Thomas J. Mariani, Ph.D.

Thomas J. Mariani, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 651
Rochester, NY 14642

Office: (585) 276-4616
Fax: (585) 276-2642

Lab Information

Mariani Lab

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Research Bio

Premature infant morbidity and mortality often results from pulmonary complications, primarily insufficient lung maturation or alveolar formation. Likewise, many adult lung diseases involve obliteration of the distal respiratory structure. With the advent of clinical means to dramatically improve pre-term infant survival, there has been a growing appreciation of a relationship between developmental complications and susceptibility to chronic lung disease. The broad objectives of Dr. Mariani's laboratory are to identify the genetic mechanisms of susceptibility to chronic lung diseases, particularly focusing upon their developmental antecedents and the influence of environmental factors. Dr. Mariani's research program focuses upon defining regulatory networks involved in lung development and maturation, and which may be perturbed in diseased states. His laboratory uses a combination of animal modeling research and studies of human subjects. He is a leader in the application of gene expression array methods to pulmonary biology and lung disease. Current research projects in the Mariani lab include:



1. Defining genetic regulatory networks contributing to airspace morphogenesis using the FGFR3/4 mutant mouse model of abnormal alveolar formation.

2. Determining the physiological role of PPARg in lung epithelial cells during airspace formation and in lung injury/repair.

3. Investigating the cellular and molecular mechanisms by which the protease inhibitor SERPINE2 contributes to airspace formation and susceptibility to COPD.

This work is currently supported by the NIH and FAMRI.

Awards & Honors (National)

Mentored 2nd place winner - Respiratory Disease Young Investigators' Forum 2006
Mentored 1st place winner - Respiratory Disease Young Investigators' Forum 2005
Parker B. Francis Fellowship in Pulmonary Research 2000 - 2003
Novartis (Ciba) Foundation Bursar | Ciba 1994 - 1994
Individual National Research Service Award | NHLBI 1994 - 1997

Recent Journal Articles

Showing the 5 most recent journal articles. 60 available »

2014 Nov 11
Cuna A, Halloran B, Faye-Petersen O, Kelly D, Crossman DK, Cui X, Pandit K, Kaminski N, Bhattacharya S, Ahmad A, Mariani TJ, Ambalavanan N. "Alterations in Gene Expression and DNA Methylation During Murine and Human Lung Alveolar Septation." American journal of respiratory cell and molecular biology. 2014 Nov 11; Epub 2014 Nov 11.
2014 Nov 6
Ambalavanan N, Cotten CM, Page GP, Carlo WA, Murray JC, Bhattacharya S, Mariani TJ, Cuna AC, Faye-Petersen OM, Kelly D, Higgins RD, . "Integrated Genomic Analyses in Bronchopulmonary Dysplasia." The Journal of pediatrics. 2014 Nov 6; Epub 2014 Nov 06.
2014 Oct 1
Bhattacharya S, Zhou Z, Yee M, Chu CY, Lopez AM, Lunger VA, Solleti SK, Resseguie E, Buczynski BW, Mariani TJ, O'Reilly MA. "The genome-wide transcriptional response to neonatal hyperoxia identifies Ahr as a key regulator." American journal of physiology. Lung cellular and molecular physiology. 2014 Oct 1; 307(7):L516-23. Epub 2014 Aug 22.
2014 Sep 15
Qiu W, Rogers AJ, Damask A, Raby BA, Klanderman BJ, Duan QL, Tyagi S, Niu S, Anderson C, Cahir-McFarland E, Mariani TJ, Carey V, Tantisira KG. "Pharmacogenomics: novel loci identification via integrating gene differential analysis and eQTL analysis." Human molecular genetics. 2014 Sep 15; 23(18):5017-24. Epub 2014 Apr 25.
2013 Sep
Eckle T, Brodsky K, Bonney M, Packard T, Han J, Borchers CH, Mariani TJ, Kominsky DJ, Mittelbronn M, Eltzschig HK. "HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium." PLoS biology. 2013 Sep; 11(9):e1001665. Epub 2013 Sep 24.

Current Appointments

Associate Professor - Department of Pediatrics, Neonatology (SMD) - Primary
Associate Professor - Department of Environmental Medicine (SMD)

Education

PhD | Microbiology and Molecular Genetics | Rutgers University1993
B.S. | Biology | Rutgers University, Cook College1989

Post-Doctoral Training & Residency

Research Associate, Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 1998
Postdoctoral Fellow, Dermatology Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 1997