Luis Martinez-Sobrido, Ph.D.

Luis Martinez-Sobrido, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 672
Rochester, NY 14642

Office: (585) 276-4733

Journal Articles

Showing all 69 journal articles available.

2015 Apr 1
Cheng BY, Ortiz-Riaño E, Nogales A, de la Torre JC, Martínez-Sobrido L. "Development of live-attenuated arenavirus vaccines based on codon deoptimization." Journal of virology. 2015 Apr 1; 89(7):3523-33. Epub 2015 Jan 14.
2015 Mar 15
Cox A, Baker SF, Nogales A, Martínez-Sobrido L, Dewhurst S. "Development of a mouse-adapted live attenuated influenza virus that permits in vivo analysis of enhancements to the safety of live attenuated influenza virus vaccine." Journal of virology. 2015 Mar 15; 89(6):3421-6. Epub 2014 Dec 31.
2015 Feb
Nogales A, Baker SF, Martínez-Sobrido L. "Replication-competent influenza A viruses expressing a red fluorescent protein." Virology. 2015 Feb; 476:206-16. Epub 2014 Dec 30.
2014 Oct
Guo H, Baker S, Martínez-Sobrido L, Topham DJ. "Induction of CD8 T cell heterologous protection by a single dose of single-cycle infectious influenza virus." Journal of virology. 2014 Oct; 88(20):12006-16. Epub 2014 Aug 06.
2014 Sep
Nogales A, Baker SF, Ortiz-Riaño E, Dewhurst S, Topham DJ, Martínez-Sobrido L. "Influenza A virus attenuation by codon deoptimization of the NS gene for vaccine development." Journal of virology. 2014 Sep; 88(18):10525-40. Epub 2014 Jun 25.
2014 Sep
Baker SF, Nogales A, Finch C, Tuffy KM, Domm W, Perez DR, Topham DJ, Martínez-Sobrido L. "Influenza A and B virus intertypic reassortment through compatible viral packaging signals." Journal of virology. 2014 Sep; 88(18):10778-91. Epub 2014 Jul 09.
2014 Mar
Domm W, Brewer M, Baker SF, Feng C, Martínez-Sobrido L, Treanor J, Dewhurst S. "Use of bacteriophage particles displaying influenza virus hemagglutinin for the detection of hemagglutination-inhibition antibodies." Journal of virological methods. 2014 Mar; 197:47-50. Epub 2013 Dec 06.
2014 Jan
Ortiz-Riaño E, Ngo N, Devito S, Eggink D, Munger J, Shaw ML, de la Torre JC, Martínez-Sobrido L. "Inhibition of arenavirus by A3, a pyrimidine biosynthesis inhibitor." Journal of virology. 2014 Jan; 88(2):878-89. Epub 2013 Nov 06.
DeVito SR, Ortiz-Riaño E, Martínez-Sobrido L, Munger J. "Cytomegalovirus-mediated activation of pyrimidine biosynthesis drives UDP-sugar synthesis to support viral protein glycosylation." Proceedings of the National Academy of Sciences of the United States of America. 2014 111(50):18019-24. Epub 2014 Dec 03.
Ramon S, Baker SF, Sahler JM, Kim N, Feldsott EA, Serhan CN, Martínez-Sobrido L, Topham DJ, Phipps RP. "The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant?" The Journal of immunology : official journal of the American Association of Immunologists. 2014 193(12):6031-40. Epub 2014 Nov 12.
Mathers C, Schafer X, Martinez-Sobrido L, Munger J. "The human cytomegalovirus UL26 protein antagonizes NF-?B activation." Journal of virology. 2014 88(24):14289-300. Epub 2014 Oct 01.
2013 Nov 15
Bauman JD, Patel D, Baker SF, Vijayan RS, Xiang A, Parhi AK, Martínez-Sobrido L, Lavoie EJ, Das K, Arnold E. "Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors." ACS chemical biology. 2013 Nov 15; 8(11):2501-8. Epub 2013 Sep 13.
2013 Aug
Baker SF, Guo H, Albrecht RA, García-Sastre A, Topham DJ, Martínez-Sobrido L. "Protection against lethal influenza with a viral mimic." Journal of virology. 2013 Aug; 87(15):8591-605. Epub 2013 May 29.
