Charles J. Lowenstein, M.D.

Charles J. Lowenstein, M.D.

Contact Information

601 Elmwood Avenue
Box 679A
Rochester, NY 14642

Office: (585) 275-4290
Lab: (585) 276-9801
Administrative: (585) 275-4290
Fax: (585) 276-9830

Journal Articles

Showing all 123 journal articles available.

2014 May 1
Lomonaco MB, Lowenstein CJ. "Enhanced assay of endothelial exocytosis using extracellular matrix components." Analytical biochemistry.. 2014 May 1; 452:19-24. Epub 2014 Feb 20.
2014 May
Huang J, Huffman JE, Yamkauchi M, Trompet S, Asselbergs FW, Sabater-Lleal M, Trégouët DA, Chen WM, Smith NL, Kleber ME, Shin SY, Becker DM, Tang W, Dehghan A, Johnson AD, Truong V, Folkersen L, Yang Q, Oudot-Mellkah T, Buckley BM, Moore JH, Williams FM, Campbell H, Silbernagel G, Vitart V, Rudan I, Tofler GH, Navis GJ, Destefano A, Wright AF, Chen MH, de Craen AJ, Worrall BB, Rudnicka AR, Rumley A, Bookman EB, Psaty BM, Chen F, Keene KL, Franco OH, Böhm BO, Uitterlinden AG, Carter AM, Jukema JW, Sattar N, Bis JC, Ikram MA, , Sale MM, McKnight B, Fornage M, Ford I, Taylor K, Slagboom PE, McArdle WL, Hsu FC, Franco-Cereceda A, Goodall AH, Yanek LR, Furie KL, Cushman M, Hofman A, Witteman JC, Folsom AR, Basu S, Matijevic N, van Gilst WH, Wilson JF, Westendorp RG, Kathiresan S, Reilly MP, , Tracy RP, Polasek O, Winkelmann BR, Grant PJ, Hillege HL, Cambien F, Stott DJ, Lowe GD, Spector TD, Meigs JB, Marz W, Eriksson P, Becker LC, Morange PE, Soranzo N, Williams SM, Hayward C, van der Harst P, Hamsten A, Lowenstein CJ, Strachan DP, O'Donnell CJ, . "Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2." Arteriosclerosis, thrombosis, and vascular biology.. 2014 May; 34(5):1093-101. Epub 2014 Feb 27.
2014 Apr
Jeong Y, Du R, Zhu X, Yin S, Wang J, Cui H, Cao W, Lowenstein CJ. "Histone deacetylase isoforms regulate innate immune responses by deacetylating mitogen-activated protein kinase phosphatase-1." Journal of leukocyte biology.. 2014 Apr; 95(4):651-9. Epub 2013 Dec 27.
2011 May 26
Lowenstein CJ. "Vav-Vav-Vav-voom!" Blood.. 2011 May 26; 117(21):5557-9.
2011 Apr 1
Ito T, Yamakuchi M, Lowenstein CJ. "Thioredoxin increases exocytosis by denitrosylating N-ethylmaleimide-sensitive factor." The Journal of biological chemistry.. 2011 Apr 1; 286(13):11179-84. Epub 2011 Feb 15.
2011
Yamakuchi M, Yagi S, Ito T, Lowenstein CJ. "MicroRNA-22 regulates hypoxia signaling in colon cancer cells." PloS one. 2011 6(5):e20291. Epub 2011 May 23.
2010 Nov
Ferlito M, Fulton WB, Zauher AM, Marbán E, Steenbergen C, Lowenstein CJ. "VAMP-1, VAMP-2, and syntaxin-4 regulate ANP release from cardiac myocytes." Journal of molecular and cellular cardiology.. 2010 Nov; 49(5):791-800. Epub 2010 Aug 27.
2010 Oct
Harris TA, Yamakuchi M, Kondo M, Oettgen P, Lowenstein CJ. "Ets-1 and Ets-2 regulate the expression of microRNA-126 in endothelial cells." Arteriosclerosis, thrombosis, and vascular biology.. 2010 Oct; 30(10):1990-7. Epub 2010 Jul 29.
2010 Jul 23
Goel A, Su B, Flavahan S, Lowenstein CJ, Berkowitz DE, Flavahan NA. "Increased endothelial exocytosis and generation of endothelin-1 contributes to constriction of aged arteries." Circulation research.. 2010 Jul 23; 107(2):242-51. Epub 2010 Jun 03.
2010 Apr 21
Bie B, Zhang Z, Cai YQ, Zhu W, Zhang Y, Dai J, Lowenstein CJ, Weinman EJ, Pan ZZ. "Nerve growth factor-regulated emergence of functional delta-opioid receptors." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2010 Apr 21; 30(16):5617-28.
2010 Apr 6
Yamakuchi M, Lotterman CD, Bao C, Hruban RH, Karim B, Mendell JT, Huso D, Lowenstein CJ. "P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis." Proceedings of the National Academy of Sciences of the United States of America.. 2010 Apr 6; 107(14):6334-9. Epub 2010 Mar 22.
2010 Apr
Lowenstein CJ, Cameron SJ. "High-density lipoprotein metabolism and endothelial function." Current opinion in endocrinology, diabetes, and obesity. 2010 Apr; 17(2):166-70.
