2014 Publications

Bansaghi S, Golenar T, Madesh M, Csordas G, Ramachandrarao S, Sharma K, Yule DI, Joseph SK, Hajnoczky G. (2014) Isoform-and species-specific control of IP3 receptors by reactive oxygen species. J Biol Chem. Epub 2014 Jan 27

Dowling JJ, Lawlor MW, Dirksen RT. (2014) Triadopathies: An Emerging Class of Skeletal Muscle Diseases. Neurotherapeutics. 2014 Aug 29. [Epub ahead of print]

Gildner CD, Roy DC, Farrar CS, Hocking DC. (2014) Opposing effects of collagen I and vitronectin on fibronectin fibril structure and function. Matrix Biol. [Epub ahead of print]

Goonasekera SA, Davis J, Kwong JQ, Accornero F, Wei-Lapierre L, Sargent MA, Dirksen RT, Molkentin JD. (2014) Enhanced Ca2+ influx from STIM1-Orai1 induces muscle pathology in mouse models of muscular dystrophy. Hum Mol Genet. [Epub ahead of print]

Kamal FA, Mickelsen DM, Wegman KM, Travers JG, Moalem J, Hammes SR, Smrcka AV, Blaxall BC. (2014) Simultaneous adrenal and cardiac g-protein-coupled receptor-gβγ inhibition halts heart failure progression. J Am Coll Cardiol. 2014 Jun 17; 63(23):2549-57.

Kan W, Adjobo-Hermans M, Burroughs M, Faibis G, Malik S, Tall GG, Smrcka AV. (2014) M3 muscarinic receptor interaction with phospholipase C β3 determines its signaling efficiency. J Biol Chem. 2014 Apr 18;289(16):11206-18. doi: 10.1074/jbc.M113.538546. Epub 2014 Mar 4.

Li Y, St Louis L, Knapp BI, Muthu D, Anglin B, Giuvelis D, Bidlack JM, Bilsky EJ, Polt R. (2014)
J Med Chem. 2014 Mar 27;57(6):2237-46. doi: 10.1021/jm400879w. Epub 2014.
PMID: 24576160 [PubMed - indexed for MEDLINE] Can amphipathic helices influence the CNS antinociceptive activity of glycopeptides related to β-endorphin?

Maimon N, Titus PA, Sarelius IH. (2014) Pre-exposure to adenosine, acting via A2A receptors on endothelial cells, alters the PKA-dependence of adenosine-induced dilatation in skeletal muscle resistance arterioles. J Physiol. [Epub ahead of print]

Mercado KP, Helguera M, Hocking DC, Dalecki D. (2014) Estimating Cell Concentration in Three-Dimensional Engineered Tissues Using High Frequency Quantitative Ultrasound. Ann Biomed Eng.[Epub ahead of print]

O-Uchi J, Jhun BS, Xu S, Hurst S, Raffaello A, Liu X, Yi B, Zhang H, Gross P, Mishra J, Ainbinder A, Kettlewell S, Smith GL, Dirksen RT, Wang W, Rizzuto R, Sheu SS. (2014). <b>Adrenergic signaling regulates mitochondrial Ca</i><sup>2+</sup> uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca</i><sup>2+</sup> uniporter</b> Antioxid Redox Signal. 2014 May 7. [Epub ahead of print]

Ruisanchez É, Dancs P, Kerék M, Németh T, Faragó B, Balogh A, Patil R, Jennings BL, Liliom K, Malik KU, Smrcka AV, Tigyi G, Benyó Z. (2014) Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase. FASEB J. Epub 2013 Nov 18.

Sromek AW, Provencher BA, Russell S, Chartoff E, Knapp BI, Bidlack JM, Neumeyer JL. (2014) Preliminary Pharmacological Evaluation of Enantiomeric Morphinans. ACS Chem Neurosci. [Epub ahead of print]

Surve CR, Lehmann D, Smrcka AV. (2014) A Chemical Biology Approach Demonstrates GTP-binding Protein Gβγ Subunits are Sufficient to Mediate Directional Neutrophil Chemotaxis. J Biol Chem. 2014 May 7. [Epub ahead of print]

Wagner LE 2nd, Groom LA, Dirksen RT, Yule DI. (2014)Characterization of ryanodine receptor type 1 single channel activity using "on-nucleus" patch clamp. Cell Calcium. 2014 Jun 6.

