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Karen L. Bentley, M.S.

Karen L. Bentley, M.S.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester, NY 14642

Lab Description

The purpose of the URMC Electron Microscope Research Core Facility is to provide up-to-date and cost-effective support to researchers whose studies involve the use of electron microscopy.

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Research Bio

Ms. Bentley oversees the Electron Microscope Research Core. The Core provides services for processing and morphological assessment at the EM level. Researchers' requests often involve methods for pre- and post-embedding immunoelectron microscopy using biotin-, HRP, or gold conjugated markers for precise localization of antigens at the ultrastructural level. Other methods include: negative staining techniques for visualization of viral particles; a published innovative EM Research Core technique, "The large block tissue embedding direct off the slide/pop-off technique", to find "needle in a haystack" cells to be examined by EM; as well as customized techniques.

Recent Journal Articles

Miano JM, Ramanan N, Georger MA, de Mesy Bentley KL, Emerson RL, Balza RO, Xiao Q, Weiler H, Ginty DD, Misra RP. "Restricted inactivation of serum response factor to the cardiovascular system." Proceedings of the National Academy of Sciences of the United States of America. 2004; 101(49):17132-7. Epub 2004 Nov 29.
Sowden MP, Ballatori N, Jensen KL, Reed LH, Smith HC. "The editosome for cytidine to uridine mRNA editing has a native complexity of 27S: identification of intracellular domains containing active and inactive editing factors." Journal of cell science. 2002; 115(Pt 5):1027-39.
O'Reilly MA, Staversky RJ, Watkins RH, Reed CK, de Mesy Jensen KL, Finkelstein JN, Keng PC. "The cyclin-dependent kinase inhibitor p21 protects the lung from oxidative stress." American journal of respiratory cell and molecular biology. 2001; 24(6):703-10.

Current Appointments

Associate - Department of Pathology and Laboratory Medicine (SMD) - Primary

Education

MS | Anatomy | Univ Rochester Sch Med/Dent1984
BS | Biology | University of Rochester1982