2013 Jun
Ortiz-Riaño E, Cheng BY, de la Torre JC, Martinez-Sobrido L. "Arenavirus reverse genetics for vaccine development." The Journal of general virology. 2013 Jun; 94(Pt 6):1175-88. Epub 2013 Jan 30.
Cheng BY, Ortiz-Riaño E, de la Torre JC, Martínez-Sobrido L. "Generation of recombinant arenavirus for vaccine development in FDA-approved Vero cells." Journal of visualized experiments : JoVE. 2013 (78)Epub 2013 Aug 01.
Ayllon J, García-Sastre A, Martínez-Sobrido L. "Rescue of recombinant Newcastle disease virus from cDNA." Journal of visualized experiments : JoVE. 2013 (80)Epub 2013 Oct 11.
2012 Oct
Ortiz-Riaño E, Cheng BY, Torre JC, Martínez-Sobrido L. "D471G mutation in LCMV-NP affects its ability to self-associate and results in a dominant negative effect in viral RNA synthesis." Viruses. 2012 Oct; 4(10):2137-61. Epub 2012 Oct 16.
2012 Aug
Pythoud C, Rodrigo WW, Pasqual G, Rothenberger S, Martínez-Sobrido L, de la Torre JC, Kunz S. "Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKK?." Journal of virology. 2012 Aug; 86(15):7728-38. Epub 2012 Apr 24.
2012 Aug
Rodrigo WW, Ortiz-Riaño E, Pythoud C, Kunz S, de la Torre JC, Martínez-Sobrido L. "Arenavirus nucleoproteins prevent activation of nuclear factor kappa B." Journal of virology. 2012 Aug; 86(15):8185-97. Epub 2012 May 23.
2012 Mar
Ortiz-Riaño E, Cheng BY, de la Torre JC, Martínez-Sobrido L. "Self-association of lymphocytic choriomeningitis virus nucleoprotein is mediated by its N-terminal region and is not required for its anti-interferon function." Journal of virology. 2012 Mar; 86(6):3307-17. Epub 2012 Jan 18.
2011 Feb 5
Kou Z, Lim JY, Beltramello M, Quinn M, Chen H, Liu SN, Martnez-Sobrido L, Diamond MS, Schlesinger JJ, de Silva A, Sallusto F, Jin X. "Human antibodies against dengue enhance dengue viral infectivity without suppressing type I interferon secretion in primary human monocytes." Virology. 2011 Feb 5; 410(1):240-7. Epub 2010 Dec 04.
2011 Feb 2
Moreno JL, Kurita M, Holloway T, López J, Cadagan R, Martínez-Sobrido L, García-Sastre A, González-Maeso J. "Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT?A and mGlu? receptors in the adult offspring." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Feb 2; 31(5):1863-72.
2011 Feb
Rodrigo WW, de la Torre JC, Martínez-Sobrido L. "Use of single-cycle infectious lymphocytic choriomeningitis virus to study hemorrhagic fever arenaviruses." Journal of virology. 2011 Feb; 85(4):1684-95. Epub 2010 Dec 01.
2011 Jan
Kim D, Martinez-Sobrido L, Choi C, Petroff N, García-Sastre A, Niewiesk S, Carsillo T. "Induction of type I interferon secretion through recombinant Newcastle disease virus expressing measles virus hemagglutinin stimulates antibody secretion in the presence of maternal antibodies." Journal of virology. 2011 Jan; 85(1):200-7. Epub 2010 Oct 20.
Davtyan H, Ghochikyan A, Cadagan R, Zamarin D, Petrushina I, Movsesyan N, Martinez-Sobrido L, Albrecht RA, Garcia-Sastre A, Agadjanyan MG. "The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer's disease." Journal of translational medicine. 2011 9:127. Epub 2011 Aug 01.
Bortz E, Westera L, Maamary J, Steel J, Albrecht RA, Manicassamy B, Chase G, Martínez-Sobrido L, Schwemmle M, García-Sastre A. "Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins." mBio. 2011 2(4)Epub 2011 Aug 16.
Ortiz-Riaño E, Cheng BY, de la Torre JC, Martínez-Sobrido L. "The C-terminal region of lymphocytic choriomeningitis virus nucleoprotein contains distinct and segregable functional domains involved in NP-Z interaction and counteraction of the type I interferon response." Journal of virology. 2011 85(24):13038-48. Epub 2011 Oct 05.