Wheeler SG, Hammond CL, Jornayvaz FR, Samuel VT, Shulman GI, Soroka CJ, Boyer JL, Hinkle PM, Ballatori N. (2014) Ostα-/- mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain, and modestly improved insulin sensitivity. Am J Physiol Gastrointest Liver Physiol. Epub 2013 Dec 31


2013 Publications

Alzayady KJ, Chandrasekhar R, and Yule DI. (2013) Fragmented Inositol 1,4,5-Trisphosphate Receptors Retain Tetrameric Architecture and Form Functional Ca2+ Release Channels. J. Biol. Chem. 288:11122-11134.

Alzayady KJ, Wagner LE 2nd, Chandrasekhar R, Monteagudo AM, Godiska R, Tall GG, Joseph SK, and Yule DI. (2013) Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits. J Biol Chem. 288:29772-29784.

Anders MW. (2013) Exploiting endobiotic metabolic pathways to target xenobiotic antioxidants to mitochondria. Epub.

Beqollari D, and Kammermeier PJ. (2013) The interaction between mGluR1 and the calcium channel Cav2.1 preserves coupling in the presence of long Homer proteins. Neuropharmacology 66:302-310.

Chan P, Thomas CJ, Sprang SR, and Tall GG. (2013) Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein alpha subunits. Proc. Natl. Acad. Sci. U.S.A. 110:3609-3614.

Dusaban SS, Purcell NH, Rockenstein E, Masliah E, Cho MK, Smrcka AV, and Brown JH. (2013) Phospholipase C{varepsilon} links G protein-coupled receptor activation to inflammatory astrocytic responses. Proc. Natl. Acad. Sci. U.S.A. [Epub ahead of print].

Garvin KA, Dalecki D, Yousefhussien M, Helguera M, Hocking DC. (2013) Spatial patterning of endothelial cells and vascular network formation using ultrasound standing wave fields. J Acoust Soc Am. 134:1483-1490.

Garvin KA, Vanderburgh J, Hocking DC, Dalecki D. (2013) Controlling collagen fiber microstructure in three-dimensional hydrogels using ultrasound. J Acoust Soc Am. 134:1491-1502.

Gunter TE, Gerstner B, Gunter KK, Malecki J, Gelein R, Valentine WM, Aschner M, and Yule DI. (2013) Manganese Transport via the Transferrin Mechanism. Neurotoxicology 34:118-127.

Haber SN, and Heilbronner SR. (2013) Translational research in OCD: circuitry and mechanisms. Neuropsychopharmacology 38:252-253.

Haber SN, Safadi Z, and Milad MR. (2013) Meeting report: "Depression and Anxiety Spectrum disorders: from basic science to the clinic and back". Biol. Mood Anxiety Disord. 3:6.

Haynes WI, and Haber SN. (2013) The organization of prefrontal-subthalamic inputs in primates provides an anatomical substrate for both functional specificity and integration: implications for Basal Ganglia models and deep brain stimulation. J. Neurosci. 33:4804-4814.

Hoot MR, Sypek EI, Reilley KJ, Carey AN, Bidlack JM, and McLaughlin JP. (2013) Inhibition of Gβγ-subunit signaling potentiates morphine-induced antinociception but not respiratory depression, constipation, locomotion, and reward. Behav. Pharmacol. 24:144-152.

Jbabdi S, Lehman JF, Haber SN, Behrens TE. (2013) Human and Monkey Ventral Prefrontal Fibers Use the Same Organizational Principles to Reach Their Targets: Tracing versus Tractography. J. Neurosci. 33:3190-3201.