2010 Feb
Tseng EE, Brock MV, Lange MS, Troncoso JC, Blue ME, Lowenstein CJ, Johnston MV, Baumgartner WA. "Glutamate excitotoxicity mediates neuronal apoptosis after hypothermic circulatory arrest." The Annals of thoracic surgery.. 2010 Feb; 89(2):440-5.
2009 Mar 10
Jeong Y, Chaupin DF, Matsushita K, Yamakuchi M, Cameron SJ, Morrell CN, Lowenstein CJ. "Aldosterone activates endothelial exocytosis." Proceedings of the National Academy of Sciences of the United States of America.. 2009 Mar 10; 106(10):3782-7. Epub 2009 Feb 17.
2009 Mar 1
Yamakuchi M, Lowenstein CJ. "MiR-34, SIRT1 and p53: the feedback loop." Cell cycle.. 2009 Mar 1; 8(5):712-5. Epub 2009 Mar 02.
2008 Sep 9
Yamakuchi M, Ferlito M, Lowenstein CJ. "miR-34a repression of SIRT1 regulates apoptosis." Proceedings of the National Academy of Sciences of the United States of America.. 2008 Sep 9; 105(36):13421-6. Epub 2008 Aug 28.
2008 Jul
Yamakuchi M, Bao C, Ferlito M, Lowenstein CJ. "Epigallocatechin gallate inhibits endothelial exocytosis." Biological chemistry. 2008 Jul; 389(7):935-41.
2008 Jun 9
Cao W, Bao C, Padalko E, Lowenstein CJ. "Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling." The Journal of experimental medicine.. 2008 Jun 9; 205(6):1491-503. Epub 2008 May 26.
2008 Mar 17
Morrell CN, Sun H, Ikeda M, Beique JC, Swaim AM, Mason E, Martin TV, Thompson LE, Gozen O, Ampagoomian D, Sprengel R, Rothstein J, Faraday N, Huganir R, Lowenstein CJ. "Glutamate mediates platelet activation through the AMPA receptor." The Journal of experimental medicine.. 2008 Mar 17; 205(3):575-84. Epub 2008 Feb 18.
2008 Feb 5
Harris TA, Yamakuchi M, Ferlito M, Mendell JT, Lowenstein CJ. "MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1." Proceedings of the National Academy of Sciences of the United States of America.. 2008 Feb 5; 105(5):1516-21. Epub 2008 Jan 28.
2008 Jan
Kanno Y, Into T, Lowenstein CJ, Matsushita K. "Nitric oxide regulates vascular calcification by interfering with TGF- signalling." Cardiovascular research.. 2008 Jan; 77(1):221-30. Epub 2007 Oct 25.
2008
Yamakuchi M, Ferlito M, Morrell CN, Matsushita K, Fletcher CA, Cao W, Lowenstein CJ. "Exocytosis of endothelial cells is regulated by N-ethylmaleimide-sensitive factor." Methods in molecular biology.. 2008 440:203-15.
2007 Sep 1
Johnston CP, Qiu H, Ticehurst JR, Dickson C, Rosenbaum P, Lawson P, Stokes AB, Lowenstein CJ, Kaminsky M, Cosgrove SE, Green KY, Perl TM. "Outbreak management and implications of a nosocomial norovirus outbreak." Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.. 2007 Sep 1; 45(5):534-40. Epub 2007 Jul 18.
2007 Jul 15
Lowenstein CJ. "Nitric oxide regulation of protein trafficking in the cardiovascular system." Cardiovascular research.. 2007 Jul 15; 75(2):240-6. Epub 2007 Apr 03.
2007 Jul 15
Lamas S, Lowenstein CJ, Michel T. "Nitric oxide signaling comes of age: 20 years and thriving." Cardiovascular research.. 2007 Jul 15; 75(2):207-9. Epub 2007 Jun 02.
2007 Jun 8
Chang TC, Wentzel EA, Kent OA, Ramachandran K, Mullendore M, Lee KH, Feldmann G, Yamakuchi M, Ferlito M, Lowenstein CJ, Arking DE, Beer MA, Maitra A, Mendell JT. "Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis." Molecular cell.. 2007 Jun 8; 26(5):745-52. Epub 2007 May 31.
2007 Mar 16
Into T, Kanno Y, Dohkan J, Nakashima M, Inomata M, Shibata K, Lowenstein CJ, Matsushita K. "Pathogen recognition by Toll-like receptor 2 activates Weibel-Palade body exocytosis in human aortic endothelial cells." The Journal of biological chemistry.. 2007 Mar 16; 282(11):8134-41. Epub 2007 Jan 16.
2007 Mar 1
Saura M, Lizarbe TR, Rama-Pacheco C, Lowenstein CJ, Zaragoza C. "Inhibitor of NF kappa B alpha is a host sensor of coxsackievirus infection." Cell cycle.. 2007 Mar 1; 6(5):503-6. Epub 2007 Mar 25.
2007 Jan 23
Yamakuchi M, Kirkiles-Smith NC, Ferlito M, Cameron SJ, Bao C, Fox-Talbot K, Wasowska BA, Baldwin WM, Pober JS, Lowenstein CJ. "Antibody to human leukocyte antigen triggers endothelial exocytosis." Proceedings of the National Academy of Sciences of the United States of America.. 2007 Jan 23; 104(4):1301-6. Epub 2007 Jan 17.