Guerra S, Abaitua F, Martínez-Sobrido L, Esteban M, García-Sastre A, Rodríguez D. "Host-range restriction of vaccinia virus E3L deletion mutant can be overcome in vitro, but not in vivo, by expression of the influenza virus NS1 protein." PloS one. 2011 6(12):e28677. Epub 2011 Dec 13.
2010 Nov
Borrow P, Martínez-Sobrido L, de la Torre JC. "Inhibition of the type I interferon antiviral response during arenavirus infection." Viruses. 2010 Nov; 2(11):2443-80. Epub 2010 Nov 05.
2010 Jun
Rose KM, Elliott R, Martínez-Sobrido L, García-Sastre A, Weiss SR. "Murine coronavirus delays expression of a subset of interferon-stimulated genes." Journal of virology. 2010 Jun; 84(11):5656-69. Epub 2010 Mar 31.
2010 Feb
Martínez-Sobrido L, Cadagan R, Steel J, Basler CF, Palese P, Moran TM, García-Sastre A. "Hemagglutinin-pseudotyped green fluorescent protein-expressing influenza viruses for the detection of influenza virus neutralizing antibodies." Journal of virology. 2010 Feb; 84(4):2157-63. Epub 2009 Nov 25.
2010 Jan
Buettner N, Vogt C, Martinez-Sobrido L, Weber F, Waibler Z, Kochs G. "Thogoto virus ML protein is a potent inhibitor of the interferon regulatory factor-7 transcription factor." The Journal of general virology. 2010 Jan; 91(Pt 1):220-7. Epub 2009 Oct 07.
Martínez-Sobrido L, García-Sastre A. "Generation of recombinant influenza virus from plasmid DNA." Journal of visualized experiments : JoVE. 2010 (42)Epub 2010 Aug 03.
Steidle S, Martínez-Sobrido L, Mordstein M, Lienenklaus S, García-Sastre A, Stäheli P, Kochs G. "Glycine 184 in nonstructural protein NS1 determines the virulence of influenza A virus strain PR8 without affecting the host interferon response." Journal of virology. 2010 84(24):12761-70. Epub 2010 Oct 06.
Wortman MJ, Hanson LK, Martinez-Sobrido L, Campbell AE, Nance JA, Garcia-Sastre A, Johnson EM. "Regulation of PURA gene transcription by three promoters generating distinctly spliced 5-prime leaders: a novel means of fine control over tissue specificity and viral signals." BMC molecular biology. 2010 11:81. Epub 2010 Nov 09.
2009 Nov
Kuri T, Zhang X, Habjan M, Martínez-Sobrido L, García-Sastre A, Yuan Z, Weber F. "Interferon priming enables cells to partially overturn the SARS coronavirus-induced block in innate immune activation." The Journal of general virology. 2009 Nov; 90(Pt 11):2686-94. Epub 2009 Jul 22.
2009 Nov
Martínez-Sobrido L, Emonet S, Giannakas P, Cubitt B, García-Sastre A, de la Torre JC. "Identification of amino acid residues critical for the anti-interferon activity of the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus." Journal of virology. 2009 Nov; 83(21):11330-40. Epub 2009 Aug 26.
2009 Jul 1
Nguyen DN, Kim P, Martínez-Sobrido L, Beitzel B, García-Sastre A, Langer R, Anderson DG. "A novel high-throughput cell-based method for integrated quantification of type I interferons and in vitro screening of immunostimulatory RNA drug delivery." Biotechnology and bioengineering. 2009 Jul 1; 103(4):664-75.
2009 Jun
Dauber B, Martínez-Sobrido L, Schneider J, Hai R, Waibler Z, Kalinke U, García-Sastre A, Wolff T. "Influenza B virus ribonucleoprotein is a potent activator of the antiviral kinase PKR." PLoS pathogens. 2009 Jun; 5(6):e1000473. Epub 2009 Jun 12.
2009 Apr
Zamarin D, Martínez-Sobrido L, Kelly K, Mansour M, Sheng G, Vigil A, García-Sastre A, Palese P, Fong Y. "Enhancement of oncolytic properties of recombinant newcastle disease virus through antagonism of cellular innate immune responses." Molecular therapy : the journal of the American Society of Gene Therapy. 2009 Apr; 17(4):697-706. Epub 2009 Feb 10.
