Therese Wiedmer, Ph.D.

Therese Wiedmer, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box MED
Rochester, NY 14642

Office: (585) 276-3009
Fax: (585) 276-2272

Journal Articles

Showing all 74 journal articles available.

2014
Kassas A, Moura IC, Yamashita Y, Scheffel J, Guérin-Marchand C, Blank U, Sims PJ, Wiedmer T, Monteiro RC, Rivera J, Charles N, Benhamou M. "Regulation of the Tyrosine Phosphorylation of Phospholipid Scramblase 1 in Mast Cells That Are Stimulated through the High-Affinity IgE Receptor." PloS one. 2014 9(10):e109800. Epub 2014 Oct 07.
2012
Li D, Yang H, Nan H, Liu P, Pang S, Zhao Q, Karni R, Kamps MP, Xu Y, Zhou J, Wiedmer T, Sims PJ, Wang F. "Identification of key regulatory pathways of myeloid differentiation using an mESC-based karyotypically normal cell model." Blood. 2012 120(24):4712-9. Epub 2012 Oct 18.
2011 Aug
Chen CW, Sowden M, Zhao Q, Wiedmer T, Sims PJ. "Nuclear phospholipid scramblase 1 prolongs the mitotic expansion of granulocyte precursors during G-CSF-induced granulopoiesis." Journal of leukocyte biology. 2011 Aug; 90(2):221-33. Epub 2011 Mar 29.
2009 Jan 15
Bateman A, Finn RD, Sims PJ, Wiedmer T, Biegert A, Söding J. "Phospholipid scramblases and Tubby-like proteins belong to a new superfamily of membrane tethered transcription factors." Bioinformatics. 2009 Jan 15; 25(2):159-62. Epub 2008 Nov 13.
2007 Sep
Lu B, Sims PJ, Wiedmer T, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR. "Expression of the phospholipid scramblase (PLSCR) gene family during the acute phase response." Biochimica et biophysica acta. 2007 Sep; 1771(9):1177-85. Epub 2007 May 26.
2007
Mutch DM, O'Maille G, Wikoff WR, Wiedmer T, Sims PJ, Siuzdak G. "Mobilization of pro-inflammatory lipids in obese Plscr3-deficient mice." Genome biology. 2007 8(3):R38.
2006 Oct 26
Huang Y, Zhao Q, Zhou CX, Gu ZM, Li D, Xu HZ, Wiedmer T, Sims PJ, Zhao KW, Chen GQ. "Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells." Oncogene. 2006 Oct 26; 25(50):6618-27. Epub 2006 May 15.
2005 Oct 14
Zhou Q, Ben-Efraim I, Bigcas JL, Junqueira D, Wiedmer T, Sims PJ. "Phospholipid scramblase 1 binds to the promoter region of the inositol 1,4,5-triphosphate receptor type 1 gene to enhance its expression." The Journal of biological chemistry. 2005 Oct 14; 280(41):35062-8. Epub 2005 Aug 09.
2004 Sep 7
Wiedmer T, Zhao J, Li L, Zhou Q, Hevener A, Olefsky JM, Curtiss LK, Sims PJ. "Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3)." Proceedings of the National Academy of Sciences of the United States of America. 2004 Sep 7; 101(36):13296-301. Epub 2004 Aug 24.
2004 Sep
Dong B, Zhou Q, Zhao J, Zhou A, Harty RN, Bose S, Banerjee A, Slee R, Guenther J, Williams BR, Wiedmer T, Sims PJ, Silverman RH. "Phospholipid scramblase 1 potentiates the antiviral activity of interferon." Journal of virology. 2004 Sep; 78(17):8983-93.
2004 Mar 30
Ben-Efraim I, Zhou Q, Wiedmer T, Gerace L, Sims PJ. "Phospholipid scramblase 1 is imported into the nucleus by a receptor-mediated pathway and interacts with DNA." Biochemistry. 2004 Mar 30; 43(12):3518-26.
