Publications

2014 Publications

Gildner CD, Roy DC, Farrar CS, Hocking DC. (2014) Opposing effects of collagen I and vitronectin on fibronectin fibril structure and function. Matrix Biol. 34:33-45.

Goonasekera SA, Davis J, Kwong JQ, Accornero F, Wei-Lapierre L, Sargent MA, Dirksen RT, Molkentin JD. (2014) Enhanced Ca2+ influx from STIM1-Orai1 induces muscle pathology in mouse models of muscular dystrophy. Hum Mol Genet. 23 (14):3706-3715.

Haber SN, Behrens TE. (2014) The Neural Network Underlying Incentive-Based Learning: Implications for Interpreting Circuit Disruptions in Psychiatric Disorders.Neuron. 83 (5):1019-1039.

Heilbronner SR, Haber SN. (2014) Frontal cortical and subcortical projections provide a basis for segmenting the cingulum bundle: implications for neuroimaging and psychiatric disorders.J Neurosci. 23;34(30):10041-10054.

Hocking DC, Raeman CH, Dalecki D. (2014) Investigation of effects of ultrasound on dermal wound healing in diabetic mice. J Acoust Soc Am. 135 (4):2370.

Kamal FA, Mickelsen DM, Wegman KM, Travers JG, Moalem J, Hammes SR, Smrcka AV, Blaxall BC. (2014) Simultaneous adrenal and cardiac g-protein-coupled receptor-gβγ inhibition halts heart failure progression.J Am Coll Cardiol. 63 (23):2549-2557.

Kan W, Adjobo-Hermans M, Burroughs M, Faibis G, Malik S, Tall GG, Smrcka AV. (2014) M3 muscarinic receptor interaction with phospholipase C β3 determines its signaling efficiency.J Biol Chem. 289 (16):11206-11218.

Le NT, Takei Y, Izawa-Ishizawa Y, Heo KS, Lee H, Smrcka AV, Miller BL, Ko KA, Ture S, Morrell C, Fujiwara K, Akaike M, Abe JI. (2014) Identification of Activators of ERK5 Transcriptional Activity by High-Throughput Screening and the Role of Endothelial ERK5 in Vasoprotective Effects Induced by Statins and Antimalarial Agents. J Immunol. 193 (7):3803-3815.

Li Y, St Louis L, Knapp BI, Muthu D, Anglin B, Giuvelis D, Bidlack JM, Bilsky EJ, Polt R. (2014) Can amphipathic helices influence the CNS antinociceptive activity of glycopeptides related to β-endorphin?.J Med Chem. 57 (6):2237-2346.

Maimon N, Titus PA, Sarelius IH. (2014) Pre-exposure to adenosine, acting via A2A receptors on endothelial cells, alters the PKA-dependence of adenosine-induced dilatation in skeletal muscle resistance arterioles. J Physiol. 592 (12):2575-2590.

Mercado KP, Helguera M, Hocking DC, Dalecki D. (2014) Characterizing collagen microstructure using high frequency ultrasound. J Acoust Soc Am. 135 (4):2373.

Mercado KP, Helguera M, Hocking DC, Dalecki D. (2014) Estimating Cell Concentration in Three-Dimensional Engineered Tissues Using High Frequency Quantitative Ultrasound. Ann Biomed Eng. 42 (6):1292-1304.

O-Uchi J, Jhun BS, Xu S, Hurst S, Raffaello A, Liu X, Yi B, Zhang H, Gross P, Mishra J, Ainbinder A, Kettlewell S, Smith GL, Dirksen RT, Wang W, Rizzuto R, Sheu SS. (2014) Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter. Antioxid Redox Signal. 21 (6):863-879.

Oldenburger A, Timens W, Bos S, Smit M, Smrcka AV, Laurent AC, Cao J, Hylkema M, Meurs H, Maarsingh H, Lezoualc'h F, Schmidt M. (2014) Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke.FASEB J. {Publilshed ahead of print}

Riazi S, Kraeva N, Muldoon SM, Dowling J, Ho C, Petre MA, Parness J, Dirksen RT, Rosenberg H (2014) Malignant hyperthermia and the clinical significance of type-1 ryanodine receptor gene (RYR1) variants: proceedings of the 2013 MHAUS Scientific Conference.Can J Anaesth. 61:1040-1049.