2009 Jan
Lai C, Struckhoff JJ, Schneider J, Martinez-Sobrido L, Wolff T, García-Sastre A, Zhang DE, Lenschow DJ. "Mice lacking the ISG15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus infection." Journal of virology. 2009 Jan; 83(2):1147-51. Epub 2008 Nov 12.
Kochs G, Martinez-Sobrido L, Lienenklaus S, Weiss S, Garcia-Sastre A, Staeheli P. "Strong interferon-inducing capacity of a highly virulent variant of influenza A virus strain PR8 with deletions in the NS1 gene." The Journal of general virology. 2009 90(Pt 12):2990-4. Epub 2009 Sep 02.
2008 Nov
Hai R, Martínez-Sobrido L, Fraser KA, Ayllon J, García-Sastre A, Palese P. "Influenza B virus NS1-truncated mutants: live-attenuated vaccine approach." Journal of virology. 2008 Nov; 82(21):10580-90. Epub 2008 Sep 03.
2008 Aug 4
Muñoz-Fontela C, Macip S, Martínez-Sobrido L, Brown L, Ashour J, García-Sastre A, Lee SW, Aaronson SA. "Transcriptional role of p53 in interferon-mediated antiviral immunity." The Journal of experimental medicine. 2008 Aug 4; 205(8):1929-38. Epub 2008 Jul 28.
2008 Aug
Andersson I, Karlberg H, Mousavi-Jazi M, Martínez-Sobrido L, Weber F, Mirazimi A. "Crimean-Congo hemorrhagic fever virus delays activation of the innate immune response." Journal of medical virology. 2008 Aug; 80(8):1397-404.
2008 Jan
Loo YM, Fornek J, Crochet N, Bajwa G, Perwitasari O, Martinez-Sobrido L, Akira S, Gill MA, García-Sastre A, Katze MG, Gale M. "Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity." Journal of virology. 2008 Jan; 82(1):335-45. Epub 2007 Oct 17.
2007 Nov
Martínez-Sobrido L, Giannakas P, Cubitt B, García-Sastre A, de la Torre JC. "Differential inhibition of type I interferon induction by arenavirus nucleoproteins." Journal of virology. 2007 Nov; 81(22):12696-703. Epub 2007 Sep 05.
2007 Sep 1
Vigil A, Park MS, Martinez O, Chua MA, Xiao S, Cros JF, Martínez-Sobrido L, Woo SL, García-Sastre A. "Use of reverse genetics to enhance the oncolytic properties of Newcastle disease virus." Cancer research. 2007 Sep 1; 67(17):8285-92.
2007 Sep
He Q, Martinez-Sobrido L, Eko FO, Palese P, Garcia-Sastre A, Lyn D, Okenu D, Bandea C, Ananaba GA, Black CM, Igietseme JU. "Live-attenuated influenza viruses as delivery vectors for Chlamydia vaccines." Immunology. 2007 Sep; 122(1):28-37. Epub 2007 Apr 23.
2007 Jul
Martínez-Sobrido L, Garcia-Sastre A. "Recombinant influenza virus vectors". Future Virology. 2007; 2(4): 401-416.
2007 Jul
Kochs G, García-Sastre A, Martínez-Sobrido L. "Multiple anti-interferon actions of the influenza A virus NS1 protein." Journal of virology. 2007 Jul; 81(13):7011-21. Epub 2007 Apr 18.
2007 Jul
Roth-Cross JK, Martínez-Sobrido L, Scott EP, García-Sastre A, Weiss SR. "Inhibition of the alpha/beta interferon response by mouse hepatitis virus at multiple levels." Journal of virology. 2007 Jul; 81(13):7189-99. Epub 2007 Apr 25.
2007 May 10
Stertz S, Reichelt M, Spiegel M, Kuri T, Martínez-Sobrido L, García-Sastre A, Weber F, Kochs G. "The intracellular sites of early replication and budding of SARS-coronavirus." Virology. 2007 May 10; 361(2):304-15. Epub 2007 Jan 08.
2007 Apr 17
Grimm D, Staeheli P, Hufbauer M, Koerner I, Martínez-Sobrido L, Solórzano A, García-Sastre A, Haller O, Kochs G. "Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene." Proceedings of the National Academy of Sciences of the United States of America. 2007 Apr 17; 104(16):6806-11. Epub 2007 Apr 10.
