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-Topics - MAPKinase Pathways and Signaling to the Nucleus G Protein Coupled Receptor Turnoff
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Signal Transduction (IND 447)Signaling in Apoptosis Over the last decade, research on cell death and cell survival has evolved from a descriptive
analysis of phenomenology to a rather detailed understanding of the
molecular mechanisms that control cell fate. An underlying principle
that has emerged from this research is that cell fate, like cell proliferation
and cell differentiation, can be regulated by specific signal transduction
pathways activated in response to extracellular cues. In this series
of lectures we will discuss in detail the cell death signaling pathway
that is initiated when the Fas receptor is bound by its extracellular
ligand, FasL. Important themes from these lectures are: Ø
that protein-protein interactions play a key role in activating
cell death events, Ø
that regulation of cell death occurs in part by interfacing
signals generated at the cell surface with events at the mitochondria, Ø
that the ultimate effectors of cell death are a unique class
of cysteine proteases called caspases. The papers that will be discussed during the reading day concern signal transduction mechanisms
that regulate cell survival. In some cases, these survival pathways directly and negatively
regulate cell death effectors. References
Paper Readings:
Azad Bonni et al., Cell
survival promoted by the Ras-MAPK signaling pathway by transcription-dependent
and -independent mechanisms. Science Vol. 286, 1358, 12 November 1999
Antonella
Riccio et al., Mediation by a CREB family transcription factor of NGF-dependent
survival of sympathetic neurons. Science Vol. 286, 2358, 17 December 1999
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