John J. Krolewski, M.D., Ph.D.

John J. Krolewski, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester, NY 14642


Journal Articles

Showing all 44 journal articles available.

2012 Jul
Pioli PD, Saleh AM, El Fiky A, Nastiuk KL, Krolewski JJ. "Sequential proteolytic processing of an interferon-alpha receptor subunit by TNF-alpha converting enzyme and presenilins." Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2012 Jul; 32(7):312-25. Epub 2012 Mar 29.
2011 Apr
Davis JS, Nastiuk KL, Krolewski JJ. "TNF is necessary for castration-induced prostate regression, whereas TRAIL and FasL are dispensable." Molecular endocrinology.. 2011 Apr; 25(4):611-20. Epub 2011 Feb 03.
2009 Feb 15
Yoo KS, Nastiuk KL, Krolewski JJ. "Transforming growth factor beta1 induces apoptosis by suppressing FLICE-like inhibitory protein in DU145 prostate epithelial cells." International journal of cancer. Journal international du cancer. 2009 Feb 15; 124(4):834-42.
2008 Aug
Nastiuk KL, Krolewski JJ. "FLIP-ping out: death receptor signaling in the prostate." Cancer biology & therapy.. 2008 Aug; 7(8):1171-9. Epub 2008 Aug 01.
2008 Jul 24
Cornforth AN, Davis JS, Khanifar E, Nastiuk KL, Krolewski JJ. "FOXO3a mediates the androgen-dependent regulation of FLIP and contributes to TRAIL-induced apoptosis of LNCaP cells." Oncogene. 2008 Jul 24; 27(32):4422-33. Epub 2008 Apr 07.
2008 Jul
El Fiky A, Pioli P, Azam A, Yoo K, Nastiuk KL, Krolewski JJ. "Nuclear transit of the intracellular domain of the interferon receptor subunit IFNaR2 requires Stat2 and Irf9." Cellular signalling. 2008 Jul; 20(7):1400-8. Epub 2008 Mar 21.
2008 Feb
Nastiuk KL, Yoo K, Lo K, Su K, Yeung P, Kutaka J, Danielpour D, Krolewski JJ. "FLICE-like inhibitory protein blocks transforming growth factor beta 1-induced caspase activation and apoptosis in prostate epithelial cells." Molecular cancer research : MCR. 2008 Feb; 6(2):231-42.
Nastiuk KL, Liu H, Hamamura M, Muftuler LT, Nalcioglu O, Krolewski JJ. "In vivo MRI volumetric measurement of prostate regression and growth in mice." BMC urology. 2007 7:12. Epub 2007 Jul 24.
2005 Aug 16
Saleh AZ, Greenman KL, Billings S, Van Vranken DL, Krolewski JJ. "Binding of madindoline A to the extracellular domain of gp130." Biochemistry.. 2005 Aug 16; 44(32):10822-7.
2005 Aug
El Fiky A, Arch AE, Krolewski JJ. "Intracellular domain of the IFNaR2 interferon receptor subunit mediates transcription via Stat2." Journal of cellular physiology. 2005 Aug; 204(2):567-73.
2005 Jun 1
Krolewski JJ. "Cytokine and growth factor receptors in the nucleus: what's up with that?" Journal of cellular biochemistry. 2005 Jun 1; 95(3):478-87.
2004 Nov 5
Kumar KG, Krolewski JJ, Fuchs SY. "Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor." The Journal of biological chemistry.. 2004 Nov 5; 279(45):46614-20. Epub 2004 Aug 26.
2004 Sep 16
Saleh AZ, Fang AT, Arch AE, Neupane D, El Fiky A, Krolewski JJ. "Regulated proteolysis of the IFNaR2 subunit of the interferon-alpha receptor." Oncogene. 2004 Sep 16; 23(42):7076-86.
2003 Aug
Nastiuk KL, Kim JW, Mann M, Krolewski JJ. "Androgen regulation of FLICE-like inhibitory protein gene expression in the rat prostate." Journal of cellular physiology. 2003 Aug; 196(2):386-93.
