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Publications

2013 Publications

Alzayady KJ, Chandrasekhar R, and Yule DI. (2013) Fragmented Inositol 1,4,5-Trisphosphate Receptors Retain Tetrameric Architecture and Form Functional Ca2+ Release Channels. J. Biol. Chem. 288:11122-11134.

Chan P, Thomas CJ, Sprang SR, and Tall GG. (2013) Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein alpha subunits. Proc. Natl. Acad. Sci. U.S.A. 110:3609-3614.

Dusaban SS, Purcell NH, Rockenstein E, Masliah E, Cho MK, Smrcka AV, and Brown JH. (2013) Phospholipase C{varepsilon} links G protein-coupled receptor activation to inflammatory astrocytic responses. Proc. Natl. Acad. Sci. U.S.A. [Epub ahead of print].

Gunter TE, Gerstner B, Gunter KK, Malecki J, Gelein R, Valentine WM, Aschner M, and Yule DI. (2013) Manganese Transport via the Transferrin Mechanism. Neurotoxicology 34:118-127.

Haber SN, and Heilbronner SR. (2013) Translational research in OCD: circuitry and mechanisms. Neuropsychopharmacology 38:252-253.

Haber SN, Safadi Z, and Milad MR. (2013) Meeting report: "Depression and Anxiety Spectrum disorders: from basic science to the clinic and back". Biol. Mood Anxiety Disord. 3:6.

Haynes WI, and Haber SN. (2013) The organization of prefrontal-subthalamic inputs in primates provides an anatomical substrate for both functional specificity and integration: implications for Basal Ganglia models and deep brain stimulation. J. Neurosci. 33:4804-4814.

Hoot MR, Sypek EI, Reilley KJ, Carey AN, Bidlack JM, and McLaughlin JP. (2013) Inhibition of Gβγ-subunit signaling potentiates morphine-induced antinociception but not respiratory depression, constipation, locomotion, and reward. Behav. Pharmacol. [Epub ahead of print].

Jbabdi S, Lehman JF, Haber SN, Behrens TE. (2013) Human and Monkey Ventral Prefrontal Fibers Use the Same Organizational Principles to Reach Their Targets: Tracing versus Tractography. J. Neurosci. 33:3190-3201.

Lefebvre R, Legrand C, Groom L, Dirksen RT, and Jacquemond V. (2013) Ca(2+) Release in Muscle Fibers Expressing R4892W and G4896V Type 1 Ryanodine Receptor Disease Mutants. PLoS One 8:e54042.

Mailly P, Aliane V, Groenewegen HJ, Haber SN, and Deniau JM. (2013) The Rat Prefrontostriatal System Analyzed in 3D: Evidence for Multiple Interacting Functional Units. J. Neurosci. 33:5718-5727.

Oner SS, Maher EM, Gabay M, Tall GG, Blumer JB, and Lanier SM. (2013) Regulation of the G-protein regulatory-Gαi signaling complex by nonreceptor guanine nucleotide exchange factors. J. Biol. Chem. 288:3003-3015.

Roy DC and Hocking DC. (2013) Recombinant Fibronectin Matrix Mimetics Specify Integrin Adhesion and Extracellular Matrix Assembly. Tissue Eng. Part A. 19:558-570.

Smrcka AV. (2013) Molecular targeting of Gα and Gβγ subunits: a potential approach for cancer therapeutics. Trends Pharmacol. Sci. Epub ahead of print]

Sun Z, Smrcka AV, and Chen S. (2013) WDR26 functions as a scaffolding protein to promote Gβγ-mediated PLCβ2 activation in leukocytes. J. Biol. Chem. [Epub ahead of print].

Tall GG (2013) Ric-8 regulation of heterotrimeric G proteins. J. Recept. Signal. Transduct. Res. [Epub ahead of print].

