Research Bio
Dr. Zhang's graduate work revealed a role for the Wnt regulator Axin in the regulation of Jun N-terminal kinase. As a postdoc, he discovered a connection between the anti-angiogenesis drug fumagillin and the Wnt signaling pathway, which both provided strong evidence for the role of the Wnt pathway in angiogenesis, as well as explained the role of the fumagillin target, MetAP2, in cellular growth control.
2011 Oct 6
Zhang Y, Stehling-Sun S, Lezon-Geyda K, Juneja SC, Coillard L, Chatterjee G, Wuertzer CA, Camargo F, Perkins AS. "PR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function." Blood. 2011 Oct 6; 118(14):3853-61. Epub 2011 Jun 10. |
2011
Zhang Y, Sicot G, Cui X, Vogel M, Wuertzer CA, Lezon-Geyda KA, Wheeler JC, Harki DA, Muzikar KA, Stolper DA, Dervan PB, Perkins AS. "Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide." Biochemistry. 2011 50(48):10431-41. Epub 2011 Nov 10. |
2008
Cirone P, Lin S, Griesbach HL, Zhang Y, Slusarski DC, Crews CM. "A role for planar cell polarity signaling in angiogenesis." Angiogenesis. 2008 11(4):347-60. Epub 2008 Sep 17. |
2006 Sep
Zhang Y, Yeh JR, Mara A, Ju R, Hines JF, Cirone P, Griesbach HL, Schneider I, Slusarski DC, Holley SA, Crews CM. "A chemical and genetic approach to the mode of action of fumagillin." Chemistry & biology. 2006 Sep 0; 13(9):1001-9. |
2006 Jul 5
Yeh JR, Ju R, Brdlik CM, Zhang W, Zhang Y, Matyskiela ME, Shotwell JD, Crews CM. "Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest." Proceedings of the National Academy of Sciences of the United States
of America. 2006 Jul 5; 103(27):10379-84. Epub 2006 Jun 21. |