2004
Zhao KW, Li X, Zhao Q, Huang Y, Li D, Peng ZG, Shen WZ, Zhao J, Zhou Q, Chen Z, Sims PJ, Wiedmer T, Chen GQ. "Protein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation." Blood. 2004 104(12):3731-8. Epub 2004 Aug 12.
2003 Sep 26
Nanjundan M, Sun J, Zhao J, Zhou Q, Sims PJ, Wiedmer T. "Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor." The Journal of biological chemistry. 2003 Sep 26; 278(39):37413-8. Epub 2003 Jul 18.
2003 Jun
de Vries KJ, Wiedmer T, Sims PJ, Gadella BM. "Caspase-independent exposure of aminophospholipids and tyrosine phosphorylation in bicarbonate responsive human sperm cells." Biology of reproduction. 2003 Jun; 68(6):2122-34. Epub 2003 Jan 22.
2003 Feb 11
Wiedmer T, Zhao J, Nanjundan M, Sims PJ. "Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane." Biochemistry. 2003 Feb 11; 42(5):1227-33.
2002 Jun 1
Zhou Q, Zhao J, Wiedmer T, Sims PJ. "Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1." Blood. 2002 Jun 1; 99(11):4030-8.
2002 May 21
Sun J, Nanjundan M, Pike LJ, Wiedmer T, Sims PJ. "Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor." Biochemistry. 2002 May 21; 41(20):6338-45.
2002 Jan 15
Silverman RH, Halloum A, Zhou A, Dong B, Al-Zoghaibi F, Kushner D, Zhou Q, Zhao J, Wiedmer T, Sims PJ. "Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1." Cancer research. 2002 Jan 15; 62(2):397-402.
2001 Aug 3
Sun J, Zhao J, Schwartz MA, Wang JY, Wiedmer T, Sims PJ. "c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1." The Journal of biological chemistry. 2001 Aug 3; 276(31):28984-90. Epub 2001 Jun 04.
2001 Jul
Sims PJ, Wiedmer T. "Unraveling the mysteries of phospholipid scrambling." Thrombosis and haemostasis. 2001 Jul; 86(1):266-75.
2000 Jul 31
Wiedmer T, Zhou Q, Kwoh DY, Sims PJ. "Identification of three new members of the phospholipid scramblase gene family." Biochimica et biophysica acta. 2000 Jul 31; 1467(1):244-53.
2000 Jul 10
Tepper AD, Ruurs P, Wiedmer T, Sims PJ, Borst J, van Blitterswijk WJ. "Sphingomyelin hydrolysis to ceramide during the execution phase of apoptosis results from phospholipid scrambling and alters cell-surface morphology." The Journal of cell biology. 2000 Jul 10; 150(1):155-64.
2000 Apr 15
Zhou Q, Zhao J, Al-Zoghaibi F, Zhou A, Wiedmer T, Silverman RH, Sims PJ. "Transcriptional control of the human plasma membrane phospholipid scramblase 1 gene is mediated by interferon-alpha." Blood. 2000 Apr 15; 95(8):2593-9.
1999
Fadeel B, Gleiss B, Högstrand K, Chandra J, Wiedmer T, Sims PJ, Henter JI, Orrenius S, Samali A. "Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression." Biochemical and biophysical research communications. 1999 266(2):504-11.
1999
Sims, PJ and Wiedmer, T (R. Hoffman, E.J. Benz, H.J. Cohen, S.J. Shattil, B. Furie, L.E. Silberstein, P. McGlave, eds). "Complement Biology". Hematology: Basic Principles and Practice. 1999; : 651-667. Link
1998 Oct 20
Stout JG, Zhou Q, Wiedmer T, Sims PJ. "Change in conformation of plasma membrane phospholipid scramblase induced by occupancy of its Ca2+ binding site." Biochemistry. 1998 Oct 20; 37(42):14860-6.
1998 Sep 1
Zhou Q, Sims PJ, Wiedmer T. "Expression of proteins controlling transbilayer movement of plasma membrane phospholipids in the B lymphocytes from a patient with Scott syndrome." Blood. 1998 Sep 1; 92(5):1707-12.
