Tall Lab

Gregory G. Tall, Ph.D.

Gregory G. Tall, Ph.D.
View Tall profile
Assistant Professor

Affiliations:

Research Overview

In canonical G protein signaling, G protein coupled receptors (GPCRs) activate heterotrimeric G proteins, which in turn regulate intracellular effector enzymes.  Our lab studies G protein signaling and new classes of enzymes that activate heterotrimeric G proteins apart from GPCR-initiated activation.  We found the biochemical function of one new G protein activator, Ric-8.  Ric-8A activates G protein alpha subunits by serving as a guanine nucleotide exchange catalyst.   A major focus of our research group is to investigate the physiological roles that Ric-8 proteins have in directing non-traditional G protein signaling pathways in the cell.  Observations made in genetic model systems suggest that Ric-8 proteins work with G proteins to regulate asymmetric cell division, the subcellular localization of G protein subunits, and as modulators of traditional GPCR signaling.

Research Projects

Guanine Nucleotide Exchange Factors

Enzymology and Structural/Functional Biology of Ric-8 G Protein Guanine Nucleotide Exchange Factors (GEFs)

Cell division

Ric-8 and G Protein Control of (Asymmetric) Cell Division

Embryonic stem cell models

Embryonic Stem Cell Models to Ascertain Ric-8 Function

Stable mouse cell line

Intracellular Trafficking of G Proteins

 

Purification of G Proteins

Recent Publications

Chan P, Thomas CJ, Sprang SR, Tall GG. (2013) Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein α subunits. Proc Natl Acad Sci U S A. [Epub ahead of print]

Oner SS, Maher EM, Gabay M, Tall GG, Blumer JB, and Lanier SM. (2013) Regulation of the G-protein regulatory-Gαi signaling complex by nonreceptor guanine nucleotide exchange factors. J. Biol. Chem. 288:3003-3015.

Tall GG. (2013) Ric-8 regulation of heterotrimeric G proteins. J Recept Signal Transduct Res. [Epub ahead of print]

Oner SS, Maher EM, Gabay M, Tall GG, Blumer JB, Lanier SM. (2013) Regulation of the G-protein Regulatory-Gαi Signaling Complex by Nonreceptor Guanine Nucleotide Exchange Factors. J Biol Chem. 288:3003-3015.

Chan P, Gabay M, Wright FA, and Tall GG. (2011) Ric-8B is a GTP-dependent G protein {alpha}s guanine nucleotide exchange factor. J. Biol. Chem. 286:19932-19942.

More papers

Contact Us

Gregory G. Tall, Ph.D.
University of Rochester
School of Medicine and Dentistry
Box 711
601 Elmwood Avenue
Rochester, NY 14642

Telephone: 585-273-2069
Fax: 585-273-2652

Gregory_Tall@
urmc.rochester.edu

Lab Members

Makaia M. Papasergi
Graduate Student
Ph.D. Program
Bharti R. Patel
Graduate Student
Ph.D. Program
Hannah_Stoveken
Graduate Student
Ph.D. Program
Elena Marvin
Technical Associate I