Steve N. Georas, M.D.

Steve N. Georas, M.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 692
Rochester, NY 14642

Office: (585) 275-4861
Fax: (585) 273-1114
Lab: (585) 276-3238
Administrative: (585) 275-4861

Journal Articles

Showing all 75 journal articles available.

2014 Sep
Georas SN, Rezaee F. "Epithelial barrier function: At the front line of asthma immunology and allergic airway inflammation." The Journal of allergy and clinical immunology.. 2014 Sep; 134(3):509-520. Epub 2014 Jul 29.
2014 May
Rezaee F, Georas SN. "Breaking barriers. New insights into airway epithelial barrier function in health and disease." American journal of respiratory cell and molecular biology.. 2014 May; 50(5):857-69.
2014 Feb 1
Knowlden S, Georas SN. "The autotaxin-LPA axis emerges as a novel regulator of lymphocyte homing and inflammation." The Journal of immunology : official journal of the American Association of Immunologists.. 2014 Feb 1; 192(3):851-7.
2014
Abdolahi A, Georas SN, Thomas Brenna J, Cai X, Thevenet-Morrison K, Phipps RP, Lawrence P, Mousa SA, Block RC. "The effects of aspirin and fish oil consumption on lysophosphatidylcholines and lysophosphatidic acids and their correlates with platelet aggregation in adults with diabetes mellitus." Prostaglandins, leukotrienes, and essential fatty acids.. 2014 90(2-3):61-8. Epub 2013 Dec 18.
2014
Georas SN, Upham J. "Environmental exposures and innate immunity in the lung." Journal of environmental immunology and toxicology.. 2014 2(1):1-3.
2014
Knowlden SA, Capece T, Popovic M, Chapman TJ, Rezaee F, Kim M, Georas SN. "Regulation of T cell motility in vitro and in vivo by LPA and LPA2." PloS one. 2014 9(7):e101655. Epub 2014 Jul 08.
2013
Chapman TJ, Georas SN. "Adjuvant effect of diphtheria toxin after mucosal administration in both wild type and diphtheria toxin receptor engineered mouse strains." Journal of immunological methods.. 2013 400-401:122-6. Epub 2013 Nov 05.
2012 Apr 15
Emo J, Meednu N, Chapman TJ, Rezaee F, Balys M, Randall T, Rangasamy T, Georas SN. "Lpa2 is a negative regulator of both dendritic cell activation and murine models of allergic lung inflammation." The Journal of immunology : official journal of the American Association of Immunologists.. 2012 Apr 15; 188(8):3784-90. Epub 2012 Mar 16.
2011 Jul
Rangasamy T, Semenza GL, Georas SN. "What is hypoxia-inducible factor-1 doing in the allergic lung?" Allergy. 2011 Jul; 66(7):815-7. Epub 2011 Apr 11.
2011 Jul
De Benedetto A, Slifka MK, Rafaels NM, Kuo IH, Georas SN, Boguniewicz M, Hata T, Schneider LC, Hanifin JM, Gallo RL, Johnson DC, Barnes KC, Leung DY, Beck LA. "Reductions in claudin-1 may enhance susceptibility to herpes simplex virus 1 infections in atopic dermatitis." The Journal of allergy and clinical immunology.. 2011 Jul; 128(1):242-246.e5. Epub 2011 Apr 13.
2011 Jun 15
Lin X, Sime PJ, Xu H, Williams MA, Larussa L, Georas SN, Guo J. "Yin yang 1 is a novel regulator of pulmonary fibrosis." American journal of respiratory and critical care medicine.. 2011 Jun 15; 183(12):1689-97. Epub 2010 Dec 17.
2011 Mar
De Benedetto A, Rafaels NM, McGirt LY, Ivanov AI, Georas SN, Cheadle C, Berger AE, Zhang K, Vidyasagar S, Yoshida T, Boguniewicz M, Hata T, Schneider LM, Hanifin JM, Gallo RL, Novak N, Weidinger S, Beaty TH, Leung DY, Barnes KC, Beck LA. "Tight junction defects in patients with atopic dermatitis." The Journal of allergy and clinical immunology.. 2011 Mar; 127(3):773-86.e1-7. Epub 2010 Dec 15.
