Nina F. Schor, M.D., Ph.D.

Nina F. Schor, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 777
Rochester, NY 14642

Office: (585) 275-4673
Fax: (585) 273-1079

Research Bio

The laboratory of Dr. Nina F. Schor began with a focus on designing and testing in preclinical models targeted therapy for neuroblastoma, the most common solid tumor of childhood and a derivative of the neural crest. Therapeutic approaches that have been pioneered in Dr. Schor's laboratory include:



(1) adjunctive use of 6-hydroxydopamine (tumor cell ablative agent) with TEMPOL (selective normal cell chemoprotectant);

(2) adjunctive use of neocarzinostatin (non-selective chemotherapeutic prodrug) with 6-mercaptodopamine (neural crest-selective activator of neocarzinostatin);

(3) caspase 3-dependent potentiation of apoptosis induced by enediyne chemotherapeutic agents in Bcl-2-overexpressing tumors; and

(4) potentiation of apoptosis induced by chemotherapeutic agents with agonists and antagonists at specific neurotrophin receptors.

In the process of this work, Dr. Schor's laboratory has evolved several distinct lines of inquiry and drug and mechanism discovery. For example, the peripheral administration of 6-hydroxydopamine alone resulted in an autonomic neuropathy that mimicked that seen in patients with Parkinson's disease. Dr. Schor's group has used this model to examine the development of auto-recycling antioxidants for use in Parkinson's disease. Since moving from the University of Pittsburgh to the University of Rochester, Dr. Schor and her colleagues have been piloting mitochondrially-targeted auto-recycling antioxidants and gene therapy with constructs that code for endogenous neuroprotective species (e.g., the intracellular domain of the p75 neurotrophin receptor), respectively, in this model system.

Another example of work that developed from the targeted chemotherapeutic strategies relates to the discovery by Dr. Schor and her group that, not only is the p75 neurotrophin receptor an excellent substrate for presenilin, liberating its intracellular domain; this intracellular domain is protective against oxidative stress and facilitatory of antimitotic activity by a mechanism that involves translocation of NF-kappaB to the nucleus and up-regulation of all of the enzymes responsible for cholesterol biosynthesis. This is of particular interest in Alzheimer's disease because, while p75 is ubiquitously expressed in the embryonic brain, it is selectively highly expressed in the nucleus basalis of Meynert in the adult brain. Furthermore, genetically engineered cells that express only the familial Alzheimer's disease mutant presenilin do not exhibit p75-mediated protection from oxidative stress.

Awards & Honors (National)

Annual Pediatric Neurology Invited Lecturer | Cleveland Clinic | Cleveland OH 2010
Keynote Speaker, University of Utah Neurology Retreat | University of Utah | Salt Lake City, UT 2010
Baldwin Lecturer | University of Maryland Medical Center | Baltimore, MD 2009
Dean's Distinguished Lecturer | University of Arkansas Medical Center | Fayetteville, AR 2008
E. Stanley Emery Professor | University of Vermont Medical Center | Burlington, VT 2008
Distinguished Neurology Teacher Award | American Neurological Association | San Diego, CA 2005
Best Doctors in America 2004 - Present
Named to Best Doctors in America 2002
Named to Best Doctors in America 1999
Alfred A. Richman Award for Cardiopulmonary Research | American College of Chest Physicians 1980

Awards & Honors (Local)

Keynote Speaker/Panel Member, Tri-Institutional MD-PhD Program 40th Anniversary Student Retreat | Weill Cornell/Rockefeller/Sloan-Kettering | New York City, NY 2012
William H. Eilinger Endowed Chair of Pediatrics | University of Rochester Medical Center | Rochester NY 2007
Keynote Speaker | University of Rochester MSTP Program Retreat | Rochester, NY 2006
Distinguished Alumni Speaker Series Speaker | Tri-Institutional Distinguished Alumni Speaker | Cornell-Rockefeller-Memorial Sloan Kettering, NY 2004
Distinguished Alumni Speaker | Intel Science Talent Search | Washington, DC 2004
Craumer Endowed Professorship for Pediatrics Research | Children's Hospital of Pittsburgh | Pittsburgh, PA 2000
Volunteer in the Schools Award | Pittsburgh Elementary Gifted Center | Pittsburgh, PA 1999
Teaching Excellence Award, Second Year Medical School Class | University of Pittsburgh | Pittsburgh, PA 1997
Chancellor's Distinguished Teaching Award | University of Pittsburgh | Pittsburgh, PA 1996
Kenneth E. Schuitt-Dean's Master Educator Award | University of Pittsburgh School of Medicine | Pittsburgh, PA 1995
Conferral of tenure | University of Pittsburgh School of Medicine | Pittsburgh, PA 1991
Presidential Citation | Jewish Community Center of Pittsburgh 1991
Benjamin N. Cardozo High School Women in Science Award 1990
Michael E. Miller Young Investigator Award | Children's Hospital of Pittsburgh 1990
Child Neurology Fellows' Award for Excellence in Teaching 1987 - 1989
Ruth Estrin Goldberg Memorial Award for Cancer Research | Ruth Estrin Goldberg Memorial Foundation 1985
Cold Spring Harbor Laboratory Undergraduate Research Participant 1973
Westinghouse Science Talent Search, First Prize 1972
Yale National Scholar 1972
National Merit Scholar 1972
Tomorrow's Scientists and Engineers Award 1972
American Academy of Achievement Award 1972

Recent Journal Articles

Showing the 5 most recent journal articles. 118 available »

2014 Jul 15
Schor NF, Mink J. "Abstracts." Annals of neurology.. 2014 Jul 15; Epub 2014 Jul 15.
2014 Feb
Ganeshan VR, Schor NF. "p75 neurotrophin receptor and fenretinide-induced signaling in neuroblastoma." Cancer chemotherapy and pharmacology. 2014 Feb; 73(2):271-9. Epub 2013 Nov 20.
2013 Nov
Rogers DA, Schor NF. "Kidins220/ARMS is expressed in neuroblastoma tumors and stabilizes neurotrophic signaling in a human neuroblastoma cell line." Pediatric research.. 2013 Nov; 74(5):517-24. Epub 2013 Sep 02.
2013 Oct 22
Schor NF. "Reflections: neurology and the humanities: personal health information in verse." Neurology.. 2013 Oct 22; 81(17):e123.
2013 Oct
Schor NF. "Introductory address for the John Howland Award recipient, Elizabeth R. McAnarney, MD." Pediatric research.. 2013 Oct; 74(4):473-4. Epub 2013 Aug 07.

Current Appointments

Chair - Department of Pediatrics (SMD) - Primary Administrative
William H. Eilinger Chair of Pediatrics - Department of Pediatrics (SMD)
Professor - Department of Pediatrics (SMD) - Primary
Professor - Department of Neurobiology and Anatomy (SMD)
Professor - Department of Neurology (SMD)

Specialties

Neurology with Special Qualifications in Child Neurology - American Board of Psychiatry and Neurology
Pediatrics - American Board of Pediatrics

Education

MD | Medicine | Cornell University Medical School1981
PhD | Medical Biochemistry | Rockefeller University1980
BS | Molecular Biophysics Biochemistry | Yale University1975

Post-Doctoral Training & Residency

Fellowship in Pediatric Neurology at Children s Hospital07/01/1983 - 06/30/1986
Residency in Pediatrics at Children s Hospital07/01/1982 - 06/30/1983
Internship in Pediatrics at Children's Hospital Boston07/01/1981 - 06/30/1982