2007
Calvert JW, Gundewar S, Yamakuchi M, Park PC, Baldwin WM, Lefer DJ, Lowenstein CJ. "Inhibition of N-ethylmaleimide-sensitive factor protects against myocardial ischemia/reperfusion injury." Circulation research.. 2007 101(12):1247-54. Epub 2007 Oct 11.
2007
Lowenstein CJ. "Myocardial reperfusion injury." The New England journal of medicine.. 2007 357(23):2409; author reply 2409-10.
2006 Oct 6
Saura M, Zaragoza C, Bao C, Herranz B, Rodriguez-Puyol M, Lowenstein CJ. "Stat3 mediates interleukin-6 [correction of interelukin-6] inhibition of human endothelial nitric-oxide synthase expression." The Journal of biological chemistry.. 2006 Oct 6; 281(40):30057-62. Epub 2006 Aug 03.
2006 Aug 18
Lowenstein CJ. "Integrin-linked kinase plays a key role in coxsackievirus replication." Circulation research.. 2006 Aug 18; 99(4):346-7.
2006 Aug 1
Ferlito M, Irani K, Faraday N, Lowenstein CJ. "Nitric oxide inhibits exocytosis of cytolytic granules from lymphokine-activated killer cells." Proceedings of the National Academy of Sciences of the United States of America.. 2006 Aug 1; 103(31):11689-94. Epub 2006 Jul 20.
2006 Aug
Lowenstein CJ, Michel T. "What's in a name? eNOS and anaphylactic shock." The Journal of clinical investigation.. 2006 Aug; 116(8):2075-8.
2006 Jul
Lowenstein CJ. "Beneficial effects of neuronal nitric oxide synthase in atherosclerosis." Arteriosclerosis, thrombosis, and vascular biology.. 2006 Jul; 26(7):1417-8.
2006 Jun 1
Ohnishi T, Kakimoto K, Bandow K, Lowenstein CJ, Daikuhara Y, Matsuguchi T. "Mature hepatocyte growth factor/scatter factor on the surface of human granulocytes is released by a mechanism involving activated factor Xa." The Journal of immunology : official journal of the American Association of Immunologists.. 2006 Jun 1; 176(11):6945-53.
2006
Zaragoza C, Saura M, Padalko EY, Lopez-Rivera E, Lizarbe TR, Lamas S, Lowenstein CJ. "Viral protease cleavage of inhibitor of kappaBalpha triggers host cell apoptosis." Proceedings of the National Academy of Sciences of the United States of America.. 2006 103(50):19051-6. Epub 2006 Nov 30.
2006
Lowenstein CJ, Tsuda H. "N-ethylmaleimide-sensitive factor: a redox sensor in exocytosis." Biological chemistry. 2006 387(10-11):1377-83.
2005 Nov
Lowenstein CJ, Morrell CN, Yamakuchi M. "Regulation of Weibel-Palade body exocytosis." Trends in cardiovascular medicine. 2005 Nov; 15(8):302-8.
2005 Oct
Kittleson MM, Lowenstein CJ, Hare JM. "Novel pathogenetic mechanisms in myocarditis: nitric oxide signaling." Heart failure clinics. 2005 Oct; 1(3):345-61.
2005 Jul 4
Matsushita K, Morrell CN, Mason RJ, Yamakuchi M, Khanday FA, Irani K, Lowenstein CJ. "Hydrogen peroxide regulation of endothelial exocytosis by inhibition of N-ethylmaleimide sensitive factor." The Journal of cell biology.. 2005 Jul 4; 170(1):73-9.
2005 Jul
Morrell CN, Matsushita K, Lowenstein CJ. "A novel inhibitor of N-ethylmaleimide-sensitive factor decreases leukocyte trafficking and peritonitis." The Journal of pharmacology and experimental therapeutics.. 2005 Jul; 314(1):155-61. Epub 2005 Mar 18.
2005 Jun 10
Yamakuchi M, Greer JJ, Cameron SJ, Matsushita K, Morrell CN, Talbot-Fox K, Baldwin WM, Lefer DJ, Lowenstein CJ. "HMG-CoA reductase inhibitors inhibit endothelial exocytosis and decrease myocardial infarct size." Circulation research.. 2005 Jun 10; 96(11):1185-92. Epub 2005 May 19.
2005 May 19
Huang Y, Man HY, Sekine-Aizawa Y, Han Y, Juluri K, Luo H, Cheah J, Lowenstein C, Huganir RL, Snyder SH. "S-nitrosylation of N-ethylmaleimide sensitive factor mediates surface expression of AMPA receptors." Neuron.. 2005 May 19; 46(4):533-40.
2005 Apr
Matsushita K, Morrell CN, Lowenstein CJ. "A novel class of fusion polypeptides inhibits exocytosis." Molecular pharmacology.. 2005 Apr; 67(4):1137-44. Epub 2004 Dec 17.
2005 Mar 8
Morrell CN, Matsushita K, Chiles K, Scharpf RB, Yamakuchi M, Mason RJ, Bergmeier W, Mankowski JL, Baldwin WM, Faraday N, Lowenstein CJ. "Regulation of platelet granule exocytosis by S-nitrosylation." Proceedings of the National Academy of Sciences of the United States of America.. 2005 Mar 8; 102(10):3782-7. Epub 2005 Feb 28.
