Research Bio
Dr. Sowden received the University of Rochester Deans Institutional Award in 2002-04 to study the role of activation induced deaminase as an RNA editing enzyme in human B-cell function. Since then, he has received support from the UR Environmental Health Sciences Center and the Philip Morris External Research Program for related studies of smoking-associated carcinogenesis and teh APOBEC family of deaminases.
He is currently working with Dr. Peter Sims and Dr. Therese Wiedmer in studies of phospholipid scramblases.
| Lehmann DM, Galloway CA, MacElrevey C, Sowden MP, Wedekind JE, Smith HC. "Functional characterization of APOBEC-1 complementation factor phosphorylation sites." Biochimica et biophysica acta. 2007; 1773(3):408-18. Epub 2006 Dec 08. |
| Bennett RP, Diner E, Sowden MP, Lees JA, Wedekind JE, Smith HC. "APOBEC-1 and AID are nucleo-cytoplasmic trafficking proteins but APOBEC3G cannot traffic." Biochemical and biophysical research communications. 2006; 350(1):214-9. Epub 2006 Sep 18. |
| Ichikawa HT, Sowden MP, Torelli AT, Bachl J, Huang P, Dance GS, Marr SH, Robert J, Wedekind JE, Smith HC, Bottaro A. "Structural phylogenetic analysis of activation-induced deaminase function." Journal of immunology (Baltimore, Md. : 1950). 2006; 177(1):355-61. |
| Sparks JD, Collins HL, Chirieac DV, Cianci J, Jokinen J, Sowden MP, Galloway CA, Sparks CE. "Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase." The Biochemical journal. 2006; 395(2):363-71. |
| Lehmann DM, Galloway CA, Sowden MP, Smith HC. "Metabolic regulation of apoB mRNA editing is associated with phosphorylation of APOBEC-1 complementation factor." Nucleic acids research. 2006; 34(11):3299-308. Epub 2006 Jul 04. |