Kemeny LV, Schnur A, Czepan M, Rakonczay Z Jr, Gal E, Lonovics J, Lázár G, Simonka Z, Venglovecz V, Maleth J, Judak L, Németh IB, Szabó K, Almássy J, Virag L, Geisz A, Tiszlavicz L, Yule DI, Wittmann T, Varro A, Hegyi P. (2013) Na+/Ca2+ exchangers regulate the migration and proliferation of human gastric myofibroblasts. Am J Physiol Gastrointest Liver Physiol. 305:G552-63

Kraeva N, Zvaritch E, Rossi AE, Goonasekera SA, Zaid H, Frodis W, Kraev A, Dirksen RT, Maclennan DH, Riazi S. (2013) Novel excitation-contraction uncoupled RYR1 mutations in patients with central core disease. Neuromuscul Disord. 23:120-132.

Lefebvre R, Legrand C, Groom L, Dirksen RT, and Jacquemond V. (2013) Ca(2+) Release in Muscle Fibers Expressing R4892W and G4896V Type 1 Ryanodine Receptor Disease Mutants. PLoS One 8:e54042.

Mailly P, Aliane V, Groenewegen HJ, Haber SN, and Deniau JM. (2013) The Rat Prefrontostriatal System Analyzed in 3D: Evidence for Multiple Interacting Functional Units. J. Neurosci. 33:5718-5727.

McLaughlin NC, Didie ER, Machado AG, Haber SN, Eskandar EN, Greenberg BD. (2013) Improvements in anorexia symptoms after deep brain stimulation for intractable obsessive-compulsive disorder. Biol Psychiatry. 73:e29-e31.

Monaco G, Decrock E, Nuyts K, Wagner Ii LE, Luyten T, Strelkov SV, Missiaen L, De Borggraeve WM, Leybaert L, Yule DI, De Smedt H, Parys JB, Bultynck G. (2013) Alpha-Helical Destabilization of the Bcl-2-BH4-Domain Peptide Abolishes Its Ability to Inhibit the IP3 Receptor. PLoS One 8:e73386.

Oner SS, Maher EM, Gabay M, Tall GG, Blumer JB, and Lanier SM. (2013) Regulation of the G-protein regulatory-Gαi signaling complex by nonreceptor guanine nucleotide exchange factors. J. Biol. Chem. 288:3003-3015.

Provencher BA, Sromek AW, Li W, Russell SE, Chartoff E, Knapp BI, Bidlack JM, and Neumeyer JL. (2013) Synthesis and Pharmacological Evaluation Aminothiazolomorphinans at Mu and Kappa Opioid Receptors. J Med Chem. 14;56(21):8872-8.

Ram R, Wescott AP, Varandas K, Dirksen RT, Blaxall BC. (2013) Mena associates with Rac1 and modulates connexin43 remodeling in cardiomyocytes.Am J Physiol Heart Circ Physiol. [Epub ahead of print]

Reifler A, Lenk GM, Li X, Groom L, Brooks SV, Wilson D, Bowerson M, Dirksen RT, Meisler MH, Dowling JJ. (2013) Murine Fig4 is dispensable for muscle development but required for muscle function. Skelet Muscle [Epub ahead of print]

Roy DC and Hocking DC. (2013) Recombinant Fibronectin Matrix Mimetics Specify Integrin Adhesion and Extracellular Matrix Assembly. Tissue Eng. Part A. 19:558-570.

Roy DC, Mooney NA, Raeman CH, Dalecki D, Hocking DC. Fibronectin matrix mimetics promote full-thickness wound repair in diabetic mice. Tissue Eng Part A. 2013 Nov;19(21-22):2517-26.

Ruisanchez E, Dancs P, Kerék M, Németh T, Faragó B, Balogh A, Patil R, Jennings BL, Liliom K, Malik KU, Smrcka AV, Tigyi G, Benyó Z. (2013) Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase. FASEB J. [Epub ahead of print]

Sebag JA, Zhang C, Hinkle PM, Bradshaw AM, Cone RD. (2013) Developmental control of the melanocortin-4 receptor by MRAP2 proteins in zebrafish. Science 341:278-281.