Tziortzi AC, Haber SN, Searle GE, Tsoumpas C, Long CJ, Shotbolt P, Douaud G, Jbabdi S, Behrens TE, Rabiner EA, Jenkinson M, and Gunn RN. (2013) Connectivity-Based Functional Analysis of Dopamine Release in the Striatum Using Diffusion-Weighted MRI and Positron Emission Tomography. Cereb. Cortex. [Epub ahead of print]

Vanalstine MA, Wentland MP, Alvarez J, Cao Q, Cohen DJ, Knapp BI, and Bidlack JM. (2013) Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 9: Synthesis, characterization and molecular modeling of pyridinyl isosteres of N-BPE-8-CAC (1), a high affinity ligand for opioid receptors. Bioorg. Med. Chem. Lett. [Epub ahead of print]

Wei-Lapierre L, Gong G, Gerstner BJ, Ducreux S, Yule DI, Pouvreau S, Wang X, Sheu SS, Cheng H, Dirksen RT, and Wang W. (2013) Respective Contribution of Mitochondrial Superoxide and pH to Mt-cpYFP Flash Activity. J. Biol. Chem. [Epub ahead of print]

Zhang L, Malik S, Pang J, Wang H, Park KM, Yule DI, Blaxall BC, and Smrcka AV. (2013) Phospholipase cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy. Cell 153:216-227.

2012 Publications

Almassy J, and Begenisich T. (2012) The LRRC26 protein selectively alters the efficacy of BK channel activators. Mol. Pharmacol. 81:21-30.

Almassy J, Won JH, Begenisich TB, and Yule DI. (2012) Apical Ca2+-activated potassium channels in mouse parotid acinar cells. J. Gen. Physiol. 139:121-133.

Anders MW (2012) Exploiting endobiotic metabolic pathways to target xenobiotic antioxidants to mitochondria. Mitochondrion [Epub ahead of print].

Beqollari D, and Kammermeier PJ (2012) The interaction between mGluR1 and the calcium channel Ca(V2.1) preserves coupling in the presence of long Homer proteins. Neuropharmacology [Epub ahead of print]

Bhattacharya S, Verrill DS, Carbone KM, Brown S, Yule DI, and Giovannucci DR. (2012) Distinct Contributions By Ionotropic Purinoceptor Subtypes To Atp-Evoked Calcium Signals In Mouse Parotid Acinar Cells. J. Physiol. 590:2721-2737.

Christian WV, Li N, Hinkle PM, Ballatori N. (2012) The beta subunit of the Ostα-Ostβ organic solute transporter is required not only for heterodimerization and trafficking but also for function. J. Biol. Chem. 287:21233-21243.

Corr M, Lerman I, Keubel JM, Ronacher L, Misra R, Lund F, Sarelius IH, and Glading AJ. (2012) Decreased Krev Interaction-Trapped 1 Expression Leads to Increased Vascular Permeability and Modifies Inflammatory Responses In Vivo. Arterioscler. Thromb. Vasc. Biol. 32:2702-2710.

Dalecki D and Hocking DC. (2012) Engineering tissues with ultrasound heating, radiation force, and cavitation. J. Acoust. Soc. Am. 132:1907.

Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, Taussig R, Bresnick AR, Nürnberg B, Williams RL, and Backer JM. (2012) G Protein-Coupled Receptor-Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness. Sci. Signal. 5:ra89.

Dean RL, Eyerman D, Todtenkopf MS, Turncliff RZ, Bidlack JM, and Deaver DR. (2012) Effects of oral loperamide on efficacy of naltrexone, baclofen and AM-251 in blocking ethanol self-administration in rats. Pharmacol. Biochem. Behav. 100:530-537.

Dzhura I, Chepurny OG, Kelley GG, Leech CA, Roe MW, Dzhura E, Afshari P, Malik S, Rindler MJ, Xu X, Lu Y, Smrcka AV, and Holz GG. (2012) Epac2-dependent mobilization of intracellular Ca2+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in beta-cells of phospholipase C-epsilon knockout mice. J. Physiol. [Epub ahead of print]

Fernandes KA, Harder JM, Fornarola LB, Freeman RS, Clark AF, Pang IH, John SW, and Libby RT. (2012) JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death. Neurobiol. Dis. 46:393-401.