2005 Jan 1
Matsushita K, Yamakuchi M, Morrell CN, Ozaki M, O'Rourke B, Irani K, Lowenstein CJ. "Vascular endothelial growth factor regulation of Weibel-Palade-body exocytosis." Blood.. 2005 Jan 1; 105(1):207-14. Epub 2004 Sep 02.
2004 Sep 7
Lowenstein CJ. "Exogenous thioredoxin reduces inflammation in autoimmune myocarditis." Circulation.. 2004 Sep 7; 110(10):1178-9.
2004 Aug 10
Padalko E, Ohnishi T, Matsushita K, Sun H, Fox-Talbot K, Bao C, Baldwin WM, Lowenstein CJ. "Peroxynitrite inhibition of Coxsackievirus infection by prevention of viral RNA entry." Proceedings of the National Academy of Sciences of the United States of America.. 2004 Aug 10; 101(32):11731-6. Epub 2004 Jul 30.
2004 Aug 6
Bhatia R, Matsushita K, Yamakuchi M, Morrell CN, Cao W, Lowenstein CJ. "Ceramide triggers Weibel-Palade body exocytosis." Circulation research.. 2004 Aug 6; 95(3):319-24. Epub 2004 Jun 24.
2004 Aug 3
Matsushita K, Morrell CN, Lowenstein CJ. "Sphingosine 1-phosphate activates Weibel-Palade body exocytosis." Proceedings of the National Academy of Sciences of the United States of America.. 2004 Aug 3; 101(31):11483-7. Epub 2004 Jul 23.
2004 Aug
Yang SX, Yan J, Deshpande SS, Irani K, Lowenstein CJ. "Rac1 regulates the release of Weibel-Palade Bodies in human aortic endothelial cells." Chinese medical journal.. 2004 Aug; 117(8):1143-50.
2004 Jun 15
Lowenstein CJ, Padalko E. "iNOS (NOS2) at a glance." Journal of cell science.. 2004 Jun 15; 117(Pt 14):2865-7.
2004
Gellman J, Hare JM, Lowenstein CJ, Gerstenblith G, Coombs V, Langenberg P, Brinker JA, Resar JR. "L-arginine ameliorates the abnormal sympathetic response of the dysfunctional human coronary microvasculature." Angiology. 2004 55(1):1-8.
2003 Oct 17
Matsushita K, Morrell CN, Cambien B, Yang SX, Yamakuchi M, Bao C, Hara MR, Quick RA, Cao W, O'Rourke B, Lowenstein JM, Pevsner J, Wagner DD, Lowenstein CJ. "Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor." Cell.. 2003 Oct 17; 115(2):139-50.
2003 Jun 24
Cao W, Bao C, Lowenstein CJ. "Inducible nitric oxide synthase expression inhibition by adenovirus E1A." Proceedings of the National Academy of Sciences of the United States of America.. 2003 Jun 24; 100(13):7773-8. Epub 2003 Jun 13.
2003 Apr 18
Li Q, Guo Y, Xuan YT, Lowenstein CJ, Stevenson SC, Prabhu SD, Wu WJ, Zhu Y, Bolli R. "Gene therapy with inducible nitric oxide synthase protects against myocardial infarction via a cyclooxygenase-2-dependent mechanism." Circulation research.. 2003 Apr 18; 92(7):741-8.
2003
Cao W, Baniecki ML, McGrath WJ, Bao C, Deming CB, Rade JJ, Lowenstein CJ, Mangel WF. "Nitric oxide inhibits the adenovirus proteinase in vitro and viral infectivity in vivo." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2003 17(15):2345-6. Epub 2003 Oct 02.
2002 Nov 1
Saura M, Zaragoza C, Cao W, Bao C, Rodríguez-Puyol M, Rodríguez-Puyol D, Lowenstein CJ. "Smad2 mediates transforming growth factor-beta induction of endothelial nitric oxide synthase expression." Circulation research.. 2002 Nov 1; 91(9):806-13.
2002 Jul
Cao W, Mattagajasingh SN, Xu H, Kim K, Fierlbeck W, Deng J, Lowenstein CJ, Ballermann BJ. "TIMAP, a novel CAAX box protein regulated by TGF-beta1 and expressed in endothelial cells." American journal of physiology. Cell physiology.. 2002 Jul; 283(1):C327-37.
2002 Mar 1
López-Ongil S, Saura M, Zaragoza C, Gónzalez-Santiago L, Rodríguez-Puyol M, Lowenstein CJ, Rodríguez-Puyol D. "Hydrogen peroxide regulation of bovine endothelin-converting enzyme-1." Free radical biology & medicine.. 2002 Mar 1; 32(5):406-13.
2002
Lowenstein CJ. "Purification and assessment of proteins associated with nitric oxide synthase." Methods in enzymology. 2002 353:233-40.
2002
Lowenstein CJ. "Measuring reactive oxygen species inhibition of endothelin-converting enzyme." Methods in enzymology. 2002 353:263-8.