Smrcka AV. (2013) Molecular targeting of Gα and Gβγ subunits: a potential approach for cancer therapeutics. Trends Pharmacol. Sci. Epub ahead of print]

Sevilla CA, Dalecki D, Hocking DC. (2013) Regional Fibronectin and Collagen Fibril Co-Assembly Directs Cell Proliferation and Microtissue Morphology. PLoS One. 8:e77316.

Sumagin R, and Sarelius IH (2013) Emerging Understanding of Roles for Arterioles in Inflammation. Microcirculation [Epub ahead of print]

Sun Z, Smrcka AV, and Chen S. (2013) WDR26 functions as a scaffolding protein to promote Gβγ-mediated PLCβ2 activation in leukocytes. J. Biol. Chem. 288:16715-16725.

Tall GG (2013) Ric-8 regulation of heterotrimeric G proteins. J. Recept. Signal. Transduct. Res. 33:139-43.

Tall GG, Patel BR, and Chan P (2013) Ric-8 folding of G proteins better explains Ric-8 apparent amplification of G protein-coupled receptor signaling. Proc. Natl. Acad. Sci. U.S.A. [Epub ahead of print]

Thompson JL, and Shuttleworth TJ. (2013) Exploring the unique features of the ARC channel, a Store-independent Orai channel. Channels (Austin) 11;7(5). [Epub ahead of print]

Thompson JL and Shuttleworth TJ (2013) How Many Orai's Does It Take to Make a CRAC Channel? Sci. Rep. 3:1961.

Thompson JL, and Shuttleworth TJ. (2013) Molecular basis of activation of the arachidonate-regulated ARC channel, a store-independent Orai channel, by plasma membrane STIM1. J. Physiol. 591:3507-3523.

Thompson JL, Mignen O, Shuttleworth TJ. (2013) The ARC Channel-An Endogenous Store-Independent Orai Channel. Curr Top Membr. 71:125-148.

Tziortzi AC, Haber SN, Searle GE, Tsoumpas C, Long CJ, Shotbolt P, Douaud G, Jbabdi S, Behrens TE, Rabiner EA, Jenkinson M, and Gunn RN. (2013) Connectivity-Based Functional Analysis of Dopamine Release in the Striatum Using Diffusion-Weighted MRI and Positron Emission Tomography. Cereb. Cortex. [Epub ahead of print]

Vanalstine MA, Wentland MP, Alvarez J, Cao Q, Cohen DJ, Knapp BI, and Bidlack JM. (2013) Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 9: Synthesis, characterization and molecular modeling of pyridinyl isosteres of N-BPE-8-CAC (1), a high affinity ligand for opioid receptors. Bioorg. Med. Chem. Lett. 23:2128-2133.

Wei-Lapierre L, Carrell EM, Boncompagni S, Protasi F, Dirksen RT. Orai1-dependent calcium entry promotes skeletal muscle growth and limits fatigue. Nat Commun. 4:2805.

Wei-Lapierre L, Gong G, Gerstner BJ, Ducreux S, Yule DI, Pouvreau S, Wang X, Sheu SS, Cheng H, Dirksen RT, and Wang W. (2013) Respective Contribution of Mitochondrial Superoxide and pH to Mt-cpYFP Flash Activity. J. Biol. Chem. 288:10567-10577.

Wheeler SG, Hammond CL, Jornayvaz FR, Samuel VT, Shulman GI, Soroka CJ, Boyer JL, Hinkle PM, Ballatori N. (2013) Ostα-/- mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain and modestly improved insulin sensitivity. Am J Physiol Gastrointest Liver Physiol. [Epub ahead of print]

Xiang SY, Ouyang K, Yung BS, Miyamoto S, Smrcka AV, Chen J, Brown JH. (2013) PLC {varepsilon}, PKD1, and SSH1L Transduce RhoA Signaling to Protect Mitochondria from Oxidative Stress in the Heart Sci Signal. 17:6(306)

Yarotskyy V, Protasi F, Dirksen RT. (2013) Accelerated Activation of SOCE Current in Myotubes from Two Mouse Models of Anesthetic- and Heat-Induced Sudden Death.PLoS One 8:e77633.