2011
Bezemer GF, Bauer SM, Oberdörster G, Breysse PN, Pieters RH, Georas SN, Williams MA. "Activation of pulmonary dendritic cells and Th2-type inflammatory responses on instillation of engineered, environmental diesel emission source or ambient air pollutant particles in vivo." Journal of innate immunity. 2011 3(2):150-66. Epub 2010 Nov 23.
2011
Rezaee F, Meednu N, Emo JA, Saatian B, Chapman TJ, Naydenov NG, Debenedetto A, Beck LA, Ivanov AI, Georas SN. "Polyinosinic:polycytidylic acid induces protein kinase D-dependent disassembly of apical junctions and barrier dysfunction in airway epithelial cells." The Journal of allergy and clinical immunology.. 2011 128(6):1216-1224.e11. Epub 2011 Oct 11.
2010 Nov
Lee FE, Georas SN, Beck LA. "IL-17: important for host defense, autoimmunity, and allergy?" The Journal of investigative dermatology.. 2010 Nov; 130(11):2540-2.
2010 Sep
Rangasamy T, Williams MA, Bauer S, Trush MA, Emo J, Georas SN, Biswal S. "Nuclear erythroid 2 p45-related factor 2 inhibits the maturation of murine dendritic cells by ragweed extract." American journal of respiratory cell and molecular biology.. 2010 Sep; 43(3):276-85. Epub 2009 Oct 05.
2010 Mar
Georas SN, Rezaee F, Lerner L, Beck L. "Dangerous allergens: why some allergens are bad actors." Current allergy and asthma reports. 2010 Mar; 10(2):92-8.
2010 Jan
Roman J, Rangasamy T, Guo J, Sugunan S, Meednu N, Packirisamy G, Shimoda L, Golding A, Semenza G, Georas SN. "T-cell activation under hypoxic conditions enhances IFN-gamma secretion." American journal of respiratory cell and molecular biology.. 2010 Jan; 42(1):123-8. Epub 2009 Apr 16.
2010
Williams MA, Bauer S, Lu W, Guo J, Walter S, Bushnell TP, Lillehoj EP, Georas SN. "Deletion of the mucin-like molecule muc1 enhances dendritic cell activation in response to toll-like receptor ligands." Journal of innate immunity. 2010 2(2):123-43. Epub 2009 Nov 02.
2010
Qi Y, Operario DJ, Oberholzer CM, Kobie JJ, Looney RJ, Georas SN, Mosmann TR. "Human basophils express amphiregulin in response to T cell-derived IL-3." The Journal of allergy and clinical immunology.. 2010 126(6):1260-6.e4. Epub 2010 Oct 30.
2009 Oct
Pietropaoli A, Georas SN. "Resolving lung injury: a new role for Tregs in controlling the innate immune response." The Journal of clinical investigation.. 2009 Oct; 119(10):2891-4. Epub 2009 Sep 21.
2009
Guo J, Lu W, Shimoda LA, Semenza GL, Georas SN. "Enhanced interferon-gamma gene expression in T Cells and reduced ovalbumin-dependent lung eosinophilia in hypoxia-inducible factor-1-alpha-deficient mice." International archives of allergy and immunology. 2009 149(2):98-102. Epub 2009 Jan 06.
2009
Georas SN. "Lysophosphatidic acid and autotaxin: emerging roles in innate and adaptive immunity." Immunologic research. 2009 45(2-3):229-38. Epub 2009 Jan 30.
2008 Nov
Georas SN, Beck L. "Dangerous allergens: innate immunity, dendritic cells and allergic asthma." Expert review of clinical immunology.. 2008 Nov; 4(6):777-85.
2008 Oct 15
Guo J, Williams MA, Georas SN. "Epigenetic studies should focus on specific cell types." American journal of respiratory and critical care medicine.. 2008 Oct 15; 178(8):882-3; author reply 883.
2008 Oct 1
Williams MA, Rangasamy T, Bauer SM, Killedar S, Karp M, Kensler TW, Yamamoto M, Breysse P, Biswal S, Georas SN. "Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter." The Journal of immunology : official journal of the American Association of Immunologists.. 2008 Oct 1; 181(7):4545-59.
