Yujun Cai, Ph.D.

Yujun Cai, Ph.D.

Contact Information

Aab Cardiovascular Research Institute
211 Bailey Road
West Henrietta, NY 14586

Journal Articles

Showing all 29 journal articles available.

2013 Nov
Oikawa M, Wu M, Lim S, Knight WE, Miller CL, Cai Y, Lu Y, Blaxall BC, Takeishi Y, Abe JI, Yan C. "Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury." Journal of molecular and cellular cardiology. 2013 Nov; 64:11-9. Epub 2013 Aug 27.
2013 May 10
Cai Y, Li JD, Yan C. "Vinpocetine attenuates lipid accumulation and atherosclerosis formation." Biochemical and biophysical research communications. 2013 May 10; 434(3):439-43. Epub 2013 Apr 10.
2012 Nov
Cai Y, Knight WE, Guo S, Li JD, Knight PA, Yan C. "Vinpocetine suppresses pathological vascular remodeling by inhibiting vascular smooth muscle cell proliferation and migration." The Journal of pharmacology and experimental therapeutics. 2012 Nov; 343(2):479-88. Epub 2012 Aug 22.
2012 Jan
Lu JJ, Cai YJ, Ding J. "The short-time treatment with curcumin sufficiently decreases cell viability, induces apoptosis and copper enhances these effects in multidrug-resistant K562/A02 cells." Molecular and cellular biochemistry. 2012 Jan; 360(1-2):253-60. Epub 2011 Sep 22.
2011 Nov
Miller CL, Cai Y, Oikawa M, Thomas T, Dostmann WR, Zaccolo M, Fujiwara K, Yan C. "Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart." Basic research in cardiology. 2011 Nov; 106(6):1023-39. Epub 2011 Oct 20.
2011 Aug
Lu JJ, Cai YJ, Ding J. "Curcumin induces DNA damage and caffeine-insensitive cell cycle arrest in colorectal carcinoma HCT116 cells." Molecular and cellular biochemistry. 2011 Aug; 354(1-2):247-52. Epub 2011 Apr 28.
2011 Mar
Cai Y, Miller CL, Nagel DJ, Jeon KI, Lim S, Gao P, Knight PA, Yan C. "Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells." Arteriosclerosis, thrombosis, and vascular biology. 2011 Mar; 31(3):616-23. Epub 2010 Dec 09.
Jeon KI, Jono H, Miller CL, Cai Y, Lim S, Liu X, Gao P, Abe JI, Li JD, Yan C. "Ca2+/calmodulin-stimulated PDE1 regulates the beta-catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells." The FEBS journal. 2010 277(24):5026-39. Epub 2010 Nov 16.
2009 Nov 6
Miller CL, Oikawa M, Cai Y, Wojtovich AP, Nagel DJ, Xu X, Xu H, Florio V, Rybalkin SD, Beavo JA, Chen YF, Li JD, Blaxall BC, Abe JI, Yan C. "Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy." Circulation research. 2009 Nov 6; 105(10):956-64. Epub 2009 Sep 24.
2009 Nov
Zhu H, Miao ZH, Huang M, Feng JM, Zhang ZX, Lu JJ, Cai YJ, Tong LJ, Xu YF, Qian XH, Ding J. "Naphthalimides induce G(2) arrest through the ATM-activated Chk2-executed pathway in HCT116 cells." Neoplasia : an international journal for oncology research. 2009 Nov; 11(11):1226-34.
2008 Sep 1
Cai YJ, Lu JJ, Zhu H, Xie H, Huang M, Lin LP, Zhang XW, Ding J. "Salvicine triggers DNA double-strand breaks and apoptosis by GSH-depletion-driven H2O2 generation and topoisomerase II inhibition." Free radical biology & medicine. 2008 Sep 1; 45(5):627-35. Epub 2008 May 28.
2008 Jul
Lu JJ, Meng LH, Cai YJ, Chen Q, Tong LJ, Lin LP, Ding J. "Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species." Cancer biology & therapy. 2008 Jul; 7(7):1017-23. Epub 2008 Apr 04.
2008 Jun
Huang M, Miao ZH, Zhu H, Cai YJ, Lu W, Ding J. "Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins." Molecular cancer therapeutics. 2008 Jun; 7(6):1440-9.
2008 Jan 10
Yang SP, Cai YJ, Zhang BL, Tong LJ, Xie H, Wu Y, Lin LP, Ding J, Yue JM. "Structural modification of an angiogenesis inhibitor discovered from traditional Chinese medicine and a structure-activity relationship study." Journal of medicinal chemistry. 2008 Jan 10; 51(1):77-85. Epub 2007 Dec 14.
2007 Nov