2002 Sep 17
Saleh AZ, Nguyen VP, Krolewski JJ. "Affinity of Stat2 for the subunits of the interferon alpha receptor." Biochemistry.. 2002 Sep 17; 41(37):11261-8.
2002 Mar 22
Nguyen VP, Saleh AZ, Arch AE, Yan H, Piazza F, Kim J, Krolewski JJ. "Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling." The Journal of biological chemistry.. 2002 Mar 22; 277(12):9713-21. Epub 2002 Jan 10.
2001 Jun 29
Lukashova V, Asselin C, Krolewski JJ, Rola-Pleszczynski M, Stankov√° J. "G-protein-independent activation of Tyk2 by the platelet-activating factor receptor." The Journal of biological chemistry.. 2001 Jun 29; 276(26):24113-21. Epub 2001 Apr 17.
2000 Aug 11
Zhang Y, Turkson J, Carter-Su C, Smithgall T, Levitzki A, Kraker A, Krolewski JJ, Medveczky P, Jove R. "Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity." The Journal of biological chemistry.. 2000 Aug 11; 275(32):24935-44.
1999 Aug 1
Nastiuk KL, Mansukhani M, Terry MB, Kularatne P, Rubin MA, Melamed J, Gammon MD, Ittmann M, Krolewski JJ. "Common mutations in BRCA1 and BRCA2 do not contribute to early prostate cancer in Jewish men." The Prostate. 1999 Aug 1; 40(3):172-7.
1998 Jul 31
Krishnan K, Singh B, Krolewski JJ. "Identification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon alpha receptor." The Journal of biological chemistry.. 1998 Jul 31; 273(31):19495-501.
1998 Feb 13
Yan H, Piazza F, Krishnan K, Pine R, Krolewski JJ. "Definition of the interferon-alpha receptor-binding domain on the TYK2 kinase." The Journal of biological chemistry.. 1998 Feb 13; 273(7):4046-51.
1998 Feb
Singh B, Ittmann MM, Krolewski JJ. "Sporadic breast cancers exhibit loss of heterozygosity on chromosome segment 10q23 close to the Cowden disease locus." Genes, chromosomes & cancer. 1998 Feb; 21(2):166-71.
1997 Aug
Mansukhani MM, Nastiuk KL, Hibshoosh H, Kularatne P, Russo D, Krolewski JJ. "Convenient, nonradioactive, heteroduplex-based methods for identifying recurrent mutations in the BRCA1 and BRCA2 genes." Diagnostic molecular pathology : the American journal of surgical pathology, part B. 1997 Aug; 6(4):229-37.
1997 Jul 1
Krishnan K, Pine R, Krolewski JJ. "Kinase-deficient forms of Jak1 and Tyk2 inhibit interferon alpha signaling in a dominant manner." European journal of biochemistry / FEBS. 1997 Jul 1; 247(1):298-305.
1997 Jul
Stancato LF, Sakatsume M, David M, Dent P, Dong F, Petricoin EF, Krolewski JJ, Silvennoinen O, Saharinen P, Pierce J, Marshall CJ, Sturgill T, Finbloom DS, Larner AC. "Beta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a JAK1-dependent pathway." Molecular and cellular biology. 1997 Jul; 17(7):3833-40.
1997 Feb 10
Uddin S, Sweet M, Colamonici OR, Krolewski JJ, Platanias LC. "The vav proto-oncogene product (p95vav) interacts with the Tyk-2 protein tyrosine kinase." FEBS letters.. 1997 Feb 10; 403(1):31-4.
1996 Jul 4
Krishnan K, Yan H, Lim JT, Krolewski JJ. "Dimerization of a chimeric CD4-interferon-alpha receptor reconstitutes the signaling events preceding STAT phosphorylation." Oncogene. 1996 Jul 4; 13(1):125-33.
1996 May
Yan H, Krishnan K, Lim JT, Contillo LG, Krolewski JJ. "Molecular characterization of an alpha interferon receptor 1 subunit (IFNaR1) domain required for TYK2 binding and signal transduction." Molecular and cellular biology. 1996 May; 16(5):2074-82.
