Jian Zhu, Ph.D.

Jian Zhu, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 672
Rochester, NY 14642

Office: (585) 275-6916
Lab: (585) 275-0013
Administrative: (585) 275-3402
Fax: (585) 473-9573

Research Bio

Virus and host are equivalent opponents and have been playing a dynamic and "never-ending" match for a long time. Virus highly depends on host cellular machineries to replicate, while host cells develop multi-layered antiviral mechanisms to control or prevent viral invasion. Short-term acute or long-term chronic viral infection might yield different yet complicated consequences in host cells. Our lab studies the host-virus interactions, particularly for HIV and herpesviruses, by using recently developed, "state-of-the-art", multidisciplinary systematic approaches. We work at the interface of virology, immunology, cellular and molecular biology, proteomics, and functional genomics.

The goal is to not only pinpoint key genes that play a role in viral replication or mediate the consequences of viral infection for further dissection of their mechanistic functions using classic cell and/or animal models, but also construct a global landscape of gene network modulating viral infection from the massive data generated by integrative multiple systematic approaches at a higher resolution with the aid of powerful bioinformatic analyses. Currently, one of our major directions is to identify key host factors that regulate viral latency and reactivation for HIV and herpesviruses, by combining the genome-wide RNA interference (RNAi) screening together with various modern proteomic approaches including our recently developed PLATO (ParalleL Analysis of Translated ORFs) synthetic display method. Meanwhile, we're also interested in improving current systematic approaches or developing new ones to facilitate the study of host-virus interactions at various (genetic, biochemical and serological) levels, as well as to improve such study in a more quantitative, dynamic, and in vivo condition. Continuing to improve systematic approaches will increase their reliability and accuracy for better applications reaching a greater scope and depth of current host-virus studies. With more advanced systematic tools we will be led towards a complete understanding of viral pathogenesis, antiviral defense mechanisms, and their consequences in critical diseases such as autoimmunity and cancer.

Awards & Honors (National)

the 18th Annual Centers for AIDS Research (CFAR) National Meeting Junior Faculty Award | NIH/CFAR | Providence, RI, United States 2014
National Research Service Award (NRSA) F32 Individual Postdoctoral Fellowship Award | NIH/NIAID 2012 - 2013
The 19th Conference on Retroviruses and Opportunistic Infections (CROI) Young Investigator Award | Boston, MA, United States 2011
American Heart Association (AHA) Predoctoral Fellowship Award | American Heart Association | Dallas, TX, United States 2007 - 2009

Awards & Honors (Local)

Undergraduate Thesis Presentation Award | Peking University | Beijing, P.R. China 2000
Annual University Fellowship Award for Excellent Undergraduates | Peking University | Beijing, P.R. China 1997 - 2000

Recent Journal Articles

Showing the 5 most recent journal articles. 18 available »

2014 Oct 23
Zhu J, Davoli T, Perriera JM, Chin CR, Gaiha GD, John SP, Sigiollot FD, Gao G, Xu Q, Qu H, Pertel T, Sims JS, Smith JA, Baker RE, Maranda L, Ng A, Elledge SJ, Brass AL. "Comprehensive identification of host modulators of HIV-1 replication using multiple orthologous RNAi reagents." Cell reports. 2014 Oct 23; 9(2):752-66. Epub 2014 Oct 16.
2014 Jan
Larman HB, Liang AC, Elledge SJ, Zhu J. "Discovery of protein interactions using parallel analysis of translated ORFs (PLATO)." Nature protocols. 2014 Jan; 9(1):90-103. Epub 2013 Dec 12.
2014
Bera A, Perkins EM, Zhu J, Zhu H, Desai P. "DNA binding and condensation properties of the herpes simplex virus type 1 triplex protein VP19C." PloS one. 2014 9(8):e104640. Epub 2014 Aug 14.
2014
Liu ZP, Wu H, Zhu J, Miao H. "Systematic identification of transcriptional and post-transcriptional regulations in human respiratory epithelial cells during influenza A virus infection." BMC bioinformatics. 2014 15:336. Epub 2014 Oct 04.
2013 Apr
Zhu J, Larman HB, Gao G, Somwar R, Zhang Z, Laserson U, Ciccia A, Pavlova N, Church G, Zhang W, Kesari S, Elledge SJ. "Protein interaction discovery using parallel analysis of translated ORFs (PLATO)." Nature biotechnology. 2013 Apr; 31(4):331-4. Epub 2013 Mar 17.

Current Appointments

Assistant Professor - Department of Microbiology and Immunology (SMD) - Primary
Assistant Professor - Department of Biochemistry and Biophysics (SMD)

Education

PhD | Pharmacology and Molecular Sciences | The Johns Hopkins University School of Medicine2009
MS | Pharmacology | University of Nebraska Medical Center2004
BS (summa cum laude) | Pharmacology | Health Science Center, Peking University2000

Post-Doctoral Training & Residency

Research Fellow, Laboratory of Dr. Stephen Elledge, The Howard Hughes Medical Institute (HHMI) & Brigham and Women's Hospital at Harvard Medical School, Boston, MA, United States 2013