Ruisanchez É, Dancs P, Kerék M, Németh T, Faragó B, Balogh A, Patil R, Jennings BL, Liliom K, Malik KU, Smrcka AV, Tigyi G, Benyó Z. (2014) Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase.FASEB J. 28 (2):880-890.

Sevastyanova TN, Kammermeier PJ. (2014) Cooperative Signaling Between Homodimers of Metabotropic Glutamate Receptors 1 and 5.Mol Pharmacol. 86 (5):492-504.

Sromek AW, Provencher BA, Russell S, Chartoff E, Knapp BI, Bidlack JM, Neumeyer JL. (2014) Preliminary Pharmacological Evaluation of Enantiomeric Morphinans.ACS Chem Neurosci. 5 (2): 93-99.

Surve CR, Lehmann D, Smrcka AV. (2014) A Chemical Biology Approach Demonstrates GTP-binding Protein Gβγ Subunits are Sufficient to Mediate Directional Neutrophil Chemotaxis.J Biol Chem. 289 (25):17791-17801.

Wagner LE 2nd, Groom LA, Dirksen RT, Yule DI. (2014) Characterization of ryanodine receptor type 1 single channel activity using "on-nucleus" patch clamp.Cell Calcium. 56:96-107.

Wheeler SG, Hammond CL, Jornayvaz FR, Samuel VT, Shulman GI, Soroka CJ, Boyer JL, Hinkle PM, Ballatori N. (2014) Ostα-/- mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain, and modestly improved insulin sensitivity. Am J Physiol Gastrointest Liver Physiol. 306:G425-G438.

Yarotskyy V, Dirksen RT (2014). Monovalent cationic channel activity in the inner membrane of nuclei from skeletal muscle fibersBiophys J. 107(9):2027-36.

2013 Publications

Alzayady KJ, Chandrasekhar R, Yule DI. (2013) Fragmented Inositol 1,4,5-Trisphosphate Receptors Retain Tetrameric Architecture and Form Functional Ca2+ Release Channels. J. Biol. Chem. 288:11122-11134.

Alzayady KJ, Wagner LE 2nd, Chandrasekhar R, Monteagudo AM, Godiska R, Tall GG, Joseph SK, Yule DI. (2013) Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits. J Biol Chem. 288:29772-29784.

Anders MW. (2013) Exploiting endobiotic metabolic pathways to target xenobiotic antioxidants to mitochondria. Mitochondrion 13 (5) 454-463..

Beqollari D, Kammermeier PJ. (2013) The interaction between mGluR1 and the calcium channel Cav2.1 preserves coupling in the presence of long Homer proteins. Neuropharmacology 66:302-310.

Chan P, Thomas CJ, Sprang SR, Tall GG. (2013) Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein alpha subunits. Proc. Natl. Acad. Sci. U.S.A. 110:3609-3614.

Dusaban SS, Purcell NH, Rockenstein E, Masliah E, Cho MK, Smrcka AV, Brown JH. (2013) Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses. Proc. Natl. Acad. Sci. U.S.A. 110 (9):3609-3614.

Garvin KA, Dalecki D, Yousefhussien M, Helguera M, Hocking DC. (2013) Spatial patterning of endothelial cells and vascular network formation using ultrasound standing wave fields. J Acoust Soc Am. 134:1483-1490.

Garvin KA, Vanderburgh J, Hocking DC, Dalecki D. (2013) Controlling collagen fiber microstructure in three-dimensional hydrogels using ultrasound. J Acoust Soc Am. 134:1491-1502.

Gunter TE, Gerstner B, Gunter KK, Malecki J, Gelein R, Valentine WM, Aschner M, Yule DI. (2013) Manganese Transport via the Transferrin Mechanism. Neurotoxicology 34:118-127.

Haber SN, Heilbronner SR. (2013) Translational research in OCD: circuitry and mechanisms. Neuropsychopharmacology 38:252-253.

Haber SN, Safadi Z, Milad MR. (2013) Meeting report: "Depression and Anxiety Spectrum disorders: from basic science to the clinic and back". Biol. Mood Anxiety Disord. 3:6.

Haynes WIA, Haber SN. (2013) The organization of prefrontal-subthalamic inputs in primates provides an anatomical substrate for both functional specificity and integration: implications for Basal Ganglia models and deep brain stimulation. J. Neurosci. 33:4804-4814.

