Stephen R. Hammes, M.D., Ph.D.

Stephen R. Hammes, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 693
Rochester, NY 14642

Administrative: (585) 275-2901
Fax: (585) 273-1288

Professional Bio

Dr. Hammes received his B.A. in chemistry from Cornell University in 1985, where he worked with Dr. Barbara Baird studying the IgE receptor. Dr. Hammes then entered the MD/PhD program at Duke. For his PhD, Dr. Hammes studied retroviral gene regulation with Dr. Warner Greene. He then traveled to San Francisco, where he completed an internship and residency in General Medicine, followed by a fellowship in Endocrinology. For his postdoctoral research, Dr. Hammes again chose an alternative direction, working with a cardiologist rather than an endocrinologist. He trained with Dr. Shaun Coughlin, where he studied G protein-coupled receptors.



In 1999, Dr. Hammes left UCSF to become faculty at the UT Southwestern Medical Center in Dallas, where he started an entirely new research program, choosing to study transcription-independent, or nongenomic, steroid signaling. Specifically, Dr. Hammes studies steroid-triggered maturation (meiotic progression) of oocytes, one of the few physiologically relevant steroid-triggered processes that is generally accepted to be nongenomic. Dr. Hammes has recently expanded his work to study ovarian development and function, with a focus on diseases of androgen excess such as polycystic ovarian syndrome.

Finally, in 2009 Dr. Hammes moved back to Upstate New York, where he is the Louis S. Wolk Professor of Biomedical Research and the Chief of the Division of Endocrinology at the University of Rochester Medical Center.

Research Bio

The Hammes laboratory studies how steroidogenesis and steroid signaling in the ovary regulate ovarian development and function.



First, they use frog and mouse models of steroid-triggered oocyte maturation (meiotic resumption) to study transcription-independent, or nongenomic, steroid signaling. The laboratory has made many important discoveries regarding the roles of androgens, androgen receptors, and G proteins in regulating the maturation process. They are interested in studying how this nongenomic androgen signaling might affect ovarian development and function in diseases of androgen excess, such as polycystic ovarian syndrome (PCOS).

Second, the laboratory uses mouse models to characterize the intracellular signaling pathways triggered by gonadotropins during steroidogenesis, focusing on potential signaling molecules that can be specifically targeted to reduce ovarian androgen production in PCOS.

Third, the laboratory is interested in understanding ovarian follicle development, and is studying a novel GATA-like protein that is expressed in granulosa cells, may regulate steroidogenesis, and is essential for normal embryonic follicle development and germ cell survival.

Finally, the laboratory has recently begun to study how transcription-independent androgen signaling can regulate steroid-sensitive tumors, such as prostate cancer. This work involves characterization of the mechanisms regulating steroid-triggered MAPK signaling, focusing on potential therapeutic targets that can be translated into the clinic.

Recent Journal Articles

Showing the 5 most recent journal articles. 57 available »

2014 Aug
Hammes SR, Lange CA. "Lost in translation: can we afford to miss the trees for the forest?" Hormones & cancer.. 2014 Aug; 5(4):203-6.
2014 Aug
Hammes SR. "Editorial: Sex matters in preclinical research." Molecular endocrinology.. 2014 Aug; 28(8):1209-10. Epub 2014 Jul 28.
2014 Jun 17
Kamal FA, Mickelsen DM, Wegman KM, Travers JG, Moalem J, Hammes SR, Smrcka AV, Blaxall BC. "Simultaneous adrenal and cardiac g-protein-coupled receptor-g?? inhibition halts heart failure progression." Journal of the American College of Cardiology.. 2014 Jun 17; 63(23):2549-57. Epub 2014 Apr 02.
2014 Feb 25
Sen A, Prizant H, Light A, Biswas A, Hayes E, Lee HJ, Barad D, Gleicher N, Hammes SR. "Androgens regulate ovarian follicular development by increasing follicle stimulating hormone receptor and microRNA-125b expression." Proceedings of the National Academy of Sciences of the United States of America.. 2014 Feb 25; 111(8):3008-13. Epub 2014 Feb 10.
2014 Jan
Hammes SR. "Editorial: welcome to molecular endocrinology: pitfalls and promises for the future." Molecular endocrinology.. 2014 Jan; 28(1):1-2.

Current Appointments

Professor - Department of Medicine, Endocrine/Metabolism (SMD) - Primary
Professor - Department of Pharmacology and Physiology (SMD)

Specialties

Internal Medicine - American Board of Internal Medicine
Endocrinology, Diabetes and Metabolism - American Board of Internal Medicine

Education

MD | Medicine | Duke University Sch Medicine1992
PhD | Microbiology | Duke University1992
BA | Chemistry | Cornell University1985

Post-Doctoral Training & Residency

Fellowship in Endocrinology at University of California, San Francisco Medical Center07/01/1995 - 06/30/1999
Residency in Internal Medicine at University of California, San Francisco Medical Center07/01/1994 - 06/30/1995
Internship in Internal Medicine at University of California, San Francisco Medical Center07/01/1993 - 06/30/1994
Research at Duke University Medical Center01/01/1993 - 06/30/1993