2007 Feb
Mayer D, Molawi K, Martínez-Sobrido L, Ghanem A, Thomas S, Baginsky S, Grossmann J, García-Sastre A, Schwemmle M. "Identification of cellular interaction partners of the influenza virus ribonucleoprotein complex and polymerase complex using proteomic-based approaches." Journal of proteome research. 2007 Feb; 6(2):672-82.
2007 Jan
Mibayashi M, Martínez-Sobrido L, Loo YM, Cárdenas WB, Gale M, García-Sastre A. "Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus." Journal of virology. 2007 Jan; 81(2):514-24. Epub 2006 Nov 01.
2007 Jan
Kopecky-Bromberg SA, Martínez-Sobrido L, Frieman M, Baric RA, Palese P. "Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists." Journal of virology. 2007 Jan; 81(2):548-57. Epub 2006 Nov 15.
2006 Sep
Martínez-Sobrido L, Zúñiga EI, Rosario D, García-Sastre A, de la Torre JC. "Inhibition of the type I interferon response by the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus." Journal of virology. 2006 Sep; 80(18):9192-9.
2006 Jun
Cárdenas WB, Loo YM, Gale M, Hartman AL, Kimberlin CR, Martínez-Sobrido L, Saphire EO, Basler CF. "Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling." Journal of virology. 2006 Jun; 80(11):5168-78.
2006 Feb
Martinez-Sobrido L, Gitiban N, Fernandez-Sesma A, Cros J, Mertz SE, Jewell NA, Hammond S, Flano E, Durbin RK, García-Sastre A, Durbin JE. "Protection against respiratory syncytial virus by a recombinant Newcastle disease virus vector." Journal of virology. 2006 Feb; 80(3):1130-9.
2006 Jan
Kopecky-Bromberg SA, Martinez-Sobrido L, Palese P. "7a protein of severe acute respiratory syndrome coronavirus inhibits cellular protein synthesis and activates p38 mitogen-activated protein kinase." Journal of virology. 2006 Jan; 80(2):785-93.
2005 Jul
Muñoz-Jordán JL, Laurent-Rolle M, Ashour J, Martínez-Sobrido L, Ashok M, Lipkin WI, García-Sastre A. "Inhibition of alpha/beta interferon signaling by the NS4B protein of flaviviruses." Journal of virology. 2005 Jul; 79(13):8004-13.
2005 Apr
García-Barreno B, Steel J, Payá M, Martínez-Sobrido L, Delgado T, Yeo RP, Melero JA. "Epitope mapping of human respiratory syncytial virus 22K transcription antitermination factor: role of N-terminal sequences in protein folding." The Journal of general virology. 2005 Apr; 86(Pt 4):1103-7.
2005 Feb
Spiegel M, Pichlmair A, Martínez-Sobrido L, Cros J, García-Sastre A, Haller O, Weber F. "Inhibition of Beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3." Journal of virology. 2005 Feb; 79(4):2079-86.
2005 Jan 5
Jennings S, Martínez-Sobrido L, García-Sastre A, Weber F, Kochs G. "Thogoto virus ML protein suppresses IRF3 function." Virology. 2005 Jan 5; 331(1):63-72.
Igietseme JU, He Q, Eko FO, Martínez-Sobrido L, Palese P, Garcia-Sastre A, Black CM. "Development of vaccines to prevent chlamydial STDs". Mucosal Immunology Update. 2005; Volume 13(No. 4).
2004 Aug 1
Vecino WH, Quanquin NM, Martinez-Sobrido L, Fernandez-Sesma A, García-Sastre A, Jacobs WR, Fennelly GJ. "Mucosal immunization with attenuated Shigella flexneri harboring an influenza hemagglutinin DNA vaccine protects mice against a lethal influenza challenge." Virology. 2004 Aug 1; 325(2):192-9.
2003 Jul
Basler CF, Mikulasova A, Martinez-Sobrido L, Paragas J, Mühlberger E, Bray M, Klenk HD, Palese P, García-Sastre A. "The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3." Journal of virology. 2003 Jul; 77(14):7945-56.
Schickli JH, Flandorfer A, Nakaya T, Martinez-Sobrido L, García-Sastre A, Palese P. "Plasmid-only rescue of influenza A virus vaccine candidates." Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 2001 356(1416):1965-73.