2001 Nov 6
Qian Z, Gelzer-Bell R, Yang Sx SX, Cao W, Ohnishi T, Wasowska BA, Hruban RH, Rodriguez ER, Baldwin WM, Lowenstein CJ. "Inducible nitric oxide synthase inhibition of weibel-palade body release in cardiac transplant rejection." Circulation.. 2001 Nov 6; 104(19):2369-75.
2001 May 1
Tendler DS, Bao C, Wang T, Huang EL, Ratovitski EA, Pardoll DA, Lowenstein CJ. "Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis." Cancer research.. 2001 May 1; 61(9):3682-8.
2001 Jan 15
Rothstein NM, Quinn TC, Madico G, Gaydos CA, Lowenstein CJ. "Effect of azithromycin on murine arteriosclerosis exacerbated by Chlamydia pneumoniae." The Journal of infectious diseases.. 2001 Jan 15; 183(2):232-238. Epub 2000 Dec 13.
2001 Jan
Sun B, Fan H, Honda T, Fujimaki R, Lafond-Walker A, Masui Y, Lowenstein CJ, Becker LC. "Activation of NF kappa B and expression of ICAM-1 in ischemic-reperfused canine myocardium." Journal of molecular and cellular cardiology.. 2001 Jan; 33(1):109-19.
2001
Ozaki M, Deshpande S, Angkeow P, Bellan J, Lowenstein CJ, Dinauer MC, Goldschmidt-Clermont P, Suzuki S, Irani K. "Targeted inhibition of the small GTPase protects against ischemia/reperfusion liver injury in mice." Transplantation proceedings.. 2001 33(1-2):863-4.
2000 Oct
Horton MR, Olman MA, Bao C, White KE, Choi AM, Chin BY, Noble PW, Lowenstein CJ. "Regulation of plasminogen activator inhibitor-1 and urokinase by hyaluronan fragments in mouse macrophages." American journal of physiology. Lung cellular and molecular physiology.. 2000 Oct; 279(4):L707-15.
2000 Aug 25
López-Ongil S, Senchak V, Saura M, Zaragoza C, Ames M, Ballermann B, Rodríguez-Puyol M, Rodríguez-Puyol D, Lowenstein CJ. "Superoxide regulation of endothelin-converting enzyme." The Journal of biological chemistry.. 2000 Aug 25; 275(34):26423-7.
2000 Mar 17
German Z, Chambliss KL, Pace MC, Arnet UA, Lowenstein CJ, Shaul PW. "Molecular basis of cell-specific endothelial nitric-oxide synthase expression in airway epithelium." The Journal of biological chemistry.. 2000 Mar 17; 275(11):8183-9.
2000 Feb
Ozaki M, Deshpande SS, Angkeow P, Bellan J, Lowenstein CJ, Dinauer MC, Goldschmidt-Clermont PJ, Irani K. "Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion-induced necrosis and apoptosis in vivo." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2000 Feb; 14(2):418-29.
1999 Nov 15
Zaragoza C, Ocampo CJ, Saura M, Bao C, Leppo M, Lafond-Walker A, Thiemann DR, Hruban R, Lowenstein CJ. "Inducible nitric oxide synthase protection against coxsackievirus pancreatitis." The Journal of immunology : official journal of the American Association of Immunologists.. 1999 Nov 15; 163(10):5497-504.
1999 Oct 15
Ratovitski EA, Bao C, Quick RA, McMillan A, Kozlovsky C, Lowenstein CJ. "An inducible nitric-oxide synthase (NOS)-associated protein inhibits NOS dimerization and activity." The Journal of biological chemistry.. 1999 Oct 15; 274(42):30250-7.
1999 Sep 28
Lowenstein CJ. "NO news is good news." Proceedings of the National Academy of Sciences of the United States of America.. 1999 Sep 28; 96(20):10953-4.
1999 Jun 11
Saura M, Zaragoza C, Bao C, McMillan A, Lowenstein CJ. "Interaction of interferon regulatory factor-1 and nuclear factor kappaB during activation of inducible nitric oxide synthase transcription." Journal of molecular biology.. 1999 Jun 11; 289(3):459-71.
1999 Apr 1
Horton MR, Shapiro S, Bao C, Lowenstein CJ, Noble PW. "Induction and regulation of macrophage metalloelastase by hyaluronan fragments in mouse macrophages." The Journal of immunology : official journal of the American Association of Immunologists.. 1999 Apr 1; 162(7):4171-6.
1999 Jan 8
Ratovitski EA, Alam MR, Quick RA, McMillan A, Bao C, Kozlovsky C, Hand TA, Johnson RC, Mains RE, Eipper BA, Lowenstein CJ. "Kalirin inhibition of inducible nitric-oxide synthase." The Journal of biological chemistry.. 1999 Jan 8; 274(2):993-9.
1999 Jan
Saura M, Zaragoza C, McMillan A, Quick RA, Hohenadl C, Lowenstein JM, Lowenstein CJ. "An antiviral mechanism of nitric oxide: inhibition of a viral protease." Immunity.. 1999 Jan; 10(1):21-8.
1999 Jan
Tseng EE, Brock MV, Lange MS, Troncoso JC, Lowenstein CJ, Blue ME, Johnston MV, Baumgartner WA. "Nitric oxide mediates neurologic injury after hypothermic circulatory arrest." The Annals of thoracic surgery.. 1999 Jan; 67(1):65-71.