1996 Mar 1
Yan H, Krishnan K, Greenlund AC, Gupta S, Lim JT, Schreiber RD, Schindler CW, Krolewski JJ. "Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein." The EMBO journal. 1996 Mar 1; 15(5):1064-74.
1996 Mar
Davis E, Krishnan K, Yan H, Newcomb EW, Krolewski JJ. "A mutant form of p135tyk2, an interferon-alpha inducible tyrosine kinase, suppresses the transformed phenotype of Daudi cells." Leukemia.. 1996 Mar; 10(3):543-51.
1995 Nov 1
Yan H, Lim JT, Contillo LG, Krolewski JJ. "Glutathione S-transferase fusion proteins mimic receptor dimerization in permeabilized cells." Analytical biochemistry.. 1995 Nov 1; 231(2):455-8.
1995 Aug 4
Yetter A, Uddin S, Krolewski JJ, Jiao H, Yi T, Platanias LC. "Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase." The Journal of biological chemistry.. 1995 Aug 4; 270(31):18179-82.
1994 Feb 25
Colamonici OR, Domanski P, Krolewski JJ, Fu XY, Reich NC, Pfeffer LM, Sweet ME, Platanias LC. "Interferon alpha (IFN alpha) signaling in cells expressing the variant form of the type I IFN receptor." The Journal of biological chemistry.. 1994 Feb 25; 269(8):5660-5.
1994 Feb 4
Colamonici OR, Uyttendaele H, Domanski P, Yan H, Krolewski JJ. "p135tyk2, an interferon-alpha-activated tyrosine kinase, is physically associated with an interferon-alpha receptor." The Journal of biological chemistry.. 1994 Feb 4; 269(5):3518-22.
1991 Oct
Krolewski JJ, Dalla-Favera R. "The ltk gene encodes a novel receptor-type protein tyrosine kinase." The EMBO journal. 1991 Oct; 10(10):2911-9.
1990 Sep
Firmbach-Kraft I, Byers M, Shows T, Dalla-Favera R, Krolewski JJ. "tyk2, prototype of a novel class of non-receptor tyrosine kinase genes." Oncogene. 1990 Sep; 5(9):1329-36.
1990 Mar
Krolewski JJ, Lee R, Eddy R, Shows TB, Dalla-Favera R. "Identification and chromosomal mapping of new human tyrosine kinase genes." Oncogene. 1990 Mar; 5(3):277-82.
Krolewski JJ, Dalla-Favera R. "Molecular genetic approaches in the diagnosis and classification of lymphoid malignancies." Hematologic pathology. 1989 3(2):45-61.
1984 Mar 25
Krolewski JJ, Rush MG. "Some extrachromosomal circular DNAs containing the Alu family of dispersed repetitive sequences may be reverse transcripts." Journal of molecular biology. 1984 Mar 25; 174(1):31-40.
1984 Mar 25
Krolewski JJ, Schindler CW, Rush MG. "Structure of extrachromosomal circular DNAs containing both the Alu family of dispersed repetitive sequences and other regions of chromosomal DNA." Journal of molecular biology. 1984 Mar 25; 174(1):41-54.
1982 May
Schindler CW, Krolewski JJ, Rush MG. "Selective trapping of circular double-stranded DNA molecules in solidifying agarose." Plasmid. 1982 May; 7(3):263-70.
1982 Jan 25
Krolewski JJ, Bertelsen AH, Humayun MZ, Rush MG. "Members of the Alu family of interspersed, repetitive DNA sequences are in the small circular DNA population of monkey cells grown in culture." Journal of molecular biology. 1982 Jan 25; 154(3):399-415.
1981 Oct 15
Krolewski JJ, Murphy E, Novick RP, Rush MG. "Site-specificity of the chromosomal insertion of Staphylococcus aureus transposon Tn554." Journal of molecular biology. 1981 Oct 15; 152(1):19-33.
1978 Jan
Skopek TR, Liber HL, Krolewski JJ, Thilly WG. "Quantitative forward mutation assay in Salmonella typhimurium using 8-azaguanine resistance as a genetic marker." Proceedings of the National Academy of Sciences of the United States of America.. 1978 Jan; 75(1):410-4.