Gehret AU, and Hinkle PM. (2012) siRNA Screen Identifies the Phosphatase Acting on the G Protein-Coupled Thyrotropin-Releasing Hormone Receptor. ACS Chem. Biol. [Epub ahead of print]

Hinkle PM, Gehret AU, and Jones BW. (2012) Desensitization, trafficking, and resensitization of the pituitary thyrotropin-releasing hormone receptor. Front. Neurosci. 6:180.

Hocking DC, Garvin KA, and Dalecki D. (2012) Ultrasound standing wave fields for tissue engineering. J. Acoust. Soc. Am. 132:1952.

Hu JH, Yang L, Kammermeier PJ, Moore CG, Brakeman PR, Tu J, Yu S, Petralia RS, Li Z, Zhang PW, Park JM, Dong X, Xiao B, and Worley PF (2012) Preso1 dynamically regulates group I metabotropic glutamate receptors. Nat. Neurosci. 15:836-844.

Hyun YM, Sumagin R, Sarangi PP, Lomakina E, Overstreet MG, Baker CM, Fowell DJ, Waugh RE, Sarelius IH, Kim M. (2012) Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels. J. Exp. Med. 209:1349-1362.

Jhun BS, O-Uchi J, Wang W, Ha CH, Zhao J, Kim JY, Wong C, Dirksen RT, Lopes CM, and Jin ZG. (2012) Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1. Circ. Res. 110:59-70.

Kammermeier PJ (2012) Functional and Pharmacological Characteristics of mGluR2/4 heterodimers. Mol. Pharmacol. 82:438-447.

Kammermeier PJ (2012) The orthosteric agonist 2-chloro-5- hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency. BMC Pharmacol. 12:6.

Kraeva N, Zvaritch E, Rossi AE, Goonasekera SA, Zaid H, Frodis W, Kraev A, Dirksen RT, Maclennan DH, and Riazi S. (2012) Novel excitation-contraction uncoupled RYR1 mutations in patients with central core disease. Neuromuscul. Disord. [Epub ahead of print]

Lanner JT, Georgiou DK, Dagnino-Acosta A, Ainbinder A, Cheng Q, Joshi AD, Chen Z, Yarotskyy V, Oakes JM, Lee CS, Monroe TO, Santillan A, Dong K, Goodyear L, Ismailov II, Rodney GG, Dirksen RT, and Hamilton SL. AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation. Nat. Med. 18:244-251.

Li Y, Lefever MR, Muthu D, Bidlack JM, Bilsky EJ, and Polt R (2012) Opioid glycopeptide analgesics derived from endogenous enkephalins and endorphins. Future Med. Chem. 4:205-226.

Liu X, Yu L, Wang Q, Pelletier J, Fausther M, Sevigny J, Malmstroem HS, Dirksen RT, and Ren YF. (2012) Expression of ecto-ATPase NTPDase2 in human dental pulp. J. Dent. Res. 91:261-267.

Loy RE, Lueck JD, Mostajo-Radji MA, Carrell EM, and Dirksen RT. (2012) Allele-specific gene silencing in two mouse models of autosomal dominant skeletal myopathy. PLoS One 7:e49757.

McCoy KL, Gyoneva S, Vellano CP, Smrcka AV, Traynelis SF, and Helper JR. (2012) Protease-activated 1 (PAR1) coupling to G(q/11) but not to G(i/o) or G(12/13) is mediated by discrete amino acids within the receptor second intracellular loop. Cell Signal. 24:1351-1360.

McLaughlin NC, Didie ER, Machado AG, Haber SN, Eskandar EN, Greenberg BD. (2012) Improvements in Anorexia Symptoms After Deep Brain Stimulation for Intractable Obsessive-Compulsive Disorder. Biol. Psychiatry [Epub ahead of print].

Mercado KP, Helguera M, Hocking DC, and Dalecki D. (2012) Parametric imaging of three-dimensional engineered tissue constructs using high-frequency ultrasound. J. Acoust. Soc. Am. 132:2066.

