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URMC  » Pharmacology & Physiology

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Publications

2012 Publications

Almassy J, and Begenisich T. (2012) The LRRC26 protein selectively alters the efficacy of BK channel activators. Mol. Pharmacol. 81:21-30.

Almassy J, Won JH, Begenisich TB, and Yule DI. (2012) Apical Ca2+-activated potassium channels in mouse parotid acinar cells. J. Gen. Physiol. 139:121-133.

Bhattacharya S, Verrill DS, Carbone KM, Brown S, Yule DI, and Giovannucci DR. (2012) Distinct Contributions By Ionotropic Purinoceptor Subtypes To Atp-Evoked Calcium Signals In Mouse Parotid Acinar Cells. J. Physiol. [Epub ahead of print]

Christian WV, Li N, Hinkle PM, Ballatori N. (2012) The beta subunit of the Ostα-Ostβ organic solute transporter is required not only for heterodimerization and trafficking but also for function. J. Biol. Chem. [Epub ahead of print]

Dean RL, Eyerman D, Todtenkopf MS, Turncliff RZ, Bidlack JM, and Deaver DR. (2012) Effects of oral loperamide on efficacy of naltrexone, baclofen and AM-251 in blocking ethanol self-administration in rats. Pharmacol. Biochem. Behav. 100:530-537.

Dzhura I, Chepurny OG, Kelley GG, Leech CA, Roe MW, Dzhura E, Afshari P, Malik S, Rindler MJ, Xu X, Lu Y, Smrcka AV, and Holz GG. (2012) Epac2-dependent mobilization of intracellular Ca2+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in beta-cells of phospholipase C-epsilon knockout mice. J. Physiol. [Epub ahead of print]

Fernandes KA, Harder JM, Fornarola LB, Freeman RS, Clark AF, Pang IH, John SW, and Libby RT. (2012) JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death. Neurobiol. Dis. [Epub ahead of print].

Hu JH, Yang L, Kammermeier PJ, Moore CG, Brakeman PR, Tu J, Yu S, Petralia RS, Li Z, Zhang PW, Park JM, Dong X, Xiao B, and Worley PF (2012) Preso1 dynamically regulates group I metabotropic glutamate receptors. Nat. Neurosci. [Epub ahead of print].

Jhun BS, O-Uchi J, Wang W, Ha CH, Zhao J, Kim JY, Wong C, Dirksen RT, Lopes CM, and Jin ZG. (2012) Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1. Circ. Res. 110:59-70.

Lanner JT, Georgiou DK, Dagnino-Acosta A, Ainbinder A, Cheng Q, Joshi AD, Chen Z, Yarotskyy V, Oakes JM, Lee CS, Monroe TO, Santillan A, Dong K, Goodyear L, Ismailov II, Rodney GG, Dirksen RT, and Hamilton SL. AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation. Nat. Med. 18:244-251.

Li Y, Lefever MR, Muthu D, Bidlack JM, Bilsky EJ, and Polt R (2012) Opioid glycopeptide analgesics derived from endogenous enkephalins and endorphins. Future Med. Chem. 4:205-226.

Liu X, Yu L, Wang Q, Pelletier J, Fausther M, Sevigny J, Malmstroem HS, Dirksen RT, and Ren YF. (2012) Expression of ecto-ATPase NTPDase2 in human dental pulp. J. Dent. Res. 91:261-267.

McCoy KL, Gyoneva S, Vellano CP, Smrcka AV, Traynelis SF, and Helper JR. (2012) Protease-activated 1 (PAR1) coupling to G(q/11) but not to G(i/o) or G(12/13) is mediated by discrete amino acids within the receptor second intracellular loop. Cell Signal. [Epub ahead of print]

Neumeyer JL, Zhang B, Zhang T, Sromek AW, Knapp BI, Cohen DJ, and Bidlack JM. (2012) Synthesis, binding affinity, and functional In Vitro activity of 3-benzylaminomorphinan and 3-benzylaminomorphine ligands at opioid receptors. J. Med. Chem. [Epub ahead of print].

Palk L, Sneyd J, Patterson K, Shuttleworth TJ, Yule DI, Maclaren O, Crampin EJ. (2012) Modelling the effects of calcium waves and oscillations on saliva secretion. J Theor Biol. 305C:45-53.

