Mitochondria and Pathophysiology

The Department has a large mitochondrial group, centered on understanding the physiology of mitochondria and their interactions with the rest of the cell. This includes studying fundamental properties of mitochondria such as their size, shape, and redox status, as well as specific metabolic properties.  Historic interactions with the ion channel group in the department have fostered a number of studies on mitochondrial ion channels, in particular those transporting Ca2+ and K+.  More recently it has become apparent that mitochondria are important in a number of pathologies, including cardiovascular, neurodegenerative, muscular, and metabolic diseases.  This has led to their consideration as a potential drug target, and in collaboration with the Department of Anesthesiology, several members of the group are developing and testing mitochondrially targeted small molecules for the treatment of diverse diseases.Our research areas include the following:

M. W. Anders, D.V.M., Ph.D.

M. W. Anders, D.V.M., Ph.D.

Anders Research

Paul S. Brookes, Ph.D.

Paul S. Brookes, Ph.D.

Paul S. Brookes, Ph.D.
Dirksen Research
Johnson Research
Nehrke Research
Yule Research

 

Get In Touch

Department of Pharmacology and Physiology

University of Rochester Medical Center
601 Elmwood Avenue, Box 711
Rochester, NY 14642

Phone, (585) 275-1679
Fax, (585) 273-2652