Xie CY, Zhu H, Lin LP, Miao ZH, Geng MY, Cai YJ, Chen Y, Zhao HJ, Luo HB, Zhang XW, Fan LM, Shen YM, Ding J. "MFTZ-1, an actinomycetes subspecies derived antitumor macrolide, functions as a novel topoisomerase II poison." Molecular cancer therapeutics. 2007 Nov; 6(11):3059-70.
2007 Nov
Cai Y, Lu J, Miao Z, Lin L, Ding J. "Reactive oxygen species contribute to cell killing and P-glycoprotein downregulation by salvicine in multidrug resistant K562/A02 cells." Cancer biology & therapy. 2007 Nov; 6(11):1794-9. Epub 2007 Aug 12.
2007 Feb 15
Huang M, Gao H, Chen Y, Zhu H, Cai Y, Zhang X, Miao Z, Jiang H, Zhang J, Shen H, Lin L, Lu W, Ding J. "Chimmitecan, a novel 9-substituted camptothecin, with improved anticancer pharmacologic profiles in vitro and in vivo." Clinical cancer research : an official journal of the American Association for Cancer Research. 2007 Feb 15; 13(4):1298-307. Epub 2007 Feb 07.
2007 Feb
Zhu H, Huang M, Yang F, Chen Y, Miao ZH, Qian XH, Xu YF, Qin YX, Luo HB, Shen X, Geng MY, Cai YJ, Ding J. "R16, a novel amonafide analogue, induces apoptosis and G2-M arrest via poisoning topoisomerase II." Molecular cancer therapeutics. 2007 Feb; 6(2):484-95.
Zheng LF, Wei QY, Cai YJ, Fang JG, Zhou B, Yang L, Liu ZL. "DNA damage induced by resveratrol and its synthetic analogues in the presence of Cu (II) ions: mechanism and structure-activity relationship." Free radical biology & medicine. 2006 41(12):1807-16. Epub 2006 Sep 15.
2005 Nov 14
Wei QY, Ma JP, Cai YJ, Yang L, Liu ZL. "Cytotoxic and apoptotic activities of diarylheptanoids and gingerol-related compounds from the rhizome of Chinese ginger." Journal of ethnopharmacology. 2005 Nov 14; 102(2):177-84. Epub 2005 Jul 15.
2005 Oct
Lu HR, Zhu H, Huang M, Chen Y, Cai YJ, Miao ZH, Zhang JS, Ding J. "Reactive oxygen species elicit apoptosis by concurrently disrupting topoisomerase II and DNA-dependent protein kinase." Molecular pharmacology. 2005 Oct; 68(4):983-94. Epub 2005 Jul 15.
2005 Jul
Zhang YH, Wang YL, Wei QY, Cai YJ, Wang Q, Liu ZL. "Diterpenoids from the Chinese herb Caryopteris terniflora and their antibacterial and antitumor activity." Die Pharmazie. 2005 Jul; 60(7):551-3.
Cai YJ, Wei QY, Fang JG, Yang L, Liu ZL, Wyche JH, Han Z. "The 3,4-dihydroxyl groups are important for trans-resveratrol analogs to exhibit enhanced antioxidant and apoptotic activities." Anticancer research. 2004 24(2B):999-1002.
2003 Jul 23
Lin X, Cai YJ, Li ZX, Chen Q, Liu ZL, Wang R. "Structure determination, apoptosis induction, and telomerase inhibition of CFP-2, a novel lichenin from Cladonia furcata." Biochimica et biophysica acta. 2003 Jul 23; 1622(2):99-108.
2003 Jan 20
Cai YJ, Fang JG, Ma LP, Yang L, Liu ZL. "Inhibition of free radical-induced peroxidation of rat liver microsomes by resveratrol and its analogues." Biochimica et biophysica acta. 2003 Jan 20; 1637(1):31-8.
2002 Jul
Lu M, Cai YJ, Fang JG, Zhou YL, Liu ZL, Wu LM. "Efficiency and structure-activity relationship of the antioxidant action of resveratrol and its analogs." Die Pharmazie. 2002 Jul; 57(7):474-8.
Cai YJ, Ma LP, Hou LF, Zhou B, Yang L, Liu ZL. "Antioxidant effects of green tea polyphenols on free radical initiated peroxidation of rat liver microsomes." Chemistry and physics of lipids. 2002 120(1-2):109-17.
Cai YJ, Dai JQ, Fang JG, Ma LP, Hou LF, Yang L, Liu ZL. "Antioxidative and free radical scavenging effects of ecdysteroids from Serratula strangulata." Canadian journal of physiology and pharmacology. 2002 80(12):1187-94.
2001 Aug
Lin X, Cai YJ, Li ZX, Liu ZL, Yin SF, Zhao JC. "Cladonia furcata polysaccharide induced apoptosis in human leukemia K562 cells." Acta pharmacologica Sinica. 2001 Aug; 22(8):716-20.