1998 Oct 2
Tanaka K, Pracyk JB, Takeda K, Yu ZX, Ferrans VJ, Deshpande SS, Ozaki M, Hwang PM, Lowenstein CJ, Irani K, Finkel T. "Expression of Id1 results in apoptosis of cardiac myocytes through a redox-dependent mechanism." The Journal of biological chemistry.. 1998 Oct 2; 273(40):25922-8.
1998 Aug
Tseng EE, Brock MV, Lange MS, Troncoso JC, Blue ME, Lowenstein CJ, Johnston MV, Baumgartner WA. "Monosialoganglioside GM1 inhibits neurotoxicity after hypothermic circulatory arrest." Surgery.. 1998 Aug; 124(2):298-306.
1998 Mar 3
Zaragoza C, Ocampo C, Saura M, Leppo M, Wei XQ, Quick R, Moncada S, Liew FY, Lowenstein CJ. "The role of inducible nitric oxide synthase in the host response to Coxsackievirus myocarditis." Proceedings of the National Academy of Sciences of the United States of America.. 1998 Mar 3; 95(5):2469-74.
1998 Feb 6
Ratovitski EA, Kotzbauer PT, Milbrandt J, Lowenstein CJ, Burrow CR. "Midkine induces tumor cell proliferation and binds to a high affinity signaling receptor associated with JAK tyrosine kinases." The Journal of biological chemistry.. 1998 Feb 6; 273(6):3654-60.
1998 Jan
Saura M, Zaragoza C, Díaz-Cazorla M, Hernández-Perera O, Eng E, Lowenstein CJ, Pérez-Sala D, Lamas S. "Involvement of transcriptional mechanisms in the inhibition of NOS2 expression by dexamethasone in rat mesangial cells." Kidney international.. 1998 Jan; 53(1):38-49.
1997 Oct 1
Zaragoza C, Ocampo CJ, Saura M, McMillan A, Lowenstein CJ. "Nitric oxide inhibition of coxsackievirus replication in vitro." The Journal of clinical investigation.. 1997 Oct 1; 100(7):1760-7.
1997 Oct
Lafond-Walker A, Chen CL, Augustine S, Wu TC, Hruban RH, Lowenstein CJ. "Inducible nitric oxide synthase expression in coronary arteries of transplanted human hearts with accelerated graft arteriosclerosis." The American journal of pathology.. 1997 Oct; 151(4):919-25.
1997 Jun 30
Amin AR, Patel RN, Thakker GD, Lowenstein CJ, Attur MG, Abramson SB. "Post-transcriptional regulation of inducible nitric oxide synthase mRNA in murine macrophages by doxycycline and chemically modified tetracyclines." FEBS letters.. 1997 Jun 30; 410(2-3):259-64.
1997 May 15
Merrill JE, Murphy SP, Mitrovic B, Mackenzie-Graham A, Dopp JC, Ding M, Griscavage J, Ignarro LJ, Lowenstein CJ. "Inducible nitric oxide synthase and nitric oxide production by oligodendrocytes." Journal of neuroscience research.. 1997 May 15; 48(4):372-84.
1997 Mar 21
McKee CM, Lowenstein CJ, Horton MR, Wu J, Bao C, Chin BY, Choi AM, Noble PW. "Hyaluronan fragments induce nitric-oxide synthase in murine macrophages through a nuclear factor kappaB-dependent mechanism." The Journal of biological chemistry.. 1997 Mar 21; 272(12):8013-8.
1997
Tseng EE, Brock MV, Lange MS, Blue ME, Troncoso JC, Kwon CC, Lowenstein CJ, Johnston MV, Baumgartner WA. "Neuronal nitric oxide synthase inhibition reduces neuronal apoptosis after hypothermic circulatory arrest." The Annals of thoracic surgery.. 1997 64(6):1639-47.
1996 Nov
Brock MV, Blue ME, Lowenstein CJ, Northington FA, Lange MS, Johnston MV, Baumgartner WA. "Induction of neuronal nitric oxide after hypothermic circulatory arrest." The Annals of thoracic surgery.. 1996 Nov; 62(5):1313-20.
1996 Jul
Wong HR, Finder JD, Wasserloos K, Lowenstein CJ, Geller DA, Billiar TR, Pitt BR, Davies P. "Transcriptional regulation of iNOS by IL-1 beta in cultured rat pulmonary artery smooth muscle cells." The American journal of physiology.. 1996 Jul; 271(1 Pt 1):L166-71.
1996 Jun 21
Arnet UA, McMillan A, Dinerman JL, Ballermann B, Lowenstein CJ. "Regulation of endothelial nitric-oxide synthase during hypoxia." The Journal of biological chemistry.. 1996 Jun 21; 271(25):15069-73.
1996 Apr 15
Lowenstein CJ, Hill SL, Lafond-Walker A, Wu J, Allen G, Landavere M, Rose NR, Herskowitz A. "Nitric oxide inhibits viral replication in murine myocarditis." The Journal of clinical investigation.. 1996 Apr 15; 97(8):1837-43.
