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Le Zhang, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 630
Rochester, NY 14642

Office: (585) 275-4212

Journal Articles

Showing all 26 journal articles available.

2014 Jul 1
Peng H, Peng T, Wen J, Engler DA, Matsunami RK, Su J, Zhang L, Chang CC, Zhou X. "Characterization of p38 MAPK isoforms for drug resistance study using systems biology approach." Bioinformatics. 2014 Jul 1; 30(13):1899-907. Epub 2014 Mar 10.
Zhang, L.; Xue, Y.; Jiang, B.; Strouthos, C.; Wu, YK.; Duan, Z.; Su, J.; Zhou, X.;. "Multiscale agent-based modeling of ovarian cancer progression under the stimulation of the STAT 3 pathway". International Journal of Data Mining and Bioinformatics. 2014; 9(3): 9.
Su J, Zhang L, Zhang W, Choi DS, Wen J, Jiang B, Chang CC, Zhou X. "Targeting the biophysical properties of the myeloma initiating cell niches: a pharmaceutical synergism analysis using multi-scale agent-based modeling." PloS one. 2014 9(1):e85059. Epub 2014 Jan 27.
Wang J, Zhang L, Jing C, Ye G, Wu H, Miao H, Wu Y, Zhou X. "Multi-scale agent-based modeling on melanoma and its related angiogenesis analysis." Theoretical biology & medical modelling. 2013 10:41. Epub 2013 Jun 21.
2012 Nov
Sun X, Su J, Bao J, Peng T, Zhang L, Zhang Y, Yang Y, Zhou X. "Cytokine combination therapy prediction for bone remodeling in tissue engineering based on the intracellular signaling pathway." Biomaterials. 2012 Nov; 33(33):8265-76. Epub 2012 Aug 19.
Sun X, Zhang L, Tan H, Bao J, Strouthos C, Zhou X. "Multi-scale agent-based brain cancer modeling and prediction of TKI treatment response: incorporating EGFR signaling pathway and angiogenesis." BMC bioinformatics. 2012 13:218. Epub 2012 Aug 30.
Jiang, B.; Struthers, A.; Sun, Z.; Feng, Z.; Zhao, X.; Dai, W.; Zhao, K.; Zhou, X.; Berens, M.; Zhang, L.;. "Employing graphics processing unit technology, alternating direction implicit method and domain decomposition to speed up the numerical diffusion solver for the biomedical engineering research". International Journal for Numerical Methods in Biomedical Engineering. 2011; 27(11): 20.
Wu Y, Zhang L. "Comparison of two academic software packages for analyzing two-dimensional gel images." Journal of bioinformatics and computational biology. 2011 9(6):775-94.
Zhang L, Jiang B, Wu Y, Strouthos C, Sun PZ, Su J, Zhou X. "Developing a multiscale, multi-resolution agent-based brain tumor model by graphics processing units." Theoretical biology & medical modelling. 2011 8:46. Epub 2011 Dec 16.
2010 Sep 1
Zhang L, Zhong G, Wu Y, Vangel MG, Jiang B, Kong J. "Using Granger-Geweke causality model to evaluate the effective connectivity of primary motor cortex (M1), supplementary motor area (SMA) and cerebellum." Journal of biomedical science and engineering. 2010 Sep 1; 3:848-860.
2009 Apr
Zhang L, Wang Z, Sagotsky JA, Deisboeck TS. "Multiscale agent-based cancer modeling." Journal of mathematical biology. 2009 Apr; 58(4-5):545-59. Epub 2008 Sep 12.
2009 Mar 1
Zhang L, Chen LL, Deisboeck TS. "Multi-scale, multi-resolution brain cancer modeling." Mathematics and computers in simulation. 2009 Mar 1; 79(7):2021-2035.
2009 Mar
Chen LL, Zhang L, Yoon J, Deisboeck TS. "Cancer cell motility: optimizing spatial search strategies." Bio Systems. 2009 Mar; 95(3):234-42. Epub 2008 Nov 14.
2009 Jan 1
Zhang L, Strouthos CG, Wang Z, Deisboeck TS. "Simulating Brain Tumor Heterogeneity with a Multiscale Agent-Based Model: Linking Molecular Signatures, Phenotypes and Expansion Rate." Mathematical and computer modelling. 2009 Jan 1; 49(1-2):307-319.
2009 Jan
Deisboeck TS, Zhang L, Yoon J, Costa J. "In silico cancer modeling: is it ready for prime time?" Nature clinical practice. Oncology. 2009 Jan; 6(1):34-42. Epub 2008 Oct 14.
Sagotsky JA, Zhang L, Wang Z, Martin S, Deisboeck TS. "Life Sciences and the web: a new era for collaboration." Molecular systems biology. 2008 4:201. Epub 2008 Jul 01.
2007 Jan 7
Zhang L, Athale CA, Deisboeck TS. "Development of a three-dimensional multiscale agent-based tumor model: simulating gene-protein interaction profiles, cell phenotypes and multicellular patterns in brain cancer." Journal of theoretical biology. 2007 Jan 7; 244(1):96-107. Epub 2006 Jul 27.
Zhang, L.; Dai, W.; Nassar, R.;. "A numerical algorithm for obtaining an optimal temperature distribution in a 3D triple-layered cylindrical skin structure". Computer Assisted Mechanics and Engineering Science. 2007; 14: 107-125.
Wang Z, Zhang L, Sagotsky J, Deisboeck TS. "Simulating non-small cell lung cancer with a multiscale agent-based model." Theoretical biology & medical modelling. 2007 4:50. Epub 2007 Dec 21.
Deisboeck TS, Zhang L, Martin S. "Advancing cancer systems biology: introducing the Center for the Development of a Virtual Tumor, CViT." Cancer informatics. 2007 5:1-8. Epub 2007 Mar 30.
Dai, W.; Bejan, A.; Tang, X.; Zhang, L.; Nassar, R.;. "Optimal temperature distribution in a 3D triple layered skin structure with embedded vasculature". Journal of Applied Physics. 2006; 99(10): 104702-9.
Zhang, L.; Dai, W.; Nassar, R.;. "A numerical method for obtaining an optimal temperature distribution in a 3D triple-layered cylindrical skin structure embedded with a blood vessel". Numerical Heat Transfer. 2006; 49: 765-784.
Zhang, L.; Dai, W.; Nassar, R.;. "A numerical method for optimizing laser power in the irradiation of a 3D triple layered cylindrical skin structure". Numerical Heat Transfer. 2005; 48: 21-41.
Jiang, B.; Dai, W.; Khaliq, A.; Wu, Y.; Su, J.; Zhou, X.; Zhang, L.;. "Accelerating 3D diffusion model in a cylindrical coordinate system by graphics processing unit (GPU) techniques". Mathematics and Computers in Simulation. .
Shi, L.; Huang, Z.; Zhang, L.;. "Integrating Semantic Query function into D-NetWeaver". Journal of Medical Imaging and Health Informatics. .
Wang, J.; Zhang, L.;. "Association studies on mtDNA and Parkinson's disease population discrimination using the statistical classification". Current Bioinformatics. .