Kent L. Nastiuk, Ph.D.

Kent L. Nastiuk, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester, NY 14642

Office: (585) 276--628
Fax: (585) 276--227

Professional Bio

Dr. Nastiuk is a researcher primarily focused on growth control of prostate cancer and prostatic disease. He earned a BA with high honors from Oberlin College. His graduate training was at The Rockefeller University in the Laboratory of Animal Behavior. Dr. Nastiuk then undertook fellowship training in the Nobel lab of Paul Greengard on the biochemistry of signaling and protein translation control, followed by further training with Dr. John Krolewski on signaling mechanisms controlling prostate cancer. Following appointment as a research scientist in the department of Pathology at UC Irvine, Dr. Nastiuk moved to the University of Rochester in 2012.

Research Bio

Dr. Nastiuk has an active research lab investigating the regulation of apoptosis in normal prostate (N), benign prostatic hyperplasia (BPH), and prostate cancer (PrCa). ((N) and (PrCa) in collaboration with John Krolewski, University of Rochester). The ultimate goal of this research is to develop therapy for late stage disease that is resistant to androgen ablation therapies by recapitulating androgen loss regulated death-inducing downstream effectors to induce prostate cell death.



Furthering this research are a number of active collaborations. One active collaboration is developing chimeric nanoparticles for gene therapy of metastatic prostate cancer, which may also be useful for BPH. (with Y. Kwon, Pharmaceutical Sciences, UC Irvine). Imaging of rodents has allowed investigation of genetically engineered mouse models, and high resolution MRI techniques were developed, and currently dual mode SPECT/MR imaging for regression and apoptosis induction in mouse models or prostate cancer is underway (with Orhan Nalcioglu, UC Irvine). Also under development is photoacoustic imaging of prostate cancer in vivo using molecular imaging agents (with Vikram Dogra, URMC). To analyze small samples, two active collaborations seek to leverage modern engineering to examine biological processes: Development of microscale western blot utilizing microfluidics and digital imaging for clinical diagnostics. (with M. Bachman, CalIT-2, UC Irvine) and an optical waveguide capillary biosensor for ELISA and PCR in point of care testing devices. (with CapWave Sensors, Inc.)

Recent Journal Articles

Showing the 5 most recent journal articles. 21 available »

2013
Saedinia, S, Limtao, K, Nastiuk, K, Krolewski, J, Li, GP, Bachman, M. "Laminates for Miniaturized Integrated Bioelectronic Protein Analysis Systems". IEEE:ECTC. 2013; 38: 739. Link
2012 Jul
Pioli PD, Saleh AM, El Fiky A, Nastiuk KL, Krolewski JJ. "Sequential proteolytic processing of an interferon-alpha receptor subunit by TNF-alpha converting enzyme and presenilins." Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2012 Jul; 32(7):312-25. Epub 2012 Mar 29.
2011 Apr
Davis JS, Nastiuk KL, Krolewski JJ. "TNF is necessary for castration-induced prostate regression, whereas TRAIL and FasL are dispensable." Molecular endocrinology.. 2011 Apr; 25(4):611-20. Epub 2011 Feb 03.
2009 Feb 15
Yoo KS, Nastiuk KL, Krolewski JJ. "Transforming growth factor beta1 induces apoptosis by suppressing FLICE-like inhibitory protein in DU145 prostate epithelial cells." International journal of cancer. Journal international du cancer. 2009 Feb 15; 124(4):834-42.
2008 Aug
Nastiuk KL, Krolewski JJ. "FLIP-ping out: death receptor signaling in the prostate." Cancer biology & therapy.. 2008 Aug; 7(8):1171-9. Epub 2008 Aug 01.

Current Appointments

Research Associate Professor - Department of Pathology and Laboratory Medicine (SMD) - Primary

Education

PhD | Molecular Neuroendocrinology | The Rockfeller University1992
B.A. with High Honors in Psychobiology | Oberlin College1985

Post-Doctoral Training & Residency

Post-doctoral Research Scientist; Department of Pathology and Laboratory Medicine, Columbia University, College of Physicians & Surgeons; New York, NY. 1998
Post-doctoral Fellow; Laboratory of Molecular and Cellular Neuroscience, Rockefeller University; New York, NY. 1996