2009 Program

Thursday, October 15, 2009

2:00 p.m. -

Registration (Vanden Brul Pavilion)

4:20 – 4:30 p.m.

Welcome (Gallery Auditorium)

(No food or beverages are allowed in the Gallery Auditorium.)

Session I:  Van Tol Symposium, The Hubert Van Tol Model Organism Symposium (Gallery Auditorium)
Session Chair: Stephen Ferguson

4:30 – 4:45 p.m.

Introductory Remarks

4:45 – 5:15 p.m.

Henrik G. Dohlman, University of North Carolina at Chapel Hill
“G Protein regulation by mono- and poly-ubiquitination”

5:15 – 5:45 p.m.

Jurgen Wess, Molecular Signaling Section, NIDDK, National Institutes of Health
“Phenotypic analysis of conditional muscarinic V2 vasopressin receptor knockout mice:  Clinical implications”

5:45 - 6:15 p.m.

Janet Robishaw, Weis Center for Research, Geisinger Clinic
“In vivo veritas: Using zebrafish and mice to probe the biological function off G protein g subtypes”

6:15 – 6:35 p.m.

Chau Nguyen, University of Western Ontario
“RGS2 inhibits protein synthesis and cell growth”

6:35 – 8:00 p.m.

Dinner (M&T Bank Ballroom)

8:00 – 8:45 p.m.

Keynote Address, Hyman Niznik Memorial Lecture (Gallery Auditorium)
Introduction: Alan V. Smrcka

Thomas P. Sakmar, The Rockefeller University
“Molecular mechanisms of transmembrane signal transduction by G protein-coupled receptors”

8:45 –

Welcome reception (Vanden Brul Pavilion)

Friday, October 16, 2009

7:15 – 8:15 a.m.

Breakfast (Strathallan Hotel)

Session II:  Structure and Function of GPCR signaling (Gallery Auditorium)
Session Chair:  Mark Dumont

8:30 – 9:00 a.m.

Steven O. Smith, State University of New York at Stony Brook
“Structural insights into the mechanism of light-activation of the visual pigment rhodopsin”

9:00 – 9:30 a.m.

Stephen Sprang, University of Montana, Missoula
“The role of protein dynamics in Ric-8A-catalyzed nucleotide exchange”

9:30 – 10:00 a.m.

John J.G. Tesmer, University of Michigan
“Activation of G protein-coupled receptor kinases by GPCRs”

10:00 – 10:20 a.m.

Dong Soo Kang,  Thomas Jefferson University
“Structure of an arrestin2/clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking”

10:20 – 11:00 a.m.

Coffee Break (Bausch and Lomb Parlor)

Session III: Scaffolding and Trafficking of GPCRs, (Gallery Auditorium)
Session Chair:  Paul J. Kammermeier

11:00 – 11:30 a.m.

Mark Dell'acqua, University of Colorado, Denver
“Organization of cAMP and calcium second messenger signaling pathways at the postsynaptic excitatory neuronal synapses”

11:30 – 12:00 noon

Stéphane Laporte, McGill University
“Regulation of G protein coupled receptor signaling by b-arrestin”

12:00 – 12:30 p.m.

Patricia M. Hinkle, University of Rochester Medical Center
“Regulation of melanocortin receptor trafficking and signaling by novel accessory proteins”

12:30 – 1:00 p.m.

Katherine Roche, Receptor Biology Section, NINDS, National Institutes of Health
“Regulation of mGluR trafficking

1:00 – 2:00 p.m.

Lunch (M&T Bank Ballroom)

Session IV: GPCR activation and Signaling Mechanisms (Gallery Auditorium)
Sponsored by the Alejandro Zaffaroni Fund in the Department of Pharmacology and Physiology, University of Rochester Medical Center
Session Chair:  Alan V. Smrcka

2:00 – 2:30 p.m.

Michel Bouvier, Université de Montréal
“Dynamics of G protein signalling complexes determining ligand-biased signalling and functional selectivity”

2:30 – 3:00 p.m.

Roger Sunahara, University of Michigan
“Molecular mechanisms of hormone activation of G protein coupled receptors.”

3:00 – 3:30 p.m.

Maurine Linder, Cornell University
“DHHC Palmitoyltransferases”

3:30 – 3:50 p.m.

Nevin A. Lambert, Medical College of Georgia
“Constitutive association of GPCRs and G proteins studied with third-party BRET”

5:00 – 7:00 p.m.

Poster Session I (Vanden Brul Pavilion)

7:30 p.m.

Dinner (M&T Bank Ballroom)

Saturday, October 17, 2009

7:15 – 8:15 a.m.

Breakfast (Strathallan Hotel)

Session V: GPCR Directed Ligand Screening (Gallery Auditorium)
Session Chair:  Michel Bouvier

8:30 – 9:00 a.m.

Bryan Roth, University of North Carolina
“Novel GPCR-based therapeutics to treat human disease.”

9:00 – 9:30 a.m.

P. Jeffrey Conn, Vanderbilt University Medical Center
“Allosteric modulators of GPCRs as a novel approach for treatment of CNS disorders”

9:30 – 10:00 a.m.

Marlene Jacobson, Merck
“Allosteric modulators of metabotropic glutamate receptors for the treatment of schizophrenia”

10:00 – 10:20 a.m.

Wayne Stallaert, Université de Montréal
“Monitoring the multiple signalling pathways of G protein-coupled receptors using a label-free impedance-based detection method

10:30 – 11:00 a.m.

Coffee Break (Bausch and Lomb Parlor)

Session VI: G protein Coupled Receptor Signaling (Gallery Auditorium)
Session Chair:  Gregory G. Tall

11:00 – 11:30 a.m.

Paul Sternweis, University of Texas, Southwestern Medical Center at Dallas
“Mechanisms for regulation of RhoGEFs by the heterotrimeric G12 and G13 Proteins”

11:30 – 12:00 noon

David P. Siderovski, University of North Carolina at Chapel Hill
“GoLoco and RGS proteins: Emerging genetic and small molecule tools to assess function

12:00 – 12:30 p.m.

Joe Blumer, Medical University of South Carolina
“Receptor regulation of the AGS4 – G-protein interaction”

12:30 – 12:50 p.m.

Lily Jiang, University of Texas Southwestern Medical Center at Dallas
“A novel regulation of cAMP signaling in the immune system”

1:00 – 2:00 p.m.

Lunch (M&T Bank Ballroom)

Session VII: Translational/Pharmacogenomics (Gallery Auditorium)
Session Chair:  Louis M. Luttrell

2:00 – 2:30 p.m.

Stephen B. Liggett, University of Maryland School of Medicine
“Pharmacogenomics of cardiovascular disease”

2:30 – 3:00 p.m.

Paul Insel, University of California at San Diego
“GPCRs and cAMP signaling components as novel drug targets in disease”

3:00 – 3:30 p.m.

Ross Feldman, Robarts Research Institute
“Regulation of cAMP synthesis beyond GPCR/G protein activation: Implications in cardiovascular regulation”

3:30 – 3:50 p.m.

Kristina Lorenz, University of Würzburg
“A new pathway for cardiac hypertrophy: G-proteins and ERK-phosphorylation”

5:00 – 7:00 p.m.

Poster Session II (Vanden Brul Pavilion)

7:30 p.m.

Dinner (M&T Bank Ballroom)

Sunday, October 18, 2009

7:15 – 8:15 a.m.

Breakfast (Strathallan Hotel)

Depart