2008 Jul
Guo J, Lin X, Williams MA, Hamid Q, Georas SN. "Yin-Yang 1 regulates effector cytokine gene expression and T(H)2 immune responses." The Journal of allergy and clinical immunology.. 2008 Jul; 122(1):195-201, 201.e1-5. Epub 2008 Apr 18.
2008 Mar
Hansel NN, Cheadle C, Diette GB, Wright J, Thompson KM, Barnes KC, Georas SN. "Analysis of CD4+ T-cell gene expression in allergic subjects using two different microarray platforms." Allergy. 2008 Mar; 63(3):366-9.
2007 Apr 6
Zhao Y, He D, Zhao J, Wang L, Leff AR, Spannhake EW, Georas S, Natarajan V. "Lysophosphatidic acid induces interleukin-13 (IL-13) receptor alpha2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cells." The Journal of biological chemistry.. 2007 Apr 6; 282(14):10172-9. Epub 2007 Feb 06.
2007 Mar
Georas SN, Berdyshev E, Hubbard W, Gorshkova IA, Usatyuk PV, Saatian B, Myers AC, Williams MA, Xiao HQ, Liu M, Natarajan V. "Lysophosphatidic acid is detectable in human bronchoalveolar lavage fluids at baseline and increased after segmental allergen challenge." Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2007 Mar; 37(3):311-22.
2007 Feb
Williams MA, Porter M, Horton M, Guo J, Roman J, Williams D, Breysse P, Georas SN. "Ambient particulate matter directs nonclassic dendritic cell activation and a mixed TH1/TH2-like cytokine response by naive CD4+ T cells." The Journal of allergy and clinical immunology.. 2007 Feb; 119(2):488-97. Epub 2006 Dec 21.
2007
Porter M, Karp M, Killedar S, Bauer SM, Guo J, Williams D, Breysse P, Georas SN, Williams MA. "Diesel-enriched particulate matter functionally activates human dendritic cells." American journal of respiratory cell and molecular biology.. 2007 37(6):706-19. Epub 2007 Jul 13.
2007
Williams MA, Cheadle C, Watkins T, Tailor A, Killedar S, Breysse P, Barnes KC, Georas SN. "TLR2 and TLR4 as Potential Biomarkers of Environmental Particulate Matter Exposed Human Myeloid Dendritic Cells." Biomarker insights. 2007 2:226-40. Epub 2007 May 30.
2006 Jun
Barekzi E, Roman J, Hise K, Georas S, Steinke JW. "Lysophosphatidic acid stimulates inflammatory cascade in airway epithelial cells." Prostaglandins, leukotrienes, and essential fatty acids.. 2006 Jun; 74(6):357-63. Epub 2006 May 24.
2006 Feb 1
Saatian B, Zhao Y, He D, Georas SN, Watkins T, Spannhake EW, Natarajan V. "Transcriptional regulation of lysophosphatidic acid-induced interleukin-8 expression and secretion by p38 MAPK and JNK in human bronchial epithelial cells." The Biochemical journal.. 2006 Feb 1; 393(Pt 3):657-68.
2006 Jan
Rubenfeld J, Guo J, Sookrung N, Chen R, Chaicumpa W, Casolaro V, Zhao Y, Natarajan V, Georas S. "Lysophosphatidic acid enhances interleukin-13 gene expression and promoter activity in T cells." American journal of physiology. Lung cellular and molecular physiology.. 2006 Jan; 290(1):L66-74. Epub 2005 Sep 30.
2006 Jan
Keen JC, Cianferoni A, Florio G, Guo J, Chen R, Roman J, Wills-Karp M, Casolaro V, Georas SN. "Characterization of a novel PMA-inducible pathway of interleukin-13 gene expression in T cells." Immunology.. 2006 Jan; 117(1):29-37.
2006 Jan
Williams M, Georas S. "Gene expression patterns and susceptibility to allergic responses." Expert review of clinical immunology.. 2006 Jan; 2(1):59-73.
