Research Bio
We are interested in the mechanisms of the ribosome function. The ribosome is a central component of cell metabolism, translating genetic code and synthesizing proteins in all living organism. The ribosome is an extremely complex and highly dynamic machine. Our research is focused on the mechanics of ribosome movement along mRNA during protein synthesis. Movement of ribosomes along mRNA is essential attribute of protein synthesis in all organisms and often used to regulate protein expression.
2013 Feb
Ermolenko DN, Cornish PV, Ha T, Noller HF. "Antibiotics that bind to the A site of the large ribosomal subunit can induce mRNA translocation." RNA (New York, N.Y.). 2013 Feb 0; 19(2):158-66. Epub 2012 Dec 17. |
2011 Apr
Ermolenko DN, Noller HF. "mRNA translocation occurs during the second step of ribosomal intersubunit rotation." Nature structural & molecular biology. 2011 Apr 0; 18(4):457-62. Epub 2011 Mar 13. |
2009 Feb 24
Cornish PV, Ermolenko DN, Staple DW, Hoang L, Hickerson RP, Noller HF, Ha T. "Following movement of the L1 stalk between three functional states in single ribosomes." Proceedings of the National Academy of Sciences of the United States
of America. 2009 Feb 24; 106(8):2571-6. Epub 2009 Feb 03. |
2008 Jun 6
Cornish PV, Ermolenko DN, Noller HF, Ha T. "Spontaneous intersubunit rotation in single ribosomes." Molecular cell. 2008 Jun 6; 30(5):578-88. |
2008
Korostelev A, Ermolenko DN, Noller HF. "Structural dynamics of the ribosome." Current opinion in chemical biology. 2008 12(6):674-83. Epub 2008 Oct 09. |
