Kyungsun Heo, Ph.D.

Kyungsun Heo, Ph.D.

Contact Information

Aab Cardiovascular Research Institute
211 Bailey Road
West Henrietta, NY 14586

Lab: (585) 276-9846

Journal Articles

Showing all 18 journal articles available.

2014 Jul 8
Heo KS, Cushman HJ, Akaike M, Woo CH, Wang X, Qiu X, Fujiwara K, Abe J. "ERK5 Activation in Macrophages Promotes Efferocytosis and Inhibits Atherosclerosis." Circulation.. 2014 Jul 8; 130(2):180-91. Epub 2014 Apr 28.
2014 Jun 30
Heo KS, Fujiwara K, Abe JI. "Shear stress and atherosclerosis." Molecules and cells.. 2014 Jun 30; 37(6):435-40. Epub 2014 Apr 30.
2013 Mar 15
Heo KS, Chang E, Le NT, Cushman HJ, Yeh ET, Fujiwara K, Abe JI. "De-SUMOylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis." Circulation research.. 2013 Mar 15; 112(6):911-23. Epub 2013 Feb 04.
2013 Feb
Heo KS, Chang E, Takei Y, Le NT, Woo CH, Sullivan MA, Morrell C, Fujiwara K, Abe JI. "Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity." Arteriosclerosis, thrombosis, and vascular biology.. 2013 Feb; 33(2):321-9. Epub 2012 Nov 29.
2013 Jan 29
Le NT, Heo KS, Takei Y, Lee H, Woo CH, Chang E, McClain C, Hurley C, Wang X, Li F, Xu H, Morrell C, Sullivan MA, Cohen MS, Serafimova IM, Taunton J, Fujiwara K, Abe JI. "A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis." Circulation.. 2013 Jan 29; 127(4):486-99. Epub 2012 Dec 14.
2012 Oct
Heo KS, Fujiwara K, Abe JI. "Glucagon-like peptide-1 and its cardiovascular effects." Current atherosclerosis reports. 2012 Oct; 14(5):422-8.
2012 Feb 17
Le NT, Takei Y, Shishido T, Woo CH, Chang E, Heo KS, Lee H, Lu Y, Morrell C, Oikawa M, McClain C, Wang X, Tournier C, Molina CA, Taunton J, Yan C, Fujiwara K, Patterson C, Yang J, Abe JI. "p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction." Circulation research.. 2012 Feb 17; 110(4):536-50. Epub 2012 Jan 19.
2011 May 30
Heo KS, Lee H, Nigro P, Thomas T, Le NT, Chang E, McClain C, Reinhart-King CA, King MR, Berk BC, Fujiwara K, Woo CH, Abe J. "PKC? mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation." The Journal of cell biology. 2011 May 30; 193(5):867-84.
2011 Feb 24
Chang E, Heo KS, Woo CH, Lee H, Le NT, Thomas TN, Fujiwara K, Abe JI. "MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation." Blood.. 2011 Feb 24; 117(8):2527-37. Epub 2010 Dec 03.
Heo KS, Fujiwara K, Abe JI. "Disturbed-flow-mediated vascular reactive oxygen species induce endothelial dysfunction." Circulation journal : official journal of the Japanese Circulation Society. 2011 75(12):2722-30. Epub 2011 Nov 10.
2010 Sep 16
Nigro P, Abe JI, Woo CH, Satoh K, McClain C, O'Dell MR, Lee H, Lim JH, Li JD, Heo KS, Fujiwara K, Berk BC. "PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5." Blood.. 2010 Sep 16; 116(11):1971-9. Epub 2010 Jun 10.
2010 Jun
Kim DU, Hayles J, Kim D, Wood V, Park HO, Won M, Yoo HS, Duhig T, Nam M, Palmer G, Han S, Jeffery L, Baek ST, Lee H, Shim YS, Lee M, Kim L, Heo KS, Noh EJ, Lee AR, Jang YJ, Chung KS, Choi SJ, Park JY, Park Y, Kim HM, Park SK, Park HJ, Kang EJ, Kim HB, Kang HS, Park HM, Kim K, Song K, Song KB, Nurse P, Hoe KL. "Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe." Nature biotechnology. 2010 Jun; 28(6):617-23. Epub 2010 May 16.
Woo CH, Le NT, Shishido T, Chang E, Lee H, Heo KS, Mickelsen DM, Lu Y, McClain C, Spangenberg T, Yan C, Molina CA, Yang J, Patterson C, Abe JI. "Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2010 24(12):4917-28. Epub 2010 Aug 19.
2008 Nov 30
Heo KS, Ryoo SW, Kim L, Nam M, Baek ST, Lee H, Lee AR, Park SK, Park Y, Myung CS, Kim DU, Hoe KL. "Cl- -channel is essential for LDL-induced cell proliferation via the activation of Erk1/2 and PI3k/Akt and the upregulation of Egr-1 in human aortic smooth muscle cells." Molecules and cells.. 2008 Nov 30; 26(5):468-73.
2008 Jun
Baek ST, Han S, Nam M, Kim YD, Kim L, Lee HJ, Heo KS, Lee H, Lee M, Park SK, Maeng PJ, Park Y, Lee S, Kim DU, Kim D, Hoe KL. "Genome-wide identification of haploinsufficiency in fission yeast." Journal of microbiology and biotechnology. 2008 Jun; 18(6):1059-63.
2008 Mar 28
Heo KS, Kim DU, Kim L, Nam M, Baek ST, Park SK, Park Y, Myung CS, Hwang SO, Hoe KL. "Activation of PKCbeta(II) and PKCtheta is essential for LDL-induced cell proliferation of human aortic smooth muscle cells via Gi-mediated Erk1/2 activation and Egr-1 upregulation." Biochemical and biophysical research communications.. 2008 Mar 28; 368(1):126-31. Epub 2008 Jan 22.
2008 Feb
Baek ST, Kim DU, Han S, Woo IS, Nam M, Kim L, Heo KS, Lee H, Hwang HR, Choi SJ, Won M, Lee M, Park SK, Lee S, Kwon HJ, Maeng PJ, Park HM, Park Y, Kim D, Hoe KL. "Genome-wide drug-induced haploinsufficient screening of fission yeast for identification of hydrazinocurcumin targets." Journal of microbiology and biotechnology. 2008 Feb; 18(2):263-9.
2007 Aug 10
Heo KS, Kim DU, Ryoo S, Nam M, Baek ST, Kim L, Park SK, Myung CS, Hoe KL. "PPARgamma activation abolishes LDL-induced proliferation of human aortic smooth muscle cells via SOD-mediated down-regulation of superoxide." Biochemical and biophysical research communications.. 2007 Aug 10; 359(4):1017-23. Epub 2007 Jun 08.