1996 Mar 5
Perrella MA, Hsieh CM, Lee WS, Shieh S, Tsai JC, Patterson C, Lowenstein CJ, Long NC, Haber E, Shore S, Lee ME. "Arrest of endotoxin-induced hypotension by transforming growth factor beta1." Proceedings of the National Academy of Sciences of the United States of America.. 1996 Mar 5; 93(5):2054-9.
1995 Sep
Ungureanu-Longrois D, Balligand JL, Okada I, Simmons WW, Kobzik L, Lowenstein CJ, Kunkel SL, Michel T, Kelly RA, Smith TW. "Contractile responsiveness of ventricular myocytes to isoproterenol is regulated by induction of nitric oxide synthase activity in cardiac microvascular endothelial cells in heterotypic primary culture." Circulation research.. 1995 Sep; 77(3):486-93.
1995 Sep
Ungureanu-Longrois D, Balligand JL, Simmons WW, Okada I, Kobzik L, Lowenstein CJ, Kunkel SL, Michel T, Kelly RA, Smith TW. "Induction of nitric oxide synthase activity by cytokines in ventricular myocytes is necessary but not sufficient to decrease contractile responsiveness to beta-adrenergic agonists." Circulation research.. 1995 Sep; 77(3):494-502.
1995 Aug
Shaul PW, North AJ, Brannon TS, Ujiie K, Wells LB, Nisen PA, Lowenstein CJ, Snyder SH, Star RA. "Prolonged in vivo hypoxia enhances nitric oxide synthase type I and type III gene expression in adult rat lung." American journal of respiratory cell and molecular biology.. 1995 Aug; 13(2):167-74.
1995 Jun
Flynn JL, Goldstein MM, Chan J, Triebold KJ, Pfeffer K, Lowenstein CJ, Schreiber R, Mak TW, Bloom BR. "Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice." Immunity.. 1995 Jun; 2(6):561-72.
1995 Mar
Balligand JL, Ungureanu-Longrois D, Simmons WW, Kobzik L, Lowenstein CJ, Lamas S, Kelly RA, Smith TW, Michel T. "Induction of NO synthase in rat cardiac microvascular endothelial cells by IL-1 beta and IFN-gamma." The American journal of physiology.. 1995 Mar; 268(3 Pt 2):H1293-303.
1995 Jan
Lomis TJ, Siffring CW, Chalasani S, Ziegler DW, Lentz KE, Stauffer KE, McMillan A, Agarwal N, Lowenstein CJ, Rhoads JE. "First place winner of the Conrad Jobst Award in the gold medal paper competition. Nitric oxide synthase inhibitors N-monomethylarginine and aminoguanidine prevent the progressive and severe hypotension associated with a rat model of pancreatitis." The American surgeon.. 1995 Jan; 61(1):7-10.
1995
Day JD, Rayburn BK, Gaudin PB, Baldwin WM, Lowenstein CJ, Kasper EK, Baughman KL, Baumgartner WA, Hutchins GM, Hruban RH. "Cardiac allograft vasculopathy: the central pathogenetic role of ischemia-induced endothelial cell injury." The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 1995 14(6 Pt 2):S142-9.
1994 Nov 4
Balligand JL, Ungureanu-Longrois D, Simmons WW, Pimental D, Malinski TA, Kapturczak M, Taha Z, Lowenstein CJ, Davidoff AJ, Kelly RA. "Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro." The Journal of biological chemistry.. 1994 Nov 4; 269(44):27580-8.
1994 Aug
Felley-Bosco E, Ambs S, Lowenstein CJ, Keefer LK, Harris CC. "Constitutive expression of inducible nitric oxide synthase in human bronchial epithelial cells induces c-fos and stimulates the cGMP pathway." American journal of respiratory cell and molecular biology.. 1994 Aug; 11(2):159-64.
1994 Jun
Johnson BA, Lowenstein CJ, Schwarz MA, Nakayama DK, Pitt BR, Davies P. "Culture of pulmonary microvascular smooth muscle cells from intraacinar arteries of the rat: characterization and inducible production of nitric oxide." American journal of respiratory cell and molecular biology.. 1994 Jun; 10(6):604-12.
1994 Jun
North AJ, Star RA, Brannon TS, Ujiie K, Wells LB, Lowenstein CJ, Snyder SH, Shaul PW. "Nitric oxide synthase type I and type III gene expression are developmentally regulated in rat lung." The American journal of physiology.. 1994 Jun; 266(6 Pt 1):L635-41.
1994 Feb 1
Lowenstein CJ, Dinerman JL, Snyder SH. "Nitric oxide: a physiologic messenger." Annals of internal medicine.. 1994 Feb 1; 120(3):227-37.
1994
Wynn TA, Oswald IP, Eltoum IA, Caspar P, Lowenstein CJ, Lewis FA, James SL, Sher A. "Elevated expression of Th1 cytokines and nitric oxide synthase in the lungs of vaccinated mice after challenge infection with Schistosoma mansoni." The Journal of immunology : official journal of the American Association of Immunologists.. 1994 153(11):5200-9.
1994
Lowenstein CJ, Snyder SH. "Purification, cloning, and expression of nitric-oxide synthase." Methods in enzymology. 1994 233:264-9.
1993 Oct 15
Lowenstein CJ, Alley EW, Raval P, Snowman AM, Snyder SH, Russell SW, Murphy WJ. "Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide." Proceedings of the National Academy of Sciences of the United States of America.. 1993 Oct 15; 90(20):9730-4.
