Xin Lin, Ph.D.

Xin Lin, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 777
Rochester, NY 14642

Research Bio

My research focuses on investigating gene therapy approaches and underlying mechanisms for protection and treatment for lung diseases emphasizing on acute lung injury/acute respiratory distress syndrome or pulmonary fibrosis.



Gene therapy is a promising approach to provide protection and treatment of acute and chronic lung diseases by restoring lung function. Our laboratory has developed a technique, electroporation, to efficiently deliver naked DNA to various tissues, including the living lung, with high-level gene expression and without damage. Our goal is to lead to a safe and effective approach to overexpress desired gene(s) in the injured lung to regulate lung function. It will provide evidence to move gene therapy toward clinical application.

Awards & Honors (Local)

Abstract Scholarship Award | ATS International Conference in Philadelphia, PA 2013
Travel Award | Pittsburgh International Lung Conference, Pittsburgh, PA 2012
Best Postdoctoral Poster Award | 3rd Annual Lung Research & Trainee Day, University of Rochester | Rochester, NY 2011
T32 Training Grant (HL66988) | American National Institutes of Health (NIH) 2011 - 2013
Postdoctoral Fellowship | China Postdoctoral Science Foundation 2005
Zhong-He Award | 8th Chinese International Peptide Symposium | Kunming, China 2004
Qiushi Award | Hong Kong, China 2003
The 7th Fudan University Tan Jiazhen Prize Life Sciences Jiuyuan Award | China 2003
Science and Technology Award of Graduate Students | Lanzhou University, China 2003
Excellent Graduate Student Award | Lanzhou University, China 2002 - 2003

Recent Journal Articles

Showing the 5 most recent journal articles. 15 available »

2013 Jan
Roy S, Habashi N, Sadowitz B, Andrews P, Ge L, Wang G, Roy P, Ghosh A, Kuhn M, Satalin J, Gatto LA, Lin X, Dean DA, Vodovotz Y, Nieman G. "Early airway pressure release ventilation prevents ARDS-a novel preventive approach to lung injury." Shock.. 2013 Jan; 39(1):28-38.
2012 Aug
Roy S, Sadowitz B, Andrews P, Gatto LA, Marx W, Ge L, Wang G, Lin X, Dean DA, Kuhn M, Ghosh A, Satalin J, Snyder K, Vodovotz Y, Nieman G, Habashi N. "Early stabilizing alveolar ventilation prevents acute respiratory distress syndrome: a novel timing-based ventilatory intervention to avert lung injury." The journal of trauma and acute care surgery.. 2012 Aug; 73(2):391-400.
2011 Jul
Lin X, Dean DA. "Gene therapy for ALI/ARDS." Critical care clinics. 2011 Jul; 27(3):705-18.
2011 Jun 15
Lin X, Sime PJ, Xu H, Williams MA, Larussa L, Georas SN, Guo J. "Yin yang 1 is a novel regulator of pulmonary fibrosis." American journal of respiratory and critical care medicine.. 2011 Jun 15; 183(12):1689-97. Epub 2010 Dec 17.
2011
Dean DA, Barravecchia M, Danziger B, Lin X. "Use of Electroporation for Efficacious Gene Delivery to the Lungs". ECS Trans. 2011; 35: 167-77.

Current Appointments

Research Assistant Professor - Department of Pediatrics, Neonatology (SMD) - Primary

Education

PhD | Biochemistry and Molecular Biology | China-Lanzhou University2004
MS | Pathogenic Biology | China-Lanzhou University2001

Post-Doctoral Training & Residency

Molecular and Cell Biology, University of Rochester, Rochester, NY 0
Pharmacology, Shanghai Institute of Material Medica, Chinese Academy of Science, China 2006