Zhang L, Malik S, Pang J, Wang H, Park KM, Yule DI, Blaxall BC, and Smrcka AV. (2013) Phospholipase cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy. Cell 153:216-227.

2012 Publications

Almassy J, and Begenisich T. (2012) The LRRC26 protein selectively alters the efficacy of BK channel activators. Mol. Pharmacol. 81:21-30.

Almassy J, Won JH, Begenisich TB, and Yule DI. (2012) Apical Ca2+-activated potassium channels in mouse parotid acinar cells. J. Gen. Physiol. 139:121-133.

Anders MW (2012) Exploiting endobiotic metabolic pathways to target xenobiotic antioxidants to mitochondria. Mitochondrion [Epub ahead of print].

Beqollari D, and Kammermeier PJ (2012) The interaction between mGluR1 and the calcium channel Ca(V2.1) preserves coupling in the presence of long Homer proteins. Neuropharmacology [Epub ahead of print]

Bhattacharya S, Verrill DS, Carbone KM, Brown S, Yule DI, and Giovannucci DR. (2012) Distinct Contributions By Ionotropic Purinoceptor Subtypes To Atp-Evoked Calcium Signals In Mouse Parotid Acinar Cells. J. Physiol. 590:2721-2737.

Christian WV, Li N, Hinkle PM, Ballatori N. (2012) The beta subunit of the Ostα-Ostβ organic solute transporter is required not only for heterodimerization and trafficking but also for function. J. Biol. Chem. 287:21233-21243.

Corr M, Lerman I, Keubel JM, Ronacher L, Misra R, Lund F, Sarelius IH, and Glading AJ. (2012) Decreased Krev Interaction-Trapped 1 Expression Leads to Increased Vascular Permeability and Modifies Inflammatory Responses In Vivo. Arterioscler. Thromb. Vasc. Biol. 32:2702-2710.

Dalecki D and Hocking DC. (2012) Engineering tissues with ultrasound heating, radiation force, and cavitation. J. Acoust. Soc. Am. 132:1907.

Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, Taussig R, Bresnick AR, Nürnberg B, Williams RL, and Backer JM. (2012) G Protein-Coupled Receptor-Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness. Sci. Signal. 5:ra89.

Dean RL, Eyerman D, Todtenkopf MS, Turncliff RZ, Bidlack JM, and Deaver DR. (2012) Effects of oral loperamide on efficacy of naltrexone, baclofen and AM-251 in blocking ethanol self-administration in rats. Pharmacol. Biochem. Behav. 100:530-537.

Dzhura I, Chepurny OG, Kelley GG, Leech CA, Roe MW, Dzhura E, Afshari P, Malik S, Rindler MJ, Xu X, Lu Y, Smrcka AV, and Holz GG. (2012) Epac2-dependent mobilization of intracellular Ca2+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in beta-cells of phospholipase C-epsilon knockout mice. J. Physiol. [Epub ahead of print]

Fernandes KA, Harder JM, Fornarola LB, Freeman RS, Clark AF, Pang IH, John SW, and Libby RT. (2012) JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death. Neurobiol. Dis. 46:393-401.

Gehret AU, and Hinkle PM. (2012) siRNA Screen Identifies the Phosphatase Acting on the G Protein-Coupled Thyrotropin-Releasing Hormone Receptor. ACS Chem. Biol. [Epub ahead of print]

Hinkle PM, Gehret AU, and Jones BW. (2012) Desensitization, trafficking, and resensitization of the pituitary thyrotropin-releasing hormone receptor. Front. Neurosci. 6:180.

Hocking DC, Garvin KA, and Dalecki D. (2012) Ultrasound standing wave fields for tissue engineering. J. Acoust. Soc. Am. 132:1952.

Hu JH, Yang L, Kammermeier PJ, Moore CG, Brakeman PR, Tu J, Yu S, Petralia RS, Li Z, Zhang PW, Park JM, Dong X, Xiao B, and Worley PF (2012) Preso1 dynamically regulates group I metabotropic glutamate receptors. Nat. Neurosci. 15:836-844.

