Research Bio
Congenital Diaphragmatic Hernia (CDH) is a relatively common birth defect that results in a high rate of neonatal illness or death. The focus of Dr. Ackerman's laboratory is to identify genes that are necessary for development of the diaphragm and the lung.
Current research projects include:
- To identify mechnisms and pathway genes in Fog2 mediated diaphragm development and Fog2 mediated pulmonary lobar braching
-To investigate mechanisms of development in Barx1 homeobox gene associated posterior medical diaphragmatic hernia.
_To develop models for conditional deletion of genes on mesenchymal tissue of the diaphragm
-To develop new models of abnormal diaphragm and lung development from forward genetic screening
-To characterize human diaphragmatic defects and translate findings in animal models to the human disease with the hopes of modulating outcome in fetuses and neonates with congenital diaphragmatic defects
| Henry C. and Bertha H. Buswell Fellow | University of Rochester |
2008 - 2009 |
| Harvard Medical School Leadership Development for Physicians and Scientists | Harvard Medical School |
2006 |
| Children's Hospital Faculty Development Award/Eleanor and Miles Shore Scholar | Harvard Medical School |
2005 |
| Children's Hospital Fellow Research Award | Harvard Medical School |
2002 |
| Glascow Award | University at Buffalo School of Medicine |
1995 |
| Association of Pathology Chairs Honor Society | University at Buffalo School of Medicine |
1995 |
| Honors and Distinction in Research | University at Buffalo School of Medicine |
1995 |
| Thesis Honors | University at Buffalo School of Medicine |
1995 |
| Honors Poster Award | University at Buffalo School of Medicine |
1992 |
| Dean's Letters of Commendation | University at Buffalo School of Medicine |
1991 - 1995 |
2013 May 6
Coles GL, Ackerman KG. "Kif7 is required for the patterning and differentiation of the diaphragm in a model of syndromic congenital diaphragmatic hernia." Proceedings of the National Academy of Sciences of the United States
of America. 2013 May 6; Epub 2013 May 06. |
2012
Ackerman KG, Vargas SO, Wilson JM, Jennings RW, Kozakewich HP, Pober B. "Congenital diaphragmatic defects: proposal for a new classification based on observations in 234 patients." Pediatric and developmental pathology : the official journal of the
Society for Pediatric Pathology and the Paediatric Pathology Society. 2012 15(4):265-74. Epub 2012 Mar 07. |
2010
Kantarci S, Ackerman KG, (co-first authors Russell M, Longoni M, Sougnez C, Noonan KM, Hatchwell E, Zhang X, Canmarcke, RP,Anyane-Yeboe K, Dickman P, Wilson J, Donahue P, Pober BR). "Characterization of the Chromosome 1q41q42.12 region and the Candidate Gene DISP1, in Patients with CDH". American Journal of Medical Genetics. 2010; . |
2009 Feb
Stevens TP, van Wijngaarden E, Ackerman KG, Lally PA, Lally KP, . "Timing of delivery and survival rates for infants with prenatal diagnoses of congenital diaphragmatic hernia." Pediatrics. 2009 Feb 0; 123(2):494-502. |
2009
Liu, X.; Ramjiganesh, T.; Chen, Y.H.; Chung, S.W.; Hall, S.R.; Schissel, S.L.; Padera, R.F. Jr.; Liao, R.; Ackerman, K.G.; Kajstura, J.; Leri, A.; Anversa, P.; Yet, S.F.; Layne, M.D.; Perrella M.A. "Disruption of striated preferentially expressed gene locus leads to dilated cardiomyopathy in mice." Circulation. 2009; 119(2): 261-268. |