1998 May 5
Zhao J, Zhou Q, Wiedmer T, Sims PJ. "Palmitoylation of phospholipid scramblase is required for normal function in promoting Ca2+-activated transbilayer movement of membrane phospholipids." Biochemistry. 1998 May 5; 37(18):6361-6.
1998 Mar 20
Zhao J, Zhou Q, Wiedmer T, Sims PJ. "Level of expression of phospholipid scramblase regulates induced movement of phosphatidylserine to the cell surface." The Journal of biological chemistry. 1998 Mar 20; 273(12):6603-6.
1998 Feb 24
Zhou Q, Sims PJ, Wiedmer T. "Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids." Biochemistry. 1998 Feb 24; 37(8):2356-60.
1997 Jul 18
Zhou Q, Zhao J, Stout JG, Luhm RA, Wiedmer T, Sims PJ. "Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids." The Journal of biological chemistry. 1997 Jul 18; 272(29):18240-4.
1997 Jun 5
Zhao J, Sims PJ, Wiedmer T. "Production and characterization of a mutant cell line defective in aminophospholipid translocase." Biochimica et biophysica acta. 1997 Jun 5; 1357(1):57-64.
1997 May 1
Stout JG, Bassé F, Luhm RA, Weiss HJ, Wiedmer T, Sims PJ. "Scott syndrome erythrocytes contain a membrane protein capable of mediating Ca2+-dependent transbilayer migration of membrane phospholipids." The Journal of clinical investigation. 1997 May 1; 99(9):2232-8.
1996 Jul 19
Bassé F, Stout JG, Sims PJ, Wiedmer T. "Isolation of an erythrocyte membrane protein that mediates Ca2+-dependent transbilayer movement of phospholipid." The Journal of biological chemistry. 1996 Jul 19; 271(29):17205-10.
1995 Oct
Sims PJ, Wiedmer T. "Induction of cellular procoagulant activity by the membrane attack complex of complement." Seminars in cell biology. 1995 Oct; 6(5):275-82.
1995 Sep 1
Bevers EM, Wiedmer T, Comfurius P, Zhao J, Smeets EF, Schlegel RA, Schroit AJ, Weiss HJ, Williamson P, Zwaal RF, Sims PJ. "The complex of phosphatidylinositol 4,5-bisphosphate and calcium ions is not responsible for Ca2+-induced loss of phospholipid asymmetry in the human erythrocyte: a study in Scott syndrome, a disorder of calcium-induced phospholipid scrambling." Blood. 1995 Sep 1; 86(5):1983-91.
1994 Oct 21
Chang CP, Hüsler T, Zhao J, Wiedmer T, Sims PJ. "Identity of a peptide domain of human C9 that is bound by the cell-surface complement inhibitor, CD59." The Journal of biological chemistry. 1994 Oct 21; 269(42):26424-30.
1994
Sims PJ and Wiedmer T (E. Benz, H. Cohen, B. Furie, R. Hoffman, S. Shattil, eds). Churchill Livingstone, New York. "Immunology: Complement Biology". Hematology: Basic Principles and Practice. 1994; Chapter 12. Link
1994
Kojima H, Newton-Nash D, Weiss HJ, Zhao J, Sims PJ, Wiedmer T. "Production and characterization of transformed B-lymphocytes expressing the membrane defect of Scott syndrome." The Journal of clinical investigation. 1994 94(6):2237-44.
1993 Aug 15
Wiedmer T, Hall SE, Ortel TL, Kane WH, Rosse WF, Sims PJ. "Complement-induced vesiculation and exposure of membrane prothrombinase sites in platelets of paroxysmal nocturnal hemoglobinuria." Blood. 1993 Aug 15; 82(4):1192-6.
1993 Apr 5
Chang CP, Zhao J, Wiedmer T, Sims PJ. "Contribution of platelet microparticle formation and granule secretion to the transmembrane migration of phosphatidylserine." The Journal of biological chemistry. 1993 Apr 5; 268(10):7171-8.
1992 Sep 15
Shattil SJ, Cunningham M, Wiedmer T, Zhao J, Sims PJ, Brass LF. "Regulation of glycoprotein IIb-IIIa receptor function studied with platelets permeabilized by the pore-forming complement proteins C5b-9." The Journal of biological chemistry. 1992 Sep 15; 267(26):18424-31.