Neumeyer JL, Zhang B, Zhang T, Sromek AW, Knapp BI, Cohen DJ, and Bidlack JM. (2012) Synthesis, binding affinity, and functional In Vitro activity of 3-benzylaminomorphinan and 3-benzylaminomorphine ligands at opioid receptors. J. Med. Chem. 55:3878-3890.

Oner SS, Maher E, Gabay M, Tall GG, Blumer JB, Lanier SM. (2012) Regulation of the GPR-Gαi Signaling Complex by non-receptor Guanine Nucleotide Exchange Factors. J. Biol. Chem. [Epub ahead of print]

Palk L, Sneyd J, Patterson K, Shuttleworth TJ, Yule DI, Maclaren O, Crampin EJ. (2012) Modelling the effects of calcium waves and oscillations on saliva secretion. J Theor Biol. 305C:45-53.

Park HS, Betzenhauser MJ, Zhang Y, and Yule DI. (2012) Regulation of Ca² release through inositol 1,4,5-trisphosphate receptors by adenine nucleotides in parotid acinar cells. Am. J. Physiol. Gastrointest. Liver Physiol. 302:G97-G104.

Patterson K, Catalán MA, Melvin JE, Yule DI, Crampin EJ, and Sneyd J. (2012) A Quantitative Analysis of Electrolyte Exchange in the Salivary Duct. Am. J. Physiol. Gastrointest. Liver Physiol. 303:G1153-G1163.

Sheu SS, Dirksen RT, and Pugh EN Jr. (2012) Perspectives on: SGP Symposium on Mitochondrial Physiology and Medicine: Mitochondria take center stage. J. Gen. Physiol. 139:391-393.

Shuttleworth TJ. (2012) Orai3 - the 'exceptional' Orai? J. Physiol. 590(Pt 2):241-257.

Shuttleworth TJ. (2012 Orai channels - New insights, new ideas. J. Physiol. 590(Pt 17):4155-4156.

Shuttleworth TJ. (2012) STIM and Orai proteins and the non-capacitative ARC channels. Front. Biosci. 17:847-860.

Smrcka AV, Brown JH, and Holz GG. (2012) Role of phospholipase Cε in physiological phosphoinositide signaling networks. Cell Signal. 24:1333-1343.

Strong DR, Haber SN, Tyrka AR, Bernier JA, Rassmussen SA, and Greenberg BD. (2012) Reversible increase in smoking after withdrawal of ventral capsule/ventral striatum deep brain stimulation in a depressed smoker. J. Addict Med. 6:94-95.

Tang ZZ, Yarotskyy V, Wei L, Sobczak K, Nakamori M, Eichinger K, Moxley RT, Dirksen RT, and Thornton CA. (2012) Muscle weakness in myotonic dystrophy associated with misregulated splicing and altered gating of Ca(V)1.1 calcium channel. Hum. Mol. Genet. 21:1312-13124.

Thal DM, Homan KT, Chen J, Wu EK, Hinkle PM, Huang ZM, Chuprun JK, Song J, Gao E, Cheung JY, Sklar LA, Koch WJ, and Tesmer JJ. (2012) Paroxetine Is a Direct Inhibitor of G Protein-Coupled Receptor Kinase 2 and Increases Myocardial Contractility. ACS Chem. Biol. 7:1830-1839.

Thompson J and Begenisich T. (2012) Selectivity filter gating in large-conductance Ca2+-activated K+ channels. J. Gen. Physiol. 139:235-244.

Thompson JL and Shuttleworth TJ. (2012) A plasma membrane-targeted cytosolic domain of STIM1 selectively activates ARC channels, an arachidonate-regulated store-independent Orai channel. Channels 6:1-9.

Wagner LE and Yule DI (2012) Differential regulation of the InsP3 receptor type-1 and -2 single channel properties by InsP3, Ca2+ and ATP. J. Physiol. 590:3245-3259.

Wei L and Dirksen RT (2012) Perspectives on: SGP Symposium on Mitochondrial Physiology and Medicine: Mitochondrial superoxide flashes: From discovery to new controversies. J. Gen. Physiol. 139:425-434.

