Our overall laboratory research program focuses on studying human viral immunology and pathogenesis in two model systems: HIV and dengue virus.
In the HIV model, we current investigate a number of issues including but not limited to (a) Measurement of the global and epitope-specific T cell immune responses elicited in human subjects who have received candidate HIV vaccines. (b) Improvement of the clonal diversity of CTL responses by manipulating pMHC structure employing computational tools (in collaboration with Dr Lee of Computation Biology).
In the dengue virus model, we have several ongoing projects: (a) Investigation of the increased vascular permeability during dengue-virus infection in an endothelial cell culture model (in collaboration with Dr Simpson-Haidaris of Pathology and Laboratory Medicine) ; (b) Examining intrinsic mechanisms of antibody-dependent-enhancement of dengue virus infection in primary human cells and cell lines; and (c) Assessing the in vivo immunological and virological correlates of dengue disease severity (in collaboration with clinical investigators in China and Taiwan).
Novel Vaccine Strategies for Flavivirus Prophylaxis|
United States Serial NO.: 13/876,893
Filed Date: October 3, 2011
Title: Flavivirus Domain III Vaccine
Invented by: Robert Rose, Olivia K.T. Block, W.W. Shanaka Rodrigo, Jacob Schlesinger, Xia Jin
Targeting Syndecan-Dengue Interaction for Screening Dengue Therapeutics in vitro and for Treatment of Severe Dengue Viral Disease in vivo|
United States Serial NO.: 13/701,710
Filed Date: June 3, 2011
Title: Compositions and Methods for Inhibition or Treatment of Dengue Virus Infection
Invented by: Maria Arevalo, Patricia Simpson-Haidaris, Xia Jin, Huiyuan Chen, Matthew Quinn
Miao H, Jin X, Perelson AS, Wu H. "Evaluation of multitype mathematical models for CFSE-labeling experiment data." Bulletin of mathematical biology. 2012 Feb; 74(2):300-26. Epub 2011 Jun 17.
Kobie JJ, Alcena DC, Zheng B, Bryk P, Mattiacio JL, Brewer M, Labranche C, Young FM, Dewhurst S, Montefiori DC, Rosenberg AF, Feng C, Jin X, Keefer MC, Sanz I. "9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activity." PloS one. 2012 7(4):e35356. Epub 2012 Apr 18.
2011 Feb 24
Keefer MC, Frey SE, Elizaga M, Metch B, De Rosa SC, Barroso PF, Tomaras G, Cardinali M, Goepfert P, Kalichman A, Philippon V, McElrath MJ, Jin X, Ferrari G, Defawe OD, Mazzara GP, Montefiori D, Pensiero M, Panicali DL, Corey L, . "A phase I trial of preventive HIV vaccination with heterologous poxviral-vectors containing matching HIV-1 inserts in healthy HIV-uninfected subjects." Vaccine. 2011 Feb 24; 29(10):1948-58. Epub 2011 Jan 07.
2011 Feb 5
Kou Z, Lim JY, Beltramello M, Quinn M, Chen H, Liu SN, Martnez-Sobrido L, Diamond MS, Schlesinger JJ, de Silva A, Sallusto F, Jin X. "Human antibodies against dengue enhance dengue viral infectivity without suppressing type I interferon secretion in primary human monocytes." Virology. 2011 Feb 5; 410(1):240-7. Epub 2010 Dec 04.
Zhihua Kou; Joanne Y. H. Lim; Martina Beltramello; Matthew Quinn; Huiyuan Chen; Shengyoung Liu; Luis Martnez-Sobrido; Michael S. Diamond;Jacob J. Schlesinger;
Aravinda de Silva; Federica Sallusto; and Xia Jin. "Human antibodies against dengue enhance dengue viral infectivity without suppressing type I interferon secretion in primary human monocytes". Virology. 2011; 410: 240-247.