Park HS, Betzenhauser MJ, Zhang Y, and Yule DI. (2012) Regulation of Ca² release through inositol 1,4,5-trisphosphate receptors by adenine nucleotides in parotid acinar cells. Am. J. Physiol. Gastrointest. Liver Physiol. 302:G97-G104.

Shuttleworth TJ. (2012) Orai3 - the 'exceptional' Orai? J. Physiol. 590(Pt 2):241-257.

Shuttleworth TJ. (2012) STIM and Orai proteins and the non-capacitative ARC channels. Front. Biosci. 17:847-860.

Smrcka AV, Brown JH, and Holz GG. (2012) Role of phospholipase Cε in physiological phosphoinositide signaling networks. Cell Signal. [Epub ahead of print].

Strong DR, Haber SN, Tyrka AR, Bernier JA, Rassmussen SA, and Greenberg BD. (2012) Reversible increase in smoking after withdrawal of ventral capsule/ventral striatum deep brain stimulation in a depressed smoker. J. Addict Med. 6:94-95.

Thompson J and Begenisich T. (2012) Selectivity filter gating in large-conductance Ca2+-activated K+ channels. J. Gen. Physiol. 139:235-244.

Wagner LE and Yule DI (2012) Differential regulation of the InsP3 receptor type-1 and -2 single channel properties by InsP3, Ca2+ and ATP. J. Physiol. [Epub ahead of print]

Williams JA and Yule, DI (2012) Stimulus-secretion coupling in pancreatic acinar cells. In: Physiology of the Gastrointestinal Tract, Two Volume Set. Ed., Johnson L, et al., Elsevier, pp. 1361-1398.

2011 Publications

Anders MW. (2011) Putting bioactivation reactions to work: Targeting antioxidants to mitochondria. Chem Biol Interact. 192:8-13.

Balboni G, Salvadori S, Marczak ED, Knapp BI, Bidlack JM, Lazarus LH, Peng X, Si YG, Neumeyer JL. (2011) Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic. Eur J Med Chem. 46:799-803.

Board PG, Anders MW. (2011) Glutathione transferase zeta: discovery, polymorphic variants, catalysis, inactivation, and properties of Gstz1-/- mice. Drug Metab Rev. 43:215-225.

Chan P, Gabay M, Wright FA, Tall GG. (2011) Ric-8B is a GTP-dependent G protein alphas guanine nucleotide exchange factor. J Biol Chem. 286:19932-19942.

Chan P, Gabay M, Wright FA, Kan W, Oner SS, Lanier SM, Smrcka AV, Blumer JB, Tall GG. (2011) Purification of heterotrimeric G protein alpha subunits by GST-Ric-8 association: primary characterization of purified G alpha(olf). J Biol Chem. 286:2625-2635.

Dean RL, Eyerman D, Todtenkopf MS, Turncliff RZ, Bidlack JM, Deaver DR. (2011) Effects of oral loperamide on efficacy of naltrexone, baclofen and AM-251 in blocking ethanol self-administration in rats. Pharmacol Biochem Behav. 100:530-537.

Dzhura I, Chepurny OG, Leech CA, Roe MW, Dzhura E, Xu X, Lu Y, Schwede F, Genieser HG, Smrcka AV, Holz GG. (2011) Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans. Islets. 3:121-128.

Gabay M, Pinter ME, Wright FA, Chan P, Murphy AJ, Valenzuela DM, Yancopoulos GD, Tall GG. (2011) Ric-8 proteins are molecular chaperones that direct nascent G protein α subunit membrane association. Sci Signal. 4:ra79.

Garvin KA, Dalecki D, Hocking DC. (2011) Vascularization of three-dimensional collagen hydrogels using ultrasound standing wave fields. Ultrasound Med Biol. 37:1853-1864.

Guo H, Barrett TM, Zhong Z, Fernández JA, Griffin JH, Freeman RS, Zlokovic BV. (2011) Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway. Mol Neurodegener. 6:13.

Groom L, Muldoon SM, Tang ZZ, Brandom BW, Bayarsaikhan M, Bina S, Lee HS, Qiu  X, Sambuughin N, Dirksen RT. (2011) Identical de novo mutation in the type 1 ryanodine receptor gene associated with fatal, stress-induced malignant hyperthermia in two unrelated families. Anesthesiology. 115:938-945.