Wentland MP, Jo S, Gargano JM, Vanalstine MA, Cohen DJ, and Bidlack JM. (2012) Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 8. High affinity ligands for opioid receptors in the picomolar K(i) range: Oxygenated N-(2-[1,1'-biphenyl]-4-ylethyl) analogues of 8-CAC. Bioorg. Med. Chem. Lett. [Epub ahead of print].

Williams JA and Yule, DI (2012) Stimulus-secretion coupling in pancreatic acinar cells. In: Physiology of the Gastrointestinal Tract, Two Volume Set. Ed., Johnson L, et al., Elsevier, pp. 1361-1398.

Yarotskyy V and Dirksen RT. (2012) Temperature and RyR1 Regulate the Activation Rate of Store-Operated Ca(2+) Entry Current in Myotubes. Biophys. J. 103:202-211.

2011 Publications

Anders MW. (2011) Putting bioactivation reactions to work: Targeting antioxidants to mitochondria. Chem Biol Interact. 192:8-13.

Balboni G, Salvadori S, Marczak ED, Knapp BI, Bidlack JM, Lazarus LH, Peng X, Si YG, Neumeyer JL. (2011) Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic. Eur J Med Chem. 46:799-803.

Board PG, Anders MW. (2011) Glutathione transferase zeta: discovery, polymorphic variants, catalysis, inactivation, and properties of Gstz1-/- mice. Drug Metab Rev. 43:215-225.

Chan P, Gabay M, Wright FA, Tall GG. (2011) Ric-8B is a GTP-dependent G protein alphas guanine nucleotide exchange factor. J Biol Chem. 286:19932-19942.

Chan P, Gabay M, Wright FA, Kan W, Oner SS, Lanier SM, Smrcka AV, Blumer JB, Tall GG. (2011) Purification of heterotrimeric G protein alpha subunits by GST-Ric-8 association: primary characterization of purified G alpha(olf). J Biol Chem. 286:2625-2635.

Dean RL, Eyerman D, Todtenkopf MS, Turncliff RZ, Bidlack JM, Deaver DR. (2011) Effects of oral loperamide on efficacy of naltrexone, baclofen and AM-251 in blocking ethanol self-administration in rats. Pharmacol Biochem Behav. 100:530-537.

Dzhura I, Chepurny OG, Leech CA, Roe MW, Dzhura E, Xu X, Lu Y, Schwede F, Genieser HG, Smrcka AV, Holz GG. (2011) Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans. Islets. 3:121-128.

Gabay M, Pinter ME, Wright FA, Chan P, Murphy AJ, Valenzuela DM, Yancopoulos GD, Tall GG. (2011) Ric-8 proteins are molecular chaperones that direct nascent G protein α subunit membrane association. Sci Signal. 4:ra79.

Garvin KA, Dalecki D, Hocking DC. (2011) Vascularization of three-dimensional collagen hydrogels using ultrasound standing wave fields. Ultrasound Med Biol. 37:1853-1864.

Guo H, Barrett TM, Zhong Z, Fernández JA, Griffin JH, Freeman RS, Zlokovic BV. (2011) Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway. Mol Neurodegener. 6:13.

Groom L, Muldoon SM, Tang ZZ, Brandom BW, Bayarsaikhan M, Bina S, Lee HS, Qiu  X, Sambuughin N, Dirksen RT. (2011) Identical de novo mutation in the type 1 ryanodine receptor gene associated with fatal, stress-induced malignant hyperthermia in two unrelated families. Anesthesiology. 115:938-945.

Haber SN (2011) Neuroanatomy of Reward: A View from the Ventral Striatum. In, Neurobiology of Sensation and Reward, Gottfried JA, editor, Boca Raton (FL): CRC Press; Chapter 11.

Hinkle PM, Serasinghe MN, Jakabowski A, Sebag JA, Wilson KR, Haskell-Luevano C. (2011) Use of chimeric melanocortin-2 and -4 receptors to identify regions responsible for ligand specificity and dependence on melanocortin 2 receptor accessory protein. Eur J Pharmacol. 660:94-102.

