. "Neuroprotective effect of 4-amino-1,8-napthalimide, a poly(ADP ribose) polymerase inhibitor in middle cerebral artery occlusion-induced focal cerebral ischemia in rat." Brain research bulletin. 2004 Feb 1; 62(5):425-33.
2004 Jan 9
Thiyagarajan M, Sharma SS. "Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats." Life sciences. 2004 Jan 9; 74(8):969-85.
2002 Oct 25
Thiyagarajan M, Kaul CL, Ramarao P. "Enhancement of alpha-adrenoceptor-mediated responses in prostate of testosterone-treated rat." European journal of pharmacology. 2002 Oct 25; 453(2-3):335-44.
2002 Jul
Thiyagarajan M. "alpha-Adrenoceptor antagonists in the treatment of benign prostate hyperplasia." Pharmacology. 2002 Jul; 65(3):119-28.


Sharma SS and Thiyagarajan M. "Molecular mechanisms of cerebral ischemia". Molecular and cellular neurobiology. Thakur MK and Prasad S. New Delhi, India: Narosa Publishing House, 2005. 191-202