Hyun YM, Sumagin R, Sarangi PP, Lomakina E, Overstreet MG, Baker CM, Fowell DJ, Waugh RE, Sarelius IH, Kim M. (2012) Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels. J. Exp. Med. 209:1349-1362.

Jhun BS, O-Uchi J, Wang W, Ha CH, Zhao J, Kim JY, Wong C, Dirksen RT, Lopes CM, and Jin ZG. (2012) Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1. Circ. Res. 110:59-70.

Kammermeier PJ (2012) Functional and Pharmacological Characteristics of mGluR2/4 heterodimers. Mol. Pharmacol. 82:438-447.

Kammermeier PJ (2012) The orthosteric agonist 2-chloro-5- hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency. BMC Pharmacol. 12:6.

Kraeva N, Zvaritch E, Rossi AE, Goonasekera SA, Zaid H, Frodis W, Kraev A, Dirksen RT, Maclennan DH, and Riazi S. (2012) Novel excitation-contraction uncoupled RYR1 mutations in patients with central core disease. Neuromuscul. Disord. [Epub ahead of print]

Lanner JT, Georgiou DK, Dagnino-Acosta A, Ainbinder A, Cheng Q, Joshi AD, Chen Z, Yarotskyy V, Oakes JM, Lee CS, Monroe TO, Santillan A, Dong K, Goodyear L, Ismailov II, Rodney GG, Dirksen RT, and Hamilton SL. AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation. Nat. Med. 18:244-251.

Li Y, Lefever MR, Muthu D, Bidlack JM, Bilsky EJ, and Polt R (2012) Opioid glycopeptide analgesics derived from endogenous enkephalins and endorphins. Future Med. Chem. 4:205-226.

Liu X, Yu L, Wang Q, Pelletier J, Fausther M, Sevigny J, Malmstroem HS, Dirksen RT, and Ren YF. (2012) Expression of ecto-ATPase NTPDase2 in human dental pulp. J. Dent. Res. 91:261-267.

Loy RE, Lueck JD, Mostajo-Radji MA, Carrell EM, and Dirksen RT. (2012) Allele-specific gene silencing in two mouse models of autosomal dominant skeletal myopathy. PLoS One 7:e49757.

McCoy KL, Gyoneva S, Vellano CP, Smrcka AV, Traynelis SF, and Helper JR. (2012) Protease-activated 1 (PAR1) coupling to G(q/11) but not to G(i/o) or G(12/13) is mediated by discrete amino acids within the receptor second intracellular loop. Cell Signal. 24:1351-1360.

McLaughlin NC, Didie ER, Machado AG, Haber SN, Eskandar EN, Greenberg BD. (2012) Improvements in Anorexia Symptoms After Deep Brain Stimulation for Intractable Obsessive-Compulsive Disorder. Biol. Psychiatry [Epub ahead of print].

Mercado KP, Helguera M, Hocking DC, and Dalecki D. (2012) Parametric imaging of three-dimensional engineered tissue constructs using high-frequency ultrasound. J. Acoust. Soc. Am. 132:2066.

Neumeyer JL, Zhang B, Zhang T, Sromek AW, Knapp BI, Cohen DJ, and Bidlack JM. (2012) Synthesis, binding affinity, and functional In Vitro activity of 3-benzylaminomorphinan and 3-benzylaminomorphine ligands at opioid receptors. J. Med. Chem. 55:3878-3890.

Oner SS, Maher E, Gabay M, Tall GG, Blumer JB, Lanier SM. (2012) Regulation of the GPR-Gαi Signaling Complex by non-receptor Guanine Nucleotide Exchange Factors. J. Biol. Chem. [Epub ahead of print]

Palk L, Sneyd J, Patterson K, Shuttleworth TJ, Yule DI, Maclaren O, Crampin EJ. (2012) Modelling the effects of calcium waves and oscillations on saliva secretion. J Theor Biol. 305C:45-53.

Park HS, Betzenhauser MJ, Zhang Y, and Yule DI. (2012) Regulation of Ca² release through inositol 1,4,5-trisphosphate receptors by adenine nucleotides in parotid acinar cells. Am. J. Physiol. Gastrointest. Liver Physiol. 302:G97-G104.