Hoot MR, Sypek EI, Reilley KJ, Carey AN, Bidlack JM, McLaughlin JP. (2013) Inhibition of Gβγ-subunit signaling potentiates morphine-induced antinociception but not respiratory depression, constipation, locomotion, and reward. Behav. Pharmacol. 24:144-152.

Jbabdi S, Lehman JF, Haber SN, Behrens TE. (2013) Human and Monkey Ventral Prefrontal Fibers Use the Same Organizational Principles to Reach Their Targets: Tracing versus Tractography. J. Neurosci. 33:3190-3201.

Kemeny LV, Schnur A, Czepan M, Rakonczay Z Jr, Gal E, Lonovics J, Lázár G, Simonka Z, Venglovecz V, Maleth J, Judak L, Németh IB, Szabó K, Almássy J, Virag L, Geisz A, Tiszlavicz L, Yule DI, Wittmann T, Varro A, Hegyi P. (2013) Na+/Ca2+ exchangers regulate the migration and proliferation of human gastric myofibroblasts. Am J Physiol Gastrointest Liver Physiol. 305:G552-63

Kraeva N, Zvaritch E, Rossi AE, Goonasekera SA, Zaid H, Frodis W, Kraev A, Dirksen RT, Maclennan DH, Riazi S. (2013) Novel excitation-contraction uncoupled RYR1 mutations in patients with central core disease. Neuromuscul Disord. 23:120-132.

Lefebvre R, Legrand C, Groom L, Dirksen RT, Jacquemond V. (2013) Ca(2+) Release in Muscle Fibers Expressing R4892W and G4896V Type 1 Ryanodine Receptor Disease Mutants.PLoS One 8 (1):e54042.

Mailly P, Aliane V, Groenewegen HJ, Haber SN, Deniau JM. (2013) The Rat Prefrontostriatal System Analyzed in 3D: Evidence for Multiple Interacting Functional Units. J. Neurosci. 33:5718-5727.

McLaughlin NC, Didie ER, Machado AG, Haber SN, Eskandar E, Greenberg BD. (2013) Improvements in anorexia symptoms after deep brain stimulation for intractable obsessive-compulsive disorder. Biol Psychiatry. 73:e29-e31.

Monaco G, Decrock E, Nuyts K, Wagner Ii LE, Luyten T, Strelkov SV, Missiaen L, De Borggraeve WM, Leybaert L, Yule DI, De Smedt H, Parys JB, Bultynck G. (2013) Alpha-Helical Destabilization of the Bcl-2-BH4-Domain Peptide Abolishes Its Ability to Inhibit the IP3 Receptor. PLoS One 8 (8):e73386.

Oner SS, Maher EM, Gabay M, Tall GG, Blumer JB, Lanier SM. (2013) Regulation of the G-protein regulatory-Gαi signaling complex by nonreceptor guanine nucleotide exchange factors.J. Biol. Chem. 288:3003-3015.

Provencher BA, Sromek AW, Li W, Russell SE, Chartoff E, Knapp BI, Bidlack JM, Neumeyer JL. (2013) Synthesis and Pharmacological Evaluation Aminothiazolomorphinans at Mu and Kappa Opioid Receptors. J Med Chem. 14;56(21):8872-8.

Ram R, Wescott AP, Varandas K, Dirksen RT, Blaxall BC. (2013) Mena associates with Rac1 and modulates connexin43 remodeling in cardiomyocytes.Am J Physiol Heart Circ Physiol. 306:H154-H159.

Reifler A, Lenk GM, Li X, Groom L, Brooks SV, Wilson D, Bowerson M, Dirksen RT, Meisler MH, Dowling JJ. (2013) Murine Fig4 is dispensable for muscle development but required for muscle function. Skelet Muscle 3 (21):1-12.

Roy DC, Hocking DC. (2013) Recombinant Fibronectin Matrix Mimetics Specify Integrin Adhesion and Extracellular Matrix Assembly. Tissue Eng. Part A. 19:558-570.

Roy DC, Mooney NA, Raeman CH, Dalecki D, Hocking DC. (2013) Fibronectin matrix mimetics promote full-thickness wound repair in diabetic mice. Tissue Eng Part A. 19 (21-22):2517-26.

