Nhat Tu Le, Ph.D.

Nhat Tu Le, Ph.D.

Contact Information

Aab Cardiovascular Research Institute
211 Bailey Road
West Henrietta, NY 14586

Journal Articles

Showing all 9 journal articles available.

2013 Feb
Heo KS, Chang E, Takei Y, Le NT, Woo CH, Sullivan MA, Morrell C, Fujiwara K, Abe JI. "Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity." Arteriosclerosis, thrombosis, and vascular biology.. 2013 Feb; 33(2):321-9. Epub 2012 Nov 29.
2013 Jan 29
Le NT, Heo KS, Takei Y, Lee H, Woo CH, Chang E, McClain C, Hurley C, Wang X, Li F, Xu H, Morrell C, Sullivan MA, Cohen MS, Serafimova IM, Taunton J, Fujiwara K, Abe JI. "A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis." Circulation.. 2013 Jan 29; 127(4):486-99. Epub 2012 Dec 14.
2012 Feb 17
Le NT, Takei Y, Shishido T, Woo CH, Chang E, Heo KS, Lee H, Lu Y, Morrell C, Oikawa M, McClain C, Wang X, Tournier C, Molina CA, Taunton J, Yan C, Fujiwara K, Patterson C, Yang J, Abe JI. "p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction." Circulation research.. 2012 Feb 17; 110(4):536-50. Epub 2012 Jan 19.
Le NT, Corsetti JP, Dehoff-Sparks JL, Sparks CE, Fujiwara K, Abe J. "Reactive Oxygen Species, SUMOylation, and Endothelial Inflammation." International journal of inflammation. 2012 2012:678190. Epub 2012 Sep 06.
2011 May 30
Heo KS, Lee H, Nigro P, Thomas T, Le NT, Chang E, McClain C, Reinhart-King CA, King MR, Berk BC, Fujiwara K, Woo CH, Abe J. "PKC? mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation." The Journal of cell biology. 2011 May 30; 193(5):867-84.
2011 Feb 24
Chang E, Heo KS, Woo CH, Lee H, Le NT, Thomas TN, Fujiwara K, Abe JI. "MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation." Blood.. 2011 Feb 24; 117(8):2527-37. Epub 2010 Dec 03.
Woo CH, Le NT, Shishido T, Chang E, Lee H, Heo KS, Mickelsen DM, Lu Y, McClain C, Spangenberg T, Yan C, Molina CA, Yang J, Patterson C, Abe JI. "Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2010 24(12):4917-28. Epub 2010 Aug 19.
2009 May
Jeong JK, Kwon O, Lee YM, Oh DB, Lee JM, Kim S, Kim EH, Le TN, Rhee DK, Kang HA. "Characterization of the Streptococcus pneumoniae BgaC protein as a novel surface beta-galactosidase with specific hydrolysis activity for the Galbeta1-3GlcNAc moiety of oligosaccharides." Journal of bacteriology.. 2009 May; 191(9):3011-23. Epub 2009 Mar 06.
Le NT, Jeong H.Y, Kwon HY, AD. Ogunniyi, Jame C.P., Pyo SN, Rhee DK. "Modulation of Adherence, Invasion, and Tumor Necrosis Factor Alpha Secretion during the Early Stages of Infection by Streptococcus pneumoniae ClpL". Infect Immun. 2007; 75(6): 2996-3005. Link


Le NT, Yang J. , AbeJ.. "MEK5/ERK5". Encyclopedia of Signaling Molecules (in press). : Springer Science+Business Media, LLC2012, 2012.