1992 Sep
Braga LL, Ninomiya H, McCoy JJ, Eacker S, Wiedmer T, Pham C, Wood S, Sims PJ, Petri WA. "Inhibition of the complement membrane attack complex by the galactose-specific adhesion of Entamoeba histolytica." The Journal of clinical investigation. 1992 Sep; 90(3):1131-7.
1992 Jan 15
Bevers EM, Wiedmer T, Comfurius P, Shattil SJ, Weiss HJ, Zwaal RF, Sims PJ. "Defective Ca(2+)-induced microvesiculation and deficient expression of procoagulant activity in erythrocytes from a patient with a bleeding disorder: a study of the red blood cells of Scott syndrome." Blood. 1992 Jan 15; 79(2):380-8.
1992
Dahlbäck B, Wiedmer T, Sims PJ. "Binding of anticoagulant vitamin K-dependent protein S to platelet-derived microparticles." Biochemistry. 1992 31(51):12769-77.
1992
Braga LL, Ninomiya H, McCoy JJ, Adal K, Wiedmer T, Pham C, Sims PJ, Petri WA. "Inhibition of the complement membrane attack complex by the galactose-specific adhesin of Entamoeba histolytica." Archives of medical research. 1992 23(2):133.
1991 Sep 15
Gilbert GE, Sims PJ, Wiedmer T, Furie B, Furie BC, Shattil SJ. "Platelet-derived microparticles express high affinity receptors for factor VIII." The Journal of biological chemistry. 1991 Sep 15; 266(26):17261-8.
1991 Sep
Sims PJ, Wiedmer T. "The response of human platelets to activated components of the complement system." Immunology today. 1991 Sep; 12(9):338-42.
1991 Jan 1
Gerrard JM, Lint D, Sims PJ, Wiedmer T, Fugate RD, McMillan E, Robertson C, Israels SJ. "Identification of a platelet dense granule membrane protein that is deficient in a patient with the Hermansky-Pudlak syndrome." Blood. 1991 Jan 1; 77(1):101-12.
1991
Wiedmer T, Sims PJ. "Participation of protein kinases in complement C5b-9-induced shedding of platelet plasma membrane vesicles." Blood. 1991 78(11):2880-6.
1990 Jan 23
Wiedmer T, Shattil SJ, Cunningham M, Sims PJ. "Role of calcium and calpain in complement-induced vesiculation of the platelet plasma membrane and in the exposure of the platelet factor Va receptor." Biochemistry. 1990 Jan 23; 29(3):623-32.
1989 Nov 15
Sims PJ, Rollins SA, Wiedmer T. "Regulatory control of complement on blood platelets. Modulation of platelet procoagulant responses by a membrane inhibitor of the C5b-9 complex." The Journal of biological chemistry. 1989 Nov 15; 264(32):19228-35.
1989 Oct 15
Sims PJ, Wiedmer T, Esmon CT, Weiss HJ, Shattil SJ. "Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. Studies in Scott syndrome: an isolated defect in platelet procoagulant activity." The Journal of biological chemistry. 1989 Oct 15; 264(29):17049-57.
1989 Feb
Ando B, Wiedmer T, Sims PJ. "The secretory release reaction initiated by complement proteins C5b-9 occurs without platelet aggregation through glycoprotein IIb-IIIa." Blood. 1989 Feb; 73(2):462-7.
1988 Aug 25
Ando B, Wiedmer T, Hamilton KK, Sims PJ. "Complement proteins C5b-9 initiate secretion of platelet storage granules without increased binding of fibrinogen or von Willebrand factor to newly expressed cell surface GPIIb-IIIa." The Journal of biological chemistry. 1988 Aug 25; 263(24):11907-14.
1988
Sims PJ, Faioni EM, Wiedmer T, Shattil SJ. "Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity." The Journal of biological chemistry. 1988 263(34):18205-12.
1987 Oct 5
Wiedmer T, Ando B, Sims PJ. "Complement C5b-9-stimulated platelet secretion is associated with a Ca2+-initiated activation of cellular protein kinases." The Journal of biological chemistry. 1987 Oct 5; 262(28):13674-81.