Hough LB, Nalwalk JW, Yang J, Conroy JL, VanAlstine MA, Yang W, Gargano J, Shan Z, Zhang SZ, Wentland MP, Phillips JG, Knapp BI, Bidlack JM, Zuiderveld OP, Leurs R, Ding X. (2011) Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic. Pain. 152:878-887.

Huang Z, Zhang W, Fang H, Zheng M, Wang X, Xu J, Cheng H, Gong G, Wang W, Dirksen RT, Sheu SS. (2011) Response to "A critical evaluation of cpYFP as a probe for superoxide". Free Radic Biol Med. 51:1937-1940.

Jhun BS, O-Uchi J, Wang W, Ha CH, Zhao J, Kim JY, Wong C, Dirksen RT, Lopes CM, Jin ZG. (2011) Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1. Circ Res. Nov 10. [Epub ahead of print] PubMed PMID: 22076634.

Kamal FA, Smrcka AV, Blaxall BC. (2011) Taking the heart failure battle inside the cell: small molecule targeting of Gβγ subunits. J Mol Cell Cardiol. 51:462-467.

Lefebvre R, Legrand C, González-Rodríguez E, Groom L, Dirksen RT, Jacquemond V. (2011) Defects in Ca2+ release associated with local expression of pathological ryanodine receptors in mouse muscle fibres. J Physiol. 589(Pt 22):5361-5382.

Lefort CT, Wojciechowski K, Hocking DC. (2011) N-cadherin cell-cell adhesion complexes are regulated by fibronectin matrix assembly. J Biol Chem. 286:3149-3160.

Lehman JF, Greenberg BD, McIntyre CC, Rasmussen SA, Haber SN. (2011) Rules ventral prefrontal cortical axons use to reach their targets: implications for diffusion  tensor imaging tractography and deep brain stimulation for psychiatric illness. J Neurosci. 31:10392-10402.

Liang L, Sebag JA, Eagelston L, Serasinghe MN, Veo K, Reinick C, Angleson J, Hinkle PM, Dores RM. (2011) Functional expression of frog and rainbow trout melanocortin 2 receptors using heterologous MRAP1s. Gen Comp Endocrinol. 1745-14.

Lin Y, Smrcka AV. (2011) Understanding molecular recognition by G protein βγ subunits on the path to pharmacological targeting. Mol Pharmacol. 80:551-557.

Lowery JJ, Raymond TJ, Giuvelis D, Bidlack JM, Polt R, Bilsky EJ. (2011) In vivo characterization of MMP-2200, a mixed δ/μ opioid agonist, in mice. J Pharmacol Exp Ther. 336:767-778.

Loy RE, Orynbayev M, Xu L, Andronache Z, Apostol S, Zvaritch E, MacLennan DH, Meissner G, Melzer W, Dirksen RT. (2011) Muscle weakness in Ryr1I4895T/WT knock-in mice  as a result of reduced ryanodine receptor Ca2+ ion permeation and release from the sarcoplasmic reticulum. J Gen Physiol. 137:43-57.

Park H, Betzenhauser MJ, Zhang Y, Yule DI. (2011) Regulation of Ca2+ release through inositol 1,4,5-trisphosphate receptors by adenine nucleotides in parotid acinar cells. Am J Physiol Gastrointest Liver Physiol. [Epub ahead of print]

Park MS, Smrcka AV, Stern HA. (2011) Conformational flexibility and binding interactions of the G protein βγ heterodimer. Proteins. 79:518-527.

Pashkov V, Huang J, Parameswara VK, Kedzierski W, Kurrasch DM, Tall GG, Esser V, Gerard RD, Uyeda K, Towle HC, Wilkie TM. (2011) Regulator of G protein signaling (RGS16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner. J Biol Chem. 286:15116-15125.

Rosin B, Slovik M, Mitelman R, Rivlin-Etzion M, Haber SN, Israel Z, Vaadia E,  Bergman H. (2011) Closed-loop deep brain stimulation is superior in ameliorating parkinsonism. Neuron. 72:370-384.