1993 Oct
Kobzik L, Bredt DS, Lowenstein CJ, Drazen J, Gaston B, Sugarbaker D, Stamler JS. "Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization." American journal of respiratory cell and molecular biology.. 1993 Oct; 9(4):371-7.
1993 Oct
Vanderwinden JM, De Laet MH, Schiffmann SN, Mailleux P, Lowenstein CJ, Snyder SH, Vanderhaeghen JJ. "Nitric oxide synthase distribution in the enteric nervous system of Hirschsprung's disease." Gastroenterology.. 1993 Oct; 105(4):969-73.
1993 Aug
Dinerman JL, Lowenstein CJ, Snyder SH. "Molecular mechanisms of nitric oxide regulation. Potential relevance to cardiovascular disease." Circulation research.. 1993 Aug; 73(2):217-22.
1993 Jul
Burnett AL, Tillman SL, Chang TS, Epstein JI, Lowenstein CJ, Bredt DS, Snyder SH, Walsh PC. "Immunohistochemical localization of nitric oxide synthase in the autonomic innervation of the human penis." The Journal of urology.. 1993 Jul; 150(1):73-6.
1993 Apr 15
Geller DA, Lowenstein CJ, Shapiro RA, Nussler AK, Di Silvio M, Wang SC, Nakayama DK, Simmons RL, Snyder SH, Billiar TR. "Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes." Proceedings of the National Academy of Sciences of the United States of America.. 1993 Apr 15; 90(8):3491-5.
1993 Jan 25
Lorsbach RB, Murphy WJ, Lowenstein CJ, Snyder SH, Russell SW. "Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide." The Journal of biological chemistry.. 1993 Jan 25; 268(3):1908-13.
1993 Jan 15
Geller DA, Nussler AK, Di Silvio M, Lowenstein CJ, Shapiro RA, Wang SC, Simmons RL, Billiar TR. "Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes." Proceedings of the National Academy of Sciences of the United States of America.. 1993 Jan 15; 90(2):522-6.
1992 Nov
Nakayama DK, Geller DA, Lowenstein CJ, Chern HD, Davies P, Pitt BR, Simmons RL, Billiar TR. "Cytokines and lipopolysaccharide induce nitric oxide synthase in cultured rat pulmonary artery smooth muscle." American journal of respiratory cell and molecular biology.. 1992 Nov; 7(5):471-6.
1992 Sep 4
Lowenstein CJ, Snyder SH. "Nitric oxide, a novel biologic messenger." Cell.. 1992 Sep 4; 70(5):705-7.
1992 Aug 1
Lowenstein CJ, Glatt CS, Bredt DS, Snyder SH. "Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme." Proceedings of the National Academy of Sciences of the United States of America.. 1992 Aug 1; 89(15):6711-5.
1992 Jul 17
Burnett AL, Lowenstein CJ, Bredt DS, Chang TS, Snyder SH. "Nitric oxide: a physiologic mediator of penile erection." Science.. 1992 Jul 17; 257(5068):401-3.

Books

2009
Lowenstein, C.J. and Sun, H.. The Role of Nitric Oxide in Myocarditis. Giles, T.D., Given, M., Greenberg, S.S.. : Springer Verlag, 2009. SUBMITTED
2008
Yamakuchi, M., Ferlito, M., Morrell, C.n., Matsushita, K., Fletcher, C.A., Cao, W., and Lowenstein, C.J.. "Exocytosis of Endothelial Cells is Regulated by N-ethylmaleimide Sensitive Factor". Methods in Molecular Biology. Andrei Ivanov. Totowa, NJ: Humana Press, 2008. 203-215
2007
Lowenstein, C.J.. "Weibel-Palade Bodies: Vesicular Trafficking on the Vascular Highway". The Endothelium: A Comprehensive Reference. : Cambridge University Press, 2007. IN PRESS
2006
Lowenstein, C.J. and Yamakuchi, M.. "Statins, Inflammation and Cardiomyopathy: Old Pathways, New Targets". Treatment of Advanced Heart Disease. New York, NY: Taylor and Francis, 2006. 155-166
2005
Kittleson, M.M., Lowenstein, C.J., and Hare, J.M.. "Novel Pathogenetic Mechanisms in Myocarditis: Nitric Oxide Signaling". Heart Failure Clinics: Myocarditis. Dec, G.W.. Philadelphia, PA: Saunders, 2005. 345-362
2002
Hare, J.M. and Lowenstein, C.J.. "Nitric Oxide Signaling in Myocarditis". Myocarditis: From Bench to Bedside. Cooper, L.T. Jr.. Totowa, NJ: Humana Press, 2002. 135-160
2001
Lowenstein, C.J. and Ohnishi, T.. "Nitric Oxide and Myocarditis". Nitric Oxide and Inflammation. Salvemini, D., Biolliat, T.R., Vodovotz, Y.. : Birkauser, Basel, 2001. 207-224
1999
Lowenstein, C.J., Marta, S., and Zaragoza, C.. "Nitric Oxide in Viral Myocarditis". Nitric Oxide and Infection. Fang, F.. : New York, Plenum Publishers, 1999. 379-396