Tirumalai Rangasamy, Ph.D.

Tirumalai Rangasamy, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 692
Rochester, NY 14642

Office: (585) 276-4035
Lab: (585) 276-4094
Fax: (585) 273-1058

Journal Articles

Showing all 15 journal articles available.

2009
T. Rangasamy, V. Misra., L. Zhen., C. G. Tankersley., R. M. Tuder, and S. Biswal. "Cigarette Smoke-Induced Emphysema in A/J mice is Associated with Pulmonary Oxidative Stress, Apoptosis of lung Cells, and Global Loss of Gene Expression. Amer. J. Physiol." Lung Cell. Mol. Physiol. 2009; 296(6): L888-L900.
2009
S.S. An, J. Kim., K. Ahn., X. Trepat., K. J Drake., S. Kumar., G. Ling., C. Purington., T. Rangasamy., T. T. W Kensler., W. Mitzner., J. J. Fredberg., and S. Biswal. "Cell stiffness, contractile stress and the role of extracellular matrix." Biochem. Biophys. Res. Commun. 2009; 382(4): 697-703.
2009
J. Roman, T. Rangasamy, J.Guo, S.Sugunan, N.Meednu, G.Packirisamy, L.Shimoda, A.Golding, G.Semenza , S.N.Georas. "T Cell Activation Under Hypoxic Conditions Enhances Interferon-gamma Secretion." Am. J. Respir. Cell. Mol. Biol. 2009; : [Epub ahead of print].
2009
T.Rangasamy, M.A.Williams, S. Bauer, M.A.Trush, S.N.Georas, S.Biswal. "Nrf2 Inhibits the Maturation Of Murine Dendritic Cells By Ragweed Extract." Am. J Resp. Cell. Mol. Biol. 2009; .
2008
S.A. McGrath-Morrow, T. Rangasamy, C. Cho, E. Neptune, R. Wise, R. M. Tuder, and S. Biswal. "Cigarette Smoke Causes Structural Damage and Immune Response Gene Inhibition in Neonatal Mouse Lung. 38(4):393-400." Am J Respir Cell Mol Biol. 2008; 38(4): 393-400. Epub 2007 Nov 1.
2008
R.K. Thimmulappa., T. Rangasamy., J. Alam,and S. Biswal. "Dibenzoylmethane activates Nrf2- dependent detoxification pathway and inhibits benzo(a)pyrene induced DNA adducts in Lungs." Med. Chem. 2008; 4(5): 473-81.
2008
M. A. Williams*, T. Rangasamy*, S. Bauer, S. Killedar, M. Karp, T. W. Kensler, M. Yamamoto, P. Breysse, S. Biswal and S. N. Georas. "Disruption of the Transcription Factor Nrf2 Promotes Pro-oxidative Dendritic Cell that Stimulate Th2-like Immunoresponsiveness on Activation by Ambient Particulate Matter." J. Immunol. 2008; 181(7): 4545-59. *, Equal Authors.
2008
T.E. Sussan*, T. Rangasamy*, David J. Blake, Melinda Yates, Masayuki Yamamoto, Karen T-Lyby, Hunter C. Champion, Rubin M. Tuder, Thomas W. Kensler and Shyam Biswal. "Targeting Nrf2 with the Triterpinoid CDDO-Imidazole Attenuates Cigarette Smoke –Induced Emphysema and Cardiac Disfunction in Mice. Proc. Natl. Acad. Science (USA)." Proc. Natl. Acad. Science (USA). 2008; 106(1): 250-5. *, Equal Authors.
2006
S. K. Manna, T. Rangasamy, K. Wise, S. Sarkar, S. Shishodia, S. Biswal, and G. T. Ramesh. "Long term environmental tobacco smoke activates nuclear transcription factor-kappa B, activator protein1,and stress responsive kinases in mouse brain." Biochem. Pharmac. 2006; 71: 1602-1609.
2006
R. K. Thimmulappa, H. Lee, T. Rangasamy, S. P. Reddy, M. Yamamoto, T. W. Kensler, and S. Biswal. "Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis." J. Clin. Invest. 2006; : 984-995.
2006
A. Singh, T. Rangasamy, R.K. Thimmulappa, H. Lee, R. Brigelius-Flohe, T.W. Kensler, M.Yamamoto, and S. Biswal. "Regulation of the major cigarette smoke-inducible isoform of glutathione peroxidase, GPx2, in lungs by Nrf2." Am. J. Respir.Cell. Mol. Biol. 2006; 35(6): 639-50. *, Eqaul authors.
2005
T. Rangasamy, J. Guo, W.A. Mitzner, J. Roman, A. Singh, A.D. Fryer, M. Yamamoto, T.W.Kensler, R.M. Tuder, S.N. Georas, and S. Biswal. "Disruption of Nrf2 Enhances Susceptibility to Severe Airway Inflammation and Asthma in Mice." J. Exp. Med. 2005; 202: 47-59.
2004
T. Rangasamy, C.Y. Cho, R.K. Thimmulappa, L. Zhen, S. Srisuma, T.W. Kensler, Yamamoto, I. Petrache, R.M. Tuder, and S. Biswal. "Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice". J. Clin. Invest. 2004; 114: 1248-1259.
2003
S. Biswal, T. Maxwell, T. Rangasamy, and J. P. Kehrer. "Modulation of benzo [a] pyrene–induced p53 activity by acrolein." . Carcinogenesis. 2003; 24: 1401-1406.
2002
R. Tirumalai, R.K. Thimmulappa, K.H. Mai and S. Biswal. "Acrolein causes transcriptional induction of phase II genes by activation of Nrf2 in human lung type II epithelial (A549) cells." Toxicolol. Lett. 2002; 132: 27-36.