Rossi AE, Boncompagni S, Wei L, Protasi F, Dirksen RT. (2011) Differential impact of mitochondrial positioning on mitochondrial Ca(2+) uptake and Ca(2+) spark suppression in skeletal muscle. Am J Physiol Cell Physiol. 301:C1128-C1139.

Roy DC, Wilke-Mounts SJ, Hocking DC. (2011) Chimeric fibronectin matrix mimetic as a functional growth- and migration-promoting adhesive substrate. Biomaterials. 32:2077-2087.

Ryu SY, Beutner G, Kinnally KW, Dirksen RT, Sheu SS. (2011) Single channel characterization of the mitochondrial ryanodine receptor in heart mitoplasts. J Biol Chem. 286:21324-21329.

Seneviratne AM, Burroughs M, Giralt E, Smrcka AV. (2011) Direct-reversible binding of small molecules to G protein βγ subunits. Biochim Biophys Acta. 1814:1210-1218.

Sheu SS, Dirksen RT, Pugh EN Jr. (2011)The 65th Symposium of the Society for General Physiologists: Energizing research in mitochondrial physiology and medicine. J Gen Physiol. 138:563-567.

Shuttleworth TJ. (2011) Orai3 - the "exceptional" Orai? J Physiol. Oct 31. [Epub ahead of print] PubMed PMID: 22041188.

Sumagin R, Kuebel JM, Sarelius IH. (2011) Leukocyte rolling and adhesion both contribute to regulation of microvascular permeability to albumin via ligation of ICAM-1. Am J Physiol Cell Physiol. 301:C804-C813.

Tae H, Wei L, Willemse H, Mirza S, Gallant EM, Board PG, Dirksen RT, Casarotto MG, Dulhunty A. (2011) The elusive role of the SPRY2 domain in RyR1. Channels (Austin). 5:148-160.

Thomas CJ, Briknarová K, Hilmer JK, Movahed N, Bothner B, Sumida JP, Tall GG, Sprang SR. (2011) The nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Gαi1. PLoS One. 6:e23197.

Thompson JL, Shuttleworth TJ. (2011) Orai channel-dependent activation of phospholipase C-δ: a novel mechanism for the effects of calcium entry on calcium oscillations. J Physiol. 589(Pt 21):5057-5069.

Vellano CP, Shu FJ, Ramineni S, Yates CK, Tall GG, Hepler JR. (2011) Activation of the regulator of G protein signaling 14-Gαi1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A. Biochemistry. 50:752-762.

Wei L, Salahura G, Boncompagni S, Kasischke KA, Protasi F, Sheu SS, Dirksen RT. (2011) Mitochondrial superoxide flashes: metabolic biomarkers of skeletal muscle activity and disease. FASEB J. 25:3068-3078.

Won JH, Zhang Y, Ji B, Logsdon CD, Yule DI. (2011) Phenotypic changes in mouse pancreatic stellate cell Ca2+ signaling events following activation in culture and in a disease model of pancreatitis. Mol Biol Cell. 22:421-436.

Yeomans L, Muthu D, Lowery JJ, Martinez HN, Abrell L, Lin G, Strom K, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. (2011) Phosphorylation of enkephalins: NMR and CD studies in aqueous and membrane-mimicking environments. Chem Biol Drug Des. 78:749-756.

Zhang L, Malik S, Kelley GG, Kapiloff MS, Smrcka AV. (2011) Phospholipase C epsilon scaffolds to muscle-specific A kinase anchoring protein (mAKAPbeta) and integrates multiple hypertrophic stimuli in cardiac myocytes. J Biol Chem. 286:23012-23021.

Zhang T, Yan Z, Sromek A, Knapp BI, Scrimale T, Bidlack JM, Neumeyer JL. (2011) Aminothiazolomorphinans with mixed κ and μ opioid activity. J Med Chem. 54:1903-1913.

Zhang B, Zhang T, Sromek AW, Scrimale T, Bidlack JM, Neumeyer JL. (2011) Synthesis and binding affinity of novel mono- and bivalent morphinan ligands for κ, μ, and δ opioid receptors. Bioorg Med Chem. 19:2808-2816.