Charles J. Lowenstein, M.D.

Charles J. Lowenstein, M.D.

Contact Information

601 Elmwood Avenue
Box 679A
Rochester, NY 14642

Office: (585) 275-4290
Lab: (585) 276-9801
Administrative: (585) 275-4290
Fax: (585) 276-9830

Professional Bio

Charles J. Lowenstein, M.D. is Professor of Medicine, Chief of Cardiology, and Director of the Cardiovascular Research Institute at the University of Rochester School of medicine and Dentistry. Dr. Lowenstein obtained his M.D. at the Harvard Medical School. He completed his medical residency at The Massachusetts General Hospital and his cardiology fellowship at The Johns Hopkins University School of Medicine. After 18 years on the faculty at Hopkins, he became Chief of Cardiology at the University of Rochester Medical Center in 2009. He has served on the NIH Atherosclerosis and Inflammation Cardiovascular Sciences study section. He is an Associate Editor of Circulation Research. He served as Chair of the Board of the Sarnoff Cardiovascular Research Foundation, an organization that funds medical student research.

Research Bio

Dr. Lowenstein's research is focused on vascular biology. One team or researchers explores mechanisms of exocytosis, through which endothelial cells release pro-inflammatory and pro-thrombotic mediators. A second group of scientists study how platelets communicate with endothelial cells. A third area of research involves an exploration of the role of microRNA in endothelial cells. A fourth team investigates how nitric oxide affects vascular inflammation.

Awards & Honors (National)

Peter Dolphin Award | Pfizer | Paris, France 2005 - 2005
Member | American Society for Clinical Investigation 2002 - 2002

Awards & Honors (Local)

Member | InterUrban Clinical Club | Baltimore, MD 2007 - 2007
Sir William Osler Young Investigator Award | Interurban Clinical Club | Baltimore, MD 2003 - 2003
Young Investigators Conference on Atherosclerosis Award | Merck, Inc. | New York, NY 2000 - 2000

Recent Journal Articles

Showing the 5 most recent journal articles. 124 available »

2014 Oct
Zhu Q, Yamakuchi M, Ture S, de la Luz Garcia-Hernandez M, Ko KA, Modjeski KL, LoMonaco MB, Johnson AD, O'Donnell CJ, Takai Y, Morrell CN, Lowenstein CJ. "Syntaxin-binding protein STXBP5 inhibits endothelial exocytosis and promotes platelet secretion." The Journal of clinical investigation. 2014 Oct; 124(10):4503-16. Epub 2014 Sep 17.
2014 May 1
Lomonaco MB, Lowenstein CJ. "Enhanced assay of endothelial exocytosis using extracellular matrix components." Analytical biochemistry. 2014 May 1; 452:19-24. Epub 2014 Feb 20.
2014 May
Huang J, Huffman JE, Yamkauchi M, Trompet S, Asselbergs FW, Sabater-Lleal M, Trégouët DA, Chen WM, Smith NL, Kleber ME, Shin SY, Becker DM, Tang W, Dehghan A, Johnson AD, Truong V, Folkersen L, Yang Q, Oudot-Mellkah T, Buckley BM, Moore JH, Williams FM, Campbell H, Silbernagel G, Vitart V, Rudan I, Tofler GH, Navis GJ, Destefano A, Wright AF, Chen MH, de Craen AJ, Worrall BB, Rudnicka AR, Rumley A, Bookman EB, Psaty BM, Chen F, Keene KL, Franco OH, Böhm BO, Uitterlinden AG, Carter AM, Jukema JW, Sattar N, Bis JC, Ikram MA, , Sale MM, McKnight B, Fornage M, Ford I, Taylor K, Slagboom PE, McArdle WL, Hsu FC, Franco-Cereceda A, Goodall AH, Yanek LR, Furie KL, Cushman M, Hofman A, Witteman JC, Folsom AR, Basu S, Matijevic N, van Gilst WH, Wilson JF, Westendorp RG, Kathiresan S, Reilly MP, , Tracy RP, Polasek O, Winkelmann BR, Grant PJ, Hillege HL, Cambien F, Stott DJ, Lowe GD, Spector TD, Meigs JB, Marz W, Eriksson P, Becker LC, Morange PE, Soranzo N, Williams SM, Hayward C, van der Harst P, Hamsten A, Lowenstein CJ, Strachan DP, O'Donnell CJ, . "Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2." Arteriosclerosis, thrombosis, and vascular biology. 2014 May; 34(5):1093-101. Epub 2014 Feb 27.
2014 Apr
Jeong Y, Du R, Zhu X, Yin S, Wang J, Cui H, Cao W, Lowenstein CJ. "Histone deacetylase isoforms regulate innate immune responses by deacetylating mitogen-activated protein kinase phosphatase-1." Journal of leukocyte biology. 2014 Apr; 95(4):651-9. Epub 2013 Dec 27.
2011 May 26
Lowenstein CJ. "Vav-Vav-Vav-voom!" Blood. 2011 May 26; 117(21):5557-9.

Current Appointments

Chief - Department of Medicine, Cardiology (SMD)
Director - Aab Cardiovascular Research Institute - Primary Administrative
Paul N. Yu Professorship in Cardiology - Department of Medicine, Cardiology (SMD)
Professor - Department of Medicine, Cardiology (SMD) - Primary


Cardiovascular Disease - American Board of Internal Medicine
Internal Medicine - American Board of Internal Medicine


MD | Medicine | Harvard Medical School1986
BA | Biochemistry | Harvard University1982
Cardiology Fellow | The Johns Hopkins University School of MedicineAttended 1991 - 1994
Research and Clinical Fellow | Massachusetts General HospitalAttended 1989 - 1990
Research Fellow | Massachusetts Institute of TechnologyAttended 1989 - 1990
Medical Resident | Massachusetts General HospitalAttended 1986 - 1989

Post-Doctoral Training & Residency

Fellowship in Cardiology at Johns Hopkins Hospital - GME Office01/01/1991 - 06/30/1993
Research at Massachusetts General Hospital07/01/1989 - 12/31/1990
Residency in Internal Medicine at Massachusetts General Hospital07/01/1987 - 06/30/1989
Internship in Internal Medicine at Massachusetts General Hospital07/01/1986 - 06/30/1987