Smrcka Lab

Alan V. Smrcka, Ph.D.

Alan V. Smrcka, Ph.D.
View Smrcka profile
Professor and Louis C. Lasagna Professor of Experimental Therapeutics

Affiliations:

Postdoctoral Positions Available

A postdoctoral position is available in Dr. Smrcka's laboratory. Please click here to view the position description and contact Dr. Alan V. Smrcka at alan_smrcka@urmc.rochester.edu for more information.

Research Overview

We work with the tools of biology, chemistry, and genetics to understand basic mechanisms of cellular signaling and develop therapeutic strategies for heart disease, cancer, and inflammatory diseases.

Smrcka Researh

G protein coupled receptors (GPCRs) form a large family of cell surface receptors responsible for triggering cellular responses to a large number of extracellular stimuli including hormones such as adrenaline, serotonin, or acetylcholine and receive sensory stimuli responsible for perception of light, smell, and taste. This family of receptors is an important target for pharmaceuticals and defects in GPCR systems and are responsible for a number of diseases. All GPCRs function through activation of trimeric G proteins located on the inner surface of the plasma membrane. When GPCRs interact with an activating ligand they bind to the G protein and catalyze their activation. The activated G proteins then target ion channels or enzymes that produce second messengers to regulate cell physiology and growth.

We use chemical, structural and genetic methods to understand and manipulate G protein pathways.  Because of the underlying involvement of G protein signaling in many aspects of cellular physiology, targeting these pathways has many implications for therapy.

Projects

G Proteins

G Proteins

 

Phospholipases

Phospholipases

 

Recent Publications

Oldenburger A, Timens W, Bos S, Smit M, Smrcka AV, Laurent AC, Cao J, Hylkema M, Meurs H, Maarsingh H, Lezoualc'h F, Schmidt M. (2014) Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke. FASEB J. [Epub ahead of print]

Surve CR, Lehmann D, Smrcka AV. (2014) A Chemical Biology Approach Demonstrates G Protein βγ Subunits Are Sufficient to Mediate Directional Neutrophil Chemotaxis. J Biol Chem. 289:17791-17801.

Kamal FA, Mickelsen DM, Wegman KM, Travers JG, Moalem J, Hammes SR, Smrcka AV, Blaxall BC. (2014) Simultaneous adrenal and cardiac g-protein-coupled receptor-gβγ inhibition halts heart failure progression. J Am Coll Cardiol. 17;63:2549-2557.

Kan W, Adjobo-Hermans M, Burroughs M, Faibis G, Malik S, Tall GG, Smrcka AV. (2014) M3 muscarinic receptor interaction with phospholipase C β3 determines its signaling efficiency. J Biol Chem. 289:11206-11218.

Xiang SY, Ouyang K, Yung BS, Miyamoto S, Smrcka AV, Chen J, Heller Brown J. (2013) PLCε, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart. Sci Signal. 6:ra108.

Ruisanchez É, Dancs P, Kerék M, Németh T, Faragó B, Balogh A, Patil R, Jennings BL, Liliom K, Malik KU, Smrcka AV, Tigyi G, Benyó Z. (2013) Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase. FASEB J. 28:880-890.

Smrcka AV. (2013) Molecular targeting of Gα and Gβγ subunits: a potential approach for cancer therapeutics. Trends Pharmacol Sci. 34:290-298.

Zhang L, Malik S, Pang J, Wang H, Park KM, Yule DI, Blaxall BC, and Smrcka AV. (2013) Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy. Cell. 153:216-227.

More papers

Contact Us

Alan V. Smrcka, Ph.D.
University of Rochester
School of Medicine and Dentistry
Box 711
601 Elmwood Avenue
Rochester, NY 14642

Telephone: 585-275-0892
Fax: 585-273-2652

Alan_Smrcka@
urmc.rochester.edu

Lab Members

Burroughs Michael B. Burroughs
Technical Staff
Rafael Gil de Rubio Rafael H. Gil de Rubio
Graduate Student, Pharmacology and Physiology Ph.D. Program
Malik Sundeep Malik
Research Faculty
Chinmay R. Surve Chinmay R. Surve
Graduate Student, Biochemistry and Biophysics Ph.D. Program
Jesi Lee Anne To Jesi Lee Anne To
Graduate Student, Pharmacology and Physiology Ph.D. Program
Ward Nancy C. Ward
Technical Staff