2006
Sevransky, J.; Georas, S.; Barnes, K.;. "Single nucleotide polymorphisms in patients with sepsis and acute lung injury." Contemp Crit Care. 2006; 3: 1-8.
2006
Chen R, Roman J, Guo J, West E, McDyer J, Williams MA, Georas SN. "Lysophosphatidic acid modulates the activation of human monocyte-derived dendritic cells." Stem cells and development.. 2006 15(6):797-804.
2005 Jul 4
Rangasamy T, Guo J, Mitzner WA, Roman J, Singh A, Fryer AD, Yamamoto M, Kensler TW, Tuder RM, Georas SN, Biswal S. "Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice." The Journal of experimental medicine.. 2005 Jul 4; 202(1):47-59.
2005 May
Hansel NN, Hilmer SC, Georas SN, Cope LM, Guo J, Irizarry RA, Diette GB. "Oligonucleotide-microarray analysis of peripheral-blood lymphocytes in severe asthma." The Journal of laboratory and clinical medicine. 2005 May; 145(5):263-74.
2005
Sevransky, J.; Nour, S.; Susla, G.; Georas, S.;. "Recent advances in the treatment of septic shock". Contemp Crit Care. 2005; 3: 1-12.
2005
Georas SN, Guo J, De Fanis U, Casolaro V. "T-helper cell type-2 regulation in allergic disease." The European respiratory journal.. 2005 26(6):1119-37.
2004 Nov
Heller NM, Matsukura S, Georas SN, Boothby MR, Rothman PB, Stellato C, Schleimer RP. "Interferon-gamma inhibits STAT6 signal transduction and gene expression in human airway epithelial cells." American journal of respiratory cell and molecular biology.. 2004 Nov; 31(5):573-82. Epub 2004 Aug 05.
2004 Nov
Heller NM, Matsukura S, Georas SN, Boothby MR, Stellato C, Schleimer RP. "Assessment of signal transducer and activator of transcription 6 as a target of glucocorticoid action in human airway epithelial cells." Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2004 Nov; 34(11):1690-700.
2004
Hisatsune A, Hyun SW, Lee IJ, Georas S, Kim KC. "YY1 transcription factor is not responsible for the negative regulation of hamster Muc1 transcription." Anticancer research.. 2004 24(1):235-40.
2004
Georas SN. "Inhaled glucocorticoids, lymphocytes, and dendritic cells in asthma and obstructive lung diseases." Proceedings of the American Thoracic Society. 2004 1(3):215-21.
2003 Oct 10
Wang L, Cummings R, Zhao Y, Kazlauskas A, Sham JK, Morris A, Georas S, Brindley DN, Natarajan V. "Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cells." The Journal of biological chemistry.. 2003 Oct 10; 278(41):39931-40. Epub 2003 Jul 29.
2003
Sevransky, J.; Rubenfeld, J.; Fessler, H.; Georas, S.;. "New insights into ventilator management in ARDS". Contemp Crit Care. 2003; 1: 1-10.
2002 May
Wang W, Fan J, Yang X, Fürer-Galban S, Lopez de Silanes I, von Kobbe C, Guo J, Georas SN, Foufelle F, Hardie DG, Carling D, Gorospe M. "AMP-activated kinase regulates cytoplasmic HuR." Molecular and cellular biology.. 2002 May; 22(10):3425-36.
2002 Apr
Georas SN, Beck LA, Stellato C. "What is eotaxin doing in the pleura? Insights into innate immunity from pleural mesothelial cells." American journal of respiratory cell and molecular biology.. 2002 Apr; 26(4):384-7.
2002 Feb
Valapour M, Guo J, Schroeder JT, Keen J, Cianferoni A, Casolaro V, Georas SN. "Histone deacetylation inhibits IL4 gene expression in T cells." The Journal of allergy and clinical immunology.. 2002 Feb; 109(2):238-45.
2001 Nov
Ankrom M, Zelesnick L, Barofsky I, Georas S, Finucane TE, Greenough WB. "Elective discontinuation of life-sustaining mechanical ventilation on a chronic ventilator unit." Journal of the American Geriatrics Society.. 2001 Nov; 49(11):1549-54.