Sebag JA, Zhang C, Hinkle PM, Bradshaw AM, Cone RD. (2013) Developmental control of the melanocortin-4 receptor by MRAP2 proteins in zebrafish. Science 341:278-281.

Smrcka AV. (2013) Molecular targeting of Gα and Gβγ subunits: a potential approach for cancer therapeutics. Trends Pharmacol. Sci. 34 (5):290-298.

Sevilla CA, Dalecki D, Hocking DC. (2013) Regional Fibronectin and Collagen Fibril Co-Assembly Directs Cell Proliferation and Microtissue Morphology.PLoS One. 8 (10) :e77316.

Sumagin R, Sarelius IH. (2013) Emerging Understanding of Roles for Arterioles in Inflammation. Microcirculation 20 (8):679-692.

Sun Z, Smrcka AV, Chen S. (2013) WDR26 functions as a scaffolding protein to promote Gβγ-mediated PLCβ2 activation in leukocytes. J. Biol. Chem. 288:16715-16725.

Tall GG. (2013) Ric-8 regulation of heterotrimeric G proteins. J. Recept. Signal. Transduct. Res. 33:139-43.

Tall GG, Patel BR, Chan P. (2013) Ric-8 folding of G proteins better explains Ric-8 apparent amplification of G protein-coupled receptor signaling. Proc. Natl. Acad. Sci. U.S.A. 110 (34):E3148.

Thompson JL, Shuttleworth TJ. (2013) Exploring the unique features of the ARC channel, a Store-independent Orai channel. Channels (Austin) 7 (5):364-73.

Thompson JL, Shuttleworth TJ. (2013) How Many Orai's Does It Take to Make a CRAC Channel? Sci. Rep. 3:1961.

Thompson JL, Shuttleworth TJ. (2013) Molecular basis of activation of the arachidonate-regulated ARC channel, a store-independent Orai channel, by plasma membrane STIM1. J. Physiol. 591:3507-3523.

Thompson JL, Mignen O, Shuttleworth TJ. (2013) The ARC Channel-An Endogenous Store-Independent Orai Channel. Curr Top Membr. 71:125-148.

Tziortzi AC, Haber SN, Searle GE, Tsoumpas C, Long CJ, Shotbolt P, Douaud G, Jbabdi S, Behrens TE, Rabiner EA, Jenkinson M, Gunn RN. (2013) Connectivity-Based Functional Analysis of Dopamine Release in the Striatum Using Diffusion-Weighted MRI and Positron Emission Tomography. Cereb. Cortex. 24 (5):1165-1177.

Vanalstine MA, Wentland MP, Alvarez J, Cao Q, Cohen DJ, Knapp BI, Bidlack JM. (2013) Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 9: Synthesis, characterization and molecular modeling of pyridinyl isosteres of N-BPE-8-CAC (1), a high affinity ligand for opioid receptors. Bioorg. Med. Chem. Lett. 23:2128-2133.

Wei-Lapierre L, Carrell EM, Boncompagni S, Protasi F, Dirksen RT. (2013) Orai1-dependent calcium entry promotes skeletal muscle growth and limits fatigue. Nat Commun. 4:2805.

Wei-Lapierre L, Gong G, Gerstner BJ, Ducreux S, Yule DI, Pouvreau S, Wang X, Sheu SS, Cheng H, Dirksen RT, Wang W. (2013) Respective Contribution of Mitochondrial Superoxide and pH to Mt-cpYFP Flash Activity. J. Biol. Chem. 288:10567-10577.

Xiang SY, Ouyang K, Yung BS, Miyamoto S, Smrcka AV, Chen J, Brown JH. (2013) PLCε, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart.Sci Signal. 6 (306):ra108.

Yarotskyy V, Protasi F, Dirksen RT. (2013) Accelerated Activation of SOCE Current in Myotubes from Two Mouse Models of Anesthetic- and Heat-Induced Sudden Death.PLoS One 8 (10):e77633.

Zhang L, Malik S, Pang J, Wang H, Park KM, Yule DI, Blaxall BC, Smrcka AV. (2013) Phospholipase cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy. Cell 153:216-227.

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Department of Pharmacology and Physiology

University of Rochester Medical Center
601 Elmwood Avenue, Box 711
Rochester, NY 14642

Phone, (585) 275-1679
Fax, (585) 273-2652