Patterson K, Catalán MA, Melvin JE, Yule DI, Crampin EJ, and Sneyd J. (2012) A Quantitative Analysis of Electrolyte Exchange in the Salivary Duct. Am. J. Physiol. Gastrointest. Liver Physiol. 303:G1153-G1163.

Sheu SS, Dirksen RT, and Pugh EN Jr. (2012) Perspectives on: SGP Symposium on Mitochondrial Physiology and Medicine: Mitochondria take center stage. J. Gen. Physiol. 139:391-393.

Shuttleworth TJ. (2012) Orai3 - the 'exceptional' Orai? J. Physiol. 590(Pt 2):241-257.

Shuttleworth TJ. (2012 Orai channels - New insights, new ideas. J. Physiol. 590(Pt 17):4155-4156.

Shuttleworth TJ. (2012) STIM and Orai proteins and the non-capacitative ARC channels. Front. Biosci. 17:847-860.

Smrcka AV, Brown JH, and Holz GG. (2012) Role of phospholipase Cε in physiological phosphoinositide signaling networks. Cell Signal. 24:1333-1343.

Strong DR, Haber SN, Tyrka AR, Bernier JA, Rassmussen SA, and Greenberg BD. (2012) Reversible increase in smoking after withdrawal of ventral capsule/ventral striatum deep brain stimulation in a depressed smoker. J. Addict Med. 6:94-95.

Tang ZZ, Yarotskyy V, Wei L, Sobczak K, Nakamori M, Eichinger K, Moxley RT, Dirksen RT, and Thornton CA. (2012) Muscle weakness in myotonic dystrophy associated with misregulated splicing and altered gating of Ca(V)1.1 calcium channel. Hum. Mol. Genet. 21:1312-13124.

Thal DM, Homan KT, Chen J, Wu EK, Hinkle PM, Huang ZM, Chuprun JK, Song J, Gao E, Cheung JY, Sklar LA, Koch WJ, and Tesmer JJ. (2012) Paroxetine Is a Direct Inhibitor of G Protein-Coupled Receptor Kinase 2 and Increases Myocardial Contractility. ACS Chem. Biol. 7:1830-1839.

Thompson J and Begenisich T. (2012) Selectivity filter gating in large-conductance Ca2+-activated K+ channels. J. Gen. Physiol. 139:235-244.

Thompson JL and Shuttleworth TJ. (2012) A plasma membrane-targeted cytosolic domain of STIM1 selectively activates ARC channels, an arachidonate-regulated store-independent Orai channel. Channels 6:370-378.

Wagner LE and Yule DI (2012) Differential regulation of the InsP3 receptor type-1 and -2 single channel properties by InsP3, Ca2+ and ATP. J. Physiol. 590:3245-3259.

Wei L and Dirksen RT (2012) Perspectives on: SGP Symposium on Mitochondrial Physiology and Medicine: Mitochondrial superoxide flashes: From discovery to new controversies. J. Gen. Physiol. 139:425-434.

Wentland MP, Jo S, Gargano JM, Vanalstine MA, Cohen DJ, and Bidlack JM. (2012) Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 8. High affinity ligands for opioid receptors in the picomolar K(i) range: Oxygenated N-(2-[1,1'-biphenyl]-4-ylethyl) analogues of 8-CAC. Bioorg. Med. Chem. Lett. 22:7340-734.

Williams JA and Yule, DI (2012) Stimulus-secretion coupling in pancreatic acinar cells. In: Physiology of the Gastrointestinal Tract, Two Volume Set. Ed., Johnson L, et al., Elsevier, pp. 1361-1398.

Yarotskyy V and Dirksen RT. (2012) Temperature and RyR1 Regulate the Activation Rate of Store-Operated Ca(2+) Entry Current in Myotubes. Biophys. J. 103:202-211.

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Department of Pharmacology and Physiology

University of Rochester Medical Center
601 Elmwood Avenue, Box 711
Rochester, NY 14642

Phone, (585) 275-1679
Fax, (585) 273-2652