Hongwei Yao, Ph.D.

Hongwei Yao, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box EHSC
Rochester, NY 14642

Lab: (585) 273-2843

Journal Articles

Showing all 37 journal articles available.

2014 May 1
Yao H, Sundar IK, Ahmad T, Lerner C, Gerloff J, Friedman AE, Phipps RP, Sime PJ, McBurney MW, Guarente LP, Rahman I. "SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism." American journal of physiology. Lung cellular and molecular physiology. 2014 May 1; 306(9):L816-28. Epub 2014 Mar 14.
2014 Jan
Hwang JW, Sundar IK, Yao H, Sellix MT, Rahman I. "Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2014 Jan; 28(1):176-94. Epub 2013 Sep 11.
2014
Sundar IK, Yao H, Huang Y, Lyda E, Sime PJ, Sellix MT, Rahman I. "Serotonin and corticosterone rhythms in mice exposed to cigarette smoke and in patients with COPD: implication for COPD-associated neuropathogenesis." PloS one. 2014 9(2):e87999. Epub 2014 Feb 10.
2013 Nov 1
Yao H, Hwang JW, Sundar IK, Friedman AE, McBurney MW, Guarente LP, Gu W, Kinnula VL, Rahman I. "SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD." American journal of physiology. Lung cellular and molecular physiology. 2013 Nov 1; 305(9):L615-24. Epub 2013 Sep 13.
2013 Aug
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I. "Redox regulation of SIRT1 in inflammation and cellular senescence." Free radical biology & medicine. 2013 Aug; 61:95-110. Epub 2013 Mar 27.
2013 May 20
Sundar IK, Yao H, Rahman I. "Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases." Antioxidants & redox signaling. 2013 May 20; 18(15):1956-71. Epub 2012 Nov 06.
2013
Lam HC, Cloonan SM, Bhashyam AR, Haspel JA, Singh A, Sathirapongsasuti JF, Cervo M, Yao H, Chung AL, Mizumura K, An CH, Shan B, Franks JM, Haley KJ, Owen CA, Tesfaigzi Y, Washko GR, Quackenbush J, Silverman EK, Rahman I, Kim HP, Mahmood A, Biswal SS, Ryter SW, Choi AM. "Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction." The Journal of clinical investigation. 2013 123(12):5212-30. Epub 2013 Nov 08.
2013
Yao H, Sundar IK, Gorbunova V, Rahman I. "P21-PARP-1 pathway is involved in cigarette smoke-induced lung DNA damage and cellular senescence." PloS one. 2013 8(11):e80007. Epub 2013 Nov 11.
2012 Nov 15
Yao H, Rahman I. "Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence." Biochemical pharmacology. 2012 Nov 15; 84(10):1332-9. Epub 2012 Jul 14.
2012 Oct 1
Yao H, Rahman I. "Role of histone deacetylase 2 in epigenetics and cellular senescence: implications in lung inflammaging and COPD." American journal of physiology. Lung cellular and molecular physiology. 2012 Oct 1; 303(7):L557-66. Epub 2012 Jul 27.
2012 Sep 15
Basic VT, Tadele E, Elmabsout AA, Yao H, Rahman I, Sirsjö A, Abdel-Halim SM. "Exposure to cigarette smoke induces overexpression of von Hippel-Lindau tumor suppressor in mouse skeletal muscle." American journal of physiology. Lung cellular and molecular physiology. 2012 Sep 15; 303(6):L519-27. Epub 2012 Jul 27.
2012 Jun 1
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Rönty M, Kinnula VL, Rahman I. "SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice." The Journal of clinical investigation. 2012 Jun 1; 122(6):2032-45. Epub 2012 May 01.
2012 May
Rahman I, Kinnula VL, Gorbunova V, Yao H. "SIRT1 as a therapeutic target in inflammaging of the pulmonary disease." Preventive medicine. 2012 May; 54 Suppl:S20-8. Epub 2011 Dec 08.
2012
Sundar IK, Chung S, Hwang JW, Lapek JD, Bulger M, Friedman AE, Yao H, Davie JR, Rahman I. "Mitogen- and stress-activated kinase 1 (MSK1) regulates cigarette smoke-induced histone modifications on NF-?B-dependent genes." PloS one. 2012 7(2):e31378. Epub 2012 Feb 01.
2011 Oct
Nadtochiy SM, Yao H, McBurney MW, Gu W, Guarente LP, Rahman I, Brookes PS. "SIRT1-mediated acute cardioprotection." American journal of physiology. Heart and circulatory physiology. 2011 Oct; 301(4):H1506-12. Epub 2011 Aug 19.
2011 Jul 15
Yao H, Rahman I. "Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease." Toxicology and applied pharmacology. 2011 Jul 15; 254(2):72-85. Epub 2011 Feb 04.
2011 Jul 15
Hwang JW, Rajendrasozhan S, Yao H, Chung S, Sundar IK, Huyck HL, Pryhuber GS, Kinnula VL, Rahman I. "FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease." The Journal of immunology : official journal of the American Association of Immunologists. 2011 Jul 15; 187(2):987-98. Epub 2011 Jun 20.
2011 Jul
Sundar IK, Mullapudi N, Yao H, Spivack SD, Rahman I. "Lung cancer and its association with chronic obstructive pulmonary disease: update on nexus of epigenetics." Current opinion in pulmonary medicine. 2011 Jul; 17(4):279-85.
2011
