Research Bio
The salivary glands are important for their physiological role in digestion and oral health, and the site of pathological processes, from autoimmune diseases to cancer. I am using my experience in vertebrate embryology and signal transduction to understand the molecular processes underlying the development, maintenance, and regeneration of normal salivary glands, as well as their pathological alteration in oncogenesis.
2012 Aug 17
Gao H, Chakraborty G, Lee-Lim AP, Mo Q, Decker M, Vonica A, Shen R, Brogi E, Brivanlou AH, Giancotti FG. "The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites." Cell. 2012 Aug 17; 150(4):764-79. |
2012 Jul 10
Warmflash A, Zhang Q, Sorre B, Vonica A, Siggia ED, Brivanlou AH. "Dynamics of TGF-? signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4." Proceedings of the National Academy of Sciences of the United States
of America. 2012 Jul 10; 109(28):E1947-56. Epub 2012 Jun 11. |
2011 Feb 1
Vonica A, Rosa A, Arduini BL, Brivanlou AH. "APOBEC2, a selective inhibitor of TGF? signaling, regulates left-right axis specification during early embryogenesis." Developmental biology. 2011 Feb 1; 350(1):13-23. Epub 2010 Sep 27. |
2010 Apr 15
Shimomura Y, Agalliu D, Vonica A, Luria V, Wajid M, Baumer A, Belli S, Petukhova L, Schinzel A, Brivanlou AH, Barres BA, Christiano AM. "APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex." Nature. 2010 Apr 15; 464(7291):1043-7. |
2009 Sep 3
Francois P, Vonica A, Brivanlou AH, Siggia ED. "Scaling of BMP gradients in Xenopus embryos." Nature. 2009 Sep 3; 461(7260):E1; discussion E2. |