2001 Jun
Matsukura S, Stellato C, Georas SN, Casolaro V, Plitt JR, Miura K, Kurosawa S, Schindler U, Schleimer RP. "Interleukin-13 upregulates eotaxin expression in airway epithelial cells by a STAT6-dependent mechanism." American journal of respiratory cell and molecular biology.. 2001 Jun; 24(6):755-61.
2001 Mar 15
Cianferoni A, Schroeder JT, Kim J, Schmidt JW, Lichtenstein LM, Georas SN, Casolaro V. "Selective inhibition of interleukin-4 gene expression in human T cells by aspirin." Blood.. 2001 Mar 15; 97(6):1742-9.
2001 Jan
Seminario MC, Guo J, Bochner BS, Beck LA, Georas SN. "Human eosinophils constitutively express nuclear factor of activated T cells p and c." The Journal of allergy and clinical immunology.. 2001 Jan; 107(1):143-52.
2001 Jan
Keen JC, Sholl L, Wills-Karp M, Georas SN. "Preferential activation of nuclear factor of activated T cells c correlates with mouse strain susceptibility to allergic responses and interleukin-4 gene expression." American journal of respiratory cell and molecular biology.. 2001 Jan; 24(1):58-65.
2001
Guo J, Casolaro V, Seto E, Yang WM, Chang C, Seminario MC, Keen J, Georas SN. "Yin-Yang 1 activates interleukin-4 gene expression in T cells." The Journal of biological chemistry.. 2001 276(52):48871-8. Epub 2001 Oct 30.
2000 Nov 24
Casolaro V, Keane-Myers AM, Swendeman SL, Steindler C, Zhong F, Sheffery M, Georas SN, Ono SJ. "Identification and characterization of a critical CP2-binding element in the human interleukin-4 promoter." The Journal of biological chemistry.. 2000 Nov 24; 275(47):36605-11.
2000 Apr 21
Burke TF, Casolaro V, Georas SN. "Characterization of P5, a novel NFAT/AP-1 site in the human IL-4 promoter." Biochemical and biophysical research communications.. 2000 Apr 21; 270(3):1016-23.
2000 Apr
Georas S, Cumberland J, Burke T, Park E, Ono S, Casolaro V. "Characterization of a novel negative regulatory element in the human interleukin 4 promoter." Leukemia.. 2000 Apr; 14(4):629-35.
2000 Mar 15
Lee SC, Brummet ME, Shahabuddin S, Woodworth TG, Georas SN, Leiferman KM, Gilman SC, Stellato C, Gladue RP, Schleimer RP, Beck LA. "Cutaneous injection of human subjects with macrophage inflammatory protein-1 alpha induces significant recruitment of neutrophils and monocytes." The Journal of immunology : official journal of the American Association of Immunologists.. 2000 Mar 15; 164(6):3392-401.
2000 Jan 15
Chen R, Burke TF, Cumberland JE, Brummet M, Beck LA, Casolaro V, Georas SN. "Glucocorticoids inhibit calcium- and calcineurin-dependent activation of the human IL-4 promoter." The Journal of immunology : official journal of the American Association of Immunologists.. 2000 Jan 15; 164(2):825-32.
1999 Oct
O'Hearn DJ, Leiferman KM, Askin F, Georas SN. "Pulmonary infiltrates after cytokine therapy for stem cell transplantation. Massive deposition of eosinophil major basic protein detected by immunohistochemistry." American journal of respiratory and critical care medicine.. 1999 Oct; 160(4):1361-5.
1999
Matsukura S, Stellato C, Plitt JR, Bickel C, Miura K, Georas SN, Casolaro V, Schleimer RP. "Activation of eotaxin gene transcription by NF-kappa B and STAT6 in human airway epithelial cells." The Journal of immunology : official journal of the American Association of Immunologists.. 1999 163(12):6876-83.
1998
Georas SN, Cumberland JE, Burke TF, Chen R, Schindler U, Casolaro V. "Stat6 inhibits human interleukin-4 promoter activity in T cells." Blood.. 1998 92(12):4529-38.