Chung S, Sundar IK, Hwang JW, Yull FE, Blackwell TS, Kinnula VL, Bulger M, Yao H, Rahman I. "NF-?B inducing kinase, NIK mediates cigarette smoke/TNF?-induced histone acetylation and inflammation through differential activation of IKKs." PloS one. 2011 6(8):e23488. Epub 2011 Aug 24.
2010 Oct
Sundar IK, Chung S, Hwang JW, Arunachalam G, Cook S, Yao H, Mazur W, Kinnula VL, Fisher AB, Rahman I. "Peroxiredoxin 6 differentially regulates acute and chronic cigarette smoke–mediated lung inflammatory response and injury." Experimental lung research. 2010 Oct; 36(8):451-62.
2010 Sep
Caito S, Rajendrasozhan S, Cook S, Chung S, Yao H, Friedman AE, Brookes PS, Rahman I. "SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2010 Sep; 24(9):3145-59. Epub 2010 Apr 12.
2010 Aug 31
Yao H, Arunachalam G, Hwang JW, Chung S, Sundar IK, Kinnula VL, Crapo JD, Rahman I. "Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM." Proceedings of the National Academy of Sciences of the United States of America. 2010 Aug 31; 107(35):15571-6. Epub 2010 Aug 16.
2010 Aug 15
Hwang JW, Chung S, Sundar IK, Yao H, Arunachalam G, McBurney MW, Rahman I. "Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD." Archives of biochemistry and biophysics. 2010 Aug 15; 500(2):203-9. Epub 2010 May 20.
2010 Aug
Chung S, Sundar IK, Yao H, Ho YS, Rahman I. "Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation." American journal of physiology. Lung cellular and molecular physiology. 2010 Aug; 299(2):L192-203. Epub 2010 May 14.
2010 Jun
Rajendrasozhan S, Hwang JW, Yao H, Kishore N, Rahman I. "Anti-inflammatory effect of a selective IkappaB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke." Pulmonary pharmacology & therapeutics. 2010 Jun; 23(3):172-81. Epub 2010 Jan 18.
2010 Feb 26
Arunachalam G, Yao H, Sundar IK, Caito S, Rahman I. "SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol." Biochemical and biophysical research communications. 2010 Feb 26; 393(1):66-72. Epub 2010 Jan 25.
2010 Feb 19
Yao H, Hwang J, Moscat J, Diaz-Meco MT, Leitges M, Kishore N, Li X, Rahman I. "Protein kinase C zeta mediates cigarette smoke/aldehyde- and lipopolysaccharide-induced lung inflammation and histone modifications." The Journal of biological chemistry. 2010 Feb 19; 285(8):5405-16. Epub 2009 Dec 11.
2010 Feb 12
Caito S, Hwang JW, Chung S, Yao H, Sundar IK, Rahman I. "PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity." Biochemical and biophysical research communications. 2010 Feb 12; 392(3):264-70. Epub 2010 Jan 10.
2010 Feb
Rajendrasozhan S, Chung S, Sundar IK, Yao H, Rahman I. "Targeted disruption of NF-{kappa}B1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling." American journal of physiology. Lung cellular and molecular physiology. 2010 Feb; 298(2):L197-209. Epub 2009 Dec 04.
2010
Arunachalam G, Sundar IK, Hwang JW, Yao H, Rahman I. "Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD." Journal of inflammation (London, England). 2010 7:34. Epub 2010 Jul 22.
2009 Apr
Adenuga D, Yao H, March TH, Seagrave J, Rahman I. "Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke." American journal of respiratory cell and molecular biology. 2009 Apr; 40(4):464-73. Epub 2008 Oct 16.
2009 Feb
Yang SR, Yao H, Rajendrasozhan S, Chung S, Edirisinghe I, Valvo S, Fromm G, McCabe MJ, Sime PJ, Phipps RP, Li JD, Bulger M, Rahman I. "RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke." American journal of respiratory cell and molecular biology. 2009 Feb; 40(2):147-58. Epub 2008 Aug 07.
2008 Jul
Yao H, Yang SR, Edirisinghe I, Rajendrasozhan S, Caito S, Adenuga D, O'Reilly MA, Rahman I. "Disruption of p21 attenuates lung inflammation induced by cigarette smoke, LPS, and fMLP in mice." American journal of respiratory cell and molecular biology. 2008 Jul; 39(1):7-18. Epub 2008 Jan 31.
2008 Jul
Edirisinghe I, Yang SR, Yao H, Rajendrasozhan S, Caito S, Adenuga D, Wong C, Rahman A, Phipps RP, Jin ZG, Rahman I. "VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2008 Jul; 22(7):2297-310. Epub 2008 Feb 08.
2008 Jun
Yang SR, Valvo S, Yao H, Kode A, Rajendrasozhan S, Edirisinghe I, Caito S, Adenuga D, Henry R, Fromm G, Maggirwar S, Li JD, Bulger M, Rahman I. "IKK alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung." American journal of respiratory cell and molecular biology. 2008 Jun; 38(6):689-98. Epub 2008 Jan 31.
2008 Jun
Yao H, Edirisinghe I, Rajendrasozhan S, Yang SR, Caito S, Adenuga D, Rahman I. "Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice." American journal of physiology. Lung cellular and molecular physiology. 2008 Jun; 294(6):L1174-86. Epub 2008 Mar 28.
2008
Yao H; Edirisinghe I; Yang SR; Rajendrasozhan S; Kode A; Caito S; Adenuga D; Rahman I. "Genetic ablation of NADPH oxidase enhances susceptibility to cigarette smoke-induced lung inflammation and injury in mice". Am J Pathol. 2008; 172:: 1222-1237.