Jennifer Jonason, Ph.D.

Jennifer Jonason, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 665
Rochester, NY 14642

Office: (585) 276-5608
Fax: (585) 275-1121

Research Bio

The Jonason laboratory is interested in the signaling mechanisms that govern mesenchymal stem cell differentiation as well as maturation of committed chondrocytes and osteoblasts during skeletal development. Additionally, we have a strong interest in those mechanisms that function to maintain articular chondrocytes and the integrity of the articular cartilage matrix. We combine in vivo genetic mouse models with in vitro tissue culture and molecular biology techniques to better understand the role of specific signaling pathways and transcription factors in regulation of bone and joint development as well as in the onset and progression of osteoarthritis.

Awards & Honors (National)

National Research Service Award | University of Rochester 2007 - 2010
Forum on Metabolic Bone Disease Travel Award | Endocrine Fellows Foundation 2008

Awards & Honors (Local)

Young Investigator Travel Award | CMSR Annual Symposium | University of Rochester 2011
Outstanding Honor's Thesis | Otterbein College 1999
Oustanding Senior Research Project | Otterbein College 1999
Mortar Board National College Senior Honor Society | Otterbein College 1998 - 1999
Otterbein Scholar Award | Otterbein College 1995 - 1999
Endowed Scholar Award | Otterbein College 1995 - 1999

Recent Journal Articles

Showing the 5 most recent journal articles. 15 available »

2014 May
Yukata K, Xie C, Li TF, Takahata M, Hoak D, Kondabolu S, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ. "Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment." Bone. 2014 May; 62:79-89. Epub 2014 Feb 12.
2014
Jonason JH, O'Keefe RJ. "Isolation and culture of neonatal mouse calvarial osteoblasts." Methods in molecular biology. 2014 1130:295-305.
2013 Jun
Shah K, Majeed Z, Jonason J, O'Keefe RJ. "The role of muscle in bone repair: the cells, signals, and tissue responses to injury." Current osteoporosis reports. 2013 Jun; 11(2):130-5.
2013
Gao L, Sheu TJ, Dong Y, Hoak DM, Zuscik MJ, Schwarz EM, Hilton MJ, O'Keefe RJ, Jonason JH. "TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages." Journal of cell science. 2013 126(Pt 24):5704-13. Epub 2013 Oct 21.
2012 Aug
Dao DY, Jonason JH, Zhang Y, Hsu W, Chen D, Hilton MJ, O'Keefe RJ. "Cartilage-specific ?-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2012 Aug; 27(8):1680-94.

Current Appointments

Assistant Professor - Department of Orthopaedics, Center for Musculoskeletal Research (SMD) - Primary

Education

PhD | Genetics | Yale University2006
BS | Molecular Biology | Otterbein College1999

Post-Doctoral Training & Residency

Post-doctoral Fellowship | Center for Musculoskeletal Research, University of Rochester | Mentor: Regis O'Keefe 2011