Research Bio
Dr. Tyler's research interests overlap with her clinical practice and center around the treatment of patients with bone and soft tissue tumors and conditions that lead to osteolysis (bone destruction as a result of implant wear and loosening or presence of tumor). Her areas of on-going research at this time include:
1) Treatment of aggressive benign conditions, such as pigmented villonodular synovitis and giant cell tumor of bone. More specifically, the molecular and cellular signaling pathways of cells in these conditions and the genetic alterations that lead to such conditions.
2) Medical and surgical treatment of soft tissue sarcomas.
3) Inhibiting osteolysis in both benign and malignant bone conditions.
4) Allograft implantation for large bone defects.
5) Treatment of metastatic disease to bone from other organs systems.
| American Orthopaedic Association Future Leaders in Orthopaedics recipient | American Orthopaedic Association |
2006 |
| Joseph M. Lane, MD Resident Research Grant recipient |
2006 |
| Phi Beta Kappa Honors Society Inductee | Johns Hopkins School of Hygiene and Public Health |
2002 - 2002 |
| Alpha Omega Alpha National Medical Honors Society Inductee |
2002 |
| Monumental City Medical Society Scholarship Recipient |
2001 - 2002 |
| Johns Hopkins School of Hygiene and Public Health Watt-Hansel Scholarship recipient | Johns Hopkins School of Hygiene and Public Health |
2000 - 2001 |
| Phi Kappa Phi Honors Society inductee | Millersville University |
1996 - 1997 |
| Scholar Athlete Award receipient in cross country, track and field | Millersville University |
1993 - 1994 |
| The Class of 1895 Award | Millersville University |
1997 |
| The Fontes Health Professions Award in Pre-Med |
1997 |
| The Cecil Upton Organic Chemistry Award |
1997 |
| Summa Cum Laude, Department Honors and University Honors | Millersville University |
1997 |
2012 Feb
Xie C, Schwarz EM, Sampson ER, Dhillon RS, Li D, O'Keefe RJ, Tyler W. "Unique angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of bone metastasis are associated with high levels of vegf-a and decreased ang-1 expression." Journal of orthopaedic research : official publication of the
Orthopaedic Research Society. 2012 Feb 0; 30(2):325-33. Epub 2011 Aug 01. |
2011 Jan
Bukata SV, Digiovanni BF, Friedman SM, Hoyen H, Kates A, Kates SL, Mears SC, Mendelson DA, Serna FH, Sieber FE, Tyler WK. "A guide to improving the care of patients with fragility fractures." . 2011 Jan 0; 2(1):5-37. |
2009 Nov
Tyler WK, Healey JH, Morris CD, Boland PJ, O'Donnell RJ. "Compress periprosthetic fractures: interface stability and ease of revision." Clinical orthopaedics and related research. 2009 Nov 0; 467(11):2800-6. Epub 2009 Jun 30. |
2008 Aug
DiResta GR, Manoso MW, Naqvi A, Zanzonico P, Smith-Jones P, Tyler W, Morris C, Healey JH. "Bisphosphonate delivery to tubular bone allografts." Clinical orthopaedics and related research. 2008 Aug 0; 466(8):1871-9. Epub 2008 Apr 26. |
2006 Jun
Tyler WK, Vidal AF, Williams RJ, Healey JH. "Pigmented villonodular synovitis." The Journal of the American Academy of Orthopaedic Surgeons. 2006 Jun 0; 14(6):376-85. |
