Aritro Sen, Ph.D.

Aritro Sen, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 693
Rochester, NY 14642

Lab: (585) 276-5076
Administrative: (585) 276-4994
Fax: (585) 273-1288

Professional Bio

Dr. Sen received his undergraduate degree in Microbiology with minor in Chemistry and Zoology from Bangalore University in 2000 followed by Masters degree in 2002 in Biochemistry from University of Calcutta, India. Thereafter he joined the PhD program in Cell and Molecular Biology at West Virginia University, where he worked with Dr. Jorge Flores and Dr. Keith Inskeep. His PhD work focused on the intracellular mechanisms regulating the functions of corpus luteum, a transient endocrine gland that plays a vital role in the reproduction by supporting pregnancy. Following his PhD in 2005, Dr. Sen moved to Michigan State University for a post-doctoral fellowship in the Department of Animal Sciences.

At MSU, he worked with Dr. George Smith and Dr. James Ireland on the role of a novel neuropeptide called Cocaine-and Amphetamine-Regulated Transcript (CART) on follicular development. Dr. Sen was also part of a research team that discovered a novel oocyte specific protein, JY-1 involved in early embryonic development. In 2008, Dr. Sen joined the laboratory of Dr. Stephen R Hammes in the Division of Endocrinology and Metabolism at University of Texas Southwestern Medical Center, Dallas first as a post-doctoral fellow and then in 2009 he moved from Dallas to University of Rochester Medical Center. Dr. Sen is currently working as a Research Assistant Professor in the Division of Endocrinology and Metabolism at University of Rochester. Dr. Sen's research focuses on three closely related but distinct areas: (1) Understanding the role of androgens in ovarian physiology, (2) Mechanism of steroid actions in cancer development and progression, and (3) Determining local effects of obesity on ovarian function and identifying biomarkers for obesity related fertility problems.

Research Bio

My research interests are focused towards understanding how various factors like steroid hormones, intra-follicular proteins and gonadotropins regulate ovarian physiology, specifically follicular development in normal and patho-physiological conditions affecting female fertility. My present research encompasses 2 projects:
Androgen signaling in ovarian development and function: Androgens have long been referred to as the "male" hormone and almost universally were considered detrimental to normal folliculogenesis, and elevated androgens in women have been associated with poor health and reduced fertility. Interestingly, in recent years, our studies have helped in putting forth a new concept suggesting that sufficient androgen signaling through the androgen receptor (AR) is necessary for normal follicle development and function. We have developed an ovary-specific AR knockout mouse model to determine the role of granulosa cell-specific ARs in follicular development and female fertility. Another major effort of my research is to determine the intra-cellular mechanism of androgens and how it regulates ovarian physiology and female fertility in normal and patho-physiological conditions like pre-mature ovarian failure (POF) or diminished ovarian reserve (DOR). In recent years the use of androgen treatments in women with DOR or POF has become highly popular across the world. Thus, through collaboration with IVF clinicians we are now extending our observations in the mouse to a clinical setting.



My second research project involves in understanding ovarian effects of obesity and its contribution to female sub-fertility or infertility. I am specifically interested in identifying local intra-follicular regulatory molecules, their cognate signaling pathways and their respective actions affecting ovarian function under obese conditions. We have identified a novel intra-cellular mechanism of action for leptin in the ovary that accounts for most of leptin's known negative effects of obesity on ovarian function. Using transgenic mouse models and human samples our aim is to develop a potential biomarker for obesity-related fertility problems that has predictive value for in vitro fertilization (IVF) outcomes in obese patients.

Awards & Honors (National)

Outstanding Abstract Award, ENDO 2010 | The Endocrine Society | San Diego 2010

Awards & Honors (Local)

Graduate Award | Eberly College of Arts and Sciences 2005
Graduate Student Award | West Virginia University 2005
Larry Ewing Trainee Award for SSR 2005 - 2006
Outstanding Graduate Student HERF Fellowship | West Virginia University 2004 - 2005

Recent Journal Articles

Showing the 5 most recent journal articles. 20 available »

2014 Feb 25
Sen A, Prizant H, Light A, Biswas A, Hayes E, Lee HJ, Barad D, Gleicher N, Hammes SR. "Androgens regulate ovarian follicular development by increasing follicle stimulating hormone receptor and microRNA-125b expression." Proceedings of the National Academy of Sciences of the United States of America.. 2014 Feb 25; 111(8):3008-13. Epub 2014 Feb 10.
2014 Jan
Sen A, Kushnir VA, Barad DH, Gleicher N. "Endocrine autoimmune diseases and female infertility." Nature reviews. Endocrinology.. 2014 Jan; 10(1):37-50. Epub 2013 Nov 05.
2013
Sen A, Caiazza F. "Oocyte maturation: a story of arrest and release." Frontiers in bioscience (Scholar edition). 2013 5:451-77. Epub 2013 Jan 01.
2012 Jul 2
Sen A, De Castro I, Defranco DB, Deng FM, Melamed J, Kapur P, Raj GV, Rossi R, Hammes SR. "Paxillin mediates extranuclear and intranuclear signaling in prostate cancer proliferation." The Journal of clinical investigation.. 2012 Jul 2; 122(7):2469-81. Epub 2012 Jun 11.
2011 Aug
Sen A, Prizant H, Hammes SR. "Understanding extranuclear (nongenomic) androgen signaling: what a frog oocyte can tell us about human biology." Steroids. 2011 Aug; 76(9):822-8. Epub 2011 Feb 25.

Education

Ph.D. | Biology | West Virginia University2005
MS | Biochemistry | Department of Biochemistry, University of Calcutta2002
BS | Microbiology (major), Chemistry and Zoology | Bangalore University2000