1997
Casolaro, V.; Steindler, C.; Ono, S.; Georas, S.;. "Molecular mechanisms of interleukin-4 production". Int J Immunopathol Pharmacol. 1997; 10: 1-5.
1996 Jan 15
Song Z, Casolaro V, Chen R, Georas SN, Monos D, Ono SJ. "Polymorphic nucleotides within the human IL-4 promoter that mediate overexpression of the gene." The Journal of immunology : official journal of the American Association of Immunologists.. 1996 Jan 15; 156(2):424-9.
1996
Casolaro V, Georas SN, Song Z, Ono SJ. "Biology and genetics of atopic disease." Current opinion in immunology. 1996 8(6):796-803.
1995
Casolaro V, Georas SN, Song Z, Zubkoff ID, Abdulkadir SA, Thanos D, Ono SJ. "Inhibition of NF-AT-dependent transcription by NF-kappa B: implications for differential gene expression in T helper cell subsets." Proceedings of the National Academy of Sciences of the United States of America.. 1995 92(25):11623-7.
1993 Nov 1
Georas SN, McIntyre BW, Ebisawa M, Bednarczyk JL, Sterbinsky SA, Schleimer RP, Bochner BS. "Expression of a functional laminin receptor (alpha 6 beta 1, very late activation antigen-6) on human eosinophils." Blood.. 1993 Nov 1; 82(9):2872-9.
1992 Sep
Georas SN, Liu MC, Newman W, Beall LD, Stealey BA, Bochner BS. "Altered adhesion molecule expression and endothelial cell activation accompany the recruitment of human granulocytes to the lung after segmental antigen challenge." American journal of respiratory cell and molecular biology.. 1992 Sep; 7(3):261-9.
1992
Ebisawa M, Bochner BS, Georas SN, Schleimer RP. "Eosinophil transendothelial migration induced by cytokines. I. Role of endothelial and eosinophil adhesion molecules in IL-1 beta-induced transendothelial migration." The Journal of immunology : official journal of the American Association of Immunologists.. 1992 149(12):4021-8.
1987 Mar
Chong KS, Nicolosi RJ, Rodger RF, Arrigo DA, Yuan RW, MacKey JJ, Georas S, Herbert PN. "Effect of dietary fat saturation on plasma lipoproteins and high density lipoprotein metabolism of the rhesus monkey." The Journal of clinical investigation.. 1987 Mar; 79(3):675-83.

Books

2006
Petrache I, Georas S. "Common pulmonary problems: hemoptysis, dyspnea, chest pain, and the abnormal chest x-ray". Principles of Ambulatory Medicine. : Williams & Wilkins, 2006.
2002
Petrache I, Georas S. "Common pulmonary problems: hemoptysis, dyspnea, chest pain, and the abnormal chest x-ray". Principles of Ambulatory Medicine. : Williams & Wilkins, 2002.
2000
Georas, S. "Manifestations of Immunologic Diseases: Th1 and Th2 Responses". Cutaneous Medicine. : B. C. Decker, Inc., 2000.
1998
Georas S, Burke T, Chen, R, Cumberland J, Casolaro V. "The molecular basis of IL-4 dysregulation in the atopic condition". Asthma and Allergic Diseases: Physiology, Immunopharmacology and Treatment. : Academic Press, 1998.
1998
White P, Georas S. "Common pulmonary problems: hemoptysis, dyspnea, chest pain, and the abnormal chest x-ray". Principles of Ambulatory Medicine. : Williams & Wilkins, 1998.
1997
Beck L, Georas S. "Adhesion molecules and cell recruitment to the skin and nose". Adhesion Molecules and Allergic Diseases. : Marcel Dekker, Inc., 1997.
1993
Bochner B, Georas S, Ebisawa M, Schleimer R. "The role of adhesion molecules in allergic inflammation". The Proceedings of the III International Meeting on Respiratory Allergy. Amsterdam: Elsevier, 1993.
1993
Schleimer R, Ebisawa M, Georas S, Bochner B. "Eosinophils: Immunological and Clinical Aspects,". The role of adhesion molecules and cytokines in eosinophil recruitment. : Marcel Dekker, Inc., 1993.