1986 Nov 5
Wiedmer T, Esmon CT, Sims PJ. "On the mechanism by which complement proteins C5b-9 increase platelet prothrombinase activity." The Journal of biological chemistry. 1986 Nov 5; 261(31):14587-92.
1986 Oct
Wiedmer T, Esmon CT, Sims PJ. "Complement proteins C5b-9 stimulate procoagulant activity through platelet prothrombinase." Blood. 1986 Oct; 68(4):875-80.
1986 Aug
Sims PJ, Wiedmer T. "Repolarization of the membrane potential of blood platelets after complement damage: evidence for a Ca++ -dependent exocytotic elimination of C5b-9 pores." Blood. 1986 Aug; 68(2):556-61.
1986
Benz R, Schmid A, Wiedmer T, Sims PJ. "Single-channel analysis of the conductance fluctuations induced in lipid bilayer membranes by complement proteins C5b-9." The Journal of membrane biology. 1986 94(1):37-45.
1985 Jul 5
Wiedmer T, Sims PJ. "Effect of complement proteins C5b-9 on blood platelets. Evidence for reversible depolarization of membrane potential." The Journal of biological chemistry. 1985 Jul 5; 260(13):8014-9.
1985 Jul
Cheng KH, Wiedmer T, Sims PJ. "Fluorescence resonance energy transfer study of the associative state of membrane-bound complexes of complement proteins C5b-8." The Journal of immunology : official journal of the American Association of Immunologists. 1985 Jul; 135(1):459-64.
1985 Jun
Parker CJ, Wiedmer T, Sims PJ, Rosse WF. "Characterization of the complement sensitivity of paroxysmal nocturnal hemoglobinuria erythrocytes." The Journal of clinical investigation. 1985 Jun; 75(6):2074-84.
1985
Wiedmer T, Sims PJ. "Cyanine dye fluorescence used to measure membrane potential changes due to the assembly of complement proteins C5b-9." The Journal of membrane biology. 1985 84(3):249-58.
1984 Aug 28
Pink DA, Chapman D, Laidlaw DJ, Wiedmer T. "Electron spin resonance and steady-state fluorescence polarization studies of lipid bilayers containing integral proteins." Biochemistry. 1984 Aug 28; 23(18):4051-8.
1984 Jul 3
Sims PJ, Wiedmer T. "Kinetics of polymerization of a fluoresceinated derivative of complement protein C9 by the membrane-bound complex of complement proteins C5b-8." Biochemistry. 1984 Jul 3; 23(14):3260-7.
1984
Sims PJ, Wiedmer T. "The influence of electrochemical gradients of Na+ and K+ upon the membrane binding and pore forming activity of the terminal complement proteins." The Journal of membrane biology. 1984 78(2):169-76.
1981
Wiedmer T, Lauf PK. "Properties of the M antigen solubilized from genetically high potassium sheep red cells." Membrane biochemistry. 1981 4(1):31-47.
1979
Wiedmer T, Di Francesco C, Brodbeck U. "Effects of amphiphiles on structure and activity of human erythrocyte membrane acetylcholinesterase." European journal of biochemistry. 1979 102(1):59-64.
1978 Jan 19
Wiedmer T, Brodbeck U, Zahler P, Fulpius BW. "Interactions of acetylcholine receptor and acetylcholinesterase with lipid monolayers." Biochimica et biophysica acta. 1978 Jan 19; 506(2):161-72.
1975
Brodbeck, U.; Ott, P. and Wiedmer, T. "Electrophorus Electricus". Croat.Chem.Acta. 1975; 47: 201, 210. Link
1974 Oct 15
Wiedmer T, Gentinetta R, Brodbeck U. "Binding of acetylcholinesterases to concanavalin A." FEBS letters. 1974 Oct 15; 47(2):260-3.
1974
Boschetti, A.; Niggli, V.; Otz U. and Wiedmer, T. "Chlamydomonas Reinhardi". Physiologia P1. 1974; 31: 169-174. Link