Therese Wiedmer, Ph.D.

Therese Wiedmer, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box MED
Rochester, NY 14642

Office: (585) 276-3009
Fax: (585) 276-2272

Research Bio

Our laboratory is focusing on a family of proteins called phospholipid scramblases. We originally cloned phospholipid scramblase 1 (PLSCR1), a Ca2+-binding, endofacial plasma membrane protein, based on its capacity to promote rapid transbilayer movement of phospholipids in response to elevated Ca2+. Such redistribution of phospholipids is normally observed upon platelet activation, and in injured or apoptotic cells. We subsequently identified three additional members of this gene family. Recent data from our laboratory suggest a considerably more complex biology for these proteins than their putative role in mediating transbilayer lipid movement.

PLSCR1 -- and possibly other members of the PLSCR gene family -- plays a role in modulating the signal transduction through multiple growth factor receptors, and is itself transcriptionally upregulated through these same growth factor receptor pathways. We also discovered that when transcriptionally induced, a portion of the newly synthesized PLSCR1 translocates to the nucleus, in addition to its usual location at the plasma membrane, where it can increase gene transcription. One such gene identified to be upregulated in presence of PLSCR1 is the IP3-receptor type 1. Our current efforts are aimed at elucidating the role of PLSCRs in diverse signaling pathways underlying proliferation, differentiation, and apoptosis.

Awards & Honors (Local)

Merrick Award for scientific Research Oklahoma Medical Research Foundation 1989
Fellow, American Heart Association

Recent Journal Articles

Showing the 5 most recent journal articles. 73 available »

2012
Li D, Yang H, Nan H, Liu P, Pang S, Zhao Q, Karni R, Kamps MP, Xu Y, Zhou J, Wiedmer T, Sims PJ, Wang F. "Identification of key regulatory pathways of myeloid differentiation using an mESC-based karyotypically normal cell model." Blood.. 2012 120(24):4712-9. Epub 2012 Oct 18.
2011 Aug
Chen CW, Sowden M, Zhao Q, Wiedmer T, Sims PJ. "Nuclear phospholipid scramblase 1 prolongs the mitotic expansion of granulocyte precursors during G-CSF-induced granulopoiesis." Journal of leukocyte biology.. 2011 Aug; 90(2):221-33. Epub 2011 Mar 29.
2009 Jan 15
Bateman A, Finn RD, Sims PJ, Wiedmer T, Biegert A, Söding J. "Phospholipid scramblases and Tubby-like proteins belong to a new superfamily of membrane tethered transcription factors." Bioinformatics.. 2009 Jan 15; 25(2):159-62. Epub 2008 Nov 13.
2007 Sep
Lu B, Sims PJ, Wiedmer T, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR. "Expression of the phospholipid scramblase (PLSCR) gene family during the acute phase response." Biochimica et biophysica acta.. 2007 Sep; 1771(9):1177-85. Epub 2007 May 26.
2007
Mutch DM, O'Maille G, Wikoff WR, Wiedmer T, Sims PJ, Siuzdak G. "Mobilization of pro-inflammatory lipids in obese Plscr3-deficient mice." Genome biology. 2007 8(3):R38.

Current Appointments

Professor Emeritus - Department of Medicine (SMD) - Primary

Education

PhD | Biochemistry | Switzerland-Univ of Bern1977
BS | Chemistry | Switzerland-Univ of Bern1973