Hinkle PM, Serasinghe MN, Jakabowski A, Sebag JA, Wilson KR, Haskell-Luevano C. (2011) Use of chimeric melanocortin-2 and -4 receptors to identify regions responsible for ligand specificity and dependence on melanocortin 2 receptor accessory protein. Eur J Pharmacol. 660:94-102.

Hough LB, Nalwalk JW, Yang J, Conroy JL, VanAlstine MA, Yang W, Gargano J, Shan Z, Zhang SZ, Wentland MP, Phillips JG, Knapp BI, Bidlack JM, Zuiderveld OP, Leurs R, Ding X. (2011) Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic. Pain. 152:878-887.

Huang Z, Zhang W, Fang H, Zheng M, Wang X, Xu J, Cheng H, Gong G, Wang W, Dirksen RT, Sheu SS. (2011) Response to "A critical evaluation of cpYFP as a probe for superoxide". Free Radic Biol Med. 51:1937-1940.

Jhun BS, O-Uchi J, Wang W, Ha CH, Zhao J, Kim JY, Wong C, Dirksen RT, Lopes CM, Jin ZG. (2011) Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1. Circ Res. Nov 10. [Epub ahead of print] PubMed PMID: 22076634.

Kamal FA, Smrcka AV, Blaxall BC. (2011) Taking the heart failure battle inside the cell: small molecule targeting of Gβγ subunits. J Mol Cell Cardiol. 51:462-467.

Lefebvre R, Legrand C, González-Rodríguez E, Groom L, Dirksen RT, Jacquemond V. (2011) Defects in Ca2+ release associated with local expression of pathological ryanodine receptors in mouse muscle fibres. J Physiol. 589(Pt 22):5361-5382.

Lefort CT, Wojciechowski K, Hocking DC. (2011) N-cadherin cell-cell adhesion complexes are regulated by fibronectin matrix assembly. J Biol Chem. 286:3149-3160.

Lehman JF, Greenberg BD, McIntyre CC, Rasmussen SA, Haber SN. (2011) Rules ventral prefrontal cortical axons use to reach their targets: implications for diffusion  tensor imaging tractography and deep brain stimulation for psychiatric illness. J Neurosci. 31:10392-10402.

Liang L, Sebag JA, Eagelston L, Serasinghe MN, Veo K, Reinick C, Angleson J, Hinkle PM, Dores RM. (2011) Functional expression of frog and rainbow trout melanocortin 2 receptors using heterologous MRAP1s. Gen Comp Endocrinol. 1745-14.

Lin Y, Smrcka AV. (2011) Understanding molecular recognition by G protein βγ subunits on the path to pharmacological targeting. Mol Pharmacol. 80:551-557.

Lowery JJ, Raymond TJ, Giuvelis D, Bidlack JM, Polt R, Bilsky EJ. (2011) In vivo characterization of MMP-2200, a mixed δ/μ opioid agonist, in mice. J Pharmacol Exp Ther. 336:767-778.

Loy RE, Orynbayev M, Xu L, Andronache Z, Apostol S, Zvaritch E, MacLennan DH, Meissner G, Melzer W, Dirksen RT. (2011) Muscle weakness in Ryr1I4895T/WT knock-in mice  as a result of reduced ryanodine receptor Ca2+ ion permeation and release from the sarcoplasmic reticulum. J Gen Physiol. 137:43-57.

Park H, Betzenhauser MJ, Zhang Y, Yule DI. (2011) Regulation of Ca2+ release through inositol 1,4,5-trisphosphate receptors by adenine nucleotides in parotid acinar cells. Am J Physiol Gastrointest Liver Physiol. [Epub ahead of print]

Park MS, Smrcka AV, Stern HA. (2011) Conformational flexibility and binding interactions of the G protein βγ heterodimer. Proteins. 79:518-527.

Pashkov V, Huang J, Parameswara VK, Kedzierski W, Kurrasch DM, Tall GG, Esser V, Gerard RD, Uyeda K, Towle HC, Wilkie TM. (2011) Regulator of G protein signaling (RGS16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner. J Biol Chem. 286:15116-15125.

