Dmitri N. Ermolenko, Ph.D.

Dmitri N. Ermolenko, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester, NY 14642

Fax: (585) 271-2683
Office: (585) 275-3704

Research Bio

We are interested in the mechanisms of the ribosome function. The ribosome is a central component of cell metabolism, translating genetic code and synthesizing proteins in all living organism. The ribosome is an extremely complex and highly dynamic machine. Our research is focused on the mechanics of ribosome movement along mRNA during protein synthesis. Movement of ribosomes along mRNA is essential attribute of protein synthesis in all organisms and often used to regulate protein expression.

Recent Journal Articles

Showing the 5 most recent journal articles. 22 available »

2014 Sep 1
Kurosaki T, Li W, Hoque M, Popp MW, Ermolenko DN, Tian B, Maquat LE. "A post-translational regulatory switch on UPF1 controls targeted mRNA degradation." Genes & development.. 2014 Sep 1; 28(17):1900-1916.
2013 Jul 23
Svidritskiy E, Ling C, Ermolenko DN, Korostelev AA. "Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome." Proceedings of the National Academy of Sciences of the United States of America.. 2013 Jul 23; 110(30):12283-8. Epub 2013 Jul 03.
2013 Feb
Ermolenko DN, Cornish PV, Ha T, Noller HF. "Antibiotics that bind to the A site of the large ribosomal subunit can induce mRNA translocation." RNA.. 2013 Feb; 19(2):158-66. Epub 2012 Dec 17.
Brilot AF, Korostelev AA, Ermolenko DN, Grigorieff N. "Structure of the ribosome with elongation factor G trapped in the pretranslocation state." Proceedings of the National Academy of Sciences of the United States of America.. 2013 110(52):20994-9. Epub 2013 Dec 09.
2011 Apr
Ermolenko DN, Noller HF. "mRNA translocation occurs during the second step of ribosomal intersubunit rotation." Nature structural & molecular biology.. 2011 Apr; 18(4):457-62. Epub 2011 Mar 13.

Current Appointments

Assistant Professor - Department of Biochemistry and Biophysics (SMD) - Primary
Assistant Professor - Department of Biology RC (RC)