Rosin B, Slovik M, Mitelman R, Rivlin-Etzion M, Haber SN, Israel Z, Vaadia E,  Bergman H. (2011) Closed-loop deep brain stimulation is superior in ameliorating parkinsonism. Neuron. 72:370-384.

Rossi AE, Boncompagni S, Wei L, Protasi F, Dirksen RT. (2011) Differential impact of mitochondrial positioning on mitochondrial Ca(2+) uptake and Ca(2+) spark suppression in skeletal muscle. Am J Physiol Cell Physiol. 301:C1128-C1139.

Roy DC, Wilke-Mounts SJ, Hocking DC. (2011) Chimeric fibronectin matrix mimetic as a functional growth- and migration-promoting adhesive substrate. Biomaterials. 32:2077-2087.

Ryu SY, Beutner G, Kinnally KW, Dirksen RT, Sheu SS. (2011) Single channel characterization of the mitochondrial ryanodine receptor in heart mitoplasts. J Biol Chem. 286:21324-21329.

Seneviratne AM, Burroughs M, Giralt E, Smrcka AV. (2011) Direct-reversible binding of small molecules to G protein βγ subunits. Biochim Biophys Acta. 1814:1210-1218.

Sheu SS, Dirksen RT, Pugh EN Jr. (2011)The 65th Symposium of the Society for General Physiologists: Energizing research in mitochondrial physiology and medicine. J Gen Physiol. 138:563-567.

Shuttleworth TJ. (2011) Orai3 - the "exceptional" Orai? J Physiol. Oct 31. [Epub ahead of print] PubMed PMID: 22041188.

Sumagin R, Kuebel JM, Sarelius IH. (2011) Leukocyte rolling and adhesion both contribute to regulation of microvascular permeability to albumin via ligation of ICAM-1. Am J Physiol Cell Physiol. 301:C804-C813.

Tae H, Wei L, Willemse H, Mirza S, Gallant EM, Board PG, Dirksen RT, Casarotto MG, Dulhunty A. (2011) The elusive role of the SPRY2 domain in RyR1. Channels (Austin). 5:148-160.

Thomas CJ, Briknarová K, Hilmer JK, Movahed N, Bothner B, Sumida JP, Tall GG, Sprang SR. (2011) The nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Gαi1. PLoS One. 6:e23197.

Thompson JL, Shuttleworth TJ. (2011) Orai channel-dependent activation of phospholipase C-δ: a novel mechanism for the effects of calcium entry on calcium oscillations. J Physiol. 589(Pt 21):5057-5069.

Vellano CP, Shu FJ, Ramineni S, Yates CK, Tall GG, Hepler JR. (2011) Activation of the regulator of G protein signaling 14-Gαi1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A. Biochemistry. 50:752-762.

Wei L, Salahura G, Boncompagni S, Kasischke KA, Protasi F, Sheu SS, Dirksen RT. (2011) Mitochondrial superoxide flashes: metabolic biomarkers of skeletal muscle activity and disease. FASEB J. 25:3068-3078.

Won JH, Zhang Y, Ji B, Logsdon CD, Yule DI. (2011) Phenotypic changes in mouse pancreatic stellate cell Ca2+ signaling events following activation in culture and in a disease model of pancreatitis. Mol Biol Cell. 22:421-436.

Yeomans L, Muthu D, Lowery JJ, Martinez HN, Abrell L, Lin G, Strom K, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. (2011) Phosphorylation of enkephalins: NMR and CD studies in aqueous and membrane-mimicking environments. Chem Biol Drug Des. 78:749-756.

Zhang L, Malik S, Kelley GG, Kapiloff MS, Smrcka AV. (2011) Phospholipase C epsilon scaffolds to muscle-specific A kinase anchoring protein (mAKAPbeta) and integrates multiple hypertrophic stimuli in cardiac myocytes. J Biol Chem. 286:23012-23021.

Zhang T, Yan Z, Sromek A, Knapp BI, Scrimale T, Bidlack JM, Neumeyer JL. (2011) Aminothiazolomorphinans with mixed κ and μ opioid activity. J Med Chem. 54:1903-1913.

Zhang B, Zhang T, Sromek AW, Scrimale T, Bidlack JM, Neumeyer JL. (2011) Synthesis and binding affinity of novel mono- and bivalent morphinan ligands for κ, μ, and δ opioid receptors. Bioorg Med Chem. 19:2808-2816.